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Conserved domains on  [gi|1907153709|ref|XP_036019438|]
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GDH/6PGL endoplasmic bifunctional protein isoform X2 [Mus musculus]

Protein Classification

PTZ00309 and 6PGL domain-containing protein( domain architecture ID 13232975)

PTZ00309 and 6PGL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 6.09e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 6.09e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 100
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309  128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 256
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 257 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 332
Cdd:PTZ00309  286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 412
Cdd:PTZ00309  363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 413 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 486
Cdd:PTZ00309  421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                         490
                  ....*....|....*...
gi 1907153709 487 LLDSL-AFEV-PRPYPGG 502
Cdd:PTZ00309  495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 4.77e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.42  E-value: 4.77e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 554 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 6.09e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 6.09e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 100
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309  128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 256
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 257 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 332
Cdd:PTZ00309  286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 412
Cdd:PTZ00309  363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 413 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 486
Cdd:PTZ00309  421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                         490
                  ....*....|....*...
gi 1907153709 487 LLDSL-AFEV-PRPYPGG 502
Cdd:PTZ00309  495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 4.77e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.42  E-value: 4.77e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 554 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
556-780 1.23e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 265.64  E-value: 1.23e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 556 AWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQ 635
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 636 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPTGLDGDQ 712
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 713 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 780
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 25-502 3.28e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.81  E-value: 3.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAA---LTAPQQGQKLMDKVLESlscPKDLVPSRCDELKG 97
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVArrdWSVEEFRKVVREAIIKF---ETDEIDEQWDEFAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  98 QFLQLSQyrQLKTVEDYQTLNKDIEtQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:TIGR00871  77 RLSYVSG--DVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 257
Cdd:TIGR00871 154 ASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGAL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 258 RDTLQNHLTEILTLVAMELPlNISSSAAVLQHKLWAFQALRGLQK--SSAILGQYQAysGQVRRElQKP-----DGF--Q 328
Cdd:TIGR00871 233 RDMVQNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdkD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 329 SLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERhwvpEQSRCLPQQIIFYIGHGElghpA 408
Cdd:TIGR00871 309 SNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKAN----ERDANPRNALVIRIQPDE----G 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 409 ILVSRNLFKPSLpTQKWKEVQ-DQPGLRLFGRPLSdyyayrpvreqDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 487
Cdd:TIGR00871 381 VYLKFNAKKPGL-NFETRPVKlDFSYASRFGELLP-----------EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPI 448

                         490
                  ....*....|....*...
gi 1907153709 488 LDSLAF---EVPRPYPGG 502
Cdd:TIGR00871 449 LEAWAAnkgPSPPNYPAG 466
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 559-782 6.68e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 252.87  E-value: 6.68e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 559 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHL 638
Cdd:cd01400     1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 639 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSP-TGLDGDQLVVL 716
Cdd:cd01400    80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907153709 717 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 782
Cdd:cd01400   154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 25-372 8.94e-77

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 256.93  E-value: 8.94e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELK-GQFL 100
Cdd:COG0364    12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:COG0364    84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 257
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 258 RDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKS----SAILGQYQAysGQVRRELQKP----DGF-- 327
Cdd:COG0364   240 RDMVQNHLLQLLCLVAMEPPASLDAD-AIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIGGEPVPGyreePGVap 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1907153709 328 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN 372
Cdd:COG0364   317 DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
225-502 3.83e-62

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 210.76  E-value: 3.83e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 225 LWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSS 304
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAE-DIRDEKVKVLRSLRPITPED 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 305 ----AILGQYQAysGQVRRELQK---------PDgfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK 371
Cdd:pfam02781  92 vednVVRGQYGA--GWIGGEPVPgyreeegvpPD---SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 372 NrayctqserhwVP-----EQSRCLPQQIIFYIGHGElghpAILVSRNLFKpslptqkwkevqdqPGLRLFGRPLS---D 443
Cdd:pfam02781 167 D-----------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfS 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907153709 444 YYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGG 502
Cdd:pfam02781 218 YSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 558-786 9.58e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 9.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 558 PEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERC-VPLSDPDSNFQGL 634
Cdd:COG0363    10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 635 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLV 714
Cdd:COG0363    90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 715 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 780
Cdd:COG0363   162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                  ....*.
gi 1907153709 781 YMDYEA 786
Cdd:COG0363   238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 559-786 1.62e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 121.12  E-value: 1.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 559 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSpIALFQQLATGHY--SFPWAHTHLWLVDERCVPLSDPDSNFQGLQA 636
Cdd:PLN02360   20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 637 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 705
Cdd:PLN02360   99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 706 T-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 781
Cdd:PLN02360  173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                  ....*
gi 1907153709 782 MDYEA 786
Cdd:PLN02360  253 LDKPA 257
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-502 6.09e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 6.09e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  23 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 100
Cdd:PTZ00309   55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 176
Cdd:PTZ00309  128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 177 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 256
Cdd:PTZ00309  207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 257 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 332
Cdd:PTZ00309  286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 333 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 412
Cdd:PTZ00309  363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 413 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 486
Cdd:PTZ00309  421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                         490
                  ....*....|....*...
gi 1907153709 487 LLDSL-AFEV-PRPYPGG 502
Cdd:PTZ00309  495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 554-789 4.77e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.42  E-value: 4.77e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 554 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 633
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 634 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 710
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 711 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 789
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
556-780 1.23e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 265.64  E-value: 1.23e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 556 AWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQ 635
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 636 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPTGLDGDQ 712
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 713 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 780
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 20-503 1.97e-83

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 274.68  E-value: 1.97e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  20 KGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTaPQQGQKLMDKVLESLSCPKDlvpsRCDELKGQF 99
Cdd:PLN02539   15 TGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKN----APAEAVSKF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 100 LQLSQYRQ--LKTVEDYQTLNKDI-ETQVQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGH 175
Cdd:PLN02539   90 LQLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 176 DHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIILKETIDAEGRASFYEEYG 255
Cdd:PLN02539  170 DLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 256 VIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYsgqvRRELQKPDGfqSLTPTFA 335
Cdd:PLN02539  249 IIRDIIQNHLLQVLCLVAMEKPVSLKPE-HIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPDD--SNTPTFA 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 336 GVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVP-EQSRCLPQqiifyighgelghpailvSRN 414
Cdd:PLN02539  322 SVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD-----------VPgDIFKCQKQ------------------GRN 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 415 LF----KPSlPTQKWKEVQDQPGLRLFGRP----LSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 486
Cdd:PLN02539  373 EFvirlQPS-EAMYMKLTVKQPGLEMSTVQseldLSYGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTP 451

                         490
                  ....*....|....*....
gi 1907153709 487 LLDSL-AFEV-PRPYPGGA 503
Cdd:PLN02539  452 LLHRIdAGKVkPIPYKQGS 470
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 25-502 3.28e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.81  E-value: 3.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAA---LTAPQQGQKLMDKVLESlscPKDLVPSRCDELKG 97
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVArrdWSVEEFRKVVREAIIKF---ETDEIDEQWDEFAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  98 QFLQLSQyrQLKTVEDYQTLNKDIEtQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:TIGR00871  77 RLSYVSG--DVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 257
Cdd:TIGR00871 154 ASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGAL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 258 RDTLQNHLTEILTLVAMELPlNISSSAAVLQHKLWAFQALRGLQK--SSAILGQYQAysGQVRRElQKP-----DGF--Q 328
Cdd:TIGR00871 233 RDMVQNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdkD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 329 SLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERhwvpEQSRCLPQQIIFYIGHGElghpA 408
Cdd:TIGR00871 309 SNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKAN----ERDANPRNALVIRIQPDE----G 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 409 ILVSRNLFKPSLpTQKWKEVQ-DQPGLRLFGRPLSdyyayrpvreqDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 487
Cdd:TIGR00871 381 VYLKFNAKKPGL-NFETRPVKlDFSYASRFGELLP-----------EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPI 448

                         490
                  ....*....|....*...
gi 1907153709 488 LDSLAF---EVPRPYPGG 502
Cdd:TIGR00871 449 LEAWAAnkgPSPPNYPAG 466
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 25-502 2.37e-82

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 271.62  E-value: 2.37e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELKGQ-FL 100
Cdd:PRK05722   12 LVIFGATGDLARRKLLPALYNLYKA----GLlpeDFRIIGVARR-DWSDEDFREVVREAL---KEFARTPFDEEVWErFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYRQ--LKTVEDYQTLNKDIETQVQQDGLwEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHL 178
Cdd:PRK05722   84 SRLYYVSgdVTDPESYERLKELLEELDEERGT-GGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 179 SAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 257
Cdd:PRK05722  163 SARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 258 RDTLQNHLTEILTLVAMELPLNIsSSAAVLQHKLWAFQALRGLQ----KSSAILGQYQA--YSGQVRRELQKPDGF--QS 329
Cdd:PRK05722  241 RDMVQNHLLQLLALVAMEPPASL-DADSIRDEKVKVLRALRPITpedvKENTVRGQYTAgwIGGKPVPGYREEEGVnpDS 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 330 LTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKnrayctqserhwvpeqsrCLPQQiIFYIGHGELgHPAI 409
Cdd:PRK05722  320 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFK------------------PPPHN-LFEESAEEL-GPNK 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 410 LVSRnlfkpslptqkwkeVQD-----------QPGLRLFGRPLS---DYYAYRPVREQDAYSTLL-------SHIFHCRK 468
Cdd:PRK05722  380 LVIR--------------IQPdegislrfnakVPGEGMELRPVKldfSYSEAFGEASPEAYERLLldvmlgdQTLFVRRD 445

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1907153709 469 EsfittenLLASWVFWTPLLDslAFEV----PRPYPGG 502
Cdd:PRK05722  446 E-------VEAAWKWVDPILE--AWEAdggpPPPYPAG 474
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 559-782 6.68e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 252.87  E-value: 6.68e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 559 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHL 638
Cdd:cd01400     1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 639 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSP-TGLDGDQLVVL 716
Cdd:cd01400    80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907153709 717 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 782
Cdd:cd01400   154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 25-372 8.94e-77

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 256.93  E-value: 8.94e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELK-GQFL 100
Cdd:COG0364    12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 101 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 177
Cdd:COG0364    84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 178 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 257
Cdd:COG0364   161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 258 RDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKS----SAILGQYQAysGQVRRELQKP----DGF-- 327
Cdd:COG0364   240 RDMVQNHLLQLLCLVAMEPPASLDAD-AIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIGGEPVPGyreePGVap 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1907153709 328 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN 372
Cdd:COG0364   317 DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 15-503 1.13e-71

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 245.31  E-value: 1.13e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  15 QAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGKGHSFSFHGAALTAPQQgQKLMDKVLESLSCPKDlVPSRCDE 94
Cdd:PLN02640   81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRID-QRENCGD 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  95 LKGQFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAG----RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVV 168
Cdd:PLN02640  158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKEK-------EAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 169 FEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRA 248
Cdd:PLN02640  230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 249 SFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYSGQVRR------ELQ 322
Cdd:PLN02640  309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKSypaytdDPT 387

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 323 KPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN-------RAYCTQSERHWVPEQSRCLPQQi 395
Cdd:PLN02640  388 VPKH--SLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHvpgnlykRNFGTDLDKATNELVLRVQPDE- 464

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 396 ifyighgelghpAILVSRNLFKPSLptqkwkevqdqpGLRLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITT 474
Cdd:PLN02640  465 ------------AIYLKINNKVPGL------------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRS 520

                         490       500       510
                  ....*....|....*....|....*....|.
gi 1907153709 475 ENLLASWVFWTPLLDSLAFE--VPRPYPGGA 503
Cdd:PLN02640  521 DELDAAWALFTPLLKELEEKkiIPELYPYGS 551
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 23-503 3.10e-71

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 244.89  E-value: 3.10e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  23 VSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHsFSFHGAALTAPQQGQkLMDKVLESLSCPKDlVPSRCDELKGQFLQL 102
Cdd:PLN02333  118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARSKMTDAE-LRNMVSKTLTCRID-KRENCGEKMEEFLKR 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 103 SQYR--QLKTVEDYQTLNKDIEtqvQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHDHLSA 180
Cdd:PLN02333  195 CFYHsgQYDSQEHFAELDKKLK---EHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEKPFGRDSESS 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 181 QQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDT 260
Cdd:PLN02333  271 AALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDI 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 261 LQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVR-----RELQKPDGfqSLTPTF 334
Cdd:PLN02333  350 MQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMRPIQLEDVVIGQYKSHTkGGVTypaytDDKTVPKG--SLTPTF 426

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 335 AGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK-------NRAYCTQSERHWVPEQSRCLPQQiifyighgelghp 407
Cdd:PLN02333  427 AAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRhvpgnlyNRNFGTDLDQATNELVIRVQPDE------------- 493

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 408 AILVSRNLFKPSLptqkwkevqdqpGLRLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 486
Cdd:PLN02333  494 AIYLKINNKVPGL------------GMRLDRSNLNLLYAARYSKEiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTP 561

                         490
                  ....*....|....*....
gi 1907153709 487 LLDSLAFE--VPRPYPGGA 503
Cdd:PLN02333  562 LLKELEEKkiIPEYYPYGS 580
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
25-502 2.29e-68

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 233.64  E-value: 2.29e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  25 IILLGATGDLAKKYLWQGLFQLYLDEAgKGHSFSFHGAALTAPQQGQ--KLMDKVLESLScPKDLVPSRCDelkgQFLQL 102
Cdd:PRK12853   11 LVIFGATGDLARRKLLPALYRLARAGL-LPEDLRIIGVGRDDWSDEQwrARVRESLRAFG-ADGFDDAVWD----RLAAR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 103 SQYRQ--LKTVEDYQTLNKDIETQVQqdglweagRIFYFSVPPFAYADIARNINSS-CRPhpgAWLRVVFEKPFGHDHLS 179
Cdd:PRK12853   85 LSYVQgdVTDPADYARLAEALGPGGN--------PVFYLAVPPSLFAPVVENLGAAgLLP---EGRRVVLEKPFGHDLAS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 180 AQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRD 259
Cdd:PRK12853  154 ARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 260 TLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAIL--GQYQAysGQVRRE-----LQKPDGF-QSLT 331
Cdd:PRK12853  233 MVQNHLLQLLALVAMEPPASFDAD-AVRDEKAKVLRAIRPLDPDDVHTvrGQYTA--GTVGGEpvpgyREEPGVDpDSRT 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 332 PTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKnRAYCTQserhwVPEQSRCLPQQIIFYIGHGELGHPAILV 411
Cdd:PRK12853  310 ETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFK-PVPHAL-----FRGTGVEPPNRLVIRLQPDEGISLELNV 383

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 412 SRnlfkpslptqkwkevqdqPGLRLFGRPLSDYYAYR-PVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDS 490
Cdd:PRK12853  384 KR------------------PGPGMRLRPVELDADYAdDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDA 445

                         490
                  ....*....|....
gi 1907153709 491 LA--FEVPRPYPGG 502
Cdd:PRK12853  446 WAadPVPPHEYPAG 459
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 15-512 8.47e-63

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 218.75  E-value: 8.47e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  15 QAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLDE--------AGKGHSfsfhgaALTAPQQGQKLMDKVLESLSCPKD 86
Cdd:PRK12854    4 QGTGPAPPTVFVLFGATGDLAKRKLLPGLFHLARAGllppdwriVGTGRG------DVSAEAFREHARDALDEFGARKLD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  87 lvpsrcDELKGQFLQLSQYRQLK-TVEDYQTLnKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNInsscrphPGAWL 165
Cdd:PRK12854   78 ------DGEWARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRAL-------GEAGL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 166 ----RVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKET 241
Cdd:PRK12854  144 aegsRVVMEKPFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPET 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 242 IDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNIsSSAAVLQHKLWAFQALRGLQKSSAILGQYQAYsgqvRREL 321
Cdd:PRK12854  223 LGVDTRAAFYDATGAYRDMVVTHLFQVLAFVAMEPPTAL-EPDAISEEKNKVFRSMRPLDPAEVVRGQYSGY----RDEP 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 322 QKPDgfQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwvpeqsrclPQQIIFYIGH 401
Cdd:PRK12854  298 GVAP--DSTTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE-------------------PPYSMFPAGS 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 402 GELGHPAILVsrnlFKPSLPTQKWKEVQDQ---PGLRLfgRPLSDYYAYRPVREQ----DAYSTLLSHIFHCRKESFITT 474
Cdd:PRK12854  357 VGAQGPDHLT----FDLADNSKVSLSFYGKrpgPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFTTA 430

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1907153709 475 ENLLASWVFWTPLLDSLAfeVPRPYPGG-----------AENGQLLDFE 512
Cdd:PRK12854  431 DGIESLWEVSQPLLEDPP--PVKPYAPGswgpnaihqlaAPDAWRLPFE 477
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
225-502 3.83e-62

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 210.76  E-value: 3.83e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 225 LWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSS 304
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAE-DIRDEKVKVLRSLRPITPED 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 305 ----AILGQYQAysGQVRRELQK---------PDgfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK 371
Cdd:pfam02781  92 vednVVRGQYGA--GWIGGEPVPgyreeegvpPD---SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 372 NrayctqserhwVP-----EQSRCLPQQIIFYIGHGElghpAILVSRNLFKpslptqkwkevqdqPGLRLFGRPLS---D 443
Cdd:pfam02781 167 D-----------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfS 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907153709 444 YYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGG 502
Cdd:pfam02781 218 YSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 558-786 9.58e-56

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 9.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 558 PEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERC-VPLSDPDSNFQGL 634
Cdd:COG0363    10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 635 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLV 714
Cdd:COG0363    90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 715 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 780
Cdd:COG0363   162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                  ....*.
gi 1907153709 781 YMDYEA 786
Cdd:COG0363   238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
26-208 2.06e-41

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 149.50  E-value: 2.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709  26 ILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLSCPKDlvpsRCDELKGQFLQL 102
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD----GLlpeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLER 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 103 SQYRQ--LKTVEDYQTLNKDIEtqvQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSA 180
Cdd:pfam00479  72 LHYVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESA 148

                         170       180
                  ....*....|....*....|....*...
gi 1907153709 181 QQLASELGSFFQEEEMYRVDHYLGKQAV 208
Cdd:pfam00479 149 RELNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 559-786 1.62e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 121.12  E-value: 1.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 559 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSpIALFQQLATGHY--SFPWAHTHLWLVDERCVPLSDPDSNFQGLQA 636
Cdd:PLN02360   20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 637 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 705
Cdd:PLN02360   99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 706 T-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 781
Cdd:PLN02360  173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                  ....*
gi 1907153709 782 MDYEA 786
Cdd:PLN02360  253 LDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 570-769 5.90e-15

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 74.83  E-value: 5.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 570 EAAA---VQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERcVPLS--DPDSNFQGLQAHLLQHV 642
Cdd:cd01399     5 EAAAeliAELIREKPPAVLGLATGSTPLGVYEELIELHKEggLSFSNVTTFNLDEY-VGLPpdHPQSYHYFMRENLFDHI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 643 RVPYYNIHPMPVhlhqrLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPTGLDGD-QLVVLTES-- 719
Cdd:cd01399    84 DIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLDSRtRVVTLDEStr 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907153709 720 -----PFR-----PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRVGHEP--KKWPIS 769
Cdd:cd01399   154 qanarFFDgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 582-697 7.84e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 55.82  E-value: 7.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 582 KFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLhqrlc 661
Cdd:cd00458    21 DMVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSL----- 95

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907153709 662 AEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHT 697
Cdd:cd00458    96 PIEKACEKYEREILDQV---DAIDLAVDGAGYRAGT 128
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 583-769 3.71e-07

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 52.07  E-value: 3.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 583 FHLALSGGSSPIALFQQLATGH----YSFpwAHTHLWLVDERC-VPLSDPDSNFQGLQAHLLQHVrvpyyNIHPMPVHLH 657
Cdd:PTZ00285   35 FVLGLPTGSTPLPTYQELIRAYregrVSF--SNVVTFNMDEYVgLPRDHPQSYHYFMKENFFDHV-----DIKEENRHIL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 658 QRLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPtgLDGDQLVV-LTESPFR-------------P 723
Cdd:PTZ00285  108 NGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSS--LDSRTRVKsLNQETIDanarffgndiskvP 182

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1907153709 724 HQRMSLSLPLINRAKKVAVLVMGRTKREITT--LVSRVGHepkKWPIS 769
Cdd:PTZ00285  183 TMALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPAS 227
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 562-769 8.50e-06

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 47.90  E-value: 8.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 562 ISKLASDIEAAAVQA--VRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDE-RCVPLSDPDS--NFqgL 634
Cdd:PRK00443   12 VGKWAARHIANRINAflPTKERPFVLGLATGSSPLETYKALIELHKAgkVDFSRVTTFNLDEyVGLPADHPESyrYF--M 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 635 QAHLLQHVrvpyyNIHPMPVHLHQRLCAEEDQGAQTYASEIsalVANSSFDLVLLGMGTDGHTAslFPQSPTGLDGDQLV 714
Cdd:PRK00443   90 RENFFDHV-----DIPPENINLLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FNEPGSSFASRTRI 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907153709 715 V-LTESPFR-------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIT--TLVSRVGHEpkkWPIS 769
Cdd:PRK00443  160 KtLTEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 558-752 2.72e-05

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 47.72  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 558 PEELISKLASDIeAAAVQAVRHFGKFH-LALSGGSSPIALFQQLATGH----YSFPwaHTHLWLVDERcVPLS--DPDSN 630
Cdd:PRK02122   36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreegLSFK--NVITFNLDEY-YPMQpdSLQSY 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 631 FQGLQAHLLQHVRVPYYNIHPMPVHLHQrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPTGLD- 709
Cdd:PRK02122  112 HRFMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIG--FNEPGSGRNs 183

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907153709 710 GDQLVVLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREI 752
Cdd:PRK02122  184 RTRLVTLDHITRRdaasdffgeenvPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
582-696 1.28e-03

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 41.28  E-value: 1.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907153709 582 KFHLALSGGSSPIALFQQLATGHYSFPW-AHTHLWLVDErcVPLSDPDS---NFQGLQAHLLQHVRVPYYNIHPMPVhlh 657
Cdd:PRK12358   29 RVNLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI--- 103

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907153709 658 qrlcaeedqgaQTYASEISALVANSSFDLVLLGMGTDGH 696
Cdd:PRK12358  104 -----------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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