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Conserved domains on  [gi|1907125918|ref|XP_036016662|]
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fibronectin type III domain-containing protein 1 isoform X3 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637190)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-27 subunit beta that associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1534-1625 7.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 7.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1534 APRNITVVAMEgcHSFVIVDWNK-AIPGDVVTGYLVYsasYEDFIRNKW---STQTSSVTHLPIENLKPNTRYYFKVQAK 1609
Cdd:cd00063      3 PPTNLRVTDVT--STSVTLSWTPpEDDGGPITGYVVE---YREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918 1610 NPHGYGPVSPSVSFVT 1625
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 573-1146 9.69e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.19  E-value: 9.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  573 PDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAqprSHSLLQGGSS 652
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA---NEPDPHPPPT 2645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  653 RPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEedtsdggadidraagdTRRRAeataqiqqTRPALGHFSLIRNK 732
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR----------------PRRRA--------ARPTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  733 PFPAHSRNPSRFPKLRGPRLqPSRSPQSTSASKVLTRAPSLPASHTRPGSDVygdGEDEEPLPATVVNDRTPSSSSHPIS 812
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPG---GPARPARPPTTAGPPAPAPPAAPAA 2777

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  813 GGSDTLRRGSQRGASLYRKE-PIPENSKAAGADVHPGGKSPLSSKAQgfqlstdegAPQTPPSSTSRQLSPARHPASRSQ 891
Cdd:PHA03247  2778 GPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLAPAAALPPAASP---------AGPLPPPTSAQPTAPPPPPGPPPP 2848

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  892 PSP--GSTVP----RRMAPGRSSELSSSQSKD---RSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQNEGSQSSYEDN 962
Cdd:PHA03247  2849 SLPlgGSVAPggdvRRRPPSRSPAAKPAAPARppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  963 STEIEGPDPRAPTHSAHAKDTTPsilkpqqmgsQSGNSGNRPQPsRSGAserpIRPGsthpRVQVPGRAGLQATPAKKIS 1042
Cdd:PHA03247  2929 PQPPPPPPPRPQPPLAPTTDPAG----------AGEPSGAVPQP-WLGA----LVPG----RVAVPRFRVPQPAPSREAP 2989

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1043 SSkhPLPPESQQSVFTEEEEENEGILKGKEDSLSTSVKK--WPSSSSPRNNKYADRNLDRDKAAIGQLvqeeDSIPGrrS 1120
Cdd:PHA03247  2990 AS--STPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlWPPDDTEDSDADSLFDSDSERSDLEAL----DPLPP--E 3061

                          570       580
                   ....*....|....*....|....*.
gi 1907125918 1121 PGSPPiaSHPPTWYQPRNPVTASPSA 1146
Cdd:PHA03247  3062 PHDPF--AHEPDPATPEAGARESPSS 3085
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 2.63e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  258 DVPEDISVRVMSSQSVLVAWvDPLVEKQKRVVasrQYTVRYREKGESA--RWDYKQVSNRRVLVDSLIPDTVYEFAVRIS 335
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSW-TPPEDDGGPIT---GYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918  336 QGERDGKWSASIFQRT 351
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 37-117 5.88e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 5.88e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918    37 PLKPRHVKLLS-TNMGLKVTWDPPKDASSR-PVEYYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHS 114
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907125918   115 GVS 117
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 155-238 5.73e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.73e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   155 PNKPLRMRVRA-SDDRLSVAWKAPRLSGAKSPRRsrGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTN 233
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV--GYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1907125918   234 SQGQS 238
Cdd:smart00060   79 GAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1534-1625 7.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 7.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1534 APRNITVVAMEgcHSFVIVDWNK-AIPGDVVTGYLVYsasYEDFIRNKW---STQTSSVTHLPIENLKPNTRYYFKVQAK 1609
Cdd:cd00063      3 PPTNLRVTDVT--STSVTLSWTPpEDDGGPITGYVVE---YREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918 1610 NPHGYGPVSPSVSFVT 1625
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 573-1146 9.69e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.19  E-value: 9.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  573 PDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAqprSHSLLQGGSS 652
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA---NEPDPHPPPT 2645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  653 RPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEedtsdggadidraagdTRRRAeataqiqqTRPALGHFSLIRNK 732
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR----------------PRRRA--------ARPTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  733 PFPAHSRNPSRFPKLRGPRLqPSRSPQSTSASKVLTRAPSLPASHTRPGSDVygdGEDEEPLPATVVNDRTPSSSSHPIS 812
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPG---GPARPARPPTTAGPPAPAPPAAPAA 2777

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  813 GGSDTLRRGSQRGASLYRKE-PIPENSKAAGADVHPGGKSPLSSKAQgfqlstdegAPQTPPSSTSRQLSPARHPASRSQ 891
Cdd:PHA03247  2778 GPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLAPAAALPPAASP---------AGPLPPPTSAQPTAPPPPPGPPPP 2848

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  892 PSP--GSTVP----RRMAPGRSSELSSSQSKD---RSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQNEGSQSSYEDN 962
Cdd:PHA03247  2849 SLPlgGSVAPggdvRRRPPSRSPAAKPAAPARppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  963 STEIEGPDPRAPTHSAHAKDTTPsilkpqqmgsQSGNSGNRPQPsRSGAserpIRPGsthpRVQVPGRAGLQATPAKKIS 1042
Cdd:PHA03247  2929 PQPPPPPPPRPQPPLAPTTDPAG----------AGEPSGAVPQP-WLGA----LVPG----RVAVPRFRVPQPAPSREAP 2989

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1043 SSkhPLPPESQQSVFTEEEEENEGILKGKEDSLSTSVKK--WPSSSSPRNNKYADRNLDRDKAAIGQLvqeeDSIPGrrS 1120
Cdd:PHA03247  2990 AS--STPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlWPPDDTEDSDADSLFDSDSERSDLEAL----DPLPP--E 3061

                          570       580
                   ....*....|....*....|....*.
gi 1907125918 1121 PGSPPiaSHPPTWYQPRNPVTASPSA 1146
Cdd:PHA03247  3062 PHDPF--AHEPDPATPEAGARESPSS 3085
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 2.63e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  258 DVPEDISVRVMSSQSVLVAWvDPLVEKQKRVVasrQYTVRYREKGESA--RWDYKQVSNRRVLVDSLIPDTVYEFAVRIS 335
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSW-TPPEDDGGPIT---GYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918  336 QGERDGKWSASIFQRT 351
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 37-117 5.88e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 5.88e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918    37 PLKPRHVKLLS-TNMGLKVTWDPPKDASSR-PVEYYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHS 114
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907125918   115 GVS 117
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1534-1615 3.45e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 3.45e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  1534 APRNITVVAMEGchSFVIVDWNKAiPGDVVTGYLV-YSASYEDfIRNKWSTQ--TSSVTHLPIENLKPNTRYYFKVQAKN 1610
Cdd:smart00060    3 PPSNLRVTDVTS--TSVTLSWEPP-PDDGITGYIVgYRVEYRE-EGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1907125918  1611 PHGYG 1615
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 37-124 1.06e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   37 PLKPRHVKLLSTNMG-LKVTWDPPKDASSrPVEYYNIAYgKSLKSLKSIKVN---AETHSFLIKDVEPGVVYFVLVTAEN 112
Cdd:cd00063      1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGG-PITGYVVEY-REKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|..
gi 1907125918  113 HSGVSRPVYRAE 124
Cdd:cd00063     79 GGGESPPSESVT 90
fn3 pfam00041
Fibronectin type III domain;
258-344 8.39e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 8.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  258 DVPEDISVRVMSSQSVLVAWVDPlvEKQKRVVASrqYTVRYREKGESARWDYKQVSN--RRVLVDSLIPDTVYEFAVRIS 335
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPP--PDGNGPITG--YEVEYRPKNSGEPWNEITVPGttTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 1907125918  336 QGERDGKWS 344
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
52-119 4.26e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 4.26e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   52 LKVTWDPPKDASSrPVEYYNIAYGK--SLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHSGVSRP 119
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEYRPknSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1525-1630 6.18e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 6.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1525 TKSDLPPQhAPRNITVVAMEGchSFVIVDWNKAiPGDVVTGYLVYSASYEDFirnKWST--QTSSVTHLPIENLKPNTRY 1602
Cdd:COG3401    321 TTDLTPPA-APSGLTATAVGS--SSITLSWTAS-SDADVTGYNVYRSTSGGG---TYTKiaETVTTTSYTDTGLTPGTTY 393

                           90       100
                   ....*....|....*....|....*....
gi 1907125918 1603 YFKVQAKNPHG-YGPVSPSVSFVTESDNP 1630
Cdd:COG3401    394 YYKVTAVDAAGnESAPSEEVSATTASAAS 422
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 260-333 7.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 7.63e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907125918   260 PEDISVRVMSSQSVLVAWVDPLVEkqkrvvASRQYTVRYREKGESARWDYKQV----SNRRVLVDSLIPDTVYEFAVR 333
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDD------GITGYIVGYRVEYREEGSEWKEVnvtpSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1534-1618 7.88e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1534 APRNITVVAMEgcHSFVIVDWNKAIPGD-VVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPH 1612
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPPDGNgPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1907125918 1613 GYGPVS 1618
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 155-238 5.73e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.73e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   155 PNKPLRMRVRA-SDDRLSVAWKAPRLSGAKSPRRsrGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTN 233
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV--GYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1907125918   234 SQGQS 238
Cdd:smart00060   79 GAGEG 83
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1534-1625 7.57e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.20  E-value: 7.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1534 APRNITVVAMEgcHSFVIVDWNK-AIPGDVVTGYLVYsasYEDFIRNKW---STQTSSVTHLPIENLKPNTRYYFKVQAK 1609
Cdd:cd00063      3 PPTNLRVTDVT--STSVTLSWTPpEDDGGPITGYVVE---YREKGSGDWkevEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918 1610 NPHGYGPVSPSVSFVT 1625
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 573-1146 9.69e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.19  E-value: 9.69e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  573 PDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAqprSHSLLQGGSS 652
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA---NEPDPHPPPT 2645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  653 RPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEedtsdggadidraagdTRRRAeataqiqqTRPALGHFSLIRNK 732
Cdd:PHA03247  2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR----------------PRRRA--------ARPTVGSLTSLADP 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  733 PFPAHSRNPSRFPKLRGPRLqPSRSPQSTSASKVLTRAPSLPASHTRPGSDVygdGEDEEPLPATVVNDRTPSSSSHPIS 812
Cdd:PHA03247  2702 PPPPPTPEPAPHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPG---GPARPARPPTTAGPPAPAPPAAPAA 2777

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  813 GGSDTLRRGSQRGASLYRKE-PIPENSKAAGADVHPGGKSPLSSKAQgfqlstdegAPQTPPSSTSRQLSPARHPASRSQ 891
Cdd:PHA03247  2778 GPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLAPAAALPPAASP---------AGPLPPPTSAQPTAPPPPPGPPPP 2848

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  892 PSP--GSTVP----RRMAPGRSSELSSSQSKD---RSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQNEGSQSSYEDN 962
Cdd:PHA03247  2849 SLPlgGSVAPggdvRRRPPSRSPAAKPAAPARppvRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  963 STEIEGPDPRAPTHSAHAKDTTPsilkpqqmgsQSGNSGNRPQPsRSGAserpIRPGsthpRVQVPGRAGLQATPAKKIS 1042
Cdd:PHA03247  2929 PQPPPPPPPRPQPPLAPTTDPAG----------AGEPSGAVPQP-WLGA----LVPG----RVAVPRFRVPQPAPSREAP 2989

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1043 SSkhPLPPESQQSVFTEEEEENEGILKGKEDSLSTSVKK--WPSSSSPRNNKYADRNLDRDKAAIGQLvqeeDSIPGrrS 1120
Cdd:PHA03247  2990 AS--STPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQtlWPPDDTEDSDADSLFDSDSERSDLEAL----DPLPP--E 3061

                          570       580
                   ....*....|....*....|....*.
gi 1907125918 1121 PGSPPiaSHPPTWYQPRNPVTASPSA 1146
Cdd:PHA03247  3062 PHDPF--AHEPDPATPEAGARESPSS 3085
PHA03247 PHA03247
large tegument protein UL36; Provisional
 780-1217 8.61e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.11  E-value: 8.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  780 PGSDVY-GDGEDEEPLPATVVNDRtPSSSSHpisggsdtLRRGSQRGASLYRKEPIPENSKAAGADVHPGGKSPlsskaq 858
Cdd:PHA03247  2439 PGGDVLaGLAADGDPFFARTILGA-PFSLSL--------LLGELFPGAPVYRRPAEARFPFAAGAAPDPGGGGP------ 2503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  859 gfqlsTDEGAPQTPPSSTsrqlsparhPASRSQPSPGSTVPRRM-----------------APGRSSELSSSQSKDRSLS 921
Cdd:PHA03247  2504 -----PDPDAPPAPSRLA---------PAILPDEPVGEPVHPRMltwirgleelasddagdPPPPLPPAAPPAAPDRSVP 2569

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  922 QPKLSLAHTGPdrphAANSRGVLPSAPQNQNEGSQSSYEDNsteiegpDPRAPTHSAHAKDTTPSILKPQQMGSQSGNSG 1001
Cdd:PHA03247  2570 PPRPAPRPSEP----AVTSRARRPDAPPQSARPRAPVDDRG-------DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1002 NRPQPSRSGASERPiRPGSTHPRVQVPGRAGLQATPAKKISSSKHPLPPESQQSVFT-EEEEENEGILKGKEDSLSTSVK 1080
Cdd:PHA03247  2639 DPHPPPTVPPPERP-RDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHALVS 2717

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1081 KWPSSSSPRNNKYADRNLDRDKAAigQLVQEEDSIP-GRRSPGSPPIASHPPTWYQPRNPVTASPSASTH------SWPR 1153
Cdd:PHA03247  2718 ATPLPPGPAAARQASPALPAAPAP--PAVPAGPATPgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRpavaslSESR 2795

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907125918 1154 YTTRAPSTYSSTTPMLSLRQRMQRRFRTPVSRQPPP-RPVLTSGYNGRANVGENIPPGSIGKPNG 1217
Cdd:PHA03247  2796 ESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPtSAQPTAPPPPPGPPPPSLPLGGSVAPGG 2860
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 258-351 2.63e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.88  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  258 DVPEDISVRVMSSQSVLVAWvDPLVEKQKRVVasrQYTVRYREKGESA--RWDYKQVSNRRVLVDSLIPDTVYEFAVRIS 335
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSW-TPPEDDGGPIT---GYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1907125918  336 QGERDGKWSASIFQRT 351
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 37-117 5.88e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.85  E-value: 5.88e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918    37 PLKPRHVKLLS-TNMGLKVTWDPPKDASSR-PVEYYNIAYGKSLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHS 114
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITgYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1907125918   115 GVS 117
Cdd:smart00060   81 GEG 83
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 573-974 6.69e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.87  E-value: 6.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  573 PDPKAVSSPSSPKNPARSRLTSVPSRHAASNMLRDKSRMQPGTKASSSSASSQSHSSTSEEDSSAAAQPRSHSLLQGGSS 652
Cdd:PHA03307    65 FEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSP 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  653 RPALSRDRQDVHASSSRMPSQTVSSSRPSALtegseeedtsdggADIDRAAGDTRRRAEATAQIQQTRPALGHFSLIRNK 732
Cdd:PHA03307   145 GPPPAASPPAAGASPAAVASDAASSRQAALP-------------LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  733 PFPAHSRNPSRfpklRGPRLQPSRSPQSTSASkvltrapslpASHTRPGSDVYGDGEDEEPLPATVVNDRTPSSSSHPIS 812
Cdd:PHA03307   212 PISASASSPAP----APGRSAADDAGASSSDS----------SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  813 GGSDTLRRGSQRGASLYRKEPIPENSKAAGADVHPGGKSPLSSKAQGFQLSTDEGAPQTPPSSTSRQLSPARHPASrSQP 892
Cdd:PHA03307   278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP-SRP 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  893 SPGSTVPRRMAPGRSSELSSSqskdRSLSQPKLSLAHTGPDRPHAANSRGVLPSAPQNQnegSQSSYEDNSTEIEGPDPR 972
Cdd:PHA03307   357 PPPADPSSPRKRPRPSRAPSS----PAASAGRPTRRRARAAVAGRARRRDATGRFPAGR---PRPSPLDAGAASGAFYAR 429


                   ..
gi 1907125918  973 AP 974
Cdd:PHA03307   430 YP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
 409-959 3.27e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 3.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  409 PEKLQQPSSPAPK----VAASSEHTPSAKN--------VKDALSDLNKIRTNSVVPGKTQLHSKMGELDPQSTEVTGEEE 476
Cdd:PHA03247  2564 PDRSVPPPRPAPRpsepAVTSRARRPDAPPqsarprapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  477 LDSLEDPRSSRLETLNQKQPLRVPSRSGH--GVLTPGRTPARTGLP--VLPRKEVMDRRGPSLDPHLRPRVEPSASSAYH 552
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRaaQASSPPQRPRRRAARptVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  553 QLSSiDNDSVDQNEYDQAGSPDPKAVSSPSSPKNPARSRLTSVPSRHAAsnmlrdkSRMQPGTKASSSSASSQSHSSTSE 632
Cdd:PHA03247  2724 GPAA-ARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP-------PAAPAAGPPRRLTRPAVASLSESR 2795

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  633 EDSSAAAQPRSHSllqggSSRPALSRDRQDVHASSSRMPSQTVSSSRPSALTEGSEEEDTSDGGADIdrAAGDTRRRaeA 712
Cdd:PHA03247  2796 ESLPSPWDPADPP-----AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA--PGGDVRRR--P 2866

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  713 TAQIQQTRPALGHFSLIRNKPFPAHSRNPSRFPKlrgPRLQPSRSPQSTSASKVLTRAPSLPAshtrpgsdvygdgedEE 792
Cdd:PHA03247  2867 PSRSPAAKPAAPARPPVRRLARPAVSRSTESFAL---PPDQPERPPQPQAPPPPQPQPQPPPP---------------PQ 2928

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  793 PLPAtvvnDRTPSSSSHPISGGSDTLRRGSQRGASlyrkePIPENskaagadvhpGGKSPLSSKAQGFQLSTDEGAPQTP 872
Cdd:PHA03247  2929 PQPP----PPPPPRPQPPLAPTTDPAGAGEPSGAV-----PQPWL----------GALVPGRVAVPRFRVPQPAPSREAP 2989

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  873 PSSTSrqlSPARHPASR-------------SQPSPGSTVPRRMAPGRSSELSSSQSKDRSLSQPKLSLAHTGPDRPHAAN 939
Cdd:PHA03247  2990 ASSTP---PLTGHSLSRvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPF 3066

                          570       580
                   ....*....|....*....|
gi 1907125918  940 SRGVLPSAPQNQNEGSQSSY 959
Cdd:PHA03247  3067 AHEPDPATPEAGARESPSSQ 3086
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1534-1615 3.45e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 3.45e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  1534 APRNITVVAMEGchSFVIVDWNKAiPGDVVTGYLV-YSASYEDfIRNKWSTQ--TSSVTHLPIENLKPNTRYYFKVQAKN 1610
Cdd:smart00060    3 PPSNLRVTDVTS--TSVTLSWEPP-PDDGITGYIVgYRVEYRE-EGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1907125918  1611 PHGYG 1615
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 37-124 1.06e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   37 PLKPRHVKLLSTNMG-LKVTWDPPKDASSrPVEYYNIAYgKSLKSLKSIKVN---AETHSFLIKDVEPGVVYFVLVTAEN 112
Cdd:cd00063      1 PSPPTNLRVTDVTSTsVTLSWTPPEDDGG-PITGYVVEY-REKGSGDWKEVEvtpGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|..
gi 1907125918  113 HSGVSRPVYRAE 124
Cdd:cd00063     79 GGGESPPSESVT 90
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 702-1200 6.10e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.33  E-value: 6.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  702 AAGDTRRRAEATAQIQQTRPALGHFSLIRNKPFPAHSrNPSRFPKLRGPRLQPSRSPQSTSASKVLTRAPSLPASHTRPG 781
Cdd:PHA03307    16 EGGEFFPRPPATPGDAADDLLSGSQGQLVSDSAELAA-VTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  782 SDVYGDGEDEEPLPATVVNDRTPSSSSHPISGGSDTlrrgsqrgaslyrKEPIPENSKAAGADVHPGGKSPLSSKAQgfq 861
Cdd:PHA03307    95 LAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSP-------------APDLSEMLRPVGSPGPPPAASPPAAGAS--- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  862 lSTDEGAPQTPPSSTSRqLSPARHPASRSQPSPGSTVPRRMAPGRSSELSSSQskDRSLSQPKLSLAHTGPDRPHAANSR 941
Cdd:PHA03307   159 -PAAVASDAASSRQAAL-PLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRR--SSPISASASSPAPAPGRSAADDAGA 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  942 GVLPSAPqnqnegSQSSYEDNSTEIEGPDPRAPthsahakdttPSILKPQQM-GSQSGNSGNRPQPSRSGASERPIRPGS 1020
Cdd:PHA03307   235 SSSDSSS------SESSGCGWGPENECPLPRPA----------PITLPTRIWeASGWNGPSSRPGPASSSSSPRERSPSP 298

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1021 ThprvqvPGRAGLQATPAKKISSSKHPLPPESqqsvfteeeeenegilkgkeDSLSTSvkkwPSSSSPRnnkyadrnldr 1100
Cdd:PHA03307   299 S------PSSPGSGPAPSSPRASSSSSSSRES--------------------SSSSTS----SSSESSR----------- 337

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1101 dkaaigqlvqeEDSIPGRRSPGSPPIASHPPTWYQPRNPVTASPSASTHSWPRYTTRAPSTYSSTTPMLSLRQRMQRRFR 1180
Cdd:PHA03307   338 -----------GAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406

                          490       500
                   ....*....|....*....|
gi 1907125918 1181 TPVSRqPPPRPVLTSGYNGR 1200
Cdd:PHA03307   407 FPAGR-PRPSPLDAGAASGA 425
fn3 pfam00041
Fibronectin type III domain;
258-344 8.39e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 45.48  E-value: 8.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  258 DVPEDISVRVMSSQSVLVAWVDPlvEKQKRVVASrqYTVRYREKGESARWDYKQVSN--RRVLVDSLIPDTVYEFAVRIS 335
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPP--PDGNGPITG--YEVEYRPKNSGEPWNEITVPGttTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 1907125918  336 QGERDGKWS 344
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
52-119 4.26e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.56  E-value: 4.26e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   52 LKVTWDPPKDASSrPVEYYNIAYGK--SLKSLKSIKVNAETHSFLIKDVEPGVVYFVLVTAENHSGVSRP 119
Cdd:pfam00041   16 LTVSWTPPPDGNG-PITGYEVEYRPknSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1525-1630 6.18e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 47.69  E-value: 6.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1525 TKSDLPPQhAPRNITVVAMEGchSFVIVDWNKAiPGDVVTGYLVYSASYEDFirnKWST--QTSSVTHLPIENLKPNTRY 1602
Cdd:COG3401    321 TTDLTPPA-APSGLTATAVGS--SSITLSWTAS-SDADVTGYNVYRSTSGGG---TYTKiaETVTTTSYTDTGLTPGTTY 393

                           90       100
                   ....*....|....*....|....*....
gi 1907125918 1603 YFKVQAKNPHG-YGPVSPSVSFVTESDNP 1630
Cdd:COG3401    394 YYKVTAVDAAGnESAPSEEVSATTASAAS 422
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 260-333 7.63e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 7.63e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907125918   260 PEDISVRVMSSQSVLVAWVDPLVEkqkrvvASRQYTVRYREKGESARWDYKQV----SNRRVLVDSLIPDTVYEFAVR 333
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDD------GITGYIVGYRVEYREEGSEWKEVnvtpSSTSYTLTGLKPGTEYEFRVR 75
fn3 pfam00041
Fibronectin type III domain;
1534-1618 7.88e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1534 APRNITVVAMEgcHSFVIVDWNKAIPGD-VVTGYLVYSASYEDFIRNKWSTQTSSVTHLPIENLKPNTRYYFKVQAKNPH 1612
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPPDGNgPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1907125918 1613 GYGPVS 1618
Cdd:pfam00041   80 GEGPPS 85
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 634-1023 8.25e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 8.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  634 DSSAAAQPRSHSLLQGGSSRPALSRDRQDVHASSSRMPSQTVSSSRPsaltEGSEEEDTSDGGADIDRA---AGDTRRRA 710
Cdd:PHA03307    56 VAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAR----EGSPTPPGPSSPDPPPPTpppASPPPSPA 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  711 EATAQIQQTRPALGHFSLIRNKPFPAHSRNPSRFPKLRGPRLQPSRSPQSTSASKVltrapslPASHTRPGSDVYGDGED 790
Cdd:PHA03307   132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPS-------SPPAEPPPSTPPAAASP 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  791 EEPLPATVVNDRTPSSSSHPISGGSDTLRRGSQRGASLYRKEPIPENSKAAGADVHPGGKSPLSSKAQGFQLSTDEGAPQ 870
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGP 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  871 TPPSSTSRQLSPArhPASRSQPSPGSTVPRRMAPGRSSELSSSQSKDRSLSQPKLSLA-HTGPDR-PHAANSRGVLPSAP 948
Cdd:PHA03307   285 ASSSSSPRERSPS--PSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAvSPGPSPsRSPSPSRPPPPADP 362

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907125918  949 QNQNEGSQSSYEDNSTEIEGPDPRAPThsahAKDTTPSILKPQQMGSQSGnsGNRPQPSRSGASERPIRPGSTHP 1023
Cdd:PHA03307   363 SSPRKRPRPSRAPSSPAASAGRPTRRR----ARAAVAGRARRRDATGRFP--AGRPRPSPLDAGAASGAFYARYP 431
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 155-238 5.73e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.29  E-value: 5.73e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918   155 PNKPLRMRVRA-SDDRLSVAWKAPRLSGAKSPRRsrGFLLGYGESGRKMNYVPLTRDERSHEIKKLASESVYVVSLQSTN 233
Cdd:smart00060    1 PSPPSNLRVTDvTSTSVTLSWEPPPDDGITGYIV--GYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1907125918   234 SQGQS 238
Cdd:smart00060   79 GAGEG 83
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 1550-1625 5.61e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 37.77  E-value: 5.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918 1550 VIVDWNkaiPGDVVTGYLVYSASYEDFIRNKWSTQTSSVT----------HLPIENLKPNTRYYFKVQAKNphgyGPVSP 1619
Cdd:pfam16656   15 MTVSWV---TPSAVTSPVVQYGTSSSALTSTATATSSTYTtgdggtgyihRATLTGLEPGTTYYYRVGDDN----GGWSE 87


                   ....*.
gi 1907125918 1620 SVSFVT 1625
Cdd:pfam16656   88 VYSFTT 93
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 482-904 9.03e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 9.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  482 DPRSSRLETLNQKQPLRVPSRSGHGVLTPGRTPARTGLPVLPRKEVMDRRGPSLDPHLRPRvepsassayhqlssidnds 561
Cdd:PHA03307    81 ANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPV------------------- 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  562 vdqneydqAGSPDPKAVSSPSSPKNPARSRLTSVPSRHAASNmlrdkSRMQPGTKASSSSASSQSHSSTSEEDSSAAAQP 641
Cdd:PHA03307   142 --------GSPGPPPAASPPAAGASPAAVASDAASSRQAALP-----LSSPEETARAPSSPPAEPPPSTPPAAASPRPPR 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  642 RSHSLLQGGSSRPALSRDRQDVHASSSRMpsqtVSSSRPSALTEGSEEEDTSDGGADIDRAAGDTRRRAEATaqiqqtrp 721
Cdd:PHA03307   209 RSSPISASASSPAPAPGRSAADDAGASSS----DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWN-------- 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  722 alghfslirNKPFPAHSRNPSRFPKLRGPRLQPSRspqstsaskvltraPSLPASHTRPGSDVYGDGEDEEPLPATvvnd 801
Cdd:PHA03307   277 ---------GPSSRPGPASSSSSPRERSPSPSPSS--------------PGSGPAPSSPRASSSSSSSRESSSSST---- 329

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907125918  802 rtpSSSSHPISGGSDTLRRGSQRGASLYR-KEPIPENSKAAGADVHPGGKSPLSSKAQgfqlSTDEGAPQTPPSSTSRQL 880
Cdd:PHA03307   330 ---SSSSESSRGAAVSPGPSPSRSPSPSRpPPPADPSSPRKRPRPSRAPSSPAASAGR----PTRRRARAAVAGRARRRD 402

                          410       420
                   ....*....|....*....|....
gi 1907125918  881 SPARHPASRSQPSPGSTVPRRMAP 904
Cdd:PHA03307   403 ATGRFPAGRPRPSPLDAGAASGAF 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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