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Conserved domains on  [gi|1907160229|ref|XP_036020660|]
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citron Rho-interacting kinase isoform X20 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1233-1529 1.82e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


:

Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.82e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1233 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1305
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1306 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1379
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1380 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1455
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  1456 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1529
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 984-1039 4.53e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


:

Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.22  E-value: 4.53e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  984 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-827 5.47e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 113.61  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQK-----FYLET 446
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNElgrvtFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  447 QAGKLEAQNRKLEE------------QLEKISHQDHSDKSRLL-----------------ELETRLREVSLEHE------ 491
Cdd:TIGR02168  580 SIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlvvddldnalelakKLRPGYRIVTLDGDlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 ----------------EQKL-ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 554
Cdd:TIGR02168  660 vitggsaktnssilerRREIeELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE 739

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  555 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 634
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLN 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR--- 711
Cdd:TIGR02168  817 EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRsel 896

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  712 QVVELAVKEHKAEILALQQALKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ 791
Cdd:TIGR02168  897 EELSEELRELESKRSELRRELEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDD 966

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  792 ----KNHIFRLTQGLQE-------ALD-------RADLLKTERSDLEYQLENIQ 827
Cdd:TIGR02168  967 eeeaRRRLKRLENKIKElgpvnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1069-1188 8.63e-08

PH domain; PH stands for pleckstrin homology.


:

Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1069 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1148
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907160229 1149 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1188
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 699-976 1.90e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  699 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 776
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  777 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 853
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  854 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 933
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1907160229  934 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 976
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1545-1636 1.34e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1545 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1608
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1907160229 1609 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1636
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 7.40e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


:

Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883     42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883    122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                          170
                   ....*....|....
gi 1907160229  139 YESELRESRLAAEE 152
Cdd:COG3883    201 LEAELAAAEAAAAA 214
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1233-1529 1.82e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.82e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1233 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1305
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1306 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1379
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1380 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1455
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  1456 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1529
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1241-1493 4.89e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.21  E-value: 4.89e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1241 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1319
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1320 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1397
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1398 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1477
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1907160229 1478 YLFVTHFNSLEVIEIQ 1493
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 984-1039 4.53e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.22  E-value: 4.53e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  984 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-827 5.47e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 113.61  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQK-----FYLET 446
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNElgrvtFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  447 QAGKLEAQNRKLEE------------QLEKISHQDHSDKSRLL-----------------ELETRLREVSLEHE------ 491
Cdd:TIGR02168  580 SIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlvvddldnalelakKLRPGYRIVTLDGDlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 ----------------EQKL-ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 554
Cdd:TIGR02168  660 vitggsaktnssilerRREIeELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE 739

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  555 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 634
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLN 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR--- 711
Cdd:TIGR02168  817 EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRsel 896

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  712 QVVELAVKEHKAEILALQQALKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ 791
Cdd:TIGR02168  897 EELSEELRELESKRSELRRELEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDD 966

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  792 ----KNHIFRLTQGLQE-------ALD-------RADLLKTERSDLEYQLENIQ 827
Cdd:TIGR02168  967 eeeaRRRLKRLENKIKElgpvnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 215-820 1.18e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 105.79  E-value: 1.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  215 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtme 294
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE--- 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRH 374
Cdd:COG1196    281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE----LEEELEELEEELEEAEEELEEA 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  375 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAGKLEAQ 454
Cdd:COG1196    357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL---EELEEALAEL 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  455 NRKLEEQLEKISHQDhSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKt 534
Cdd:COG1196    434 EEEEEEEEEALEEAA-EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK- 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  535 eLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQL 612
Cdd:COG1196    512 -AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRAR 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  613 RSEVDHLRREITEREMQLTSQKQTMEALKTTCTM--LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQ 690
Cdd:COG1196    586 AALAAALARGAIGAAVDLVASDLREADARYYVLGdtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTG 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  691 RMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE 770
Cdd:COG1196    665 GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  771 RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-------ALD-------RADLLKTERSDLE 820
Cdd:COG1196    745 EELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-786 3.50e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 91.57  E-value: 3.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDI--REQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANE 159
Cdd:pfam02463  323 KKKAEKELKKEKEEIeeLEKELKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  160 CQHKLMKVVShpprgdsggtALDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKavKASTEAT 239
Cdd:pfam02463  399 LKSEEEKEAQ----------LLLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEK--QELKLLK 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  240 ELLQNIRQAKERAERELEKLH-NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLkDDIQTKSEQIQQMADKI 318
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQeQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI-ISAHGRLGDLGVAVENY 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:pfam02463  542 KVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRL-LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDK 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 478
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  479 LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 558
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEER 780

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  559 RKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTME 638
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLE 860

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  639 ALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRITESRQVVELA 717
Cdd:pfam02463  861 EEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILLKYEEEPEEL 940

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  718 VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 786
Cdd:pfam02463  941 LLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
PTZ00121 PTZ00121
MAEBL; Provisional
 2-871 2.01e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.96  E-value: 2.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARME 81
Cdd:PTZ00121  1096 AFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKA 1172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIR--EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKAN 158
Cdd:PTZ00121  1173 EDAKKAEAARKAEEVRkaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAE 1240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  159 ECQHklmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTE- 237
Cdd:PTZ00121  1241 EAKK------AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEa 1314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  238 --ATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQqma 315
Cdd:PTZ00121  1315 kkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--- 1391

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  316 dKILELEEKHREAQVSAQhlevHLKQKEqhyEEKIKVldNQIKKDLADKESLENMMQRHEE--EAHEKGKILSEQKamiN 393
Cdd:PTZ00121  1392 -KADEAKKKAEEDKKKAD----ELKKAA---AAKKKA--DEAKKKAEEKKKADEAKKKAEEakKADEAKKKAEEAK---K 1458

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  394 AMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS 471
Cdd:PTZ00121  1459 AEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEakKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  472 DKSRLLELETRLREVSLEHEEQKLELKRQLTElqlslQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALT 551
Cdd:PTZ00121  1537 DEAKKAEEKKKADELKKAEELKKAEEKKKAEE-----AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  552 AHRDEIQR-KFDALRNsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND-EIVQLRSEVDHLRREITEREMQ 629
Cdd:PTZ00121  1612 AKKAEEAKiKAEELKK--------AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKiKAAEEAKKAEEDKKKAEEAKKA 1683

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  630 LTSQKQTMEALKTTctmlEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITE 709
Cdd:PTZ00121  1684 EEDEKKAAEALKKE----AEEAKKAEELKKKEAEEKKKAEELKK----AEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE 1755

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  710 SRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLnDLEKKHAMLEMNARSLQQ------------KLETERELKQ 775
Cdd:PTZ00121  1756 KKKIAHLKKEEEKKaeEIRKEKEAVIEEELDEEDEKRRM-EVDKKIKDIFDNFANIIEggkegnlvindsKEMEDSAIKE 1834

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  776 RLLEEQAKLQQQMDLQKnHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK---MEGTISQQT---KLID 849
Cdd:PTZ00121  1835 VADSKNMQLEEADAFEK-HKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDkddIEREIPNNNmagKNND 1913

                          890       900
                   ....*....|....*....|..
gi 1907160229  850 FLQAKMDQPAKKKKGLFSRRKE 871
Cdd:PTZ00121  1914 IIDDKLDKDEYIKRDAEETREE 1935
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 988-1036 1.99e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.99e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1907160229   988 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1036
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1241-1492 2.31e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1241 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1312
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1313 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1381
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1382 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1460
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1907160229 1461 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1492
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1069-1188 8.63e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1069 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1148
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907160229 1149 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1188
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1069-1188 3.25e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 3.25e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1069 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1148
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1907160229  1149 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1188
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 699-976 1.90e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  699 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 776
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  777 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 853
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  854 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 933
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1907160229  934 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 976
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 983-1038 1.97e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907160229  983 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1038
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1545-1636 1.34e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1545 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1608
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1907160229 1609 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1636
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1070-1115 7.15e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907160229 1070 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1115
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2-377 8.96e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 8.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKchKMEQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARM 80
Cdd:NF033838   112 EAELTSKTKKELDAAFE--QFKKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDV 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   81 EVSQEDdkaLQLLHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRLAAEEFKRKANEC 160
Cdd:NF033838   184 EVKKAE---LELVKEEAKEPRDEEKIKQAK--AKVESKKAEATRLEK-IKTDREKAEEEAKRRADAKLKEAVEKNVATSE 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  161 QHKLMKVVShppRGDSGGTALDDlhKMQGHAgltsakDQGKPEVGEYS------KLEKINAEQQLKIQELQEKLEK---- 230
Cdd:NF033838   258 QDKPKRRAK---RGVLGEPATPD--KKENDA------KSSDSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkee 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  231 ------AVKASTEATELLQNIRQAKErAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDI 304
Cdd:NF033838   327 drrnypTNTYKTLELEIAESDVKVKE-AELELVKEEAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDR 395

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  305 QTKSEQIQQMADKILELEEKHREAQVSAQHLEVhlkQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 377
Cdd:NF033838   396 KKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP---EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 7.40e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883     42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883    122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                          170
                   ....*....|....
gi 1907160229  139 YESELRESRLAAEE 152
Cdd:COG3883    201 LEAELAAAEAAAAA 214
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 220-349 5.43e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 5.43e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIK----KKLVEA-EERRHSLENKVKRLETME 294
Cdd:smart00787  152 NLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDptelDRAKEKlKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229   295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK 349
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
 
Name Accession Description Interval E-value
CNH smart00036
Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;
1233-1529 1.82e-78

Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2;


Pssm-ID: 214481  Cd Length: 302  Bit Score: 261.90  E-value: 1.82e-78
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1233 DMNCTLPFSDQ--VVLVGTEEGLYALNVLK--NSLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKVKQS 1305
Cdd:smart00036    2 TAKWNHPITCDgkWLLVGTEEGLYVLNISDqpGTLEKLIGRRSVTQIWVLEENNVLLMISGKkpqLYSHPLSALVEKKEA 81

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1306 LAQSHLPAQPDVSPNiFEAVKGCHLFAAGKIENSLCICAAMPSKVVIL-RYNDNLSKYCIR-----KEIETSEPCSCIHF 1379
Cdd:smart00036   82 LGSARLVIRKNVLTK-IPDVKGCHLCAVVNGKRSLFLCVALQSSVVLLqWYNPLKKFKLFKskflfPLISPVPVFVELVS 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1380 TNY---SILIGTNKfYEIDMKQYTLDeFLDKNDHSLAPAVFASSSNSFPVSIVQANsagqreEYLLCFHEFGVFVDSYG- 1455
Cdd:smart00036  161 SSFerpGICIGSDK-GGGDVVQFHES-LVSKEDLSLPFLSEETSLKPISVVQVPRD------EVLLCYDEFGVFVNLYGk 232

                           250       260       270       280       290       300       310
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  1456 RRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSLGSPARAylEIPNPRYLGPaiSSGAIYLASSY 1529
Cdd:smart00036  233 RRSRNPILHWEFMPESFAYHSPYLLAFHDNGIEIRSIKTGELLQELADR--ETRKIRLLGS--SDRKILLSSSP 302
CNH pfam00780
CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished ...
 1241-1493 4.89e-68

CNH domain; Domain found in NIK1-like kinase, mouse citron and yeast ROM1, ROM2. Unpublished observations.


Pssm-ID: 459938  Cd Length: 261  Bit Score: 230.21  E-value: 4.89e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1241 SDQVVLVGTEEGLYALNV-LKNSLTHIPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKkvkqSLAQSHLPAQPDVSP 1319
Cdd:pfam00780    1 GGQNLLLGTEEGLYVLNRsGPREPVRIIDKKRVTQLAVLEEFNLLLLLSGKDKRLYVYPLS----ALDSREENDRKDAAK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1320 NIFEAVKGCHLFAAGKIENSLCICAAMPSKVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNYSILIGTNKFYE-IDMK 1397
Cdd:pfam00780   77 NKLPETKGCHFFKVGRHSNGRFLVVAVKRTIKLLEWYEPLLdKFRKFKEFYLPSPPVSIELLKSKLCVGCAKGFEiVSLD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1398 QYTLDEFLdkndhsLAPAVFASSSNSFPVSIVQANsagqREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREP 1477
Cdd:pfam00780  157 SKATESLL------TSLLFANRQENLKPLAVVRLD----RSEFLLCYNEFGVYVNLQGRRSRPWEIEWEGAPEAVAYLYP 226

                          250
                   ....*....|....*.
gi 1907160229 1478 YLFVTHFNSLEVIEIQ 1493
Cdd:pfam00780  227 YLLAFHDNFIEIRDVE 242
CRIK cd20814
protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) ...
 984-1039 4.53e-38

protein kinase C conserved region 1 (C1 domain) found in citron Rho-interacting kinase (CRIK) and similar proteins; CRIK, also called serine/threonine-protein kinase 21, is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger (C1 domain), and a pleckstrin homology (PH) domain, in addition to other motifs. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410364  Cd Length: 56  Bit Score: 136.22  E-value: 4.53e-38
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  984 HNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd20814      1 HNIPHRFTTGLNMRATKCAVCLDGVPFGRQASKCSECGIVCHPKCSSSLPNTCGLP 56
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 85-827 5.47e-25

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 113.61  E-value: 5.47e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   85 EDDKALQLLHDIREQSRKLQEIKEQ--------------EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAA 150
Cdd:TIGR02168  197 ELERQLKSLERQAEKAERYKELKAElrelelallvlrleELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEV 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 EEFKRKANECQHKLMKVVShpprgdsggtaldDLHKMQGHAGLTSAKDQGkpEVGEYSKLEKINAEQQLKIQELQEKLEK 230
Cdd:TIGR02168  277 SELEEEIEELQKELYALAN-------------EISRLEQQKQILRERLAN--LERQLEELEAQLEELESKLDELAEELAE 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  231 AVKASTEATELLQNIRQAKERAERELEKLHNR----EDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKD 302
Cdd:TIGR02168  342 LEEKLEELKEELESLEAELEELEAELEELESRleelEEQLETLRSKVAQLELQIASLNNEIERLEArlerLEDRRERLQQ 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  303 DIQTKSEQIQ--QMADKILELEEKHREAQVSAQHLEVH------LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRH 374
Cdd:TIGR02168  422 EIEELLKKLEeaELKELQAELEELEEELEELQEELERLeealeeLREELEEAEQALDAAERELAQLQARLDSLERLQENL 501

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  375 EEEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQK-----FYLET 446
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLsgiLGVLSELISVDEGYEAAIEAA--LGGRLQAVVVENLNAAKKAIAFLKQNElgrvtFLPLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  447 QAGKLEAQNRKLEE------------QLEKISHQDHSDKSRLL-----------------ELETRLREVSLEHE------ 491
Cdd:TIGR02168  580 SIKGTEIQGNDREIlkniegflgvakDLVKFDPKLRKALSYLLggvlvvddldnalelakKLRPGYRIVTLDGDlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 ----------------EQKL-ELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 554
Cdd:TIGR02168  660 vitggsaktnssilerRREIeELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE 739

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  555 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 634
Cdd:TIGR02168  740 AEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE---LAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLN 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESR--- 711
Cdd:TIGR02168  817 EEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRsel 896

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  712 QVVELAVKEHKAEILALQQALKEqklkaesLSDKLNDLEKKHAMLEMNARSLQQKLeteRELKQRLLEEQAKLQQQMDLQ 791
Cdd:TIGR02168  897 EELSEELRELESKRSELRRELEE-------LREKLAQLELRLEGLEVRIDNLQERL---SEEYSLTLEEAEALENKIEDD 966

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  792 ----KNHIFRLTQGLQE-------ALD-------RADLLKTERSDLEYQLENIQ 827
Cdd:TIGR02168  967 eeeaRRRLKRLENKIKElgpvnlaAIEeyeelkeRYDFLTAQKEDLTEAKETLE 1020
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 215-820 1.18e-22

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 105.79  E-value: 1.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  215 AEQQLKIQELQEKLEKAvkastEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLEtme 294
Cdd:COG1196    209 AEKAERYRELKEELKEL-----EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELE--- 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEkikvLDNQIKKDLADKESLENMMQRH 374
Cdd:COG1196    281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE----LEEELEELEEELEEAEEELEEA 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  375 EEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKfylETQAGKLEAQ 454
Cdd:COG1196    357 EAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL---EELEEALAEL 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  455 NRKLEEQLEKISHQDhSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKt 534
Cdd:COG1196    434 EEEEEEEEEALEEAA-EEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVK- 511

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  535 eLEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvitDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG--ANDEIVQL 612
Cdd:COG1196    512 -AALLLAGLRGLAGAVAVLIGVEAAYEAALEAA-----LAAALQNIVVEDDEVAAAAIEYLKAAKAGRATflPLDKIRAR 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  613 RSEVDHLRREITEREMQLTSQKQTMEALKTTCTM--LEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRVRELQ 690
Cdd:COG1196    586 AALAAALARGAIGAAVDLVASDLREADARYYVLGdtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA-GGSLTG 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  691 RMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE 770
Cdd:COG1196    665 GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  771 RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-------ALD-------RADLLKTERSDLE 820
Cdd:COG1196    745 EELLEEEALEELPEPPDLEELERELERLEREIEAlgpvnllAIEeyeeleeRYDFLSEQREDLE 808
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 216-919 1.11e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 102.83  E-value: 1.11e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  216 EQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEkLHNREDSSEG--IKKKLVEAEERRHSLENKVKRletM 293
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELELalLVLRLEELREELEELQEELKE---A 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  294 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 370
Cdd:TIGR02168  252 EEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  371 MQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkAQEEMISELRQQKFYLETQAGK 450
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLE--------------ELEEQLETLRSKVAQLELQIAS 397

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLrevsleHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLR 530
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELLKKL------EEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  531 QAKteleettaeaeeeiQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandEIV 610
Cdd:TIGR02168  472 EAE--------------QALDAAERELAQ----LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLS----ELI 529

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  611 QLRSEV---------DHLRREITERemqLTSQKQTMEALK----TTCTMLEEQVL---DLEALNDELLEKERQWEAWRSV 674
Cdd:TIGR02168  530 SVDEGYeaaieaalgGRLQAVVVEN---LNAAKKAIAFLKqnelGRVTFLPLDSIkgtEIQGNDREILKNIEGFLGVAKD 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  675 LGDEKSQFEcrvRELQRMLD-----------TEKQSRARADQRIT-------ESRQVVELAVKEHKAEILALQQALKEQK 736
Cdd:TIGR02168  607 LVKFDPKLR---KALSYLLGgvlvvddldnaLELAKKLRPGYRIVtldgdlvRPGGVITGGSAKTNSSILERRREIEELE 683

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  737 LKAESLSDKLNDLEKKHAMLemnaRSLQQKLETERELKQRLLEEqakLQQQMDLQKNHIFRLTQGLQEALDRADLLKTER 816
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAEL----RKELEELEEELEQLRKELEE---LSRQISALRKDLARLEAEVEQLEERIAQLSKEL 756

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  817 SDLEYQLEniqvLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKAR 896
Cdd:TIGR02168  757 TELEAEIE----ELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832

                          730       740
                   ....*....|....*....|...
gi 1907160229  897 CAELEEALQKTRIELRSAREEAA 919
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 278-838 1.75e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.94  E-value: 1.75e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  278 ERRHSLENKvkrLETMERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHREAQVSAQHLEvHLKQKEQHYEEK 349
Cdd:COG1196    172 ERKEEAERK---LEATEENLERLEDILGELERQLEPLERqaekaeryRELKEELKELEAELLLLKLR-ELEAELEELEAE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  350 IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAansslftQRNMKA 429
Cdd:COG1196    248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRREL-------EERLEE 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  430 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS----------LEHEEQKLELKR 499
Cdd:COG1196    321 LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEeeleelaeelLEALRAAAELAA 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  500 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLN 579
Cdd:COG1196    401 QLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  580 QLTEDNAELNNQNFYLSKQLDEASGAND----------------EIVQLRSEVDHLRREITEREMQLTSQ---------K 634
Cdd:COG1196    481 ELLEELAEAAARLLLLLEAEADYEGFLEgvkaalllaglrglagAVAVLIGVEAAYEAALEAALAAALQNivveddevaA 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTT----CTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITES 710
Cdd:COG1196    561 AAIEYLKAAkagrATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAV 640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  711 RQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 790
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 1907160229  791 QKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKME 838
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERE 768
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 242-827 4.53e-19

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 93.93  E-value: 4.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  242 LQNIRQAKERAERELEK--------LHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerRENRLKDDIQTKSEQIQQ 313
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKklktikneLKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQ---QIKDLNDKLKKNKDKINK 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  314 M-AD-KILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLAD--------------KESLENMMQRHEE 376
Cdd:TIGR04523  101 LnSDlSKINSEIKNDKEQKNKLEVELnKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELNLLEK 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  377 EAHEKGKILSEQKAMINAMD---SKIRSLEQRIVEL-SEANKL-AANSSLFTQRNMKAQEemISELRQQKFYLETQAGKL 451
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLElllSNLKKKIQKNKSLeSQISELkKQNNQLKDNIEKKQQE--INEKTTEISNTQTQLNQL 258

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  452 EAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLE------------HEEQKLELK---RQLTELQLSLQERESQLT 516
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEisdlnnqkeqdwNKELKSELKnqeKKLEEIQNQISQNNKIIS 338

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  517 ALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ--NFY 594
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQikKLQ 418

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  595 LSKQLDEASGAN--DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQV----LDLEALNDELLEKERQW 668
Cdd:TIGR04523  419 QEKELLEKEIERlkETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSInkikQNLEQKQKELKSKEKEL 498

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  669 EAwrsvLGDEKSQFECRVRELqrmldTEKQSraradqritesrqvvELAVKEHKAEILALQqalKEQKLKaeSLSDKLN- 747
Cdd:TIGR04523  499 KK----LNEEKKELEEKVKDL-----TKKIS---------------SLKEKIEKLESEKKE---KESKIS--DLEDELNk 549

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  748 -DLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEAL-------DRADLLKTERSDL 819
Cdd:TIGR04523  550 dDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkissleKELEKAKKENEKL 629


                   ....*...
gi 1907160229  820 EYQLENIQ 827
Cdd:TIGR04523  630 SSIIKNIK 637
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 10-769 5.89e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 93.97  E-value: 5.89e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKA 89
Cdd:TIGR02168  239 EELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQL 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   90 LQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKV 167
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEElaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  168 VSHPPRGDSGGTALDDLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQ 247
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELRE 468

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  248 AKERAERELEKLHNREDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ--------------- 312
Cdd:TIGR02168  469 ELEEAEQALDAAERELAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalgg 545

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  313 ----------QMADKILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM--- 371
Cdd:TIGR02168  546 rlqavvvenlNAAKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggv 625

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  372 -----------QRHEEEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMIS 435
Cdd:TIGR02168  626 lvvddldnaleLAKKLRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIA 694

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  436 ELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERE 512
Cdd:TIGR02168  695 ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAE 774

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  513 SQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSC-------TVITDLEEQLNQLTEDN 585
Cdd:TIGR02168  775 EELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLErriaateRRLEDLEEQIEELSEDI 854

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  586 AELNNQNFYLSKQLDEasgandeivqLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKE 665
Cdd:TIGR02168  855 ESLAAEIEELEELIEE----------LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKL 924

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  666 RQWEAWRSVLGDEKSQFECRVRELQRML--------DTEKQSRARADQRITESRQ------VVELAVKEHKAEILALQQA 731
Cdd:TIGR02168  925 AQLELRLEGLEVRIDNLQERLSEEYSLTleeaealeNKIEDDEEEARRRLKRLENkikelgPVNLAAIEEYEELKERYDF 1004

                          810       820       830
                   ....*....|....*....|....*....|....*...
gi 1907160229  732 LKEQKlkaESLSDKLNDLEKkhAMLEMNARSLQQKLET 769
Cdd:TIGR02168 1005 LTAQK---EDLTEAKETLEE--AIEEIDREARERFKDT 1037
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 2-786 3.50e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 91.57  E-value: 3.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKE 322

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDI--REQSRKLQEIKEQEYQAQVEEMRlmmnQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANE 159
Cdd:pfam02463  323 KKKAEKELKKEKEEIeeLEKELKELEIKREAEEEEEEELE----KLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELE 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  160 CQHKLMKVVShpprgdsggtALDDLHKMQGHAgLTSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKavKASTEAT 239
Cdd:pfam02463  399 LKSEEEKEAQ----------LLLELARQLEDL-LKEEKKEELEILEE---EEESIELKQGKLTEEKEELEK--QELKLLK 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  240 ELLQNIRQAKERAERELEKLH-NREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLkDDIQTKSEQIQQMADKI 318
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQeQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI-ISAHGRLGDLGVAVENY 541

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:pfam02463  542 KVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRL-LIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDK 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLE 478
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  479 LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQ 558
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEER 780

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  559 RKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTME 638
Cdd:pfam02463  781 EKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLE 860

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  639 ALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSR-ARADQRITESRQVVELA 717
Cdd:pfam02463  861 EEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERiKEEAEILLKYEEEPEEL 940

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  718 VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQ 786
Cdd:pfam02463  941 LLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 11-779 7.03e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.50  E-value: 7.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKAL 90
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   91 QLLHDIREQSRKLQEIKEqeyqaQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQHKLMKVVSH 170
Cdd:TIGR02168  334 ELAEELAELEEKLEELKE-----ELESLEAELEELEAELEELESRLEELEEQL-------ETLRSKVAQLELQIASLNNE 401

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  171 PPRGDSGGTALDDLHKMQghagltsakDQGKPEVGEySKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKE 250
Cdd:TIGR02168  402 IERLEARLERLEDRRERL---------QQEIEELLK-KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  251 RAERELEKLHNREDSSEGiKKKLVEAEERRHSLENKVKRLETMERreNRLKDDIQTKSEQIQ------------------ 312
Cdd:TIGR02168  472 EAEQALDAAERELAQLQA-RLDSLERLQENLEGFSEGVKALLKNQ--SGLSGILGVLSELISvdegyeaaieaalggrlq 548

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  313 -------QMADKILELEEKHREAQV--------SAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMM------ 371
Cdd:TIGR02168  549 avvvenlNAAKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLggvlvv 628

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  372 --------QRHEEEAHE-----KGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrNMKAQEEMISELR 438
Cdd:TIGR02168  629 ddldnaleLAKKLRPGYrivtlDGDLVRPGGVITGGSAKTNSSILERRREIEELEE-----------KIEELEEKIAELE 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  439 QQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR---QLTELQLSLQERESQL 515
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaEIEELEERLEEAEEEL 777

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  516 TALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNnqnfyl 595
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS------ 851

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  596 skqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVLDLEALNDELLEKERQWEAwrsvL 675
Cdd:TIGR02168  852 ----EDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE---LEELSEELRELESKRSELRRELEE----L 920

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  676 GDEKSQFECRVRELQRMLDtEKQSRARADQRITEsrQVVELAVKEHKAEILALQQALK--EQKLKA------------ES 741
Cdd:TIGR02168  921 REKLAQLELRLEGLEVRID-NLQERLSEEYSLTL--EEAEALENKIEDDEEEARRRLKrlENKIKElgpvnlaaieeyEE 997

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 1907160229  742 LSDKLNDLEKKHAMLEMNARSLQQKL-ETERELKQRLLE 779
Cdd:TIGR02168  998 LKERYDFLTAQKEDLTEAKETLEEAIeEIDREARERFKD 1036
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 208-751 9.99e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 90.00  E-value: 9.99e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  208 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:COG1196    267 AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESL 367
Cdd:COG1196    347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAnsslftQRNMKAQEEMISELRQQKFYLETQ 447
Cdd:COG1196    427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLE------AALAELLEELAEAAARLLLLLEAE 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  448 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEqkLELKRQLTELQLSLQERESQLTALQAARAA--- 524
Cdd:COG1196    501 ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATflp 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  525 LESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG 604
Cdd:COG1196    579 LDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSA 658

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  605 ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAlkttctMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFE- 683
Cdd:COG1196    659 GGSLTGGSRRELLAALLEAEAELEELAERLAEEEL------ELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEa 732

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  684 CRVRELQRMLDTEKQSRARADQRITE--SRQVVELAVKEHKAEI--------LALQQaLKEQKLKAESLSDKLNDLEK 751
Cdd:COG1196    733 EREELLEELLEEEELLEEEALEELPEppDLEELERELERLEREIealgpvnlLAIEE-YEELEERYDFLSEQREDLEE 809
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 70-623 3.06e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.07  E-value: 3.06e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   70 SLKRSLEQARmevsqeddKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLA 149
Cdd:COG1196    204 PLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  150 AEEFKRKANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEvgeyskLEKINAEQQLKIQELQEKLE 229
Cdd:COG1196    276 LEELELELEEAQAEEYELLAELAR-----LEQDIARLEERRRELEERLEELEEE------LAELEEELEELEEELEELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  230 KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETME----RRENRLKDDIQ 305
Cdd:COG1196    345 ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEeallERLERLEEELE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  306 TKSEQIQQMADKILELEEKHREAQ----------VSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE 375
Cdd:COG1196    425 ELEEALAELEEEEEEEEEALEEAAeeeaeleeeeEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYE 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  376 EEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQK-----FYLETQAGK 450
Cdd:COG1196    505 GFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKagratFLPLDKIRA 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  451 LEAQNRKLEEQLEK-----------------------------ISHQDHSDKSRLLELETRLREVSLEHEEQkleLKRQL 501
Cdd:COG1196    585 RAALAAALARGAIGaavdlvasdlreadaryyvlgdtllgrtlVAARLEAALRRAVTLAGRLREVTLEGEGG---SAGGS 661

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  502 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 581
Cdd:COG1196    662 LTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|..
gi 1907160229  582 TEDNAElnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREI 623
Cdd:COG1196    742 LEEEEL-------LEEEALEELPEPPDLEELERELERLEREI 776
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-626 5.36e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.42  E-value: 5.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEAR 408

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQ 161
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ 488

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  162 HKLMKVVS----HPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvgeYSK------------LEKINAEQQLKIQELQ 225
Cdd:TIGR02168  489 ARLDSLERlqenLEGFSEGVKALLKNQSGLSGILGVLSELISVDEG---YEAaieaalggrlqaVVVENLNAAKKAIAFL 565

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  226 EKLEKA------------------------------------VKASTEATELLQN--------------IRQAKE----- 250
Cdd:TIGR02168  566 KQNELGrvtflpldsikgteiqgndreilkniegflgvakdlVKFDPKLRKALSYllggvlvvddldnaLELAKKlrpgy 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  251 -------------------RAERELEKLhNREDSSEGIKKKLVEAEERRHSLENKVKRLET----MERRENRLKDDIQTK 307
Cdd:TIGR02168  646 rivtldgdlvrpggvitggSAKTNSSIL-ERRREIEELEEKIEELEEKIAELEKALAELRKeleeLEEELEQLRKELEEL 724

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  308 SEQIQQMADKILELEEKHR--EAQVSAQHLEV-HLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKI 384
Cdd:TIGR02168  725 SRQISALRKDLARLEAEVEqlEERIAQLSKELtELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA 804

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  385 LSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 464
Cdd:TIGR02168  805 LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERAS 884

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  465 ISHQDHSDKSRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRqakteleettAEAE 544
Cdd:TIGR02168  885 LEEALALLRSELEELSEELREL----ESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS----------EEYS 950

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  545 EEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDN-------AELNNQNFYLSKQLDEASGAndeIVQLRSEVD 617
Cdd:TIGR02168  951 LTLEEAEALENKIEDDEEEARRR---LKRLENKIKELGPVNlaaieeyEELKERYDFLTAQKEDLTEA---KETLEEAIE 1024


                   ....*....
gi 1907160229  618 HLRREITER 626
Cdd:TIGR02168 1025 EIDREARER 1033
PTZ00121 PTZ00121
MAEBL; Provisional
 2-871 2.01e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 85.96  E-value: 2.01e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVElKASETQRSllEQDLATYITECSSLKRSLEQARME 81
Cdd:PTZ00121  1096 AFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDAR-KAEEARKA--EDAKRVEIARKAEDARKAEEARKA 1172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIR--EQSRKLQEIKEQEYQAQVEEMRlmmnQLEEdlvsARRrsdlYESELR-ESRLAAEEFKRKAN 158
Cdd:PTZ00121  1173 EDAKKAEAARKAEEVRkaEELRKAEDARKAEAARKAEEER----KAEE----ARK----AEDAKKaEAVKKAEEAKKDAE 1240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  159 ECQHklmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTE- 237
Cdd:PTZ00121  1241 EAKK------AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEa 1314

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  238 --ATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQqma 315
Cdd:PTZ00121  1315 kkADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK--- 1391

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  316 dKILELEEKHREAQVSAQhlevHLKQKEqhyEEKIKVldNQIKKDLADKESLENMMQRHEE--EAHEKGKILSEQKamiN 393
Cdd:PTZ00121  1392 -KADEAKKKAEEDKKKAD----ELKKAA---AAKKKA--DEAKKKAEEKKKADEAKKKAEEakKADEAKKKAEEAK---K 1458

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  394 AMDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQE--EMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS 471
Cdd:PTZ00121  1459 AEEAKKKAEEAKKAD--EAKKKAEEAKKADEAKKKAEEakKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA 1536

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  472 DKSRLLELETRLREVSLEHEEQKLELKRQLTElqlslQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALT 551
Cdd:PTZ00121  1537 DEAKKAEEKKKADELKKAEELKKAEEKKKAEE-----AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE 1611

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  552 AHRDEIQR-KFDALRNsctvitdlEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND-EIVQLRSEVDHLRREITEREMQ 629
Cdd:PTZ00121  1612 AKKAEEAKiKAEELKK--------AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKiKAAEEAKKAEEDKKKAEEAKKA 1683

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  630 LTSQKQTMEALKTTctmlEEQVLDLEALNDELLEKERQWEAWRSvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITE 709
Cdd:PTZ00121  1684 EEDEKKAAEALKKE----AEEAKKAEELKKKEAEEKKKAEELKK----AEEENKIKAEEAKKEAEEDKKKAEEAKKDEEE 1755

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  710 SRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLnDLEKKHAMLEMNARSLQQ------------KLETERELKQ 775
Cdd:PTZ00121  1756 KKKIAHLKKEEEKKaeEIRKEKEAVIEEELDEEDEKRRM-EVDKKIKDIFDNFANIIEggkegnlvindsKEMEDSAIKE 1834

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  776 RLLEEQAKLQQQMDLQKnHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK---MEGTISQQT---KLID 849
Cdd:PTZ00121  1835 VADSKNMQLEEADAFEK-HKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDkddIEREIPNNNmagKNND 1913

                          890       900
                   ....*....|....*....|..
gi 1907160229  850 FLQAKMDQPAKKKKGLFSRRKE 871
Cdd:PTZ00121  1914 IIDDKLDKDEYIKRDAEETREE 1935
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 35-923 2.31e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 85.41  E-value: 2.31e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   35 EVEAVLSQKEVElkasetqRSLLEQDLATYItecssLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 114
Cdd:pfam02463  143 KIEIIAMMKPER-------RLEIEEEAAGSR-----LKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKAL 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  115 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEfKRKANECQHKLMKvvshpprgdsggtalddlhkmqghAGLT 194
Cdd:pfam02463  211 EYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD-EQEEIESSKQEIE------------------------KEEE 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  195 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 274
Cdd:pfam02463  266 KLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELK 345

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  275 EAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD 354
Cdd:pfam02463  346 ELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEK 425

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  355 NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMI 434
Cdd:pfam02463  426 KEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKA 505

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  435 SELrqqkfyletqAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLehEEQKLELKRQLTELQLSLQERESQ 514
Cdd:pfam02463  506 RSG----------LKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAV--IVEVSATADEVEERQKLVRALTEL 573

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  515 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY 594
Cdd:pfam02463  574 PLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVS 653

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  595 LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCT-MLEEQVLDLEALNDELLEKERQWEAWRS 673
Cdd:pfam02463  654 LEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKeQREKEELKKLKLEAEELLADRVQEAQDK 733

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  674 VLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQaLKEQKLKAESLSDKLNDLEKKH 753
Cdd:pfam02463  734 INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEE-EKEEKLKAQEEELRALEEELKE 812

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  754 AMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHE 833
Cdd:pfam02463  813 EAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLA-----EEELERLEEEITKEELLQELLLKEEELEEQKLKDE 887

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  834 KVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRS 913
Cdd:pfam02463  888 LESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLL 967

                          890
                   ....*....|
gi 1907160229  914 AREEAAHRKA 923
Cdd:pfam02463  968 AKEELGKVNL 977
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
206-669 3.11e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 84.73  E-value: 3.11e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEqqlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLEN 285
Cdd:PRK03918   229 EVKELEELKEE----IEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEE 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  286 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVhLKQKEQHYEEKIKVLDN--QIKKDLAD 363
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-LEERHELYEEAKAKKEEleRLKKRLTG 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  364 K--ESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRN----MKAQEEMISE 436
Cdd:PRK03918   384 LtpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAkGKCPVCGRELTEEHrkelLEEYTAELKR 463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSLEHEEQKLE----LKRQLTEL---QLS 507
Cdd:PRK03918   464 IEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKYNLEELEKKAEeyekLKEKLIKLkgeIKS 543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  508 LQERESQLTALQAARAALESQLRQAKTELEETTAEAEEE-----------IQALtahrDEIQRKFDALRNSCTVITDLEE 576
Cdd:PRK03918   544 LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesveeleerLKEL----EPFYNEYLELKDAEKELEREEK 619

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  577 QLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDH--LRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDL 654
Cdd:PRK03918   620 ELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEEYeeLREEYLELSRELAGLRAELEELEKRREEIKKTLEKL 699

                          490
                   ....*....|....*
gi 1907160229  655 EALNDELLEKERQWE 669
Cdd:PRK03918   700 KEELEEREKAKKELE 714
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
246-838 9.71e-16

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 83.19  E-value: 9.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  246 RQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKH 325
Cdd:PRK03918   144 DESREKVVRQILGLDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREEL 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  326 REAQVSAQHLEVHlkqkeqhyEEKIKVLDNQIKKDLADKESLENMMQRHEEeahekgkilseqkaMINAMDSKIRSLEQR 405
Cdd:PRK03918   224 EKLEKEVKELEEL--------KEEIEELEKELESLEGSKRKLEEKIRELEE--------------RIEELKKEIEELEEK 281

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  406 IVELSEANKLAansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETRLRE 485
Cdd:PRK03918   282 VKELKELKEKA--------EEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELE----EKEERLEELKKKLKE 349

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  486 V-----SLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsqLRQAKTELEETTAEAEEEIQALTAHRDEIQRK 560
Cdd:PRK03918   350 LekrleELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE--LEKAKEEIEEEISKITARIGELKKEIKELKKA 427

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  561 FDALRNS------CTVITDLEEQLNQLTEDNAELNNqnfyLSKQLDEASganDEIVQLRSEVDHLRREItEREMQLTSQK 634
Cdd:PRK03918   428 IEELKKAkgkcpvCGRELTEEHRKELLEEYTAELKR----IEKELKEIE---EKERKLRKELRELEKVL-KKESELIKLK 499

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQVL-DLEALNDE---LLEKERQWEAWRSVLGDE---KSQFECRVRELQRMLDTEKQSRARADQRI 707
Cdd:PRK03918   500 ELAEQLKELEEKLKKYNLeELEKKAEEyekLKEKLIKLKGEIKSLKKElekLEELKKKLAELEKKLDELEEELAELLKEL 579

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  708 TE----SRQVVELAVKEHKA---EILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEE 780
Cdd:PRK03918   580 EElgfeSVEELEERLKELEPfynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEE 659

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  781 Q-AKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIqvlyshEKVKME 838
Cdd:PRK03918   660 EyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEER------EKAKKE 712
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 29-827 1.68e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 82.81  E-value: 1.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   29 LHRRVSEVEAVLSQKEVElkASETQRSLLEQDLAtyitecsSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKE 108
Cdd:TIGR02169  216 LLKEKREYEGYELLKEKE--ALERQKEAIERQLA-------SLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  109 QEY----------QAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHpprgdsgg 178
Cdd:TIGR02169  287 EEQlrvkekigelEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE-------- 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  179 talddlhkmqghagLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKastEATELLQNIRQAKERAERELEK 258
Cdd:TIGR02169  359 --------------YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKR---EINELKRELDRLQEELQRLSEE 421

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  259 LHNREDSSEGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVH 338
Cdd:TIGR02169  422 LADLNAAIAGIEAKINELEEE---KEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQ 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  339 LKQKEQ---HYEEKIKVLDNQIKK-------------------DLADKESLENMMQRHEEEAHEKGKILSEQKAM----- 391
Cdd:TIGR02169  499 ARASEErvrGGRAVEEVLKASIQGvhgtvaqlgsvgeryataiEVAAGNRLNNVVVEDDAVAKEAIELLKRRKAGratfl 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  392 -INAMDSKIRSLE--------QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ-KFYLETQAGKLeaqnrkleeq 461
Cdd:TIGR02169  579 pLNKMRDERRDLSilsedgviGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEAARRLMgKYRMVTLEGEL---------- 648

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  462 LEKI-SHQDHSDKSRLLELETR-LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEET 539
Cdd:TIGR02169  649 FEKSgAMTGGSRAPRGGILFSRsEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQL 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  540 TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLskqldEASGANDEIVQLRSEVDHL 619
Cdd:TIGR02169  729 EQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL-----EARLSHSRIPEIQAELSKL 803

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  620 RREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQ---RMLDTE 696
Cdd:TIGR02169  804 EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEaalRDLESR 883

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  697 KQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQR 776
Cdd:TIGR02169  884 LGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDE----EIPEEELSLEDVQAE 959

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  777 LLEEQAKLQQQMDLQknhiFRLTQGLQEALDRADLLKTERSDLEYQLENIQ 827
Cdd:TIGR02169  960 LQRVEEEIRALEPVN----MLAIQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 277-980 2.32e-15

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 82.09  E-value: 2.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  277 EERRHSLENKVKRL----ETMERRENRLKD---DIQTKSEQIQQMADKILELeeKHREAQvSAQHLEVHLkQKEQHYEEK 349
Cdd:pfam15921   81 EEYSHQVKDLQRRLnesnELHEKQKFYLRQsviDLQTKLQEMQMERDAMADI--RRRESQ-SQEDLRNQL-QNTVHELEA 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  350 IKVLDNQIKKDLADK-ESLENMMQRHEEEAHE-----------KGKILSEQKAM---------------INAMDSKIRSL 402
Cdd:pfam15921  157 AKCLKEDMLEDSNTQiEQLRKMMLSHEGVLQEirsilvdfeeaSGKKIYEHDSMstmhfrslgsaiskiLRELDTEISYL 236

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  403 EQRIVELSEA-NKLAANSS----LFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKS--- 474
Cdd:pfam15921  237 KGRIFPVEDQlEALKSESQnkieLLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSmym 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  475 -RLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 553
Cdd:pfam15921  317 rQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLE 396

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  554 RDEIQRKFDALRNSCTVITDLEEQLNQ-----------LTEDNAELNNQnfyLSKQLDEASGANDEI-------VQLRSE 615
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDDrnmevqrlealLKAMKSECQGQ---MERQMAAIQGKNESLekvssltAQLEST 473

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  616 VDHLRREITEremqLTSQKQTMEALKTTctmleeqVLDLEAlndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDT 695
Cdd:pfam15921  474 KEMLRKVVEE----LTAKKMTLESSERT-------VSDLTA---SLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNE 539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  696 EKQSR-------------ARADQRITESRQVVEL-------------AVKEHKA----EILALQQALKEQKLKAESLSDK 745
Cdd:pfam15921  540 GDHLRnvqtecealklqmAEKDKVIEILRQQIENmtqlvgqhgrtagAMQVEKAqlekEINDRRLELQEFKILKDKKDAK 619

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  746 LNDLEKKHAMLEMNARSL----QQKLETERELKQrlleEQAKLQQQMDLQKNHIFRLTQGLqEALDR-----ADLLKTER 816
Cdd:pfam15921  620 IRELEARVSDLELEKVKLvnagSERLRAVKDIKQ----ERDQLLNEVKTSRNELNSLSEDY-EVLKRnfrnkSEEMETTT 694

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  817 SDLEYQLENIQ--------VLYSHE---------KVKMEGTISQQTKLIDFLQAKMD------QPAKKKKGLFSRRK--- 870
Cdd:pfam15921  695 NKLKMQLKSAQseleqtrnTLKSMEgsdghamkvAMGMQKQITAKRGQIDALQSKIQfleeamTNANKEKHFLKEEKnkl 774

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  871 --EDPALPTQVPLQYNELKLALEKE---KARCAELEEALQKT------------RIELRSAREEAAHR---KATDHP-HP 929
Cdd:pfam15921  775 sqELSTVATEKNKMAGELEVLRSQErrlKEKVANMEVALDKAslqfaecqdiiqRQEQESVRLKLQHTldvKELQGPgYT 854

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  930 STPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSR-RKESSTPEEFSRRLKE 980
Cdd:pfam15921  855 SNSSMKPRLLQPASFTRTHSNVPSSQSTASFLSHHsRKTNALKEDPTRDLKQ 906
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 215-905 4.89e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 81.27  E-value: 4.89e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  215 AEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgiKKKLVEAEERRHSLENKVKRLETME 294
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAERYQALLK--EKREYEGYELLKEKEALERQKEAIE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  295 RRENRLKDDIQTKSEQIQQMADKILELEEKHRE-------------AQVSAQHLEVH-----LKQKEQHYEEKIKVLDNQ 356
Cdd:TIGR02169  244 RQLASLEEELEKLTEEISELEKRLEEIEQLLEElnkkikdlgeeeqLRVKEKIGELEaeiasLERSIAEKERELEDAEER 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  357 IKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISE 436
Cdd:TIGR02169  324 LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE-------TRDELKDYREKLEK 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELK----------RQLTELQL 506
Cdd:TIGR02169  397 LKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEqlaadlskyeQELYDLKE 476

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  507 SLQERESQLTALQAARAALESQLRQAKTELEETTAEAE------------------------------------------ 544
Cdd:TIGR02169  477 EYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEvlkasiqgvhgtvaqlgsvgeryataievaagnrlnnvvved 556

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  545 -----EEIQALTAHR--------------------------------------DEIQRKFDALRNSCTVITDLEEQLNQL 581
Cdd:TIGR02169  557 davakEAIELLKRRKagratflplnkmrderrdlsilsedgvigfavdlvefdPKYEPAFKYVFGDTLVVEDIEAARRLM 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  582 TE--------------------DNAELNNQNFYLSkQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 641
Cdd:TIGR02169  637 GKyrmvtlegelfeksgamtggSRAPRGGILFSRS-EPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDAS 715

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  642 ttcTMLEEQVLDLEALNDElLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQSRARADQRITEsrqvVELAVKEH 721
Cdd:TIGR02169  716 ---RKIGEIEKEIEQLEQE-EEKLKE----------RLEELEEDLSSLEQEIENVKSELKELEARIEE----LEEDLHKL 777

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  722 KAEILALQQALKEQKLkaESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltqg 801
Cdd:TIGR02169  778 EEALNDLEARLSHSRI--PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQI------ 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  802 lQEALDRADLLKTERSDLEYQLENiqvlyshekvkmegtisqqtklidfLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL 881
Cdd:TIGR02169  850 -KSIEKEIENLNGKKEELEEELEE-------------------------LEAALRDLESRLGDLKKERDELEAQLRELER 903

                          810       820
                   ....*....|....*....|....
gi 1907160229  882 QYNELKLALEKEKARCAELEEALQ 905
Cdd:TIGR02169  904 KIEELEAQIEKKRKRLSELKAKLE 927
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 4-622 7.54e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.37  E-value: 7.54e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:COG1196    233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   84 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQ 161
Cdd:COG1196    313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEeeLEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  162 HKlmkvvshpprgdsggtALDDLHKMQGHAGLTSAKDQgkpevgeysKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 241
Cdd:COG1196    393 RA----------------AAELAAQLEELEEAEEALLE---------RLERLEEELEELEEALAELEEEEEEEEEALEEA 447

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  242 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQ---MADKI 318
Cdd:COG1196    448 AEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLrglAGAVA 527

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 LELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSK 398
Cdd:COG1196    528 VLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASD 607

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  399 IRSLE---QRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDhsdkSR 475
Cdd:COG1196    608 LREADaryYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAEL----EE 683

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  476 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 555
Cdd:COG1196    684 LAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLE 763

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  556 EIQRKfdalrnsctvITDLEEQLNQL-------TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE 622
Cdd:COG1196    764 ELERE----------LERLEREIEALgpvnllaIEEYEELEERYDFLSEQREDLEEARETLEEAIEEIDRETRE 827
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 206-820 1.46e-14

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 79.63  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEQQlkIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEErrhsLEN 285
Cdd:TIGR00618  201 LRSQLLTLCTPCM--PDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE----LRA 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  286 KVKRLETMERRENRlkddiQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVldnqiKKDLADKE 365
Cdd:TIGR00618  275 QEAVLEETQERINR-----ARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQ-----QSSIEEQR 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  366 SLENMMQRHEEE---AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 442
Cdd:TIGR00618  345 RLLQTLHSQEIHirdAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQG 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  443 YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLRevSLEHEEQKLELKRQLTelqlslqERESQLTALQAAR 522
Cdd:TIGR00618  425 QLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQ--SLKEREQQLQTKEQIH-------LQETRKKAVVLAR 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  523 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ------NFYLS 596
Cdd:TIGR00618  496 LLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQmqeiqqSFSIL 575

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  597 KQLDEASGANDEIVQ------------LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLE- 663
Cdd:TIGR00618  576 TQCDNRSKEDIPNLQnitvrlqdltekLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTl 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  664 -KERQWEAWRSVLGDEKSQFECRVRELQRMldtekQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESL 742
Cdd:TIGR00618  656 tQERVREHALSIRVLPKELLASRQLALQKM-----QSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  743 SDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALD-RADLLKTERSDLE 820
Cdd:TIGR00618  731 GSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREeDTHLLKTLEAEIG 809
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 2-774 5.78e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 77.80  E-value: 5.78e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEavlsqKEVELKASETQRSLLEQdLATYITECSSLKRSLEQARME 81
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN-----KKIKDLGEEEQLRVKEK-IGELEAEIASLERSIAEKERE 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIREQSRKLQEIKEQeyqaqVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQ 161
Cdd:TIGR02169  317 LEDAEERLAKLEAEIDKLLAEIEELERE-----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYR 391

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  162 HKLMKVVSHpprgdsggtaLDDLHKMQGHAGLTSAKDQGKPEVGEySKLEKINAeqqlKIQELQEKLEKAVKASTEATEL 241
Cdd:TIGR02169  392 EKLEKLKRE----------INELKRELDRLQEELQRLSEELADLN-AAIAGIEA----KINELEEEKEDKALEIKKQEWK 456

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  242 LQNIRQAKERAERELEKLhnredssegiKKKLVEAEERRHSLENKVKRLETMER------RENR-----LKDDIQTKSEQ 310
Cdd:TIGR02169  457 LEQLAADLSKYEQELYDL----------KEEYDRVEKELSKLQRELAEAEAQARaseervRGGRaveevLKASIQGVHGT 526

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  311 IQQMadkiLELEEKHREAqvsaqhLEVHLKQKeqhyeekikvLDNQIKKDLADKESLENMMQRHE------------EEA 378
Cdd:TIGR02169  527 VAQL----GSVGERYATA------IEVAAGNR----------LNNVVVEDDAVAKEAIELLKRRKagratflplnkmRDE 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  379 HEKGKILSEQKAMINAMD--------------------------------SKIR--SLEQRIVELSEANKLAANSSLFTQ 424
Cdd:TIGR02169  587 RRDLSILSEDGVIGFAVDlvefdpkyepafkyvfgdtlvvedieaarrlmGKYRmvTLEGELFEKSGAMTGGSRAPRGGI 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  425 RNMKAQEEMISELRQQKfyletqaGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE--EQKLE-LKRQL 501
Cdd:TIGR02169  667 LFSRSEPAELQRLRERL-------EGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEqlEQEEEkLKERL 739

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  502 TELQLSLQERESQLTALQAARAALESQLrQAKTELEETTAEAEEEIQALTAHR--DEIQRKFDALRnscTVITDLEEQLN 579
Cdd:TIGR02169  740 EELEEDLSSLEQEIENVKSELKELEARI-EELEEDLHKLEEALNDLEARLSHSriPEIQAELSKLE---EEVSRIEARLR 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  580 QLtedNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALND 659
Cdd:TIGR02169  816 EI---EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERD 892

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  660 ELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA-----VKEHKAEILALQQALKE 734
Cdd:TIGR02169  893 ELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEElsledVQAELQRVEEEIRALEP 972

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....
gi 1907160229  735 QKLKA----ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELK 774
Cdd:TIGR02169  973 VNMLAiqeyEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKK 1016
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-527 7.86e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 77.03  E-value: 7.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKElqDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQdLATYITECSSLKRSLEQarmE 81
Cdd:PRK03918   180 RLEKFIKRTE--NIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEE-LKEEIEELEKELESLEG---S 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIREQSRKLQEIKE--------QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLA-A 150
Cdd:PRK03918   254 KRKLEEKIRELEERIEELKKEIEELEEkvkelkelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINgiEERIKeL 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPE---VGEYSKLEKINAEQQLKIQELQEK 227
Cdd:PRK03918   334 EEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPeklEKELEELEKAKEEIEEEISKITAR 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  228 LEKAVKASTEATELLQNIRQAKERAE---RELEKLHNREDSSE------GIKKKLVEAEERRHSLENKVKRLETMERREN 298
Cdd:PRK03918   414 IGELKKEIKELKKAIEELKKAKGKCPvcgRELTEEHRKELLEEytaelkRIEKELKEIEEKERKLRKELRELEKVLKKES 493

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  299 RLKddiqtkseQIQQMADKILELEEKHREaqVSAQHLEVHLKQKEQHYEEKIKVLDNQ--IKKDLADKESLENMMQRHEE 376
Cdd:PRK03918   494 ELI--------KLKELAEQLKELEEKLKK--YNLEELEKKAEEYEKLKEKLIKLKGEIksLKKELEKLEELKKKLAELEK 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  377 EAHEKGKILSE-QKAMINAMDSKIRSLEQRIVELSEANK---LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 452
Cdd:PRK03918   564 KLDELEEELAElLKELEELGFESVEELEERLKELEPFYNeylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLE 643

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  453 AQNRKLEEQLEKISHQDHSDKS-RLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 527
Cdd:PRK03918   644 ELRKELEELEKKYSEEEYEELReEYLELSRELAGL----RAELEELEKRREEIKKTLEKLKEELEEREKAKKELEK 715
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 21-630 9.14e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.08  E-value: 9.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   21 KMEQEMTRLHRRVSEVEAVL------SQKEVELKASETQRSLlEQDLATYITECSSLKRSLEQARmevSQEDDKALQLlH 94
Cdd:pfam15921  228 ELDTEISYLKGRIFPVEDQLealkseSQNKIELLLQQHQDRI-EQLISEHEVEITGLTEKASSAR---SQANSIQSQL-E 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   95 DIREQSRKlqeiKEQEYQAQVEEMRLMMNQLEEDLVSARRRSD-----------LYESELRESRLAAEEFKRKANECQHK 163
Cdd:pfam15921  303 IIQEQARN----QNSMYMRQLSDLESTVSQLRSELREAKRMYEdkieelekqlvLANSELTEARTERDQFSQESGNLDDQ 378

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  164 LMKVvshpprgdsggtaLDDLHKMQGHagLTSAKDQGK----PEVGEYSKLEKINAEQQLKIQELQ--EKLEKAVKASTE 237
Cdd:pfam15921  379 LQKL-------------LADLHKREKE--LSLEKEQNKrlwdRDTGNSITIDHLRRELDDRNMEVQrlEALLKAMKSECQ 443

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  238 A-TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEaeerrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMAD 316
Cdd:pfam15921  444 GqMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVE------ELTAKKMTLESSERTVSDLTASLQEKERAIEATNA 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  317 KILELEEKhreAQVSAQHLEvHLKQKEQHYEEkIKVLDNQIKKDLADK--------ESLENMMQ---------------- 372
Cdd:pfam15921  518 EITKLRSR---VDLKLQELQ-HLKNEGDHLRN-VQTECEALKLQMAEKdkvieilrQQIENMTQlvgqhgrtagamqvek 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  373 -RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSlftqRNMKAqeemISELRQQKFYLETQAGK 450
Cdd:pfam15921  593 aQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElEKVKLVNAGS----ERLRA----VKDIKQERDQLLNEVKT 664

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  451 LEAQNRKLEEQLEKishqdhsdksrlleLETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA-ALESQL 529
Cdd:pfam15921  665 SRNELNSLSEDYEV--------------LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGhAMKVAM 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  530 RQAKTeleettaeaeeeiqaLTAHRDEIqrkfDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLD----EASGA 605
Cdd:pfam15921  731 GMQKQ---------------ITAKRGQI----DALQSK---IQFLEEAMTNANKEKHFLKEEKNKLSQELStvatEKNKM 788

                          650       660
                   ....*....|....*....|....*
gi 1907160229  606 NDEIVQLRSEVDHLRREITEREMQL 630
Cdd:pfam15921  789 AGELEVLRSQERRLKEKVANMEVAL 813
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
197-705 1.37e-13

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 75.96  E-value: 1.37e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  197 KDQGKPEVGEYSKLEKinAEQQLK-IQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKkklvE 275
Cdd:COG4717     60 KPQGRKPELNLKELKE--LEEELKeAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQ----E 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  276 AEERRHSLENKVKRLETMERRENRLKD---DIQTKSEQIQQMADKILELEE-----KHREAQVSAQHLEvHLKQKEQHYE 347
Cdd:COG4717    134 LEALEAELAELPERLEELEERLEELREleeELEELEAELAELQEELEELLEqlslaTEEELQDLAEELE-ELQQRLAELE 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  348 EKIKVLDNQIKKDLADKESLENMMQRHEEEAH-EKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL-AANSSLFTQR 425
Cdd:COG4717    213 EELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLvLGLLALLFLL 292

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  426 NMKAQEEMISELRQqkfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREV-----SLEHEEQKLELKRQ 500
Cdd:COG4717    293 LAREKASLGKEAEE----LQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELqellrEAEELEEELQLEEL 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  501 LTELQLSLQ--------------ERESQLTALQAARAALESQLRQAKTELEEttaeaeeeiQALTAHRDEIQRKFDALRN 566
Cdd:COG4717    369 EQEIAALLAeagvedeeelraalEQAEEYQELKEELEELEEQLEELLGELEE---------LLEALDEEELEEELEELEE 439

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  567 SctvITDLEEQLNQLTEDNAELNNQNFYLSKQldeasganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTM 646
Cdd:COG4717    440 E---LEELEEELEELREELAELEAELEQLEED--------GELAELLQELEELKAELRELAEEWAALKLALELLEEAREE 508

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229  647 LEEQVLdlealnDELLEKERQW------EAWRSVLGDEKSQFECRvRELQRMLDTEKQSRARADQ 705
Cdd:COG4717    509 YREERL------PPVLERASEYfsrltdGRYRLIRIDEDLSLKVD-TEDGRTRPVEELSRGTREQ 566
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 208-663 7.47e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 73.52  E-value: 7.47e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  208 SKLEKINAEQQLKIQELQEKLEKAVkasteatellQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:TIGR04523  228 NQLKDNIEKKQQEINEKTTEISNTQ----------TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEI 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  288 KRLETMERRE--NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLA 362
Cdd:TIGR04523  298 SDLNNQKEQDwnKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEekqNEIEKLKK 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  363 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQrivelsEANKLAANSSLFTQRNMKAQEEmISELRQQKF 442
Cdd:TIGR04523  378 ENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ------EKELLEKEIERLKETIIKNNSE-IKDLTNQDS 450

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  443 YLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHE---EQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:TIGR04523  451 VKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLTKKISSLKEKIEKLE 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  520 AARAALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSC--TVITDLEEQLNQLTEDNAELNNQNFYLSK 597
Cdd:TIGR04523  531 SEKKEKESKISDLE---------------------DELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLKKKQEEKQE 589

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  598 QLDeasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLE 663
Cdd:TIGR04523  590 LID----------QKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQ 645
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
210-785 1.02e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 73.54  E-value: 1.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  210 LEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAER---ELEKLhnREDSSEGIKKKLVEAEERRhslENK 286
Cdd:PRK02224   211 LESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETleaEIEDL--RETIAETEREREELAEEVR---DLR 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  287 VKRLETMERRENRLKD------DIQTKSEQIQQMADKILELEEKHREAQVSAQHlevHLKQKEQhYEEKIKVLDNQIKKD 360
Cdd:PRK02224   286 ERLEELEEERDDLLAEaglddaDAEAVEARREELEDRDEELRDRLEECRVAAQA---HNEEAES-LREDADDLEERAEEL 361

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  361 LADKESLENMMQRHEEEahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQ 440
Cdd:PRK02224   362 REEAAELESELEEAREA-------VEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEAT 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  441 kfyLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PRK02224   435 ---LRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIE--------EDRERVEELEAELEDLEEEVEEVEERLERAED 503

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  521 ARAAlESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKfdalrnsctvitdlEEQLNQLTEDNAELNnqnfylskqlD 600
Cdd:PRK02224   504 LVEA-EDRIERLEERREDLE-------ELIAERRETIEEK--------------RERAEELRERAAELE----------A 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  601 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKS 680
Cdd:PRK02224   552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAA-IADAEDEIERLREKREALAELNDERRERLA 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  681 QFECRVRELQRMLDTEKQSRARADQRITESRQvvelavkehkaeilalqqalkeqklkaESLSDKLNDLEKKHAMLEMNA 760
Cdd:PRK02224   631 EKRERKRELEAEFDEARIEEAREDKERAEEYL---------------------------EQVEEKLDELREERDDLQAEI 683

                          570       580
                   ....*....|....*....|....*
gi 1907160229  761 RSLQQKLETERELKQRLLEEQAKLQ 785
Cdd:PRK02224   684 GAVENELEELEELRERREALENRVE 708
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 254-839 2.12e-12

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 72.52  E-value: 2.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  254 RELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLetMERReNRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQ 333
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQL--CEEK-NALQEQLQAETELCAEAEEMRARLAARKQELEEILH 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  334 HLEVHLKQKeqhyEEKIKVLDNQIKKDLADKESLENmmQRHEEEAhekgkilSEQKAMIN--AMDSKIRSLEQRIVELSE 411
Cdd:pfam01576   79 ELESRLEEE----EERSQQLQNEKKKMQQHIQDLEE--QLDEEEA-------ARQKLQLEkvTTEAKIKKLEEDILLLED 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  412 AN-KLaansslftQRNMKAQEEMISELRQQKFYLETQAGKL-------EAQNRKLEEQLEKishqdhSDKSRlLELETRL 483
Cdd:pfam01576  146 QNsKL--------SKERKLLEERISEFTSNLAEEEEKAKSLsklknkhEAMISDLEERLKK------EEKGR-QELEKAK 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  484 REV---SLEHEEQKLELKRQLTELQLSLQERESQLTALQaARAALESQLRQAkteleettaeAEEEIQALTAHRDEIQRK 560
Cdd:pfam01576  211 RKLegeSTDLQEQIAELQAQIAELRAQLAKKEEELQAAL-ARLEEETAQKNN----------ALKKIRELEAQISELQED 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  561 FDALRNSCTVIT----DLEEQLNQLTEDnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQT 636
Cdd:pfam01576  280 LESERAARNKAEkqrrDLGEELEALKTE----------LEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQE 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  637 MEALKTTCtmleeqvldLEALNDELLEKER---QWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQritesrQV 713
Cdd:pfam01576  350 MRQKHTQA---------LEELTEQLEQAKRnkaNLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEG------QL 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  714 VELAVKEHKAEILALQQALKEQKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRllEEQAKLQ-----Q 786
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSKLQSEleSVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE--ETRQKLNlstrlR 492

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  787 QMDLQKNhifrltqGLQEALDRADllkTERSDLEYQLENIQVLYSHEKVKMEG 839
Cdd:pfam01576  493 QLEDERN-------SLQEQLEEEE---EAKRNVERQLSTLQAQLSDMKKKLEE 535
C1_MgcRacGAP cd20821
protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and ...
 986-1040 2.71e-12

protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins; MgcRacGAP, also called Rac GTPase-activating protein 1 (RACGAP1) or protein CYK4, plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling; and ii) after phosphorylation by aurora B, MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain an N-terminal C1 domain, and a C-terminal RhoGAP domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410371  Cd Length: 55  Bit Score: 62.81  E-value: 2.71e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229  986 IPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLPA 1040
Cdd:cd20821      1 RPHRFVSKTVIKPETCVVCGKRIKFGKKALKCKDCRVVCHPDCKDKLPLPCVPTS 55
PRK01156 PRK01156
chromosome segregation protein; Provisional
 43-642 2.90e-12

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 71.86  E-value: 2.90e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   43 KEV--ELKASETQRSLLEQDLATYITECSSLKRSLEQarmevsqeDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRL 120
Cdd:PRK01156   172 KDVidMLRAEISNIDYLEEKLKSSNLELENIKKQIAD--------DEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  121 MMNQLEEdlvsarrrSDLYESELR--ESRLAAEEFKR-KANECQHKLMKVVSHPprgdsggtALDDLHKMQGHAGLtsak 197
Cdd:PRK01156   244 LSSLEDM--------KNRYESEIKtaESDLSMELEKNnYYKELEERHMKIINDP--------VYKNRNYINDYFKY---- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  198 dqgKPEVGEYSK-LEKINAEqqlkIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEA 276
Cdd:PRK01156   304 ---KNDIENKKQiLSNIDAE----INKYHAIIKKL--------SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSY 368

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  277 EErrhSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL-ELEEKHREAQ------VSAQHLEVHLKQKEQHYEEK 349
Cdd:PRK01156   369 LK---SIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKkELNEINVKLQdisskvSSLNQRIRALRENLDELSRN 445

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  350 IKVLDNQIK-----KDLADKESlENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRI--VELSEANKLAANSSLF 422
Cdd:PRK01156   446 MEMLNGQSVcpvcgTTLGEEKS-NHIINHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKeyLESEEINKSINEYNKI 524

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  423 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR-LLELETrlrevsleHEEQKLELKRQL 501
Cdd:PRK01156   525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSKRTSWLNALAVIsLIDIET--------NRSRSNEIKKQL 596

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  502 TELQLSLQERESQLTALQAAraaLESQLRQAKTELEETTAEAEEeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQL 581
Cdd:PRK01156   597 NDLESRLQEIEIGFPDDKSY---IDKSIREIENEANNLNNKYNE-IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEI 672

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  582 TEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKT 642
Cdd:PRK01156   673 TSRINDIEDNLKKSRKALDD---AKANRARLESTIEILRTRINELSDRINDINETLESMKK 730
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
458-918 2.92e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 71.99  E-value: 2.92e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEQLEKISHQDHSDksRLLELETRLREVS--LEH-EEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQAKT 534
Cdd:PRK02224   192 LKAQIEEKEEKDLHE--RLNGLESELAELDeeIERyEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIA 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  535 ELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTV----ITDLEEQLNQLTEDNAE----LNNQNFYLSKQLDEASGAN 606
Cdd:PRK02224   269 ETEREREELAEEVRDLRERLEELEEERDDLLAEAGLddadAEAVEARREELEDRDEElrdrLEECRVAAQAHNEEAESLR 348

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  607 DEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRV 686
Cdd:PRK02224   349 EDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRERE 428

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  687 RELQRMLDTEKQSRARAD------------QRITESRQVVELAVKEHKAEILALQqaLKEQKLKAESLSDKLN------D 748
Cdd:PRK02224   429 AELEATLRTARERVEEAEalleagkcpecgQPVEGSPHVETIEEDRERVEELEAE--LEDLEEEVEEVEERLEraedlvE 506

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  749 LEKKHAMLEMNARSLQQKLET-------ERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEY 821
Cdd:PRK02224   507 AEDRIERLEERREDLEELIAErretieeKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKE 586

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  822 QLENIqvlyshekvkmeGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRkedpalptqvplqyNELKLALEKEKARCAELE 901
Cdd:PRK02224   587 RIESL------------ERIRTLLAAIADAEDEIERLREKREALAELN--------------DERRERLAEKRERKRELE 640

                          490
                   ....*....|....*...
gi 1907160229  902 EALQKTRIE-LRSAREEA 918
Cdd:PRK02224   641 AEFDEARIEeAREDKERA 658
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 570-922 6.18e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 6.18e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  570 VITDLEEQLNQLtEDNAELNNQNFYLSKQLDEAsgandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE 649
Cdd:TIGR02168  194 ILNELERQLKSL-ERQAEKAERYKELKAELREL-----ELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEE 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  650 QvldLEALNDELLEKERQWEAWRSVLGD---EKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavKEHKAEIL 726
Cdd:TIGR02168  268 K---LEELRLEVSELEEEIEELQKELYAlanEISRLEQQKQILRERLANLERQLEELEAQLEELESK-----LDELAEEL 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  727 A-LQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrlleEQAKLQQQMDLQKNHIFRLTQGLQEA 805
Cdd:TIGR02168  340 AeLEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRS-------KVAQLELQIASLNNEIERLEARLERL 412

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  806 LDRADLLKTERSDLEYQLENiqvlysHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEdpalptqVPLQYNE 885
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREELEE-------AEQALDA 479

                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 1907160229  886 LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRK 922
Cdd:TIGR02168  480 AERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 249-923 1.19e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.10  E-value: 1.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  249 KERAERELEKLHNREDSSEGIKKKLVE-----AEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEE 323
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEKRQqlerlRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  324 KHREAQVSAQHLEVHLKQKEQHYEE---KIKVLD----NQIKKDLADKESLENMMQRHEEEAHEKGKILSEQ----KAMI 392
Cdd:TIGR02169  252 ELEKLTEEISELEKRLEEIEQLLEElnkKIKDLGeeeqLRVKEKIGELEAEIASLERSIAEKERELEDAEERlaklEAEI 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  393 NAMDSKIRSLEQRIVElsEANKLAANSSLFtqrnmKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHS- 471
Cdd:TIGR02169  332 DKLLAEIEELEREIEE--ERKRRDKLTEEY-----AELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINEl 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  472 --DKSRLLELETRLREVSLEH-------EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 542
Cdd:TIGR02169  405 krELDRLQEELQRLSEELADLnaaiagiEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKE 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  543 AEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD----- 617
Cdd:TIGR02169  485 LSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVakeai 564

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  618 -HLRREITEREMQLTSQK-QTMEALKTtcTMLEEQVLDLeALNdeLLEKERQWE-AWRSVLGDE--KSQFECRVRELQ-- 690
Cdd:TIGR02169  565 eLLKRRKAGRATFLPLNKmRDERRDLS--ILSEDGVIGF-AVD--LVEFDPKYEpAFKYVFGDTlvVEDIEAARRLMGky 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  691 RM--LDTE------------KQSRARADQRITESRQVVELA--VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 754
Cdd:TIGR02169  640 RMvtLEGElfeksgamtggsRAPRGGILFSRSEPAELQRLRerLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIG 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  755 MLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLT---QGLQEALD--RADLLKTERSDLEYQLENIQVL 829
Cdd:TIGR02169  720 EIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHklEEALNDLEARLSHSRIPEIQAE 799

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  830 YShekvKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRI 909
Cdd:TIGR02169  800 LS----KLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEA 875

                          730
                   ....*....|....
gi 1907160229  910 ELRSAREEAAHRKA 923
Cdd:TIGR02169  876 ALRDLESRLGDLKK 889
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 211-878 1.49e-11

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 69.37  E-value: 1.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  211 EKINAEQQLKIQElQEKLEKAVKASTEATELLQNI--RQAKERAERELEKLHNRE---DSSEGIKKKLVEAEERRHSLEN 285
Cdd:pfam05483  130 EKVSLKLEEEIQE-NKDLIKENNATRHLCNLLKETcaRSAEKTKKYEYEREETRQvymDLNNNIEKMILAFEELRVQAEN 208

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  286 -------KVKR-LETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQI 357
Cdd:pfam05483  209 arlemhfKLKEdHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTF----LLEESRDKANQLEEKTKLQDENL 284

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  358 KKDLADKESLENMMqrhEEEAHEKGKILSEQKAMINAMDSKIRSL----EQRIVELSEANKLAANSSLFT---QRNMKAQ 430
Cdd:pfam05483  285 KELIEKKDHLTKEL---EDIKMSLQRSMSTQKALEEDLQIATKTIcqltEEKEAQMEELNKAKAAHSFVVtefEATTCSL 361

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  431 EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKL------ELKRQLTEL 504
Cdd:pfam05483  362 EELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQfekiaeELKGKEQEL 441

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  505 QLSLQERES-------QLTALQAARAALESQLRQAKTELEETTAEAEEeiqaLTAHRDEIQRKFDALRNSCtviTDLEEQ 577
Cdd:pfam05483  442 IFLLQAREKeihdleiQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIE----LTAHCDKLLLENKELTQEA---SDMTLE 514

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  578 LNQLTEDnaeLNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREIteremqltsqKQTMEALKTTCTMLEEQVLDLEAl 657
Cdd:pfam05483  515 LKKHQED---IINCKKQEERMLKQIENLEEKEMNLRDELESVREEF----------IQKGDEVKCKLDKSEENARSIEY- 580

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  658 ndELLEKERQWEAWRSVLGDEKSQFECRVRELQRMldtEKQSRARADQRITESRQvveLAVKEHKAEILALQQALKEQKL 737
Cdd:pfam05483  581 --EVLKKEKQMKILENKCNNLKKQIENKNKNIEEL---HQENKALKKKGSAENKQ---LNAYEIKVNKLELELASAKQKF 652

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  738 KaESLSDKLNDLEKKhamlemnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNH-IFRLTQGLQEALDRADLLKTER 816
Cdd:pfam05483  653 E-EIIDNYQKEIEDK--------KISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHkIAEMVALMEKHKHQYDKIIEER 723

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  817 SDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQ 878
Cdd:pfam05483  724 DSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1-514 3.32e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 68.61  E-value: 3.32e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ-RSLLEQDLATYITeCSSLKRSLEQAR 79
Cdd:pfam15921  347 LEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQnKRLWDRDTGNSIT-IDHLRRELDDRN 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   80 MEV-----------SQEDDKALQLLHDIREQSRKLQEIkeQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRL 148
Cdd:pfam15921  426 MEVqrleallkamkSECQGQMERQMAAIQGKNESLEKV--SSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTA 503

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  149 AAEEFKRKANECQHKLMKVVSHPprgdsggtaldDLhKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKL 228
Cdd:pfam15921  504 SLQEKERAIEATNAEITKLRSRV-----------DL-KLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQI 571

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  229 EKAVK-----ASTEATELLQNIRQAKERAERELEK-----LHNREDSsegikkKLVEAEERRHSLE-NKVKRLETMERRE 297
Cdd:pfam15921  572 ENMTQlvgqhGRTAGAMQVEKAQLEKEINDRRLELqefkiLKDKKDA------KIRELEARVSDLElEKVKLVNAGSERL 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 377
Cdd:pfam15921  646 RAVKDIKQERDQLLNEVKTSRNELNSLSEDYEV----LKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGS 721

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  378 AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRK 457
Cdd:pfam15921  722 DGHAMKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERR 801

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  458 LEEqlekishqdhsdksRLLELETRLREVSLEHEEQKLELKRQLTE-----LQLSLQERESQ 514
Cdd:pfam15921  802 LKE--------------KVANMEVALDKASLQFAECQDIIQRQEQEsvrlkLQHTLDVKELQ 849
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
72-615 4.89e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.76  E-value: 4.89e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   72 KRSLEQARMEVSQEDDKAL--------QLLHDIREQSRKLQEIKEQEyQAQVEEMRLMMNQLEEdlvsARRRSDLYESEL 143
Cdd:PRK02224   186 RGSLDQLKAQIEEKEEKDLherlngleSELAELDEEIERYEEQREQA-RETRDEADEVLEEHEE----RREELETLEAEI 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  144 RESRLAAEEFKRKANECQHKLMKvvshppRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvgEYSKLEKINAEQQlkiQE 223
Cdd:PRK02224   261 EDLRETIAETEREREELAEEVRD------LRERLEELEEERDDLLAEAGLDDADAEAVEA--RREELEDRDEELR---DR 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  224 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKlhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRenrlkdd 303
Cdd:PRK02224   330 LEECRVAAQAHNEEAESLREDADDLEERAEELREE---AAELESELEEAREAVEDRREEIEELEEEIEELRER------- 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  304 IQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD-------NQIKKDLADKESLENMMQRHEE 376
Cdd:PRK02224   400 FGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecGQPVEGSPHVETIEEDRERVEE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  377 EAHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQR------NMKAQEEMISELRQQKFYLETQAGK 450
Cdd:PRK02224   480 LEAE----LEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELiaerreTIEEKRERAEELRERAAELEAEAEE 555

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVS--------LEHEEQKLE-LKRQLTELQLSLQERESQLTALQAA 521
Cdd:PRK02224   556 KREAAAEAEEEAEEAREEVAELNSKLAELKERIESLErirtllaaIADAEDEIErLREKREALAELNDERRERLAEKRER 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  522 RAALES--------QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCtvitdleEQLNQLTEDNAELNNQNF 593
Cdd:PRK02224   636 KRELEAefdearieEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL-------EELEELRERREALENRVE 708

                          570       580
                   ....*....|....*....|..
gi 1907160229  594 YLSKQLDEASGANDEIVQLRSE 615
Cdd:PRK02224   709 ALEALYDEAEELESMYGDLRAE 730
mukB PRK04863
chromosome partition protein MukB;
217-827 5.79e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 68.06  E-value: 5.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  217 QQLKIQ-------ELQEKLEKAVKASTEATELLQNIRQAKERAERE-------------------------------LEK 258
Cdd:PRK04863   346 QQEKIEryqadleELEERLEEQNEVVEEADEQQEENEARAEAAEEEvdelksqladyqqaldvqqtraiqyqqavqaLER 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  259 -----------LHNREDSSEGIKKKLVEAEERRHSLENKVkrletmerrenRLKDDIQTKSEQIQQMADKIL-------- 319
Cdd:PRK04863   426 akqlcglpdltADNAEDWLEEFQAKEQEATEELLSLEQKL-----------SVAQAAHSQFEQAYQLVRKIAgevsrsea 494

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  320 -----ELEEKHREAQ---VSAQHLEVHLKQKEQHYEEKIKV--LDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQK 389
Cdd:PRK04863   495 wdvarELLRRLREQRhlaEQLQQLRMRLSELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESV 574

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  390 AMINAMDSKIR----SLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQN 455
Cdd:PRK04863   575 SEARERRMALRqqleQLQARIQRLAarAPAWLAAQDALARLREQSGEEfedsQDVTEYMQQLLERERELtverDELAARK 654

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  456 RKLEEQLEKISHQDHSDKSRLLELETRLREVSLE--HEEQKLE-----------------------LKRQLTELQ----- 505
Cdd:PRK04863   655 QALDEEIERLSQPGGSEDPRLNALAERFGGVLLSeiYDDVSLEdapyfsalygparhaivvpdlsdAAEQLAGLEdcped 734

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  506 LSLQE------RESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD 573
Cdd:PRK04863   735 LYLIEgdpdsfDDSVFSVEELEKAVVvkiaDRQWRYSRFPEVPLfgRAAREKRIEQLRAEREELAERYATLSFDVQKLQR 814

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  574 LEEQLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE---- 649
Cdd:PRK04863   815 LHQAFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRllpr 883

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  650 -QVLDLEALNDELLEKERQWEAWR--------------------SVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI- 707
Cdd:PRK04863   884 lNLLADETLADRVEEIREQLDEAEeakrfvqqhgnalaqlepivSVLQSDPEQFE----QLKQDYQQAQQTQRDAKQQAf 959

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  708 --TESRQVVELAVKEHKAEILA----LQQALKEQKLKAESLSDKLNDLEKKHA--MLEMNAR------SLQQKLETEREL 773
Cdd:PRK04863   960 alTEVVQRRAHFSYEDAAEMLAknsdLNEKLRQRLEQAEQERTRAREQLRQAQaqLAQYNQVlaslksSYDAKRQMLQEL 1039

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  774 KQRL----------LEEQAKLQQQmdlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 827
Cdd:PRK04863  1040 KQELqdlgvpadsgAEERARARRD---------ELHARLSANRSRRNQLEKQLTFCEAEMDNLT 1094
C1_ScPKC1-like_rpt2 cd20823
second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 984-1041 7.57e-11

second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410373  Cd Length: 59  Bit Score: 58.86  E-value: 7.57e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  984 HNIPHRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATCGLPAE 1041
Cdd:cd20823      1 HRIPHRFEPFTNLGANWCCHCGQMLPLGRkQIRKCTECGKTAHAQCAHLVPNFCGLSME 59
PRK01156 PRK01156
chromosome segregation protein; Provisional
 298-792 8.19e-11

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 67.23  E-value: 8.19e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYeekikvldNQIKKDLADKESLENMMQRHEEE 377
Cdd:PRK01156   186 DYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDY--------NNLKSALNELSSLEDMKNRYESE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  378 AHEkgkiLSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQeemISELRQQKFYLETQAGKLEAQNRK 457
Cdd:PRK01156   258 IKT----AESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKND---IENKKQILSNIDAEINKYHAIIKK 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEqLEKISHQDHSDKSRLLELETRLREVSLEH-----------------EEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PRK01156   331 LSV-LQKDYNDYIKKKSRYDDLNNQILELEGYEmdynsylksieslkkkiEEYSKNIERMSAFISEILKIQEIDPDAIKK 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  521 ARAALESQLRQakteLEETTAEAEEEIQALTAHRDEIQRKFDAL--RNSCTVI-TDL-EEQLNQLTED-NAELNNQNFYL 595
Cdd:PRK01156   410 ELNEINVKLQD----ISSKVSSLNQRIRALRENLDELSRNMEMLngQSVCPVCgTTLgEEKSNHIINHyNEKKSRLEEKI 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  596 SKQLDEASGANDEIVQLRSEVDHLR-----------REITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEK 664
Cdd:PRK01156   486 REIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDS 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  665 ER-QW------------EAWRSVLGDEKSQF---ECRVRELQ--------------RMLDTE------KQSRARADQRIT 708
Cdd:PRK01156   566 KRtSWlnalavislidiETNRSRSNEIKKQLndlESRLQEIEigfpddksyidksiREIENEannlnnKYNEIQENKILI 645

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  709 ESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKL 784
Cdd:PRK01156   646 EKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRtrinELSDRINDINETL 725


                   ....*...
gi 1907160229  785 QQQMDLQK 792
Cdd:PRK01156   726 ESMKKIKK 733
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2-496 1.70e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 66.24  E-value: 1.70e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQ---KEVELKASETQRSLLEQDLAtyitecsSLKRSLEqa 78
Cdd:PRK03918   292 AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRLE-------ELEERHE-- 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   79 rmevsqEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAN 158
Cdd:PRK03918   363 ------LYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKG 436

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  159 ECQhklmkvvshpprgdSGGTALDDLHKMQGHAGLTSakdqgkpEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEA 238
Cdd:PRK03918   437 KCP--------------VCGRELTEEHRKELLEEYTA-------ELKRIEKELKEIEEKERKLRKELRELEKVLKKESEL 495

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  239 TELLQNIRQAKERAER----ELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM 314
Cdd:PRK03918   496 IKLKELAEQLKELEEKlkkyNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAEL 575

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  315 ADKILELEEKhreaqvSAQHLEVHLKQKEQHYEEKIKVLDnqIKKDLadkESLENMMQRHEEEAHEKGKILSEQKAMINA 394
Cdd:PRK03918   576 LKELEELGFE------SVEELEERLKELEPFYNEYLELKD--AEKEL---EREEKELKKLEEELDKAFEELAETEKRLEE 644

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  395 MDSKIRSLEQRIVElsEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSdKS 474
Cdd:PRK03918   645 LRKELEELEKKYSE--EEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKA-LE 721

                          490       500
                   ....*....|....*....|..
gi 1907160229  475 RLLELETRLREVSLEHEEQKLE 496
Cdd:PRK03918   722 RVEELREKVKKYKALLKERALS 743
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 77-802 1.92e-10

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 66.15  E-value: 1.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   77 QARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEmrlmmNQLEEDLVSARRRSDLYESELresrlAAEEFKRK 156
Cdd:TIGR00618  215 DTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ-----LKKQQLLKQLRARIEELRAQE-----AVLEETQE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  157 ANECQHKLMKVVSHPPRgdsggTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEkLEKAVKAST 236
Cdd:TIGR00618  285 RINRARKAAPLAAHIKA-----VTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT-LHSQEIHIR 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  237 EATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQiQQMAD 316
Cdd:TIGR00618  359 DAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQ-QELQQ 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  317 KILELEEKHREAQVSAQHLE-VHLKQKEQHYEEKIKVLDNqikkdladkesLENMMQRHEEEAHEKGKILSEQKaminam 395
Cdd:TIGR00618  438 RYAELCAAAITCTAQCEKLEkIHLQESAQSLKEREQQLQT-----------KEQIHLQETRKKAVVLARLLELQ------ 500

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  396 dSKIRSLEQRIVELSEANKLAANSSLFTQRnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR 475
Cdd:TIGR00618  501 -EEPCPLCGSCIHPNPARQDIDNPGPLTRR--------MQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQS 571

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  476 LLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRD 555
Cdd:TIGR00618  572 FSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHAL 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  556 EIQRKFDALRNSCTVITDLEEQLNQLTEdNAELNNQNFY--LSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQ 633
Cdd:TIGR00618  652 QLTLTQERVREHALSIRVLPKELLASRQ-LALQKMQSEKeqLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  634 KQTMEALKTTCTML--EEQVLDLEALNDELLEKERQWEAWRSVL--GDEKSQFECRVRELQRMLDTEKQSRARADQRITE 709
Cdd:TIGR00618  731 GSDLAAREDALNQSlkELMHQARTVLKARTEAHFNNNEEVTAALqtGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQ 810

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  710 SRQVVELAVKehkAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 789
Cdd:TIGR00618  811 EIPSDEDILN---LQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQ 887

                          730
                   ....*....|...
gi 1907160229  790 LQKNHIFRLTQGL 802
Cdd:TIGR00618  888 FDGDALIKFLHEI 900
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
367-603 1.94e-10

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 65.81  E-value: 1.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  367 LENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAAnsslfTQRNMKAQEEMISELRQQKFYLET 446
Cdd:COG3206    162 LEQNLELRREEARKALEFLEEQ---LPELRKELEEAEAALEEFRQKNGLVD-----LSEEAKLLLQQLSELESQLAEARA 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  447 QAGKLEAQNRKLEEQLEKISHQ--DHSDKSRLLELETRLREvsleheeqkleLKRQLTELQLSLQERESQLTALQAARAA 524
Cdd:COG3206    234 ELAEAEARLAALRAQLGSGPDAlpELLQSPVIQQLRAQLAE-----------LEAELAELSARYTPNHPDVIALRAQIAA 302

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  525 LESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDnAELNNQNF-YLSKQLDEAS 603
Cdd:COG3206    303 LRAQLQQE---AQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLERE-VEVARELYeSLLQRLEEAR 378
C1 smart00109
Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol ...
 988-1036 1.99e-10

Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains); Some bind phorbol esters and diacylglycerol. Some bind RasGTP. Zinc-binding domains.


Pssm-ID: 197519  Cd Length: 50  Bit Score: 57.48  E-value: 1.99e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1907160229   988 HRFNVGLNMRATKCAVCLDTVHFGR-QASKCLECQVMCHPKCSTCLPATC 1036
Cdd:smart00109    1 HKHVFRTFTKPTFCCVCRKSIWGSFkQGLRCSECKVKCHKKCADKVPKAC 50
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
239-801 2.36e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.56  E-value: 2.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  239 TELLQNIRQA-KERAERELEKLHNREDssegikKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADK 317
Cdd:COG4717     37 STLLAFIRAMlLERLEKEADELFKPQG------RKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAE 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  318 ILELEEKHREAQVSAQHLEVHLKQKEqhyeekikvldnqikkdlaDKESLENMMQRHEEeahekgkiLSEQKAMINAMDS 397
Cdd:COG4717    111 LEELREELEKLEKLLQLLPLYQELEA-------------------LEAELAELPERLEE--------LEERLEELRELEE 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  398 KIRSLEQRIVELSEA-NKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS--HQDHSDKS 474
Cdd:COG4717    164 ELEELEAELAELQEElEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEneLEAAALEE 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  475 RLLELETRLREVSLEHEeqklelkrqLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 554
Cdd:COG4717    244 RLKEARLLLLIAAALLA---------LLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  555 DEIQRKfdalrnsctvitdLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQK 634
Cdd:COG4717    315 ELEEEE-------------LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALLAEAGV 381

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQV---LDLEALNDELLEKERQWEAWRSVLGDEksqfecrvrELQRMLDTEKQSRARADQRITESR 711
Cdd:COG4717    382 EDEEELRAALEQAEEYQelkEELEELEEQLEELLGELEELLEALDEE---------ELEEELEELEEELEELEEELEELR 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  712 QvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAklqqqmdlq 791
Cdd:COG4717    453 E--ELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPPVLERA--------- 521

                          570
                   ....*....|.
gi 1907160229  792 kNHIF-RLTQG 801
Cdd:COG4717    522 -SEYFsRLTDG 531
C1 cd00029
protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich ...
 988-1036 2.38e-10

protein kinase C conserved region 1 (C1 domain) superfamily; The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains. It contains the motif HX12CX2CXnCX2CX4HX2CX7C, where C and H are cysteine and histidine, respectively; X represents other residues; and n is either 13 or 14. C1 has a globular fold with two separate Zn(2+)-binding sites. It was originally discovered as lipid-binding modules in protein kinase C (PKC) isoforms. C1 domains that bind and respond to phorbol esters (PE) and diacylglycerol (DAG) are referred to as typical, and those that do not respond to PE and DAG are deemed atypical. A C1 domain may also be referred to as PKC or non-PKC C1, based on the parent protein's activity. Most C1 domain-containing non-PKC proteins act as lipid kinases and scaffolds, except PKD which acts as a protein kinase. PKC C1 domains play roles in membrane translocation and activation of the enzyme.


Pssm-ID: 410341  Cd Length: 50  Bit Score: 57.14  E-value: 2.38e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907160229  988 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd00029      1 HRFVPTTFSSPTFCDVCGKLIwGLFKQGLKCSDCGLVCHKKCLDKAPSPC 50
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
376-827 2.45e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 65.71  E-value: 2.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  376 EEAHEKGKILSEQKAM---INAMDSKIRSLEQRIVELSEAnkLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 452
Cdd:COG4913    238 ERAHEALEDAREQIELlepIRELAERYAAARERLAELEYL--RAALRLWFAQRRLELLEAELEELRAELARLEAELERLE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  453 AQNRKLEEQLEKISHQ-DHSDKSRLLELETRLREVSLEHEEQK---LELKRQLTELQLSLQERESQLTALQAARAALESQ 528
Cdd:COG4913    316 ARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERErrrARLEALLAALGLPLPASAEEFAALRAEAAALLEA 395

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  529 LRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVI--------TDLEEQLN-------------QLTEDNAE 587
Cdd:COG4913    396 LEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIparllalrDALAEALGldeaelpfvgeliEVRPEEER 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  588 --------LNNQNFYL---SKQLDEASGANDEIvqlrsevdHLRREI-TEREMQLTSQKQTMEALKTTctmleeqvldle 655
Cdd:COG4913    476 wrgaiervLGGFALTLlvpPEHYAAALRWVNRL--------HLRGRLvYERVRTGLPDPERPRLDPDS------------ 535

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  656 aLNDELLEKERQWEAW-RSVLGDEKSqFEC--RVRELQR---------MLDTEKQSRARADQRITESRQV----VELAVK 719
Cdd:COG4913    536 -LAGKLDFKPHPFRAWlEAELGRRFD-YVCvdSPEELRRhpraitragQVKGNGTRHEKDDRRRIRSRYVlgfdNRAKLA 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  720 EHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEM---------NARSLQQKLETERELKQRLLEEQ---AKLQQQ 787
Cdd:COG4913    614 ALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASAEREIAELEAELERLDASSddlAALEEQ 693

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1907160229  788 MDlqknhifRLTQGLQEALDRADLLKTERSDLEYQLENIQ 827
Cdd:COG4913    694 LE-------ELEAELEELEEELDELKGEIGRLEKELEQAE 726
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
93-585 2.65e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 2.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   93 LHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEDLVSARRRSDLYESELR--ESRLAAEEFKRKANECQHKLmkvvsh 170
Cdd:COG4717     70 LKELKELEEELKEAEEKE--EEYAELQEELEELEEELEELEAELEELREELEklEKLLQLLPLYQELEALEAEL------ 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  171 pprgdsggtalddlhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEllQNIRQAKE 250
Cdd:COG4717    142 --------------------AELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATE--EELQDLAE 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  251 RAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMER-RENRLKDDIQTKSEQIQQMADKILELEEKHRE-- 327
Cdd:COG4717    200 ELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlKEARLLLLIAAALLALLGLGGSLLSLILTIAGvl 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  328 ---AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKEsLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQ 404
Cdd:COG4717    280 flvLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEE-LEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  405 RIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAgKLEAQNRKLEEQLEKISHQ-DHSDKSRLLELETRL 483
Cdd:COG4717    359 LEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKE-ELEELEEQLEELLGELEELlEALDEEELEEELEEL 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  484 REVSLEHEEQKLELKRQLTELQLSLQERESQ--LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKf 561
Cdd:COG4717    438 EEELEELEEELEELREELAELEAELEQLEEDgeLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP- 516

                          490       500
                   ....*....|....*....|....
gi 1907160229  562 dalrnsctVITDLEEQLNQLTEDN 585
Cdd:COG4717    517 --------VLERASEYFSRLTDGR 532
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 211-861 2.78e-10

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 65.74  E-value: 2.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  211 EKInAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE--------------LEKLHNREDSSEGIKKKLVEA 276
Cdd:COG3096    347 EKI-ERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEvdslksqladyqqaLDVQQTRAIQYQQAVQALEKA 425

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  277 EERRH----SLENKVKRLETMERREN-------------RLKDDIQTKSEQIQQMADKIL-------------ELEEKHR 326
Cdd:COG3096    426 RALCGlpdlTPENAEDYLAAFRAKEQqateevleleqklSVADAARRQFEKAYELVCKIAgeversqawqtarELLRRYR 505

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  327 EAQVSAQ---HLEVHLKQKEQHY------EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 397
Cdd:COG3096    506 SQQALAQrlqQLRAQLAELEQRLrqqqnaERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQ 585

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  398 KIRSLEQRIVELS--EANKLAANSSLFTQRNMKAQE----EMISELRQQKFYLETQA----GKLEAQNRKLEEQLEKISH 467
Cdd:COG3096    586 QLEQLRARIKELAarAPAWLAAQDALERLREQSGEAladsQEVTAAMQQLLEREREAtverDELAARKQALESQIERLSQ 665

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  468 QDHSDKSRLLELETRLREV--SLEHEEQKLE-----------------------LKRQLTELQ-----LSLQER------ 511
Cdd:COG3096    666 PGGAEDPRLLALAERLGGVllSEIYDDVTLEdapyfsalygparhaivvpdlsaVKEQLAGLEdcpedLYLIEGdpdsfd 745

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  512 ESQLTALQAARAAL----ESQLRQAKTELEET--TAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLtedn 585
Cdd:COG3096    746 DSVFDAEELEDAVVvklsDRQWRYSRFPEVPLfgRAAREKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQF---- 821

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  586 aelnnqnfyLSKQLDEASGANDE--IVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTML---------------E 648
Cdd:COG3096    822 ---------VGGHLAVAFAPDPEaeLAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLnkllpqanlladetlA 892

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  649 EQVLDLEALNDELLEKER----------QWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRI---TESRQVVE 715
Cdd:COG3096    893 DRLEELREELDAAQEAQAfiqqhgkalaQLEPLVAVLQSDPEQFE----QLQADYLQAKEQQRRLKQQIfalSEVVQRRP 968

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  716 LAVKEHKAEIL----ALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ 791
Cdd:COG3096    969 HFSYEDAVGLLgensDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQ 1048

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  792 KNHifrltqglqEALDRAdllKTERSDLEYQLeniqvlyshekVKMEGTISQQTKLIDFLQAKMDQPAKK 861
Cdd:COG3096   1049 ADA---------EAEERA---RIRRDELHEEL-----------SQNRSRRSQLEKQLTRCEAEMDSLQKR 1095
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
458-918 3.02e-10

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 65.17  E-value: 3.02e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEQLEKISHQDHSDKSRLLELE-TRLREVSLEHEEQKlELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 536
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNlKELKELEEELKEAE-EKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  537 EETTAEAEeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgANDEIVQLRSEV 616
Cdd:COG4717    126 QLLPLYQE--LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLA--TEEELQDLAEEL 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  617 DHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNdELLEKERQWEAWRSVL-----GDEKSQFECRVRELQR 691
Cdd:COG4717    202 EELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE-RLKEARLLLLIAAALLallglGGSLLSLILTIAGVLF 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  692 MLdtekqSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLE--MNARSLQQKLET 769
Cdd:COG4717    281 LV-----LGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLEllDRIEELQELLRE 355

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  770 ERELKQRLLEEQAKLQQQMDLQKNHI-----FRltqGLQEALDRADLLKTERSDLEYQLENI-----QVLYSHEKVKMEG 839
Cdd:COG4717    356 AEELEEELQLEELEQEIAALLAEAGVedeeeLR---AALEQAEEYQELKEELEELEEQLEELlgeleELLEALDEEELEE 432

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  840 TISQQTKLIDFLQAKMDQpAKKKKGLFSRRKEDpaLPTQVPLQynELKLALEKEKARCAELEE---ALQKTRIELRSARE 916
Cdd:COG4717    433 ELEELEEELEELEEELEE-LREELAELEAELEQ--LEEDGELA--ELLQELEELKAELRELAEewaALKLALELLEEARE 507


                   ..
gi 1907160229  917 EA 918
Cdd:COG4717    508 EY 509
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 3-466 4.55e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.66  E-value: 4.55e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    3 KKLLIKSKELQDSQDKCHK---MEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQAR 79
Cdd:TIGR04523  194 NKLLKLELLLSNLKKKIQKnksLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQ 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   80 MEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAqveemrlMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANe 159
Cdd:TIGR04523  274 KELEQNNKKIKELEKQLNQLKSEISDLNNQKEQD-------WNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQIS- 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  160 cqhKLMKVVSHpprgdsggtalddlhkmqghagLTSAKDQGKPEVGE-YSKLEKINAEQQLKIQELQeKLEkavkasTEA 238
Cdd:TIGR04523  346 ---QLKKELTN----------------------SESENSEKQRELEEkQNEIEKLKKENQSYKQEIK-NLE------SQI 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  239 TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQmadKI 318
Cdd:TIGR04523  394 NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLET---QL 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 LELEEKHREAQVSAQHLEVHLKQKEQHYE---EKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAM 395
Cdd:TIGR04523  471 KVLSRSINKIKQNLEQKQKELKSKEKELKklnEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKD 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  396 DS---------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIS 466
Cdd:TIGR04523  551 DFelkkenlekEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLS 630
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-790 7.52e-10

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 64.04  E-value: 7.52e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARME 81
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRL-------MMNQLEED-LVSARRRSDLY-ESELRESRLAa 150
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQldEEEAARQKLQLekvtteaKIKKLEEDiLLLEDQNSKLSkERKLLEERIS- 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 eEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEvGEYSKLEKINAEQQLKIQELQEKL-- 228
Cdd:pfam01576  163 -EFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLE-GESTDLQEQIAELQAQIAELRAQLak 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  229 -EKAVKASTEATELLQNIRQAKERAERELE-KLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenRLKDDIQT 306
Cdd:pfam01576  241 kEEELQAALARLEEETAQKNNALKKIRELEaQISELQEDLESERAARNKAEKQRRDLGEELEALKT------ELEDTLDT 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  307 KSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILS 386
Cdd:pfam01576  315 TAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELR 394

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  387 EQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEE------MISELRQQKFYLETQAGKLEAQNRKLE 459
Cdd:pfam01576  395 TLQQAKQDSEHKRKKLEGQLQELqARLSESERQRAELAEKLSKLQSElesvssLLNEAEGKNIKLSKDVSSLESQLQDTQ 474

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  460 EQLEKISHQDHSDKSRLLELE---TRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTEL 536
Cdd:pfam01576  475 ELLQEETRQKLNLSTRLRQLEderNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQREL 554

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  537 EETTAEAEEEIQA---------------------------LTAHRDEIQRKFD-ALRNSCTVITDLEEQLNQLTEDNAEL 588
Cdd:pfam01576  555 EALTQQLEEKAAAydklektknrlqqelddllvdldhqrqLVSNLEKKQKKFDqMLAEEKAISARYAEERDRAEAEAREK 634

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  589 NNQNFYLSKQLDEASGANDEI----VQLRSEVDHL-------RREITEREMQLTSQKQTMEALKTTCTMLEEQvldLEAL 657
Cdd:pfam01576  635 ETRALSLARALEEALEAKEELertnKQLRAEMEDLvsskddvGKNVHELERSKRALEQQVEEMKTQLEELEDE---LQAT 711

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  658 NDELLEKERQWEAW----------RSVLGDEK-SQFECRVRELQRMLDTEKQSRARAdqriTESRQVVELAVKEHKAEIL 726
Cdd:pfam01576  712 EDAKLRLEVNMQALkaqferdlqaRDEQGEEKrRQLVKQVRELEAELEDERKQRAQA----VAAKKKLELDLKELEAQID 787

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  727 ALQQ----ALKEQKLKAESLSDKLNDLEKKHAMLEmnaRSLQQKLETERELKQRlleEQAKLQQQMDL 790
Cdd:pfam01576  788 AANKgreeAVKQLKKLQAQMKDLQRELEEARASRD---EILAQSKESEKKLKNL---EAELLQLQEDL 849
PTZ00121 PTZ00121
MAEBL; Provisional
 194-925 1.03e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 64.01  E-value: 1.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  194 TSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKAstEATELLQNIRQAKE--RAE--RELEKLHNREDSSEGI 269
Cdd:PTZ00121  1090 DEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKA--EEARKAEDARKAEEarKAEdaKRVEIARKAEDARKAE 1167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  270 KKKLVE----AEERRHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQhlEVHLKQKEQH 345
Cdd:PTZ00121  1168 EARKAEdakkAEAARKAEE--VRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAE--EAKKDAEEAK 1243

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  346 YEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKiRSLEQRIVElsEANKLAANSSLFTQR 425
Cdd:PTZ00121  1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAK-KAEEKKKAD--EAKKKAEEAKKADEA 1320

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  426 NMKAQEemiSELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQ 505
Cdd:PTZ00121  1321 KKKAEE---AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK 1397

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  506 LSLQERESQLTALQAARAAlESQLRQAKTELEETTAEAEEEIQALTAHR-DEIQRKFDALRNSctvitdleEQLNQLTED 584
Cdd:PTZ00121  1398 KKAEEDKKKADELKKAAAA-KKKADEAKKKAEEKKKADEAKKKAEEAKKaDEAKKKAEEAKKA--------EEAKKKAEE 1468

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  585 naelnnqnfylSKQLDEASGANDEivqlRSEVDHLRREITEREMQLTSQKQTMEALKTTctmleeqvldlealnDELLEK 664
Cdd:PTZ00121  1469 -----------AKKADEAKKKAEE----AKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------------DEAKKA 1518

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  665 ERQWEAWRSVLGDEKSQFEcrvrELQRMLDTEKQSRARADQRITESRQV--VELAVKEHKAEILALQQAlkeqklkaesl 742
Cdd:PTZ00121  1519 EEAKKADEAKKAEEAKKAD----EAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKA----------- 1583

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  743 sDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 822
Cdd:PTZ00121  1584 -EEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  823 LENIQVLYSHEKVKMEgtisqqtklidflQAKMDQPAKKKKGLFSRRKEDPALPTQvplqynELKLALEKEKARCAEL-- 900
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAE-------------EAKKAEEDEKKAAEALKKEAEEAKKAE------ELKKKEAEEKKKAEELkk 1723

                          730       740
                   ....*....|....*....|....*
gi 1907160229  901 EEALQKTRIELRSAREEAAHRKATD 925
Cdd:PTZ00121  1724 AEEENKIKAEEAKKEAEEDKKKAEE 1748
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
91-724 1.28e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 63.40  E-value: 1.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   91 QLLHDIREQSRKLQEIKE--QEYQAQVEEMRLMmNQLEEDLVS--ARRRSDLYESELRESRLAAEEFKRKANECQHKLmk 166
Cdd:COG4913    242 EALEDAREQIELLEPIRElaERYAAARERLAEL-EYLRAALRLwfAQRRLELLEAELEELRAELARLEAELERLEARL-- 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  167 vvshpprgDSGGTALDDLHK-MQGHAGltSAKDQGKPEVGEyskLEKINAEQQLKIQELQEKLEKA-VKASTEATELLQN 244
Cdd:COG4913    319 --------DALREELDELEAqIRGNGG--DRLEQLEREIER---LERELEERERRRARLEALLAALgLPLPASAEEFAAL 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  245 IRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLE----TMERRENRLKDDIqtkSEQIQQMADKI-- 318
Cdd:COG4913    386 RAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLErrksNIPARLLALRDAL---AEALGLDEAELpf 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 ----LELEEKHREAQ---------------VSAQHL--------EVHLKQK-------------------EQHYEEKIKV 352
Cdd:COG4913    463 vgelIEVRPEEERWRgaiervlggfaltllVPPEHYaaalrwvnRLHLRGRlvyervrtglpdperprldPDSLAGKLDF 542

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  353 LDNQ----IKKDLADK------ESLENM-----------MQRHEEEAHEKG---KILSEQ------KAMINAMDSKIRSL 402
Cdd:COG4913    543 KPHPfrawLEAELGRRfdyvcvDSPEELrrhpraitragQVKGNGTRHEKDdrrRIRSRYvlgfdnRAKLAALEAELAEL 622

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  403 EQRIVELSEANKLAANSslftQRNMKAQEEMISELRQQKFYlETQAGKLEAQNRKLEEQLEKIShqdhSDKSRLLELETR 482
Cdd:COG4913    623 EEELAEAEERLEALEAE----LDALQERREALQRLAEYSWD-EIDVASAEREIAELEAELERLD----ASSDDLAALEEQ 693

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  483 LREVSLEH---EEQKLELKRQLTELQLSLQERESQLTALQAA------------RAALESQLRQAKTELEETTAEAEEEi 547
Cdd:COG4913    694 LEELEAELeelEEELDELKGEIGRLEKELEQAEEELDELQDRleaaedlarlelRALLEERFAAALGDAVERELRENLE- 772

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  548 QALTAHRDEIQRKFDALRN------------SCTVITDLE------EQLNQLTEDNAELNNQNFylSKQLDEASgaNDEI 609
Cdd:COG4913    773 ERIDALRARLNRAEEELERamrafnrewpaeTADLDADLEslpeylALLDRLEEDGLPEYEERF--KELLNENS--IEFV 848

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  610 VQLRSEVDHLRREITER-----------------EMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKerqweawr 672
Cdd:COG4913    849 ADLLSKLRRAIREIKERidplndslkripfgpgrYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEA-------- 920

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  673 svlgdeksQFEcRVREL-QRMLDTEKQSRARADQRITESRQVVELAVKEHKAE 724
Cdd:COG4913    921 --------RFA-ALKRLiERLRSEEEESDRRWRARVLDVRNHLEFDAEEIDRE 964
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
 1241-1492 2.31e-09

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 62.60  E-value: 2.31e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1241 SDQVVLVGTEEGLYALNVLKNS--------LTHIPGIGavfQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLp 1312
Cdd:COG5422    868 SGRKLLTGTNKGLYISNRKDNVnrfnkpidLLQEPNIS---QIIVIEEYKLMLLLSDKKLYSCPLDVIDASTEENVKKS- 943

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1313 aqpDVSPNIFEAVK-----GCHLFAAGKiENSLCICAAMPSKVVILRYNDN------LSKYCIRKEIETSEPCScIHFTN 1381
Cdd:COG5422    944 ---RIVNGHVSFFKqgfcnGKRLVCAVK-SSSLSATLAVIEAPLALKKNKSgnlkkaLTIELSTELYVPSEPLS-VHFLK 1018

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1382 YSILIGTNKFYEI-DMKQYTLDEFLDKNDHSlaPAVFASSSNSFPVSIVQANSagqreEYLLCFHEFGVFVDSYGRRSRT 1460
Cdd:COG5422   1019 NKLCIGCKKGFEIvSLENLRTESLLNPADTS--PLFFEKKENTKPIAIFRVSG-----EFLLCYSEFAFFVNDQGWRKRT 1091

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1907160229 1461 DDL-KWSRLPLAFAYREPYlfVTHFNSlEVIEI 1492
Cdd:COG5422   1092 SWIfHWEGEPQEFALSYPY--ILAFEP-NFIEI 1121
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 451-818 4.04e-09

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 60.85  E-value: 4.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  451 LEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEeqklELKRQLTELQLSLQERESQLTALQAARAALESQLR 530
Cdd:pfam19220   25 LKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYG----KLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  531 QAKTELEETTAeaeeeiqaltahrdeiqrkfdALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASgandeiv 610
Cdd:pfam19220  101 EAEAAKEELRI---------------------ELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAE------- 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  611 QLRSEVDHLRREITEREMQLTSQKQTMEALkttctmLEEQVLDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQ 690
Cdd:pfam19220  153 KALQRAEGELATARERLALLEQENRRLQAL------SEEQAAELAELTRRLAELETQLDATRA-----------RLRALE 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  691 RMLDTEKQSRARADQRItesrqvvELAVKEHKAEILALqqalkeqKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETE 770
Cdd:pfam19220  216 GQLAAEQAERERAEAQL-------EEAVEAHRAERASL-------RMKLEALTARAAATEQ---LLAEARNQLRDRDEAI 278

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  771 RELKQRLLE---EQAKLQQQMDLQKNHIFRLTQGLQEaLDRADLLKTERSD 818
Cdd:pfam19220  279 RAAERRLKEasiERDTLERRLAGLEADLERRTQQFQE-MQRARAELEERAE 328
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 242-828 4.76e-09

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 61.39  E-value: 4.76e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  242 LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSlenkvkRLETMERRENRLKDDIQTKSEQIQQMADKiLEL 321
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIAS------RQEERQETSAELNQLLRTLDDQWKEKRDE-LNG 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  322 EEKHREAQVSA--QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKI 399
Cdd:pfam12128  309 ELSAADAAVAKdrSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQN 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  400 RSLEQRIVELSEANKLAANSSLFTQRNMKAQEEmiSELRQQkfyletqagkLEAQNRKLEEQLEKIshqdhsdKSRLLEL 479
Cdd:pfam12128  389 NRDIAGIKDKLAKIREARDRQLAVAEDDLQALE--SELREQ----------LEAGKLEFNEEEYRL-------KSRLGEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  480 ETRLREVSLEHeeqklELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEettaeaeeeiQALTAHRDEIQR 559
Cdd:pfam12128  450 KLRLNQATATP-----ELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRD----------QASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  560 kfdalrnsctvitdLEEQLNQLTEDNAELNNQNFYLSKQL-DEASGANDEIVQLRSEvDHLRREITEREMQLTSQKQTME 638
Cdd:pfam12128  515 --------------LEERQSALDELELQLFPQAGTLLHFLrKEAPDWEQSIGKVISP-ELLHRTDLDPEVWDGSVGGELN 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  639 ALKTTCTMLEEQVLDLEALNDELLEKERQWEawrSVLGDEKS---QFECRVRELQRMLDTEKQSRARADQRITESRQVVE 715
Cdd:pfam12128  580 LYGVKLDLKRIDVPEWAASEEELRERLDKAE---EALQSAREkqaAAEEQLVQANGELEKASREETFARTALKNARLDLR 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  716 LAVKEHKAEILALQQALKEQKLKAE----SLSDKLNDLEKKH-AMLEMNARSLQ----QKLETERELKQRLLEEQAKLQQ 786
Cdd:pfam12128  657 RLFDEKQSEKDKKNKALAERKDSANerlnSLEAQLKQLDKKHqAWLEEQKEQKReartEKQAYWQVVEGALDAQLALLKA 736

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  787 QMDLQKNHIFRLTQGLQEALDRaDL------------LKTERSDLEYQLENIQV 828
Cdd:pfam12128  737 AIAARRSGAKAELKALETWYKR-DLaslgvdpdviakLKREIRTLERKIERIAV 789
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 8-822 5.04e-09

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 61.60  E-value: 5.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    8 KSKELQDSQDKCHKMEQEMTRLHRRVSEVEavLSQKEVELKASETQrslleqdlatyiteCSSLKRSLEQARMEVSQEDD 87
Cdd:TIGR00606  317 KERELVDCQRELEKLNKERRLLNQEKTELL--VEQGRLQLQADRHQ--------------EHIRARDSLIQSLATRLELD 380

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   88 kALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKV 167
Cdd:TIGR00606  381 -GFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFV 459

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  168 VShppRGDSGGTALDDLHKMQghAGLTSAKdqgkpevGEYSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQ 247
Cdd:TIGR00606  460 IK---ELQQLEGSSDRILELD--QELRKAE-------RELSKAEKNSLTETLKKEVKSLQNEKA--------DLDRKLRK 519

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  248 AKERAErELEKLHNREDSSEGIKKKLVEAEER------RHSLEnkVKRLETMERRENRLKDDIQTKSEQIQQMADKILEL 321
Cdd:TIGR00606  520 LDQEME-QLNHHTTTRTQMEMLTKDKMDKDEQirkiksRHSDE--LTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKL 596

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  322 EEKHREAQVSAQHLEVHLKQKEQH---YEEKIKvldnqikkDLADKESLENMMQRHEEEAHEKGKilseQKAMINAmdsK 398
Cdd:TIGR00606  597 NKELASLEQNKNHINNELESKEEQlssYEDKLF--------DVCGSQDEESDLERLKEEIEKSSK----QRAMLAG---A 661

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  399 IRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI--------SHQDH 470
Cdd:TIGR00606  662 TAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrqSIIDL 741

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  471 SDKsRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERES------QLTALQAARAALESQLRQ-AKTELEETTAEA 543
Cdd:TIGR00606  742 KEK-EIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESakvcltDVTIMERFQMELKDVERKiAQQAAKLQGSDL 820

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  544 EEEIQALTAHRDEIQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHL 619
Cdd:TIGR00606  821 DRTVQQVNQEKQEKQHELDTVVSKIelnrKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  620 RREITEREMQLTSQKQTMEalkttctmleeqvlDLEALNDELLEKERQweawrsvlgdEKSQFECRVRELQRMLDTEKQS 699
Cdd:TIGR00606  901 IREIKDAKEQDSPLETFLE--------------KDQQEKEELISSKET----------SNKKAQDKVNDIKEKVKNIHGY 956

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  700 RARADQRITESRqvvELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL----------ET 769
Cdd:TIGR00606  957 MKDIENKIQDGK---DDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLtlrkrenelkEV 1033

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  770 ERELKQRLLE-----------EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQ 822
Cdd:TIGR00606 1034 EEELKQHLKEmgqmqvlqmkqEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 246-938 7.89e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 60.75  E-value: 7.89e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  246 RQAKERAE--RELEKLHNREDSSEGIKKKLVEAEERRHSLEnkvKRLETMERRENRLKDDIQTKSEqiqqmadkILELEE 323
Cdd:TIGR00618  160 AKSKEKKEllMNLFPLDQYTQLALMEFAKKKSLHGKAELLT---LRSQLLTLCTPCMPDTYHERKQ--------VLEKEL 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  324 KH-REAQVSAQHLEVHLKQKEQHYEEKIKvLDNQIKKDLADKESLENMMQRHE------EEAHEKGKILSEQKAMINaMD 396
Cdd:TIGR00618  229 KHlREALQQTQQSHAYLTQKREAQEEQLK-KQQLLKQLRARIEELRAQEAVLEetqeriNRARKAAPLAAHIKAVTQ-IE 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  397 SKIRSLEQRIVElseanKLAANSSLFTQRNMKAQEEmiSELRQQKFYLETqagkLEAQNRKLEEQLEK-ISHQDHSDKSR 475
Cdd:TIGR00618  307 QQAQRIHTELQS-----KMRSRAKLLMKRAAHVKQQ--SSIEEQRRLLQT----LHSQEIHIRDAHEVaTSIREISCQQH 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  476 LLELETRLREVSLEHEEQKLELKRQLTElqlSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeiQALTAHRD 555
Cdd:TIGR00618  376 TLTQHIHTLQQQKTTLTQKLQSLCKELD---ILQREQATIDTRTSAFRDLQGQLAHAKKQ------------QELQQRYA 440

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  556 EIQRKFdalrnsctvitdLEEQLNQLTEDNAELNNqnfylskqldeasgandeivqlrsevdhLRREITEREMQLTSQKQ 635
Cdd:TIGR00618  441 ELCAAA------------ITCTAQCEKLEKIHLQE----------------------------SAQSLKEREQQLQTKEQ 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  636 TMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRsVLGDEKSQFECRVRELQRMLDTEKQSRARAD---QRITESRQ 712
Cdd:TIGR00618  481 IHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPAR-QDIDNPGPLTRRMQRGEQTYAQLETSEEDVYhqlTSERKQRA 559

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  713 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKkhaMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 792
Cdd:TIGR00618  560 SLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD---LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQ 636

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  793 nhifrLTQGLQEALDRadlLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtKLIDFLQAKMDQPAKKKKGLFSR---- 868
Cdd:TIGR00618  637 -----CSQELALKLTA---LHALQLTLTQERVREHALSIRVLPKELLASRQ--LALQKMQSEKEQLTYWKEMLAQCqtll 706

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  869 RKEDPALPTQVPlQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQ 938
Cdd:TIGR00618  707 RELETHIEEYDR-EFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQ 775
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
346-917 1.23e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 60.08  E-value: 1.23e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  346 YEEKIKVLDNQIKKDLADKESLENMMQRhEEEAHEKgkiLSEQKAMINAMDSKIRSLEQRIVELSEanKLAANSSLFtqR 425
Cdd:PRK03918   160 YENAYKNLGEVIKEIKRRIERLEKFIKR-TENIEEL---IKEKEKELEEVLREINEISSELPELRE--ELEKLEKEV--K 231

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  426 NMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREV-SLEHEEQK-LELKRQLTE 503
Cdd:PRK03918   232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL-------KKEIEELEEKVKELkELKEKAEEyIKLSEFYEE 304

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  504 LQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 583
Cdd:PRK03918   305 YLDELREIEKRLSRLEEEINGIEERIKELEEKEER--------LEELKKKLKELEKRLEELEERHELYEEAKAKKEELER 376

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  584 DNAELNNQNF-YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTC-------------TMLEE 649
Cdd:PRK03918   377 LKKRLTGLTPeKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCpvcgrelteehrkELLEE 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  650 QVLDLEALNDELLEkerqweawrsvLGDEKSQFECRVRELQRMLdtEKQSRARADQRITESRQVVELAVKEHKAEilalq 729
Cdd:PRK03918   457 YTAELKRIEKELKE-----------IEEKERKLRKELRELEKVL--KKESELIKLKELAEQLKELEEKLKKYNLE----- 518

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  730 qALKEQKLKAESLSDKLNDLEKKhamlemnARSLQQKLETERELKQRLLEEQAKLQQqmdlqknhifrltqglqealdra 809
Cdd:PRK03918   519 -ELEKKAEEYEKLKEKLIKLKGE-------IKSLKKELEKLEELKKKLAELEKKLDE----------------------- 567

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  810 dlLKTERSDLEYQLENIQVLYSHEkvkMEGTISQQTKLID-FLQAKmdqPAKKKKglfsRRKEDpalptqvplqynelkl 888
Cdd:PRK03918   568 --LEEELAELLKELEELGFESVEE---LEERLKELEPFYNeYLELK---DAEKEL----EREEK---------------- 619

                          570       580
                   ....*....|....*....|....*....
gi 1907160229  889 ALEKEKARCAELEEALQKTRIELRSAREE 917
Cdd:PRK03918   620 ELKKLEEELDKAFEELAETEKRLEELRKE 648
mukB PRK04863
chromosome partition protein MukB;
94-941 1.67e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 59.97  E-value: 1.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   94 HDIREQSRKLQEIK------EQEYQAQVEEMRLMMNQL---------EEDLVSARRRsdLYES-----ELRESRLAAEEF 153
Cdd:PRK04863   307 YRLVEMARELAELNeaesdlEQDYQAASDHLNLVQTALrqqekieryQADLEELEER--LEEQnevveEADEQQEENEAR 384

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  154 KRKANECQHKLMKVVSHPPRgdsggtALDDLHKM-----QGHAGLTSAKDQ-GKPEVgEYSKLEKINAEQQLKIQELQEK 227
Cdd:PRK04863   385 AEAAEEEVDELKSQLADYQQ------ALDVQQTRaiqyqQAVQALERAKQLcGLPDL-TADNAEDWLEEFQAKEQEATEE 457

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  228 L----------EKAVKASTEATELLQNI----------RQAKErAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKV 287
Cdd:PRK04863   458 LlsleqklsvaQAAHSQFEQAYQLVRKIagevsrseawDVARE-LLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAE 536

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE-------------KIKVLD 354
Cdd:PRK04863   537 RLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRlaarapawlaaqdALARLR 616

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  355 NQIKKDLADKESLENMMQRHEEEAHEkgkiLSEQKAMINAmdsKIRSLEQRIVELSEANklaaNSSLFTQRNMKAQ--EE 432
Cdd:PRK04863   617 EQSGEEFEDSQDVTEYMQQLLERERE----LTVERDELAA---RKQALDEEIERLSQPG----GSEDPRLNALAERfgGV 685

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  433 MISELR-----QQKFYLETQAGK---------LEAQNRKLEEQlekishQDHSDKSRLLELE-TRLREVSLEHEEQKLEL 497
Cdd:PRK04863   686 LLSEIYddvslEDAPYFSALYGParhaivvpdLSDAAEQLAGL------EDCPEDLYLIEGDpDSFDDSVFSVEELEKAV 759

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  498 KRQLTELQLslqeRESQLTALQA-ARAALESQLRQakteleettaeaeeeiqaLTAHRDEIQRKFDALRNSCTVITDLEE 576
Cdd:PRK04863   760 VVKIADRQW----RYSRFPEVPLfGRAAREKRIEQ------------------LRAEREELAERYATLSFDVQKLQRLHQ 817

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  577 QLNQLTednaelnNQNFYLSKQLDEasgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEE-----QV 651
Cdd:PRK04863   818 AFSRFI-------GSHLAVAFEADP----EAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRllprlNL 886

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  652 LDLEALNDELLEKERQW----EAWRSVlgdekSQFECRVRELQRMLDTEKQSRARADQritesrqvVELAVKEHKAEILA 727
Cdd:PRK04863   887 LADETLADRVEEIREQLdeaeEAKRFV-----QQHGNALAQLEPIVSVLQSDPEQFEQ--------LKQDYQQAQQTQRD 953

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  728 LQQ---ALKE--QKLKAESLSDKLNDLEKKHAMLEmnarSLQQKLETERELKQRLLEEQAKLQQQMDlQKNHIFrltQGL 802
Cdd:PRK04863   954 AKQqafALTEvvQRRAHFSYEDAAEMLAKNSDLNE----KLRQRLEQAEQERTRAREQLRQAQAQLA-QYNQVL---ASL 1025

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  803 QEALDRAdllKTERSDLEYQLENIQVLYshekvkmegtisqqtklidflqakmDQPAKKKkglfSRRKEDpalptqvplq 882
Cdd:PRK04863  1026 KSSYDAK---RQMLQELKQELQDLGVPA-------------------------DSGAEER----ARARRD---------- 1063

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  883 ynELKLALEKEKARCAELEEALQKTRIELRSA--REEAAHRKATDHPHPSTPATARQQIAM 941
Cdd:PRK04863  1064 --ELHARLSANRSRRNQLEKQLTFCEAEMDNLtkKLRKLERDYHEMREQVVNAKAGWCAVL 1122
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
23-531 2.12e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.28  E-value: 2.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   23 EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyiTECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRK 102
Cdd:PRK02224   198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETR----DEADEVLEEHEERREELETLEAEIEDLRETIAETERE 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  103 LQEIKE--QEYQAQVEEMR---------LMMNQLEEDLVSARR-----RSDLYESELRESRLAAEEFKrkaNECQHKLMK 166
Cdd:PRK02224   274 REELAEevRDLRERLEELEeerddllaeAGLDDADAEAVEARReeledRDEELRDRLEECRVAAQAHN---EEAESLRED 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  167 VVSHPPRGDSGGTALDDLHkmqghAGLTSAKDQGKPEVGEYSKLEK---------INAEQQL-----KIQELQEKLEKAV 232
Cdd:PRK02224   351 ADDLEERAEELREEAAELE-----SELEEAREAVEDRREEIEELEEeieelrerfGDAPVDLgnaedFLEELREERDELR 425

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  233 KASTEATELLQNIRQAKERAERELEK------------------LHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM- 293
Cdd:PRK02224   426 EREAELEATLRTARERVEEAEALLEAgkcpecgqpvegsphvetIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLv 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  294 --ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQK-----EQHYE-----EKIKVLDNQIKKDL 361
Cdd:PRK02224   506 eaEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKreaaaEAEEEaeearEEVAELNSKLAELK 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  362 ADKESLENmmqrheeeahekgkiLSEQKAMINAMDSKIRSLEQRIVELSEAN-----KLAANSSLFTQRNMKAQEEMISE 436
Cdd:PRK02224   586 ERIESLER---------------IRTLLAAIADAEDEIERLREKREALAELNderreRLAEKRERKRELEAEFDEARIEE 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  437 LRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREvslEHEEqklelkrqltelqlsLQERESQLT 516
Cdd:PRK02224   651 AREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELE-ELRE---RREA---------------LENRVEALE 711

                          570       580
                   ....*....|....*....|..
gi 1907160229  517 A-------LQAARAALESQLRQ 531
Cdd:PRK02224   712 AlydeaeeLESMYGDLRAELRQ 733
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
425-820 2.25e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 59.01  E-value: 2.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  425 RNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH--QDHSDKSRLLELETRLREVSlEHEEQKLELKRQLT 502
Cdd:COG4717     71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEElrEELEKLEKLLQLLPLYQELE-ALEAELAELPERLE 149

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  503 ELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLT 582
Cdd:COG4717    150 ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEE---LEEAQEELEELE 226

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  583 EDNAELNNQ--NFYLSKQLDEA-------------SGAND----------EIVQLRSEVDHLRREITEREMQLTSQKQTM 637
Cdd:COG4717    227 EELEQLENEleAAALEERLKEArlllliaaallalLGLGGsllsliltiaGVLFLVLGLLALLFLLLAREKASLGKEAEE 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  638 EALKTTCTMLEEQV---------LDLEALNDELLEKERQWEAWRSVL-----GDEKSQFECRVRELQRMLDTEK-QSRAR 702
Cdd:COG4717    307 LQALPALEELEEEEleellaalgLPPDLSPEELLELLDRIEELQELLreaeeLEEELQLEELEQEIAALLAEAGvEDEEE 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  703 ADQRITESRQVVELavkehKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLEEQA 782
Cdd:COG4717    387 LRAALEQAEEYQEL-----KEELEELEEQLEELLGELEELLEALDE-----EELEEELEELEEELEELEEELEELREELA 456

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 1907160229  783 KLQQQMDLQKNhifrlTQGLQEALDRADLLKTERSDLE 820
Cdd:COG4717    457 ELEAELEQLEE-----DGELAELLQELEELKAELRELA 489
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 217-465 2.63e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  217 QQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLetmERR 296
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL---ERRIAALARRIRALEQELAALEAELAEL---EKE 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  297 ENRLKDDIQTKSEQIQQMAdkileleekhREAQVSAQHlevhlkqkeqhyeEKIKVLDNQikKDLADKESLENMMQRHEE 376
Cdd:COG4942     92 IAELRAELEAQKEELAELL----------RALYRLGRQ-------------PPLALLLSP--EDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  377 EAHEKGKILSEQKAMINAmdsKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNR 456
Cdd:COG4942    147 ARREQAEELRADLAELAA---LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223


                   ....*....
gi 1907160229  457 KLEEQLEKI 465
Cdd:COG4942    224 ELEALIARL 232
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 214-913 2.77e-08

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 58.68  E-value: 2.77e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  214 NAEQQLKIQELQEKLekavKASTEATELLQNIRQAKERAEREleKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 293
Cdd:pfam10174   69 NQHLQLTIQALQDEL----RAQRDLNQLLQQDFTTSPVDGED--KFSTPELTEENFRRLQSEHERQAKELFLLRKTLEEM 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  294 ERRENRLKDDIQTKSEQIQQMAD--------KILELEEKHR-----EAQVSAQHLEVHLKQKEqhyeekikvldnqiKKD 360
Cdd:pfam10174  143 ELRIETQKQTLGARDESIKKLLEmlqskglpKKSGEEDWERtrriaEAEMQLGHLEVLLDQKE--------------KEN 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  361 LADKESLENMMQRHEEEAHEKGkilseQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTqrnmkaqEEMISELRQ 439
Cdd:pfam10174  209 IHLREELHRRNQLQPDPAKTKA-----LQTVIEMKDTKISSLERNIRDLEdEVQMLKTNGLLHT-------EDREEEIKQ 276

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  440 QKFYletqagkleaqnrkleeqlekishQDHSDKsrlleletrlrevsleheeqkleLKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam10174  277 MEVY------------------------KSHSKF-----------------------MKNKIDQLKQELSKKESELLALQ 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  520 AARAALESQLRQAKTELEETTaeaeeeiQALTAHRDE---IQRKFDALRNSC----TVITDLEEQLNQLTEDNAELNNQN 592
Cdd:pfam10174  310 TKLETLTNQNSDCKQHIEVLK-------ESLTAKEQRaaiLQTEVDALRLRLeekeSFLNKKTKQLQDLTEEKSTLAGEI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  593 FYLSKQLDEAsgaNDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEalnDELLEKERQWEAWR 672
Cdd:pfam10174  383 RDLKDMLDVK---ERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLE---EALSEKERIIERLK 456

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  673 svlgdEKSQFECRVR--ELQRMLDTEKQSRARAD--QRITESRQVVELAVKEHkAEILALQQALKEQKLKA--------- 739
Cdd:pfam10174  457 -----EQREREDRERleELESLKKENKDLKEKVSalQPELTEKESSLIDLKEH-ASSLASSGLKKDSKLKSleiaveqkk 530

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  740 ESLSDKLNDLEKKHAMlEMNARSLQQKLETERELKQ---RLLEEQAKLQQQMDlqknhifRLTQGLQEAldradllKTER 816
Cdd:pfam10174  531 EECSKLENQLKKAHNA-EEAVRTNPEINDRIRLLEQevaRYKEESGKAQAEVE-------RLLGILREV-------ENEK 595

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  817 SDLEYQLENIQVLYSHEkvkmegtISQQTKLIDflQAKMDQPAKKKKGLfsrRKEDPALPTQVPLQYNELKLALEkekar 896
Cdd:pfam10174  596 NDKDKKIAELESLTLRQ-------MKEQNKKVA--NIKHGQQEMKKKGA---QLLEEARRREDNLADNSQQLQLE----- 658

                          730
                   ....*....|....*..
gi 1907160229  897 caELEEALQKTRIELRS 913
Cdd:pfam10174  659 --ELMGALEKTRQELDA 673
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 458-905 2.88e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 58.98  E-value: 2.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEQLEKISHQdhsdksrLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR-------AALESQLR 530
Cdd:pfam15921   76 IERVLEEYSHQ-------VKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRrresqsqEDLRNQLQ 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  531 QAKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQ--------------------------LNQ 580
Cdd:pfam15921  149 NTVHELEAAKCLKEDMLEDSNTQIEQLRKMMlsheGVLQEIRSILVDFEEAsgkkiyehdsmstmhfrslgsaiskiLRE 228

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  581 LTEDNAELNNQNFYLSKQLD--EASGANDEIVQLRSEVDHLRREITEREMQLT-------SQKQTMEALKTTCTMLEEQV 651
Cdd:pfam15921  229 LDTEISYLKGRIFPVEDQLEalKSESQNKIELLLQQHQDRIEQLISEHEVEITgltekasSARSQANSIQSQLEIIQEQA 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  652 LDLEALN-DELLEKERQWEAWRSVLGDEKSQFECRVRELQRML---DTE-KQSRARADQRITES----RQVVELAVKEHK 722
Cdd:pfam15921  309 RNQNSMYmRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLvlaNSElTEARTERDQFSQESgnldDQLQKLLADLHK 388

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  723 AEilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ-QKLETerELKQRLLEEQAKLQQQMdlqknhifRLTQG 801
Cdd:pfam15921  389 RE---KELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEvQRLEA--LLKAMKSECQGQMERQM--------AAIQG 455

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  802 LQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQakmdqpaKKKKGLFSRRKEDPALPTQVPL 881
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-------EKERAIEATNAEITKLRSRVDL 528

                          490       500
                   ....*....|....*....|....*.
gi 1907160229  882 QYNELK-LALEKEKARCAELE-EALQ 905
Cdd:pfam15921  529 KLQELQhLKNEGDHLRNVQTEcEALK 554
C1_KSR cd20812
protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) ...
 986-1037 3.11e-08

protein kinase C conserved region 1 (C1 domain) found in the kinase suppressor of Ras (KSR) family; KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. KSR proteins contain a SAM-like domain, a zinc finger cysteine-rich domain (C1), and a pseudokinase domain. This model describes the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410362  Cd Length: 48  Bit Score: 51.17  E-value: 3.11e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  986 IPHRFNVGLNMRATkCAVCLDTVHFGRqasKCLECQVMCHPKCSTCLPATCG 1037
Cdd:cd20812      1 IKHRFSKKLFMRQT-CDYCHKQMFFGL---KCKDCKYKCHKKCAKKAPPSCG 48
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 4-858 3.64e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 3.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLS---QKEVELKASETQRSLLEQDlatyitecsslKRSLEQARM 80
Cdd:TIGR00606  225 QITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSkimKLDNEIKALKSRKKQMEKD-----------NSELELKME 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   81 EVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEM---RLMMNQLEEDLVSARRRSDLyESELRESRLAAEEFKRKA 157
Cdd:TIGR00606  294 KVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLnkeRRLLNQEKTELLVEQGRLQL-QADRHQEHIRARDSLIQS 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  158 NECQHKLMKVvshpPRGDSGGTALDDLHKMqghagltsakdQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTE 237
Cdd:TIGR00606  373 LATRLELDGF----ERGPFSERQIKNFHTL-----------VIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKG 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  238 ATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQI---QQM 314
Cdd:TIGR00606  438 LGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKAdldRKL 517

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  315 ADKILELEEKHREAQVSAQHLEVHLKQ----------KEQHYEEKIKVL-DNQIKKDLADK-ESLENMMQRHEEEAHEKG 382
Cdd:TIGR00606  518 RKLDQEMEQLNHHTTTRTQMEMLTKDKmdkdeqirkiKSRHSDELTSLLgYFPNKKQLEDWlHSKSKEINQTRDRLAKLN 597

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  383 KILSEQKAMINAMDSKIRSLEQRIVELSEaNKLAANSSLFTQRNMKAQEEMISELRQQKFYLetqAGKLEAQNRKLEEQL 462
Cdd:TIGR00606  598 KELASLEQNKNHINNELESKEEQLSSYED-KLFDVCGSQDEESDLERLKEEIEKSSKQRAML---AGATAVYSQFITQLT 673

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  463 EK------ISHQDHSDKSRLLE----LETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALEsQLRQA 532
Cdd:TIGR00606  674 DEnqsccpVCQRVFQTEAELQEfisdLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIP-ELRNK 752

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  533 KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITdLEEQLNQLTEDN--------AELNNQNFYLSKQL--DEA 602
Cdd:TIGR00606  753 LQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT-IMERFQMELKDVerkiaqqaAKLQGSDLDRTVQQvnQEK 831

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  603 SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQ- 681
Cdd:TIGR00606  832 QEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQd 911

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  682 ------FECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAES----LSDKLNDLEK 751
Cdd:TIGR00606  912 spletfLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETelntVNAQLEECEK 991

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  752 KHAMLEMNARSLQQKLETEReLKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQE-ALDRADLLKTERSDLEYQLENIQvly 830
Cdd:TIGR00606  992 HQEKINEDMRLMRQDIDTQK-IQERWLQDNLTLRKRENELKEVEEELKQHLKEmGQMQVLQMKQEHQKLEENIDLIK--- 1067

                          890       900
                   ....*....|....*....|....*...
gi 1907160229  831 sHEKVKMEGTISQQTKLIDFLQAKMDQP 858
Cdd:TIGR00606 1068 -RNHVLALGRQKGYEKEIKHFKKELREP 1094
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 415-667 3.73e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.47  E-value: 3.73e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  415 LAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIShqdhsdkSRLLELETRLREVslehEEQK 494
Cdd:COG4942     10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE-------RRIAALARRIRAL----EQEL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  495 LELKRQLTELQLSLQERESQLTALqaaRAALESQLRQAKTELEETTAeaeeeiqALTAHRDEIQRKFDALRNSCTVITDL 574
Cdd:COG4942     79 AALEAELAELEKEIAELRAELEAQ---KEELAELLRALYRLGRQPPL-------ALLLSPEDFLDAVRRLQYLKYLAPAR 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  575 EEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEvdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDL 654
Cdd:COG4942    149 REQAEELRADLAELAALRAELEAERAELEALLAELEEERAA---LEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225

                          250
                   ....*....|...
gi 1907160229  655 EALNDELLEKERQ 667
Cdd:COG4942    226 EALIARLEAEAAA 238
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 8-343 3.87e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 58.21  E-value: 3.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    8 KSKELQDSQDKCHKMEQEMTRlhrrvseveavlSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDD 87
Cdd:pfam17380  282 KAVSERQQQEKFEKMEQERLR------------QEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERE 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   88 kalqlLHDIREQSRK--LQEIKEQEYQAQVEEMR-LMMNQLEEDLVSARRRSDLYESelRESRLAAEEFKRKANECQHKL 164
Cdd:pfam17380  350 -----LERIRQEERKreLERIRQEEIAMEISRMReLERLQMERQQKNERVRQELEAA--RKVKILEEERQRKIQQQKVEM 422

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  165 MKVvshppRGDSGGTALDDLHKMQGHAG--LTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELL 242
Cdd:pfam17380  423 EQI-----RAEQEEARQREVRRLEEERAreMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKIL 497

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  243 QniRQAKERAERELEKLHNR---EDSSEGIKKKLVEAEERRHSLENKVKRLETMERREnrlkddIQtksEQIQQMADKIL 319
Cdd:pfam17380  498 E--KELEERKQAMIEEERKRkllEKEMEERQKAIYEEERRREAEEERRKQQEMEERRR------IQ---EQMRKATEERS 566

                          330       340
                   ....*....|....*....|....
gi 1907160229  320 ELEEKHREAQVSAQHLEVHLKQKE 343
Cdd:pfam17380  567 RLEAMEREREMMRQIVESEKARAE 590
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 1-529 4.07e-08

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 58.19  E-value: 4.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    1 MEKKLLIKSKELQDSQDKCHKMEQEM----TRLHRRVSEVEAV--------------LSQKEV---ELKASETQRSLLEQ 59
Cdd:pfam05483  273 LEEKTKLQDENLKELIEKKDHLTKELedikMSLQRSMSTQKALeedlqiatkticqlTEEKEAqmeELNKAKAAHSFVVT 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   60 DLATYITECSSLKRSlEQARMEVSQEDDKALQLlhDIREQSRKLQEIKEQEYQAQVEemrlmmnqLEE-DLVSARRRSDL 138
Cdd:pfam05483  353 EFEATTCSLEELLRT-EQQRLEKNEDQLKIITM--ELQKKSSELEEMTKFKNNKEVE--------LEElKKILAEDEKLL 421

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  139 YESELRESrlAAEEFKRKANECQHKLMkvvshpprgdsggTALDDLHKMQGHAGLTSAKDQgkpevgEYSKlekinaeqq 218
Cdd:pfam05483  422 DEKKQFEK--IAEELKGKEQELIFLLQ-------------AREKEIHDLEIQLTAIKTSEE------HYLK--------- 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  219 lKIQELQEKLEKAVKASTEATE-----LLQNIRQAKERAERELEKLHNREDSSEGIKKKlveaeerrhslENKVKRLETM 293
Cdd:pfam05483  472 -EVEDLKTELEKEKLKNIELTAhcdklLLENKELTQEASDMTLELKKHQEDIINCKKQE-----------ERMLKQIENL 539

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  294 ERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIkvldNQIKKDLADKEslENMMQR 373
Cdd:pfam05483  540 EEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKC----NNLKKQIENKN--KNIEEL 613

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  374 HEEEAHEKGKILSEQKAMiNAMDSKIRSLEQrivelseanKLAANSSLFTQRNMKAQEEM-ISELRQQKFYLETQAGKLE 452
Cdd:pfam05483  614 HQENKALKKKGSAENKQL-NAYEIKVNKLEL---------ELASAKQKFEEIIDNYQKEIeDKKISEEKLLEEVEKAKAI 683

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  453 AQNR-KLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQ-ERESQLTALQAARAALESQL 529
Cdd:pfam05483  684 ADEAvKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKaALEIELSNIKAELLSLKKQL 762
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
557-789 5.42e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 57.72  E-value: 5.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  557 IQRKFDALRNSctvITDLEEQLNQLTE--DNAELNNQNFYLSKQL----DEASGANDEIVQLRSEVDHLRREITEREMQL 630
Cdd:COG3206    166 LELRREEARKA---LEFLEEQLPELRKelEEAEAALEEFRQKNGLvdlsEEAKLLLQQLSELESQLAEARAELAEAEARL 242

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  631 TSQKQTMEALKTTCTMLEEQVLdLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRARADQRITES 710
Cdd:COG3206    243 AALRAQLGSGPDALPELLQSPV-IQQLRAQLAELEAELAELSARYTPNHPD----VIALRAQIAALRAQLQQEAQRILAS 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  711 RQVvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLekkhamlemnaRSLQQKLETERELKQRLLE--EQAKLQQQM 788
Cdd:COG3206    318 LEA---ELEALQAREASLQAQLAQLEARLAELPELEAEL-----------RRLEREVEVARELYESLLQrlEEARLAEAL 383


                   .
gi 1907160229  789 D 789
Cdd:COG3206    384 T 384
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
555-834 5.93e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.00  E-value: 5.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  555 DEIQRKFDALRNSCTVITDLEEQLNQLTEdnaelnnqnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLtsQK 634
Cdd:COG4913    228 DALVEHFDDLERAHEALEDAREQIELLEP-----------IRELAERYAAARERLAELEYLRAALRLWFAQRRLEL--LE 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  635 QTMEALKTTCTMLEEQVLDLEALNDELLEKERQWE-AWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRItesrQV 713
Cdd:COG4913    295 AELEELRAELARLEAELERLEARLDALREELDELEaQIRGNGGDRLEQLEREIERLERELEERERRRARLEALL----AA 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  714 VELAVKEHKAEILALQQALKEQKLKAESLSDKlndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQQMDLQKN 793
Cdd:COG4913    371 LGLPLPASAEEFAALRAEAAALLEALEEELEA-----------------LEEALAEAEAALRDLRRELRELEAEIASLER 433

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 1907160229  794 HIFRLTQGLQEALDR-ADLLKTERSDLEYQLENIQVLYSHEK 834
Cdd:COG4913    434 RKSNIPARLLALRDAlAEALGLDEAELPFVGELIEVRPEEER 475
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 482-808 6.30e-08

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 58.04  E-value: 6.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  482 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettAEAEEEIQALTAHRDEIQRKF 561
Cdd:COG3096    282 ELSERALELRRELFGARRQLAEEQYRLVEMARELEELSARESDLEQDYQAA--------SDHLNLVQTALRQQEKIERYQ 353

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  562 DALrnsctviTDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK 641
Cdd:COG3096    354 EDL-------EELTERLEEQEEVVEEAAEQ---LAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAVQALE 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  642 TTCTMLEEQVLDLEALNDELLE-KERQWEAWRSVLGDE---------KSQFECRVRELQRMLDTEKQSRA--RADQRITE 709
Cdd:COG3096    424 KARALCGLPDLTPENAEDYLAAfRAKEQQATEEVLELEqklsvadaaRRQFEKAYELVCKIAGEVERSQAwqTARELLRR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  710 SRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHA-------MLEMNARSLQQKLETERELKQRLLEE 780
Cdd:COG3096    504 YRSQQALAQRLQqlRAQLAELEQRLRQQQ-NAERL---LEEFCQRIGqqldaaeELEELLAELEAQLEELEEQAAEAVEQ 579

                          330       340       350
                   ....*....|....*....|....*....|....
gi 1907160229  781 QAKLQQQMDLQKNHIFRLTQ------GLQEALDR 808
Cdd:COG3096    580 RSELRQQLEQLRARIKELAArapawlAAQDALER 613
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
3-406 7.05e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 57.47  E-value: 7.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    3 KKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLAtyitecsslKRSLEQARMEV 82
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQE---------LEALEAELAEL 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   83 SQEDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLM----------MNQLEEDLVSARRRSDLYESELRESRLAAEE 152
Cdd:COG4717    145 PERLEELEERLEELRELEEELEELEAELAELQEELEELLeqlslateeeLQDLAEELEELQQRLAELEEELEEAQEELEE 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  153 FKRKANECQHKLMK-------------------VVSHPPRGDSGGTALDDLHKMQ---------GHAGLTSAKDQGKPEV 204
Cdd:COG4717    225 LEEELEQLENELEAaaleerlkearlllliaaaLLALLGLGGSLLSLILTIAGVLflvlgllalLFLLLAREKASLGKEA 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  205 GEYSKLEKINAEQQLKIQELQEKLEKAVKAS-TEATELLQNIRQAK------ERAERELEKLHNREDSSEGIKKKLVEAE 277
Cdd:COG4717    305 EELQALPALEELEEEELEELLAALGLPPDLSpEELLELLDRIEELQellreaEELEEELQLEELEQEIAALLAEAGVEDE 384

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  278 ErrhSLENKVKRLEtmerRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsaqhlevhLKQKEQHYEEKIKVLDNQI 357
Cdd:COG4717    385 E---ELRAALEQAE----EYQELKEELEELEEQLEELLGELEELLEALDEEE---------LEEELEELEEELEELEEEL 448

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1907160229  358 KKDLADKESLENMMQRHEEEahekgKILSEQKAMINAMDSKIRSLEQRI 406
Cdd:COG4717    449 EELREELAELEAELEQLEED-----GELAELLQELEELKAELRELAEEW 492
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 339-533 7.53e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 7.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  339 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS---EANKL 415
Cdd:COG4942     25 AEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRaelEAQKE 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  416 AANSSLFTQRNMKAQEEMISELRQQKFY-LETQAGKLEAQNRKLEEQLEKIshqdHSDKSRLLELETRLREVSLEHEEQK 494
Cdd:COG4942    105 ELAELLRALYRLGRQPPLALLLSPEDFLdAVRRLQYLKYLAPARREQAEEL----RADLAELAALRAELEAERAELEALL 180

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1907160229  495 LELKRQLTELQLSLQERESQLTALQAARAALESQLRQAK 533
Cdd:COG4942    181 AELEEERAALEALKAERQKLLARLEKELAELAAELAELQ 219
PH pfam00169
PH domain; PH stands for pleckstrin homology.
 1069-1188 8.63e-08

PH domain; PH stands for pleckstrin homology.


Pssm-ID: 459697 [Multi-domain]  Cd Length: 105  Bit Score: 51.79  E-value: 8.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1069 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVeefelclpdGDVSIHGAVgASELANTAKADVPY 1148
Cdd:pfam00169    1 VVKEGWLLKKGGGKKK--SWKKRYFVLFDGSLLYYKDDKSGKSKEPK---------GSISLSGCE-VVEVVASDSPKRKF 68

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907160229 1149 ILKMESHPHTtcwPGRTLYLLAPSFPDKQRWVTALESVVA 1188
Cdd:pfam00169   69 CFELRTGERT---GKRTYLLQAESEEERKDWIKAIQSAIR 105
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 708-919 8.89e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 8.89e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  708 TESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ 787
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  788 MDLQKNHIFRLTQGLQ------------------EALDRADLLKTERSDLEYQLENIQvlysHEKVKMEGTISQQTKLID 849
Cdd:COG4942     99 LEAQKEELAELLRALYrlgrqpplalllspedflDAVRRLQYLKYLAPARREQAEELR----ADLAELAALRAELEAERA 174

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  850 FLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAA 919
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 208-788 9.16e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 57.16  E-value: 9.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  208 SKLEKINAEQQLKIQELQEKL---EKAVKASTEATELLQNirQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLE 284
Cdd:pfam12128  290 QLLRTLDDQWKEKRDELNGELsaaDAAVAKDRSELEALED--QHGAFLDADIETAAADQEQLPSWQSELENLEERLKALT 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  285 NKVKRLE-TMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSA-QHLEVHLKQKEQHYEEKIKVLDNQIKKDLA 362
Cdd:pfam12128  368 GKHQDVTaKYNRRRSKIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDlQALESELREQLEAGKLEFNEEEYRLKSRLG 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  363 DKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKF 442
Cdd:pfam12128  448 ELKLRLNQATATPELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELEL 527

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  443 YLETQAGKLEAQNRKlEEQLEKISHQDHSDKSRLL--ELETRLREVSLEHEEQ----KLELKR----QLTELQLSLQERE 512
Cdd:pfam12128  528 QLFPQAGTLLHFLRK-EAPDWEQSIGKVISPELLHrtDLDPEVWDGSVGGELNlygvKLDLKRidvpEWAASEEELRERL 606

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  513 SQL-TALQAAR---AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD--------LEEQLNQ 580
Cdd:pfam12128  607 DKAeEALQSARekqAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKalaerkdsANERLNS 686

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  581 L-TEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVdhlrreITEREMQLTSQKQTMEALKTTctmLEEQVLDLEALND 659
Cdd:pfam12128  687 LeAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVV------EGALDAQLALLKAAIAARRSG---AKAELKALETWYK 757

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  660 ELLEKerqweawRSVLGDEKSQFECRVRELQRMLDTEKQSRaradQRITESRQVVELAVKEHKaeilalqQALKEQKLKA 739
Cdd:pfam12128  758 RDLAS-------LGVDPDVIAKLKREIRTLERKIERIAVRR----QEVLRYFDWYQETWLQRR-------PRLATQLSNI 819

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  740 ESlsdKLNDLEKKHAMLEMNARSLQQKLETER----ELKQRLLEEQAKLQQQM 788
Cdd:pfam12128  820 ER---AISELQQQLARLIADTKLRRAKLEMERkaseKQQVRLSENLRGLRCEM 869
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 207-914 1.06e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 57.27  E-value: 1.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  207 YSKLEKINAEQQL---------KIQELQEKLEKAVKASTEATELLQNIRQAKERAER------EL-EKLHNREDSSEGIK 270
Cdd:COG3096    295 FGARRQLAEEQYRlvemareleELSARESDLEQDYQAASDHLNLVQTALRQQEKIERyqedleELtERLEEQEEVVEEAA 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  271 KKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM------ADKILELEEKHREAqvSAQHLEVHLKQKEQ 344
Cdd:COG3096    375 EQLAEAEARLEAAEEEVDSLKSQLADYQQALDVQQTRAIQYQQAvqalekARALCGLPDLTPEN--AEDYLAAFRAKEQQ 452

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  345 HYEEkikVLDNQIKKDLAD--KESLENMMQRHE--------EEAHEKGKIL----SEQKAMI---NAMDSKIRSLEQRIV 407
Cdd:COG3096    453 ATEE---VLELEQKLSVADaaRRQFEKAYELVCkiageverSQAWQTARELlrryRSQQALAqrlQQLRAQLAELEQRLR 529

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  408 ELSEANKLAANSSLFTQRNMKAQ---EEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSR---LLELET 481
Cdd:COG3096    530 QQQNAERLLEEFCQRIGQQLDAAeelEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARapaWLAAQD 609

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  482 RLREVSlEHEEQKLELKRQLTELQLSLQERESQLTA----LQAARAALESQLRQAKTELEETTAEAEEEIQALTAH---- 553
Cdd:COG3096    610 ALERLR-EQSGEALADSQEVTAAMQQLLEREREATVerdeLAARKQALESQIERLSQPGGAEDPRLLALAERLGGVllse 688

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  554 -RDEIQRK----FDAL----RNScTVITDLE---EQLNQLT---------EDNAELNNQNFYLSKQLDEASGANDEIVQL 612
Cdd:COG3096    689 iYDDVTLEdapyFSALygpaRHA-IVVPDLSavkEQLAGLEdcpedlyliEGDPDSFDDSVFDAEELEDAVVVKLSDRQW 767

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  613 R----------------SEVDHLRRE---ITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDEllekerqwEAWRS 673
Cdd:COG3096    768 RysrfpevplfgraareKRLEELRAErdeLAEQYAKASFDVQKLQRLHQAFSQFVGGHLAVAFAPDP--------EAELA 839

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  674 VLGDEKSQFEcrvRELQRMLDTEKQSRARADQ---RITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLE 750
Cdd:COG3096    840 ALRQRRSELE---RELAQHRAQEQQLRQQLDQlkeQLQLLNKLLPQANLLADETLADRLEELREELDAAQEAQAFIQQHG 916

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  751 KKHAMLEMNARSLQQKLETERELKQRLLEeqakLQQQMDLQKNHIFRLTQGLQ--EAL---DRADLLkTERSD----LEY 821
Cdd:COG3096    917 KALAQLEPLVAVLQSDPEQFEQLQADYLQ----AKEQQRRLKQQIFALSEVVQrrPHFsyeDAVGLL-GENSDlnekLRA 991

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  822 QLENIQVLYSHEKVKMEGtisQQTKLIDFLQAKMDQPAK---KKKGLFSRRKEDPALPTQVP--------LQYNELKLAL 890
Cdd:COG3096    992 RLEQAEEARREAREQLRQ---AQAQYSQYNQVLASLKSSrdaKQQTLQELEQELEELGVQADaeaeerarIRRDELHEEL 1068

                          810       820
                   ....*....|....*....|....
gi 1907160229  891 EKEKARCAELEEALQKTRIELRSA 914
Cdd:COG3096   1069 SQNRSRRSQLEKQLTRCEAEMDSL 1092
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 2-614 1.16e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.11  E-value: 1.16e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKelQDSQDKCHKMEQEMTRLHRRVSEVEAV-------LSQKEVELKASETQRSLLEQDLATYITECSSLKRS 74
Cdd:pfam01576  392 ELRTLQQAK--QDSEHKRKKLEGQLQELQARLSESERQraelaekLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQ 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   75 LEQARMEVSQEDDKALQLLHDIR---EQSRKLQEIKEQEYQA--------------------QVEEMRLMMNQLEEDLVS 131
Cdd:pfam01576  470 LQDTQELLQEETRQKLNLSTRLRqleDERNSLQEQLEEEEEAkrnverqlstlqaqlsdmkkKLEEDAGTLEALEEGKKR 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  132 ARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHK----MQGHAGLTSAKDQGKPEVGEY 207
Cdd:pfam01576  550 LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKkfdqMLAEEKAISARYAEERDRAEA 629

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  208 SKLEKINAEQQL-----KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNR-EDSSEGIKKKLVEAEERRH 281
Cdd:pfam01576  630 EAREKETRALSLaraleEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRAlEQQVEEMKTQLEELEDELQ 709

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  282 SLENKVKRLE-TMERRENRLKDDIQTKSEQ--------IQQMADKILELEE--KHREAQVSA-QHLEVHLKQKEQHYEEK 349
Cdd:pfam01576  710 ATEDAKLRLEvNMQALKAQFERDLQARDEQgeekrrqlVKQVRELEAELEDerKQRAQAVAAkKKLELDLKELEAQIDAA 789

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  350 IKVLDNQIKKdLADKESLENMMQRHEEEAHekgkiLSEQKAMINAMDS--KIRSLEQRIVELSEanKLAANSSLFTQRNM 427
Cdd:pfam01576  790 NKGREEAVKQ-LKKLQAQMKDLQRELEEAR-----ASRDEILAQSKESekKLKNLEAELLQLQE--DLAASERARRQAQQ 861

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  428 ---KAQEEMI------SELRQQKFYLETQAGKLEAQNRklEEQLEKISHQDHSDKSRLL--ELETRL---REVSLEHEEQ 493
Cdd:pfam01576  862 erdELADEIAsgasgkSALQDEKRRLEARIAQLEEELE--EEQSNTELLNDRLRKSTLQveQLTTELaaeRSTSQKSESA 939

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  494 KLELKRQLTELQLSLQERESQ--------LTALQAARAALESQLRQ--------AKTELEETTAEAEEEIQALTAHRDEI 557
Cdd:pfam01576  940 RQQLERQNKELKAKLQEMEGTvkskfkssIAALEAKIAQLEEQLEQesrerqaaNKLVRRTEKKLKEVLLQVEDERRHAD 1019

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  558 QRKfDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND----EIVQLRS 614
Cdd:pfam01576 1020 QYK-DQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNEsmnrEVSTLKS 1079
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
549-918 1.30e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 56.59  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  549 ALTAHRDEIQRKFDAlrNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREM 628
Cdd:PRK02224   188 SLDQLKAQIEEKEEK--DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  629 QLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQS--------- 699
Cdd:PRK02224   266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAaqahneeae 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  700 --RARADQRITESRQVVELAvKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRL 777
Cdd:PRK02224   346 slREDADDLEERAEELREEA-AELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDEL 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  778 LEEQAKLQQQMDLQKNHIfRLTQGLQEA---------------LDRADLLKTERSDLEYQLENIQVlyshEKVKMEGTIS 842
Cdd:PRK02224   425 REREAELEATLRTARERV-EEAEALLEAgkcpecgqpvegsphVETIEEDRERVEELEAELEDLEE----EVEEVEERLE 499

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  843 QQTKLIDfLQAKMDQPAKKKKGLFSRRKEDPAlptqvplQYNELKLALEKEKARCAELEEALQKTRIELRSAREEA 918
Cdd:PRK02224   500 RAEDLVE-AEDRIERLEERREDLEELIAERRE-------TIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 302-532 1.66e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.54  E-value: 1.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  302 DDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQhyeeKIKVLDNQIKKDLADKESLENMMQRHEEEAHEK 381
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER----RIAALARRIRALEQELAALEAELAELEKEIAEL 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  382 GKILSEQKAMinamdskirsLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 461
Cdd:COG4942     96 RAELEAQKEE----------LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAAL 165

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  462 LEKISHQdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 532
Cdd:COG4942    166 RAELEAE----RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 356-825 2.00e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 55.90  E-value: 2.00e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  356 QIKKDLADKEsLENMMQRHEEE--AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKlaansslftqrnmkaqeEM 433
Cdd:pfam05557   13 QLQNEKKQME-LEHKRARIELEkkASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALR-----------------EQ 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  434 ISELRQQKFYLETQAGKLEAQnrklEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE---LKRQLTELQLSLQE 510
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELELQSTNSEleeLQERLDLLKAKASE 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  511 RE---SQLTALQAARAALESQLR--QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNQLTEDN 585
Cdd:pfam05557  151 AEqlrQNLEKQQSSLAEAEQRIKelEFEIQSQEQDSEIVKNSKSELARIPELEKELERLR-------EHNKHLNENIENK 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  586 AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM---EALKTTCTMLEEQVLDLEALNDELL 662
Cdd:pfam05557  224 LLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLrspEDLSRRIEQLQQREIVLKEENSSLT 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  663 EKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI---TESRQVVELAVKEHKAEiLALQQALKEQKLKA 739
Cdd:pfam05557  304 SSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVlllTKERDGYRAILESYDKE-LTMSNYSPQLLERI 382

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  740 ESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQ-----KNHIFRLTQGLQEALDRADLLKT 814
Cdd:pfam05557  383 EEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdpsysKEEVDSLRRKLETLELERQRLRE 462

                          490
                   ....*....|.
gi 1907160229  815 ERSDLEYQLEN 825
Cdd:pfam05557  463 QKNELEMELER 473
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 602-864 2.21e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.16  E-value: 2.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  602 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTtctmleeqvlDLEALNDELLEKERQweawrsvlgdeksq 681
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLK----------QLAALERRIAALARR-------------- 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  682 fecrVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNAR 761
Cdd:COG4942     71 ----IRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  762 SLQQKLETERELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTI 841
Cdd:COG4942    147 ARREQAEELRADLAELAALRAELEAERAELE----ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEA 222

                          250       260
                   ....*....|....*....|...
gi 1907160229  842 SQQTKLIDFLQAKMDQPAKKKKG 864
Cdd:COG4942    223 EELEALIARLEAEAAAAAERTPA 245
PH smart00233
Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The ...
 1069-1188 3.25e-07

Pleckstrin homology domain; Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.


Pssm-ID: 214574 [Multi-domain]  Cd Length: 102  Bit Score: 50.24  E-value: 3.25e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  1069 LHLEGWMKVPRNNKRGqqGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELClpdgDVSIhgavgaSELANTAKADVPY 1148
Cdd:smart00233    1 VIKEGWLYKKSGGGKK--SWKKRYFVLFNSTLLYYKSKKDKKSYKPKGSIDLS----GCTV------REAPDPDSSKKPH 68

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|
gi 1907160229  1149 ILKMeshphtTCWPGRTLYLLAPSFPDKQRWVTALESVVA 1188
Cdd:smart00233   69 CFEI------KTSDRKTLLLQAESEEEREKWVEALRKAIA 102
mukB PRK04863
chromosome partition protein MukB;
246-627 3.79e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 55.35  E-value: 3.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  246 RQAKERAERELEKLHNREDSSeGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------EQIQ 312
Cdd:PRK04863   276 RHANERRVHLEEALELRRELY-TSRRQLAAEQYR---LVEMARELAELNEAESDLEQDYQAASdhlnlvqtalrqqEKIE 351

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  313 QMADKILELEEK-------HREAQVSAQHLEVHLKQKEQHYEEkikvldnqIKKDLADKESLENMMQRHEEEAHEKGKIL 385
Cdd:PRK04863   352 RYQADLEELEERleeqnevVEEADEQQEENEARAEAAEEEVDE--------LKSQLADYQQALDVQQTRAIQYQQAVQAL 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  386 SEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQN-----RKLEE 460
Cdd:PRK04863   424 ERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEawdvaRELLR 503

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  461 QLEKISHQDhsdkSRLLELETRLREVSLEHEEQKlELKRQLTELQLSLQ---ERESQLTALQAARAALESQLRQAKTELE 537
Cdd:PRK04863   504 RLREQRHLA----EQLQQLRMRLSELEQRLRQQQ-RAERLLAEFCKRLGknlDDEDELEQLQEELEARLESLSESVSEAR 578

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  538 ETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVD 617
Cdd:PRK04863   579 ERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALD 658

                          410
                   ....*....|
gi 1907160229  618 HLRREITERE 627
Cdd:PRK04863   659 EEIERLSQPG 668
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 7-515 3.93e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 55.36  E-value: 3.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    7 IKSKELQDSQdKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQ---RSLLEQDLATYITECSSLKRSLEQARMEVS 83
Cdd:TIGR00618  370 ISCQQHTLTQ-HIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRtsaFRDLQGQLAHAKKQQELQQRYAELCAAAIT 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   84 QEDDKALQLLHDIREQSRKLQEIKEQEYQAQ-----------VEEMRLMMNQLEEDLVSAR------RRSDLYESELRES 146
Cdd:TIGR00618  449 CTAQCEKLEKIHLQESAQSLKEREQQLQTKEqihlqetrkkaVVLARLLELQEEPCPLCGScihpnpARQDIDNPGPLTR 528

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  147 RLAAEEFKRKANE-----CQHKLMKVVSHPPRGDSGGTALDD--LHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQL 219
Cdd:TIGR00618  529 RMQRGEQTYAQLEtseedVYHQLTSERKQRASLKEQMQEIQQsfSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAED 608

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHnredsseGIKKKLVEAEERRHSLENKVKRLETMERRENR 299
Cdd:TIGR00618  609 MLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALH-------ALQLTLTQERVREHALSIRVLPKELLASRQLA 681

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  300 LkDDIQTKSEQIQQMADKILELEEKHREaqvsaqhLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAH 379
Cdd:TIGR00618  682 L-QKMQSEKEQLTYWKEMLAQCQTLLRE-------LETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQAR 753

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  380 EKGKILSEQKAMINamdSKIRSLEQRIVELSEAnklaansslftQRNMKAQEEMISELRQQKFYLETQAG-KLEAQNRKL 458
Cdd:TIGR00618  754 TVLKARTEAHFNNN---EEVTAALQTGAELSHL-----------AAEIQFFNRLREEDTHLLKTLEAEIGqEIPSDEDIL 819

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  459 EEQLEKISHQDHSDKSRLLELETRLREVS--LEHEEQKLELKRQLTELQLSLQERESQL 515
Cdd:TIGR00618  820 NLQCETLVQEEEQFLSRLEEKSATLGEIThqLLKYEECSKQLAQLTQEQAKIIQLSDKL 878
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 219-368 6.44e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 6.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  219 LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNRedsSEGIKKKLVEAEERRHSLENKVKRLET--MERR 296
Cdd:COG1579     10 LDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTE---LEDLEKEIKRLELEIEEVEARIKKYEEqlGNVR 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  297 ENR----LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLE 368
Cdd:COG1579     87 NNKeyeaLQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 206-368 6.81e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 52.23  E-value: 6.81e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEgikKKLVEAeerrhsleN 285
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYE---EQLGNV--------R 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  286 KVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 365
Cdd:COG1579     87 NNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAERE 166


                   ...
gi 1907160229  366 SLE 368
Cdd:COG1579    167 ELA 169
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
298-827 6.85e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 54.28  E-value: 6.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  298 NRLKDDiqtKSEQIQQMADKILELEEKHREAQVSAqhlevhLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEE 377
Cdd:PRK02224   179 ERVLSD---QRGSLDQLKAQIEEKEEKDLHERLNG------LESELAELDEEIERYEEQREQARETRDEADEVLEEHEER 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  378 AHEkgkilseqkaminamdskIRSLEQRIVELSEanKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQagkleaqnrk 457
Cdd:PRK02224   250 REE------------------LETLEAEIEDLRE--TIAE-----TEREREELAEEVRDLRERLEELEEE---------- 294

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEQLEKISHQDHSDKSRLLELEtrlrevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE 537
Cdd:PRK02224   295 RDDLLAEAGLDDADAEAVEARRE--------ELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA 366

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  538 ETTaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTE--DNAELnnqnfylskQLDEASGANDEivqLRSE 615
Cdd:PRK02224   367 ELE--------------SELEEAREAVEDRREEIEELEEEIEELRErfGDAPV---------DLGNAEDFLEE---LREE 420

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  616 VDHLRreitEREMQLTSQKQTMEalkttcTMLEEqvldlealNDELLEKERQWEAWRSVLG----DEKSQFECRVRELQR 691
Cdd:PRK02224   421 RDELR----EREAELEATLRTAR------ERVEE--------AEALLEAGKCPECGQPVEGsphvETIEEDRERVEELEA 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  692 MLDTEKQSRARADQRITESRQVVELAVK----EHKAEilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKL 767
Cdd:PRK02224   483 ELEDLEEEVEEVEERLERAEDLVEAEDRierlEERRE--DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAA 560

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  768 ETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQgLQEALDRADLLKTERSDLEYQLENIQ 827
Cdd:PRK02224   561 AEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALA 619
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 362-587 7.66e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 7.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  362 ADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQK 441
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA-------LEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  442 FYLETQAGKLEAQNRKLEEQLEKISHQDH-------SDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQ 514
Cdd:COG4942     93 AELRAELEAQKEELAELLRALYRLGRQPPlalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  515 LTALQAARAALESQlrqaKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAE 587
Cdd:COG4942    173 RAELEALLAELEEE----RAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 373-801 8.39e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 54.19  E-value: 8.39e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  373 RHEEEAHEK-GKILSEQKAMINAMDsKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQ 447
Cdd:COG3096    275 RHANERRELsERALELRRELFGARR-QLAEEQYRLVEMArELEELSARESDLEQDYQAASDHlnlVQTALRQQE-KIERY 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  448 AGKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVSLEHEEqkleLKRQLTELQLSLQERESQLTALQAARAALEs 527
Cdd:COG3096    353 QEDLEELTERLEEQEEVVEEAA----EQLAEAEARLEAAEEEVDS----LKSQLADYQQALDVQQTRAIQYQQAVQALE- 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  528 qlrQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQLD---EASG 604
Cdd:COG3096    424 ---KARALCGLPDLTPENAEDYLAAFRAKEQQATEEVL-------ELEQKLS-VADAARRQFEKAYELVCKIAgevERSQ 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  605 ANDEIVQLRSE----------VDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEkerqWEAWRSV 674
Cdd:COG3096    493 AWQTARELLRRyrsqqalaqrLQQLRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE----LEAQLEE 568

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  675 LGDEKSQFECRVRELQRmldTEKQSRARADqritesrqvvELAVKEhkAEILALQQALkeqklkaESLSDKLND-LEKKH 753
Cdd:COG3096    569 LEEQAAEAVEQRSELRQ---QLEQLRARIK----------ELAARA--PAWLAAQDAL-------ERLREQSGEaLADSQ 626

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  754 AMleMNARslQQKLETERELKQ---RLLEEQAKLQQQmdlqknhIFRLTQG 801
Cdd:COG3096    627 EV--TAAM--QQLLEREREATVerdELAARKQALESQ-------IERLSQP 666
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 571-793 8.80e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 8.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  571 ITDLEEQLNQLTEDNAELNNQnfyLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 650
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  651 vldLEALNDELleKERQWEAWRS---------VLGDEKSQFECRVRELQRMLdtekQSRARADQRITESRQVVELAVKEH 721
Cdd:COG4942     99 ---LEAQKEEL--AELLRALYRLgrqpplallLSPEDFLDAVRRLQYLKYLA----PARREQAEELRADLAELAALRAEL 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  722 KAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKN 793
Cdd:COG4942    170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 548-768 8.88e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.23  E-value: 8.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  548 QALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA----SGANDEIVQLRSEVDHLRREI 623
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALarriRALEQELAALEAELAELEKEI 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  624 TEREMQLTSQKQTM-EALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTEKQSRar 702
Cdd:COG4942     93 AELRAELEAQKEELaELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ----AEELRADLAELAALR-- 166

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  703 adQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLE 768
Cdd:COG4942    167 --AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIA 230
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 492-754 1.33e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 571
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALE--------------RRIAALARRIR------------- 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  572 tDLEEQLNQLTEDNAELNNQnfylskqldeasgandeIVQLRSEVDHLRREITE--REMQLTSQKQTMEALKTTCTMLE- 648
Cdd:COG4942     73 -ALEQELAALEAELAELEKE-----------------IAELRAELEAQKEELAEllRALYRLGRQPPLALLLSPEDFLDa 134

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  649 -EQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelaVKEHKAEILA 727
Cdd:COG4942    135 vRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKL----LARLEKELAE 210

                          250       260
                   ....*....|....*....|....*..
gi 1907160229  728 LQQALKEQKLKAESLSDKLNDLEKKHA 754
Cdd:COG4942    211 LAAELAELQQEAEELEALIARLEAEAA 237
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 424-639 1.83e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.07  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  424 QRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTE 503
Cdd:COG4942     33 QQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRA 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  504 LQLSLQERE-----SQLTALQAARAA--LESQLRQAKTELEETTaeaeEEIQALTAHRDEIQRKFDALRnscTVITDLEE 576
Cdd:COG4942    113 LYRLGRQPPlalllSPEDFLDAVRRLqyLKYLAPARREQAEELR----ADLAELAALRAELEAERAELE---ALLAELEE 185

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  577 QLNQLTEDNAELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEA 639
Cdd:COG4942    186 ERAALEALKAERQKLLARLEKELAELA---AELAELQQEAEELEALIARLEAEAAAAAERTPA 245
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 699-976 1.90e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 1.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  699 SRARADQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLET-ERELKQR- 776
Cdd:COG3883     10 TPAFADPQIQAKQK----ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEaEAEIEERr 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  777 -LLEEQAKLQQQMDLQKNHIFRLT--QGLQEALDRADLLKTErsdleyqleniqvlyshekvkmegtISQQTKLIDFLQA 853
Cdd:COG3883     86 eELGERARALYRSGGSVSYLDVLLgsESFSDFLDRLSALSKI-------------------------ADADADLLEELKA 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  854 KMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPA 933
Cdd:COG3883    141 DKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1907160229  934 TARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSR 976
Cdd:COG3883    221 AAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAG 263
C1_1 pfam00130
Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the ...
 983-1038 1.97e-06

Phorbol esters/diacylglycerol binding domain (C1 domain); This domain is also known as the Protein kinase C conserved region 1 (C1) domain.


Pssm-ID: 395079  Cd Length: 53  Bit Score: 46.28  E-value: 1.97e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907160229  983 HHNIPHRFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGL 1038
Cdd:pfam00130    1 HHFVHRNFK-----QPTFCDHCGEFLwGLGKQGLKCSWCKLNVHKRCHEKVPPECGC 52
PRK01156 PRK01156
chromosome segregation protein; Provisional
 30-439 2.56e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   30 HRRVSEVEAVLSQKEVELKASETQRSLLEqDLATYITECSSLKRSLEQARMEVsQEDDKALQLLHDIREQSRKLQEIKEQ 109
Cdd:PRK01156   328 IKKLSVLQKDYNDYIKKKSRYDDLNNQIL-ELEGYEMDYNSYLKSIESLKKKI-EEYSKNIERMSAFISEILKIQEIDPD 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  110 EYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESR------------------LAAEEFKRKANECQHKLMKVVSHP 171
Cdd:PRK01156   406 AIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSrnmemlngqsvcpvcgttLGEEKSNHIINHYNEKKSRLEEKI 485

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  172 PRGDSGGTALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAE---QQLKIQELQEKLEKAVKASTEATEL-LQNIRQ 247
Cdd:PRK01156   486 REIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADledIKIKINELKDKHDKYEEIKNRYKSLkLEDLDS 565

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  248 AKER-----AERELEKLHNREDSSEGIKKKLVEAEERRHSLE-----------NKVKRLETMERRENRLKDDIQTKSEQI 311
Cdd:PRK01156   566 KRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEigfpddksyidKSIREIENEANNLNNKYNEIQENKILI 645

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  312 QQMADKILELEE---KHREAQVSAQHLEVHLKQKEQHYEEKIKVLDnQIKKDLADKESLENMMQRHEEEahekgkiLSEQ 388
Cdd:PRK01156   646 EKLRGKIDNYKKqiaEIDSIIPDLKEITSRINDIEDNLKKSRKALD-DAKANRARLESTIEILRTRINE-------LSDR 717

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  389 KAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQ 439
Cdd:PRK01156   718 INDINETLESMKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTSLTRK 768
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 88-812 3.16e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   88 KALQLLHDIRE-QSRKLQEIKE-----QEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELresrlaaEEFKRKANECQ 161
Cdd:TIGR00606  186 KALETLRQVRQtQGQKVQEHQMelkylKQYKEKACEIRDQITSKEAQLESSREIVKSYENEL-------DPLKNRLKEIE 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  162 HKLMKVVShpprgdsggtaLDDlhkmqghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATEL 241
Cdd:TIGR00606  259 HNLSKIMK-----------LDN----------------------EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLND 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  242 LQNIRQAKERA--------ERELEKLhNREDSSEGIKKKLVEAEERRHSLenKVKRLETMERRENRLKDDIQTKSE---- 309
Cdd:TIGR00606  306 LYHNHQRTVREkerelvdcQRELEKL-NKERRLLNQEKTELLVEQGRLQL--QADRHQEHIRARDSLIQSLATRLEldgf 382

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  310 ----------------QIQQMADK-------ILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLD---NQIKKDLAD 363
Cdd:TIGR00606  383 ergpfserqiknfhtlVIERQEDEaktaaqlCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEkkqEELKFVIKE 462

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  364 KESLENMMQRHEEEAHEKGKILSE-QKAMINA------------------MDSKIRSLEQRIVELSEANKLAANSSLFTQ 424
Cdd:TIGR00606  463 LQQLEGSSDRILELDQELRKAERElSKAEKNSltetlkkevkslqnekadLDRKLRKLDQEMEQLNHHTTTRTQMEMLTK 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  425 RNMKAQEEMISELRQQKFYLETQAGKLeAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRqLTEL 504
Cdd:TIGR00606  543 DKMDKDEQIRKIKSRHSDELTSLLGYF-PNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES-KEEQ 620

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  505 QLSLQERESQLTALQAARAALES---QLRQAKTELEETTAEAEEEIQALTAHRDE-------IQRKFDALRNSCTVITDL 574
Cdd:TIGR00606  621 LSSYEDKLFDVCGSQDEESDLERlkeEIEKSSKQRAMLAGATAVYSQFITQLTDEnqsccpvCQRVFQTEAELQEFISDL 700

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  575 EEQLNQLTEDNAELNNQNFYLSKQLDEASGandeIVQLR-SEVDHLRREITEREMQLTSQKQTMEALKTTctmLEEQVLD 653
Cdd:TIGR00606  701 QSKLRLAPDKLKSTESELKKKEKRRDEMLG----LAPGRqSIIDLKEKEIPELRNKLQKVNRDIQRLKND---IEEQETL 773

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  654 LEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVElaVKEHK-----AEILAL 728
Cdd:TIGR00606  774 LGTIMPEEESAK---VCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQ--EKQHEldtvvSKIELN 848

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  729 QQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERElkqrLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDR 808
Cdd:TIGR00606  849 RKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVE----LSTEVQSLIREIKDAKEQDSPLETFLEKDQQE 924


                   ....
gi 1907160229  809 ADLL 812
Cdd:TIGR00606  925 KEEL 928
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 615-921 3.21e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.15  E-value: 3.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  615 EVDHLRREITEREmQLTSQKQTMEALKTTctMLEEQVLDLEALNDELLEKERQwEAWRSVLGDEKSQFECRVRELQRMLD 694
Cdd:pfam12128  229 DIQAIAGIMKIRP-EFTKLQQEFNTLESA--ELRLSHLHFGYKSDETLIASRQ-EERQETSAELNQLLRTLDDQWKEKRD 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  695 TEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETEREL- 773
Cdd:pfam12128  305 ELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKi 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  774 KQRLLEEQAKLQQQMDLQKNHIFRltqglQEALDRADLLKTErSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQA 853
Cdd:pfam12128  385 KEQNNRDIAGIKDKLAKIREARDR-----QLAVAEDDLQALE-SELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATA 458

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  854 kmdqpakkkkglfsrrkeDPALPTQVPLQYNELKLALEKEKARCAELEeALQKTRIELRSAREEAAHR 921
Cdd:pfam12128  459 ------------------TPELLLQLENFDERIERAREEQEAANAEVE-RLQSELRQARKRRDQASEA 507
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
382-809 5.16e-06

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444092 [Multi-domain]  Cd Length: 603  Bit Score: 51.15  E-value: 5.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  382 GKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQ 461
Cdd:COG5281      3 ALAAAAALAAAAAAAAASAAAAAAAAALAAAAAAAAAAAGLAAAAAAAAAASLAAAAAAAALAAAAAAAAAAAAADALAA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  462 LEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQlslQERESQLTALQAARAALESQLRQAKTELEETTA 541
Cdd:COG5281     83 ALAEDAAAAAAAAEAALAALAAAALALAAAALAEAALAAAAAAA---AAAAAAAAAAAAAAAAAAEAAKAAAAAAAAAAL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  542 EAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRR 621
Cdd:COG5281    160 AAAAAAAAAAAAAAAAAAALAAASAAAAAAAAKAAAEAAAEAAAAAEAAAAAAAAAAEAAAAEAQALAAAALAEQAALAA 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  622 EITE--REMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecRVRELQRMLDTEKQS 699
Cdd:COG5281    240 ASAAaqALAALAAAAAAAALALAAAAELALTAQAEAAAAAAAAAAAAAQAAEAAAAAAEAQA---LAAAAAAAAAQLAAA 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  700 RARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDlekkhAMLEMNARSLQQKLETERELKQRLLE 779
Cdd:COG5281    317 AAAAAQALRAAAQALAALAQRALAAAALAAAAQEAALAAAAAALQAALE-----AAAAAAAAELAAAGDWAAGAKAALAE 391

                          410       420       430
                   ....*....|....*....|....*....|
gi 1907160229  780 EQAKLQQQMDLQKNHIFRLTQGLQEALDRA 809
Cdd:COG5281    392 YADSATNVAAQVAQAATSAFSGLTDALAGA 421
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
 300-790 5.68e-06

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 51.34  E-value: 5.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  300 LKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKikvldNQikkDLADKESLEnmmqrheeEAH 379
Cdd:PRK10246   424 LRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALNEMRQRYKEK-----TQ---QLADVKTIC--------EQE 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  380 EKGKILSEQKAMINAMDS--KIRSLEQRIVELSEANKLAANsslftQRNMKAQEEMISELRQQKFYLEtqaGKLEAqnrk 457
Cdd:PRK10246   488 ARIKDLEAQRAQLQAGQPcpLCGSTSHPAVEAYQALEPGVN-----QSRLDALEKEVKKLGEEGAALR---GQLDA---- 555

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  458 LEEQLekisHQDHSDKSRLLELETRLRE----------VSL-------------EHEEQKLELKRQLTELQLSLQERESQ 514
Cdd:PRK10246   556 LTKQL----QRDESEAQSLRQEEQALTQqwqavcaslnITLqpqddiqpwldaqEEHERQLRLLSQRHELQGQIAAHNQQ 631

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  515 LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdaLRNSCTVITDLEEQLNQLTEDNAELnnqnfy 594
Cdd:PRK10246   632 IIQYQQQIEQRQQQLLTALAGYALTLPQEDEEASWLATRQQEAQS----WQQRQNELTALQNRIQQLTPLLETL------ 701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  595 lsKQLDEASgANDEIVQLrsevDHLrREITEREMQLTSQKQTMEALkttctmleeqvldlealndELLEKERQWEA---W 671
Cdd:PRK10246   702 --PQSDDLP-HSEETVAL----DNW-RQVHEQCLSLHSQLQTLQQQ-------------------DVLEAQRLQKAqaqF 754

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  672 RSVLgdEKSQFECRVRELQRMLDTEkqsrarADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEK 751
Cdd:PRK10246   755 DTAL--QASVFDDQQAFLAALLDEE------TLTQLEQLKQNLENQRQQAQTLVTQTAQALAQHQQHRPDGLDLTVTVEQ 826

                          490       500       510
                   ....*....|....*....|....*....|....*....
gi 1907160229  752 KHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDL 790
Cdd:PRK10246   827 IQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQAL 865
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 207-822 6.33e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.89  E-value: 6.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  207 YSKLEKINAEQQLKIQELQEKLEKAvkasteatELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSlenK 286
Cdd:pfam05557    6 ESKARLSQLQNEKKQMELEHKRARI--------ELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALRE---Q 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  287 VKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLkqKEQHYEekikvldnqikkdladkes 366
Cdd:pfam05557   75 AELNRLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELEL--QSTNSE------------------- 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  367 LENMMQRHEEEaHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTqRNMKAQEEMISElrqqkfyLET 446
Cdd:pfam05557  134 LEELQERLDLL-KAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQSQEQDSEIV-KNSKSELARIPE-------LEK 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  447 QAGKLEAQNRKLEEQLEKIS---HQDHSDKSRLLELE-TRLREVSLEHEEQKLELKrqLTELQLSLQERESQLTALQAAR 522
Cdd:pfam05557  205 ELERLREHNKHLNENIENKLllkEEVEDLKRKLEREEkYREEAATLELEKEKLEQE--LQSWVKLAQDTGLNLRSPEDLS 282

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  523 AALEsQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDea 602
Cdd:pfam05557  283 RRIE-QLQQREIVLKEENSSLTSSARQLEKARRELEQELAQYLKK---IEDLNKKLKRHKALVRRLQRRVLLLTKERD-- 356

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  603 sgandeivqlrsevdhLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELlekerqweawrsvlgdeksqf 682
Cdd:pfam05557  357 ----------------GYRAILESYDKELTMSNYSPQLLERIEEAEDMTQKMQAHNEEM--------------------- 399

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  683 ECRVRELQRMLDTEKQSRARADQRITESRQVVELA-VKEHKAEILALQQALKEQKLKAESLSDKLNDLEkkhamLEMNAR 761
Cdd:pfam05557  400 EAQLSVAEEELGGYKQQAQTLERELQALRQQESLAdPSYSKEEVDSLRRKLETLELERQRLREQKNELE-----MELERR 474

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  762 SLQQKLETER------------ELKQRLLEEQAKLQQQMDLQKnhifRLTQGLQEALDRADLLKTERSDLEYQ 822
Cdd:pfam05557  475 CLQGDYDPKKtkvlhlsmnpaaEAYQQRKNQLEKLQAEIERLK----RLLKKLEDDLEQVLRLPETTSTMNFK 543
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 239-584 7.33e-06

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.45  E-value: 7.33e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  239 TELLQNIRQAKERAErELEKLHNRE-DSSEGIKKKLVEAEERRHSLENKVKRLET-MERRENRLKDDIQTKSEQIQQMAD 316
Cdd:pfam19220   37 EAILRELPQAKSRLL-ELEALLAQErAAYGKLRRELAGLTRRLSAAEGELEELVArLAKLEAALREAEAAKEELRIELRD 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  317 KILELEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMD 396
Cdd:pfam19220  116 KTAQAEALERQLAAETEQNR-ALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQALSEEQAAELAELT 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  397 SKIRSLEQRI------VELSEANKLAANSSlfTQRNMKAQEEMISELRQQKfylETQAGKLEAQNRKLE--EQLekishq 468
Cdd:pfam19220  195 RRLAELETQLdatrarLRALEGQLAAEQAE--RERAEAQLEEAVEAHRAER---ASLRMKLEALTARAAatEQL------ 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  469 dhsdksrLLELETRLRevslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQ 548
Cdd:pfam19220  264 -------LAEARNQLR----DRDEAIRAAERRLKEASIERDTLERRLAGLEADLERRTQQFQEMQRARAELEERAEMLTK 332

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907160229  549 ALTAHRdeiqrkfDALRNSCTVITDLEEQLNQLTED 584
Cdd:pfam19220  333 ALAAKD-------AALERAEERIASLSDRIAELTKR 361
COG5022 COG5022
Myosin heavy chain [General function prediction only];
221-831 9.80e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 50.85  E-value: 9.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  221 IQELQEKLEKavkasteatELLQNIRQAKERAERELEkLHNREDSSEGIKKKlVEAEERRHSLENKVKRLETMERRENRL 300
Cdd:COG5022    819 IIKLQKTIKR---------EKKLRETEEVEFSLKAEV-LIQKFGRSLKAKKR-FSLLKKETIYLQSAQRVELAERQLQEL 887

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  301 KDDIqtksEQIQQMADKILELEEKHREAQVSAQHLEV-HLKQKEQHYEEKIKVLDN-QIKKDLA-DKESLENMMQRHEEE 377
Cdd:COG5022    888 KIDV----KSISSLKLVNLELESEIIELKKSLSSDLIeNLEFKTELIARLKKLLNNiDLEEGPSiEYVKLPELNKLHEVE 963

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  378 A--HEKGKILSeqkAMINAMDSKIRSLEQRIVELSEANKLAAnsslftqrnmkaqeemisELRQQKFYLETQAGKLEAQN 455
Cdd:COG5022    964 SklKETSEEYE---DLLKKSTILVREGNKANSELKNFKKELA------------------ELSKQYGALQESTKQLKELP 1022

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  456 RKLEE--QLEKISHQDHSDKSRLLELEtrlrEVSLEHEEQKLELKRQLTELQLslqERESQLTalqaaraaLESQLRQAK 533
Cdd:COG5022   1023 VEVAElqSASKIISSESTELSILKPLQ----KLKGLLLLENNQLQARYKALKL---RRENSLL--------DDKQLYQLE 1087

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  534 TELEETTAEAEEEIQALTahrdeiqRKFDALRNSCTVITDLEEQLNqLTEDNAELNNQNFYLSKQLDEASGANDEIVQLR 613
Cdd:COG5022   1088 STENLLKTINVKDLEVTN-------RNLVKPANVLQFIVAQMIKLN-LLQEISKFLSQLVNTLEPVFQKLSVLQLELDGL 1159

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  614 SEVDHLRREITEREMQLTSQKQTME--ALKTTCTMLEEQVLDLEalnDELLEKERQ-WEAWRSVLGDEKSQFECRVRELQ 690
Cdd:COG5022   1160 FWEANLEALPSPPPFAALSEKRLYQsaLYDEKSKLSSSEVNDLK---NELIALFSKiFSGWPRGDKLKKLISEGWVPTEY 1236

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  691 RMLDTEKQSRAR--ADQRITESRQVVELAVKehkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAM-----LEMNARSL 763
Cdd:COG5022   1237 STSLKGFNNLNKkfDTPASMSNEKLLSLLNS--------IDNLLSSYKLEEEVLPATINSLLQYINVglfnaLRTKASSL 1308

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  764 QQKLETERELKQRLLEEQAKLQQQMDLQKNhifrltqgLQEALDRADLLKTERSDLEYQLENIQVLYS 831
Cdd:COG5022   1309 RWKSATEVNYNSEELDDWCREFEISDVDEE--------LEELIQAVKVLQLLKDDLNKLDELLDACYS 1368
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 70-783 9.92e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.72  E-value: 9.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   70 SLKRSLEQARMEVSQEDDKALQLLHDIREQSRkLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--LRESR 147
Cdd:COG3096    289 ELRRELFGARRQLAEEQYRLVEMARELEELSA-RESDLEQDYQAASDHLNLVQTALRQQEKIERYQEDLEELTerLEEQE 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  148 LAAEEFKRKANECQHKLMKVVSHPPRGDSG----GTALDDLHK-----MQGHAGLTSAKDQ-GKPE-----VGEYskLEK 212
Cdd:COG3096    368 EVVEEAAEQLAEAEARLEAAEEEVDSLKSQladyQQALDVQQTraiqyQQAVQALEKARALcGLPDltpenAEDY--LAA 445

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  213 INAEQQL---KIQELQEKLEKAVKASTE---ATELLQNIRQAKERAE---------RELEKLHNREDSSEGIKKKLVEAE 277
Cdd:COG3096    446 FRAKEQQateEVLELEQKLSVADAARRQfekAYELVCKIAGEVERSQawqtarellRRYRSQQALAQRLQQLRAQLAELE 525

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  278 ERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE--------- 348
Cdd:COG3096    526 QRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKElaarapawl 605

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  349 ----KIKVLDNQIKKDLADKESLENMMQ---RHEEEAHEKGKILSEQKAminAMDSKIRSLEQ-------RIVELSE--- 411
Cdd:COG3096    606 aaqdALERLREQSGEALADSQEVTAAMQqllEREREATVERDELAARKQ---ALESQIERLSQpggaedpRLLALAErlg 682

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  412 --------------------------------------ANKLAA-------------NSSLFTQRNMKAQEE-----MIS 435
Cdd:COG3096    683 gvllseiyddvtledapyfsalygparhaivvpdlsavKEQLAGledcpedlyliegDPDSFDDSVFDAEELedavvVKL 762

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  436 ELRQQKFYL------------ETQAGKLEAQNRKLEEQLEKIS------HQDHSDKSRLLEL----------ETRLREVS 487
Cdd:COG3096    763 SDRQWRYSRfpevplfgraarEKRLEELRAERDELAEQYAKASfdvqklQRLHQAFSQFVGGhlavafapdpEAELAALR 842

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  488 leheEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteLEETTAEAEEEIQALTAHRDEIQRKFDALRNS 567
Cdd:COG3096    843 ----QRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQA---NLLADETLADRLEELREELDAAQEAQAFIQQH 915

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  568 CTVITDLEEQLNQLTED---NAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITERemqltsqkqtmealkttc 644
Cdd:COG3096    916 GKALAQLEPLVAVLQSDpeqFEQLQADYLQAKEQQRRLKQQIFALSEVVQRRPHFSYEDAVG------------------ 977

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  645 tMLEEQvldlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQvvELAVKEHKAE 724
Cdd:COG3096    978 -LLGEN----SDLNEKLRARLEQAEEARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQ--ELEELGVQAD 1050

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  725 ILALQQALKE-QKLKAE--SLSDKLNDLEKKHAMLEMNARSLQQKL-ETERELKQ-RLLEEQAK 783
Cdd:COG3096   1051 AEAEERARIRrDELHEElsQNRSRRSQLEKQLTRCEAEMDSLQKRLrKAERDYKQeREQVVQAK 1114
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1545-1636 1.34e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.07  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1545 ESGTEQHRVPSTSRSSPNKRGPP--TYNEHITKR--------------VASSPAPPEGPSHPREPSTPHRYRDREGRTEL 1608
Cdd:PTZ00449   527 KEGEEGEHEDSKESDEPKEGGKPgeTKEGEVGKKpgpakehkpskiptLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRP 606

                           90       100       110
                   ....*....|....*....|....*....|
gi 1907160229 1609 RRDKSPGRP--LEREKSPGRMLSTRRERSP 1636
Cdd:PTZ00449   607 TRPKSPKLPelLDIPKSPKRPESPKSPKRP 636
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 246-690 1.39e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 50.34  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  246 RQAKERAERELEKLHNREDSSeGIKKKLVEAEERrhsLENKVKRLETMERRENRLKDDIQTKS-------------EQIQ 312
Cdd:COG3096    275 RHANERRELSERALELRRELF-GARRQLAEEQYR---LVEMARELEELSARESDLEQDYQAASdhlnlvqtalrqqEKIE 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  313 QMADKILELEEKHREAQ-VSAQHLEVHLKQKEQ--HYEEKIKVLDNQikkdLADKESLENMMQRheeeahekgKILSEQK 389
Cdd:COG3096    351 RYQEDLEELTERLEEQEeVVEEAAEQLAEAEARleAAEEEVDSLKSQ----LADYQQALDVQQT---------RAIQYQQ 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  390 AminamdskIRSLEqRIVELSEANKLAANSSLFTQRNMKAQEEMISElrqqkfyletqagkleaqnrkleeqlekishqd 469
Cdd:COG3096    418 A--------VQALE-KARALCGLPDLTPENAEDYLAAFRAKEQQATE--------------------------------- 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  470 hsdksRLLELETRLReVSLEHEEQKlelkRQLTELQLSLQERESQLTALQAARAALEsQLRQAKTELEETtaeaeeeiQA 549
Cdd:COG3096    456 -----EVLELEQKLS-VADAARRQF----EKAYELVCKIAGEVERSQAWQTARELLR-RYRSQQALAQRL--------QQ 516

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  550 LTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 629
Cdd:COG3096    517 LRAQLAELEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLRARIKE 596

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  630 LTSQK----QTMEALKTTCTMLEEQVLDLEALND---ELLEKERQWEAWRSVLGDEKSQFECRVRELQ 690
Cdd:COG3096    597 LAARApawlAAQDALERLREQSGEALADSQEVTAamqQLLEREREATVERDELAARKQALESQIERLS 664
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
208-563 1.56e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  208 SKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNredssegikkklvEAEERRHSLENKV 287
Cdd:COG4372     27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEE-------------ELEELNEQLQAAQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  288 KRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhyeEKIKVLDNQIKKDLADKESL 367
Cdd:COG4372     94 AELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAERE----EELKELEEQLESLQEELAAL 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQ 447
Cdd:COG4372    170 EQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKE 249

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  448 AGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALES 527
Cdd:COG4372    250 ELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLE 329

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 1907160229  528 QLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA 563
Cdd:COG4372    330 LALAILLAELADLLQLLLVGLLDNDVLELLSKGAEA 365
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 9-280 1.62e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    9 SKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDK 88
Cdd:COG4942     19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   89 ALQLLHDIREQSRKLQEIKEQEYqaqveeMRLMMNQleEDLVSARRRSDLYESELRESRLAAEEFKRKANEcqhklmkvv 168
Cdd:COG4942     99 LEAQKEELAELLRALYRLGRQPP------LALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAE--------- 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  169 shpprgdsggtalddlhkmqghagLTSAKDQgkpevgeyskLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQA 248
Cdd:COG4942    162 ------------------------LAALRAE----------LEAERAELEALLAELEEERAALEALKAERQKLLARLEKE 207

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1907160229  249 KERAERELEKLHNREDSSEGIKKKLVEAEERR 280
Cdd:COG4942    208 LAELAAELAELQQEAEELEALIARLEAEAAAA 239
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 214-877 1.69e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 50.05  E-value: 1.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  214 NAEQQLKIQELQEKLEKAVKAsteatelLQNIrqakeraERELEKLH--NREDSSEGIKKKLVEAEERRHSLENKV--KR 289
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDK-------IQNM-------ETATVELHlsNIENKKNELLDIIVEIKKHIHGEINKDlnKI 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  290 LETMERRENRLKDDIQTKS---EQIQQMADKILELEEKHREaQVSAQHL-EVHLKQ---KEQHYEEKIKVLDNQIKKDLA 362
Cdd:TIGR01612  757 LEDFKNKEKELSNKINDYAkekDELNKYKSKISEIKNHYND-QINIDNIkDEDAKQnydKSKEYIKTISIKEDEIFKIIN 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  363 D----KESLENMMQRHEE-EAHEKGKILSEQKA---MINAMDSKIRSLEQRIVElseaNKLAANSSLFTQRNMKAQEEM- 433
Cdd:TIGR01612  836 EmkfmKDDFLNKVDKFINfENNCKEKIDSEHEQfaeLTNKIKAEISDDKLNDYE----KKFNDSKSLINEINKSIEEEYq 911

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  434 -ISELRQQKFYLETQAGKLEA----------QNRKLEEQLEKISHQDHSDKSRLLELETRLrevslehEEQKLELKRQLT 502
Cdd:TIGR01612  912 nINTLKKVDEYIKICENTKESiekfhnkqniLKEILNKNIDTIKESNLIEKSYKDKFDNTL-------IDKINELDKAFK 984

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  503 ELqlSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEiqaltAHRDEIQRKFDALRNSC-------TVITDLE 575
Cdd:TIGR01612  985 DA--SLNDYEAKNNELIKYFNDLKANLGKNKENMLYHQFDEKEK-----ATNDIEQKIEDANKNIPnieiaihTSIYNII 1057

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  576 EQLNQLTEDNAELNNQNFYLS-----------------------------KQLDEASGANDEIVQLRSEVDHLRREITER 626
Cdd:TIGR01612 1058 DEIEKEIGKNIELLNKEILEEaeinitnfneikeklkhynfddfgkeeniKYADEINKIKDDIKNLDQKIDHHIKALEEI 1137

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  627 EMQltsQKQTMEALKTTCTMLEEqVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcrvrELQRMLDteKQSRARADQR 706
Cdd:TIGR01612 1138 KKK---SENYIDEIKAQINDLED-VADKAISNDDPEEIEKKIENIVTKIDKKKNIYD----EIKKLLN--EIAEIEKDKT 1207

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  707 ITESRQVVELAVKEHKAEiLALQQaLKEQKLKAE----SLSDKLNDLE--KKHAMLEMNARSLQQKLETEREL------- 773
Cdd:TIGR01612 1208 SLEEVKGINLSYGKNLGK-LFLEK-IDEEKKKSEhmikAMEAYIEDLDeiKEKSPEIENEMGIEMDIKAEMETfnishdd 1285

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  774 -KQRLLEEQAKLQQQMDLqKNHIFRLTQGLQEALDRADLLKT----------ERSDLEYQLENIQVLYSHEKV----KME 838
Cdd:TIGR01612 1286 dKDHHIISKKHDENISDI-REKSLKIIEDFSEESDINDIKKElqknlldaqkHNSDINLYLNEIANIYNILKLnkikKII 1364

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 1907160229  839 GTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPT 877
Cdd:TIGR01612 1365 DEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDINLEE 1403
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 388-591 1.71e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  388 QKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISH 467
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  468 QDHSDKSRLLEL-------ETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 540
Cdd:COG4942     98 ELEAQKEELAELlralyrlGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  541 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQ 591
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEAL 228
46 PHA02562
endonuclease subunit; Provisional
 409-636 1.93e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 49.24  E-value: 1.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  409 LSEANKLaaNSSLftqrnMKAQEEMISELRQQKFYLETQagkLEAQNRKLEEQlEKISHQDHSDKSrllELETRLREVSL 488
Cdd:PHA02562   165 LSEMDKL--NKDK-----IRELNQQIQTLDMKIDHIQQQ---IKTYNKNIEEQ-RKKNGENIARKQ---NKYDELVEEAK 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  489 EHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELE------------ETTAEAEEEIQALTAHRDE 556
Cdd:PHA02562   231 TIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKE 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  557 IQRKFDALRNSctvITDLEEQLNQ-------LTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 629
Cdd:PHA02562   311 LQHSLEKLDTA---IDELEEIMDEfneqskkLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDE 387


                   ....*..
gi 1907160229  630 LTSQKQT 636
Cdd:PHA02562   388 LDKIVKT 394
C1_SpBZZ1-like cd20824
protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein ...
 987-1037 2.04e-05

protein kinase C conserved region 1 (C1 domain) found in Schizosaccharomyces pombe protein BZZ1 and similar proteins; BZZ1 is a syndapin-like F-BAR protein that plays a role in endocytosis and trafficking to the vacuole. It functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress. BZZ1 contains an N-terminal F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs), a central coiled-coil, and two C-terminal SH3 domains. Schizosaccharomyces pombe BZZ1 also harbors a C1 domain, but Saccharomyces cerevisiae BZZ1 doesn't have any. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410374  Cd Length: 53  Bit Score: 43.46  E-value: 2.04e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  987 PHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1037
Cdd:cd20824      1 PHNFKPHSFSIPTKCDYCGEKIwGLSKKGLSCKDCGFNCHIKCELKVPPECP 52
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 64-871 2.25e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 49.66  E-value: 2.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   64 YITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSrklqeIKEQEYQAQVEEMRL-MMNQLEEDLVSARRRSdlYESE 142
Cdd:TIGR01612  922 YIKICENTKESIEKFHNKQNILKEILNKNIDTIKESN-----LIEKSYKDKFDNTLIdKINELDKAFKDASLND--YEAK 994

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  143 LRE-----SRLAAEEFKRKANECQHKLmkvvshpprgDSGGTALDDLHKMQGHAGltsaKDQGKPEVGEYSKLEKINAEQ 217
Cdd:TIGR01612  995 NNElikyfNDLKANLGKNKENMLYHQF----------DEKEKATNDIEQKIEDAN----KNIPNIEIAIHTSIYNIIDEI 1060

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  218 QLKIQELQEKLEKAV--KASTEATellqNIRQAKERAereleKLHNREDSSEgikkklveaeerrhslENKVKRLETMer 295
Cdd:TIGR01612 1061 EKEIGKNIELLNKEIleEAEINIT----NFNEIKEKL-----KHYNFDDFGK----------------EENIKYADEI-- 1113

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  296 reNRLKDDIQTKSEQIQQmadKILELEEkhreaqvsaqhlevhLKQKEQHYEEKIKVLDNQIkKDLADK-------ESLE 368
Cdd:TIGR01612 1114 --NKIKDDIKNLDQKIDH---HIKALEE---------------IKKKSENYIDEIKAQINDL-EDVADKaisnddpEEIE 1172

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  369 NMMQRHEEEAHEKGKILSEQKAMINAMdSKIR----SLEQ-RIVELSEANKLAA----------NSSLFTQRNMKAQEEM 433
Cdd:TIGR01612 1173 KKIENIVTKIDKKKNIYDEIKKLLNEI-AEIEkdktSLEEvKGINLSYGKNLGKlflekideekKKSEHMIKAMEAYIED 1251

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  434 ISELRQQKFYLETQAGKLEAQNRKLEeqLEKISHQDHSDKsrlleletrlREVSLEHEEQKLELKrqltELQLSLQERES 513
Cdd:TIGR01612 1252 LDEIKEKSPEIENEMGIEMDIKAEME--TFNISHDDDKDH----------HIISKKHDENISDIR----EKSLKIIEDFS 1315

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  514 QLTALQAARAALESQLRQAKTELEEttaeaeeeiqaLTAHRDEIQRKFDALR--NSCTVITDLEEQLNQLTEDNAELNNQ 591
Cdd:TIGR01612 1316 EESDINDIKKELQKNLLDAQKHNSD-----------INLYLNEIANIYNILKlnKIKKIIDEVKEYTKEIEENNKNIKDE 1384

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  592 ---NFYLSKQLDEASGANDEIVQLRS-----EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLdLEALNDELLE 663
Cdd:TIGR01612 1385 ldkSEKLIKKIKDDINLEECKSKIEStlddkDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVL-LLFKNIEMAD 1463

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  664 KERQWeawrsVLGDEK----SQFECRVRELQRMLDTEKQSRARADQRITESRQVVELaVKEHKAEILALQQALKEQKLK- 738
Cdd:TIGR01612 1464 NKSQH-----ILKIKKdnatNDHDFNINELKEHIDKSKGCKDEADKNAKAIEKNKEL-FEQYKKDVTELLNKYSALAIKn 1537

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  739 --AESLSDK---LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQ----MDLQKNhifrlTQGLQEALDRA 809
Cdd:TIGR01612 1538 kfAKTKKDSeiiIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIEDDAAKNDKSnkaaIDIQLS-----LENFENKFLKI 1612

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  810 DLLKTERSDLEYQLENIQVLYSHEKVKMEGT-ISQQTKLIDFLQAKMDQPAKKKKGLFSRRKE 871
Cdd:TIGR01612 1613 SDIKKKINDCLKETESIEKKISSFSIDSQDTeLKENGDNLNSLQEFLESLKDQKKNIEDKKKE 1675
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 339-532 2.37e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  339 LKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMIN----AMDSKIRSLEQRIVELSEANK 414
Cdd:COG3883     28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEerreELGERARALYRSGGSVSYLDV 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  415 LAANSSL--FTQRN------MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREV 486
Cdd:COG3883    108 LLGSESFsdFLDRLsalskiADADADLLEELKADKAELEAKKAELEAKLAELEALKA--------------ELEAAKAEL 173

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1907160229  487 slehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQA 532
Cdd:COG3883    174 ----EAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 531-800 2.57e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 48.27  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  531 QAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAND--- 607
Cdd:pfam15905   66 QKNLKESKDQKELEKEIRALVQERGEQDKRLQALEEE---LEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNEllk 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  608 -----------------EIVQLRSEVDHLRREITER----EMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDElleker 666
Cdd:pfam15905  143 akfsedgtqkkmsslsmELMKLRNKLEAKMKEVMAKqegmEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE------ 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  667 qweawrsvlgdEKSQFECRVRELQRMldteKQSRARADQRITESRQVVELAvKEHKAEILALQQALKEqklKAESLSDKL 746
Cdd:pfam15905  217 -----------EKSETEKLLEYITEL----SCVSEQVEKYKLDIAQLEELL-KEKNDEIESLKQSLEE---KEQELSKQI 277

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  747 NDLEKKHAMLEmnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ 800
Cdd:pfam15905  278 KDLNEKCKLLE---SEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQ 328
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 328-552 2.74e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  328 AQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIV 407
Cdd:COG3883      3 ALALAAPTPAFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  408 ELSEA-NKLAA----NSSLFTQRNMKAQEEMISELRQQKFYLETQAgklEAQNRKLEEQLEkishqdhsDKSRLLELETR 482
Cdd:COG3883     83 ERREElGERARalyrSGGSVSYLDVLLGSESFSDFLDRLSALSKIA---DADADLLEELKA--------DKAELEAKKAE 151

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  483 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 552
Cdd:COG3883    152 LEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAA 221
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
224-440 2.77e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 2.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  224 LQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSS-------------EGIKKKLVEAEERRHSLENKVKRL 290
Cdd:COG3206    166 LELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVdlseeaklllqqlSELESQLAEARAELAEAEARLAAL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  291 ETMERRENRLKDDIQTkSEQIQQMADKILELEEkhREAQVSAQHLEVHlkqkeqhyeEKIKVLDNQIkkdladkESLENM 370
Cdd:COG3206    246 RAQLGSGPDALPELLQ-SPVIQQLRAQLAELEA--ELAELSARYTPNH---------PDVIALRAQI-------AALRAQ 306

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  371 MQRheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVEL-SEANKLAANSSLFT--QRNMKAQEEMISELRQQ 440
Cdd:COG3206    307 LQQ------EAQRILASLEAELEALQAREASLQAQLAQLeARLAELPELEAELRrlEREVEVARELYESLLQR 373
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 600-789 3.13e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 3.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  600 DEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvldLEALNDELLEKERQWEAWRSVLGDek 679
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAE---IDKLQAEIAEAEAEIEERREELGE-- 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  680 sqfecRVRELQR------MLDTEKQSRARAD--QRITESRQVVElavkeHKAEILALQQALKEQ-KLKAESLSDKLNDLE 750
Cdd:COG3883     91 -----RARALYRsggsvsYLDVLLGSESFSDflDRLSALSKIAD-----ADADLLEELKADKAElEAKKAELEAKLAELE 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1907160229  751 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMD 789
Cdd:COG3883    161 ALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLA 199
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 430-770 3.74e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 48.58  E-value: 3.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  430 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELEtRLREVSLEHEEQKLELKRQLTELQlsLQ 509
Cdd:pfam17380  280 HQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD-RQAAIYAEQERMAMERERELERIR--QE 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  510 ERESQLTALQAARAALE-SQLRQAKTELEETTAEAEEEIQALTAHR------DEIQRKfdalrnsctvitdLEEQLNQLT 582
Cdd:pfam17380  357 ERKRELERIRQEEIAMEiSRMRELERLQMERQQKNERVRQELEAARkvkileEERQRK-------------IQQQKVEME 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  583 EDNAELNNQNFYLSKQLDEasgandeivQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLD---LEALND 659
Cdd:pfam17380  424 QIRAEQEEARQREVRRLEE---------ERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDrkrAEEQRR 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  660 ELLEKErqWEAWRSVLGDEKSQfecrvrelQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEilaLQQALKEQKLKA 739
Cdd:pfam17380  495 KILEKE--LEERKQAMIEEERK--------RKLLEKEMEERQKAIYEEERRREAEEERRKQQEME---ERRRIQEQMRKA 561

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1907160229  740 ESLSDKLNDLEKKHAMLEMNARSLQQKLETE 770
Cdd:pfam17380  562 TEERSRLEAMEREREMMRQIVESEKARAEYE 592
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 283-464 4.38e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.90  E-value: 4.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  283 LENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIK---- 358
Cdd:COG3883     18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARalyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  359 -----------------KDLADKESLENMMQRHEeeahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSL 421
Cdd:COG3883     98 sggsvsyldvllgsesfSDFLDRLSALSKIADAD------ADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1907160229  422 FTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEK 464
Cdd:COG3883    172 ELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAA 214
PRK11281 PRK11281
mechanosensitive channel MscK;
483-800 4.62e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 48.37  E-value: 4.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  483 LREVSLEHEEQKLeLKRQLTELQLSLQERESQ---LTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQR 559
Cdd:PRK11281    48 LNKQKLLEAEDKL-VQQDLEQTLALLDKIDRQkeeTEQLKQQLAQAPAKLRQAQAE-----------LEALKDDNDEETR 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  560 KfdalRNSCTVITDLEEQLNQLTEDNAELNNqnfylskqldEASGANDEIVQLRSEVDHLRREITE---REMQLTSQKQT 636
Cdd:PRK11281   116 E----TLSTLSLRQLESRLAQTLDQLQNAQN----------DLAEYNSQLVSLQTQPERAQAALYAnsqRLQQIRNLLKG 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  637 MEALKTTCTMLEEQVLDLE-ALNDELLEKERQWEAWRSVLGDeksqfecrVRELQRMLDTEKQsrARADQRITESRQVV- 714
Cdd:PRK11281   182 GKVGGKALRPSQRVLLQAEqALLNAQNDLQRKSLEGNTQLQD--------LLQKQRDYLTARI--QRLEHQLQLLQEAIn 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  715 --ELAVKEHKAEilALQQALKEQKLKAESLsdklndlekkhamlemnarsLQQKLETERELKQRLLEEQAKLQQ--QMDL 790
Cdd:PRK11281   252 skRLTLSEKTVQ--EAQSQDEAARIQANPL--------------------VAQELEINLQLSQRLLKATEKLNTltQQNL 309

                          330
                   ....*....|.
gi 1907160229  791 Q-KNHIFRLTQ 800
Cdd:PRK11281   310 RvKNWLDRLTQ 320
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 211-927 4.82e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.50  E-value: 4.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  211 EKINAEQQLKIQELQEKLEKAVKASTEATEL-LQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKR 289
Cdd:TIGR00606  177 EIFSATRYIKALETLRQVRQTQGQKVQEHQMeLKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKE 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  290 LEtmerrENRLKddiqtkseqIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLEN 369
Cdd:TIGR00606  257 IE-----HNLSK---------IMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELV 322

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  370 MMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAAnSSLFTQRNMKAQEEMISELRQQKFYLETQAG 449
Cdd:TIGR00606  323 DCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLI-QSLATRLELDGFERGPFSERQIKNFHTLVIE 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  450 KLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsQLTALQAARAALESQL 529
Cdd:TIGR00606  402 RQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQ-QLEGSSDRILELDQEL 480

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  530 RQA--------KTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYL-SKQLD 600
Cdd:TIGR00606  481 RKAerelskaeKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIkSRHSD 560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  601 EASGA----------NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEalnDELLEKERQwEA 670
Cdd:TIGR00606  561 ELTSLlgyfpnkkqlEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYE---DKLFDVCGS-QD 636

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  671 WRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAE------ILALQQALKEQKLKAESLSD 744
Cdd:TIGR00606  637 EESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEaelqefISDLQSKLRLAPDKLKSTES 716

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  745 KLNDLEKKH----AMLEMNARSLQQKLETERELKQRLleeqAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSD-- 818
Cdd:TIGR00606  717 ELKKKEKRRdemlGLAPGRQSIIDLKEKEIPELRNKL----QKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDvt 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  819 ----LEYQLENIQVLYSHEKVKMEG-----TISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNEL--- 886
Cdd:TIGR00606  793 imerFQMELKDVERKIAQQAAKLQGsdldrTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELkse 872

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|.
gi 1907160229  887 KLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHP 927
Cdd:TIGR00606  873 KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSP 913
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 388-677 5.58e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 48.13  E-value: 5.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  388 QKAMINAMDSKIRSLEQRIVELSEANKLaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQ--NRKLEEQLEKI 465
Cdd:PRK10929    43 QAEIVEALQSALNWLEERKGSLERAKQY--------QQVIDNFPKLSAELRQQLNNERDEPRSVPPNmsTDALEQEILQV 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  466 SHQdHSDKSRLLELET-RLREVS---LEHEEQKLELKRQLTELQLSLQERESQLTAL-QAARAAL--ESQLRQAKTELEE 538
Cdd:PRK10929   115 SSQ-LLEKSRQAQQEQdRAREISdslSQLPQQQTEARRQLNEIERRLQTLGTPNTPLaQAQLTALqaESAALKALVDELE 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  539 TTAEAEEEIQALTAHRDEI-QRKFDALRNSctvITDLEEQLNQLTEDNAElnnQNFYLSKQLDEASG--ANDEIVQLRse 615
Cdd:PRK10929   194 LAQLSANNRQELARLRSELaKKRSQQLDAY---LQALRNQLNSQRQREAE---RALESTELLAEQSGdlPKSIVAQFK-- 265

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  616 vdhLRREITereMQLTSQKQTMEALKTTCTMLEEQVLDL-EALNDelLEKERQWEAWRSVLGD 677
Cdd:PRK10929   266 ---INRELS---QALNQQAQRMDLIASQQRQAASQTLQVrQALNT--LREQSQWLGVSNALGE 320
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 394-563 5.58e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 5.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  394 AMDSKIRSLEQRIVELSEAnklaansslftqrnmkaqeemISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDK 473
Cdd:COG1579     14 ELDSELDRLEHRLKELPAE---------------------LAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  474 SRLLELETRLREVS-------LEHEEQKLELKRQLTELQLS-----LQERESQLTALQAARAALESQLRQAKTELEETTA 541
Cdd:COG1579     73 ARIKKYEEQLGNVRnnkeyeaLQKEIESLKRRISDLEDEILelmerIEELEEELAELEAELAELEAELEEKKAELDEELA 152

                          170       180
                   ....*....|....*....|..
gi 1907160229  542 EAEEEIQALTAHRDEIQRKFDA 563
Cdd:COG1579    153 ELEAELEELEAEREELAAKIPP 174
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 195-397 6.10e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 47.52  E-value: 6.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  195 SAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLV 274
Cdd:COG3883     13 FADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERA 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  275 EAEERR-------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQ 341
Cdd:COG3883     93 RALYRSggsvsyldvllgsESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  342 KEQHYEEK---IKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDS 397
Cdd:COG3883    173 LEAQQAEQealLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
492-783 6.22e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 6.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDeiqrKFDALRNSctvI 571
Cdd:COG1340      1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELRE----KRDELNEK---V 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  572 TDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqV 651
Cdd:COG1340     74 KELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQTEVLSPEEEKELVEKIKELEKELEK-A 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  652 LDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQrITESRqvvelavKEHKAEILALQQA 731
Cdd:COG1340    153 KKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADE-LRKEA-------DELHKEIVEAQEK 224

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  732 LKEQKLKAESLSDKLNDLEKKHAMLEmnarslQQKLETERELKQRLLEEQAK 783
Cdd:COG1340    225 ADELHEEIIELQKELRELRKELKKLR------KKQRALKREKEKEELEEKAE 270
C1_CeDKF1-like_rpt2 cd20798
second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine ...
 987-1038 6.74e-05

second protein kinase C conserved region 1 (C1 domain) found in Caenorhabditis elegans serine/threonine-protein kinase DKF-1 and similar proteins; DKF-1 converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. It plays a role in the regulation of growth and neuromuscular control of movement. It is involved in immune response to Staphylococcus aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Members of this group contain two copies of the C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410348  Cd Length: 54  Bit Score: 42.10  E-value: 6.74e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  987 PHRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGL 1038
Cdd:cd20798      1 PHTLAEHNYKKPTVCKVC-DKLLVGlvRQGLKCRDCGVNVHKKCASLLPSNCRL 53
PH_ROCK cd01242
Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is ...
 1070-1115 7.15e-05

Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain; ROCK is a serine/threonine kinase that binds GTP-Rho. It consists of a kinase domain, a coiled coil region and a PH domain. The ROCK PH domain is interrupted by a C1 domain. ROCK plays a role in cellular functions, such as contraction, adhesion, migration, and proliferation and in the regulation of apoptosis. There are two ROCK isoforms, ROCK1 and ROCK2. In ROCK2 the Rho Binding Domain (RBD) and the PH domain work together in membrane localization with RBD receiving the RhoA signal and the PH domain receiving the phospholipid signal. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269948  Cd Length: 110  Bit Score: 43.50  E-value: 7.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1907160229 1070 HLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPV 1115
Cdd:cd01242      2 RLEGWLSLPNKQNIRRHGWKKQYVVVSSKKILFYNSEQDKANSNPI 47
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
10-408 7.41e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 7.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   10 KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARmevsqeddka 89
Cdd:PRK02224   370 SELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTAR---------- 439

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   90 lqllHDIREQSRKL---------QEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELREsrlaAEEFKRKANEC 160
Cdd:PRK02224   440 ----ERVEEAEALLeagkcpecgQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLER----AEDLVEAEDRI 511

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  161 QHKLMKVvshpprgdsggtalDDLHKM--QGHAGLTSAKDQgkpevgeyskLEKINAEQQlkiqELQEKLEKAVKASTEA 238
Cdd:PRK02224   512 ERLEERR--------------EDLEELiaERRETIEEKRER----------AEELRERAA----ELEAEAEEKREAAAEA 563

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  239 TELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKI 318
Cdd:PRK02224   564 EEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEF 643

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  319 LE--LEEKHREAQVSAQHLEvHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE--EEAHEKGKILSEQKAMINA 394
Cdd:PRK02224   644 DEarIEEAREDKERAEEYLE-QVEEKLDELREERDDLQAEIGAVENELEELEELRERREalENRVEALEALYDEAEELES 722

                          410
                   ....*....|....*
gi 1907160229  395 MDSKIRS-LEQRIVE 408
Cdd:PRK02224   723 MYGDLRAeLRQRNVE 737
C1_Munc13-1 cd20858
protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; ...
 986-1036 8.54e-05

protein kinase C conserved region 1 (C1 domain) found in Munc13-1 and similar proteins; Munc13-1, also called protein unc-13 homolog A (Unc13A), is a diacylglycerol (DAG) receptor that plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Loss of MUNC13-1 function causes microcephaly, cortical hyperexcitability, and fatal myasthenia. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410408  Cd Length: 60  Bit Score: 42.00  E-value: 8.54e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  986 IPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20858      6 TPHNFEVWTATTPTYCYECEGLLwGIARQGMRCTECGVKCHEKCQDLLNADC 57
C1_aPKC cd20794
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 989-1037 8.89e-05

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain one C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410344  Cd Length: 55  Bit Score: 41.87  E-value: 8.89e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907160229  989 RFNvglnmRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1037
Cdd:cd20794      9 RFN-----RRAVCAYCSDRIwGLGRQGYKCINCKLLVHKKCHKLVKVACG 53
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2-377 8.96e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 47.32  E-value: 8.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    2 EKKLLIKSKELQDSQDKchKMEQEMTRLHRRVSEVEAVLSQKEvelKASETQRsllEQDLATYITEC-SSLKRSLEQARM 80
Cdd:NF033838   112 EAELTSKTKKELDAAFE--QFKKDTLEPGKKVAEATKKVEEAE---KKAKDQK---EEDRRNYPTNTyKTLELEIAESDV 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   81 EVSQEDdkaLQLLHDIREQSRKLQEIKEQEyqAQVEEMRLMMNQLEEdLVSARRRSDLYESELRESRLAAEEFKRKANEC 160
Cdd:NF033838   184 EVKKAE---LELVKEEAKEPRDEEKIKQAK--AKVESKKAEATRLEK-IKTDREKAEEEAKRRADAKLKEAVEKNVATSE 257

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  161 QHKLMKVVShppRGDSGGTALDDlhKMQGHAgltsakDQGKPEVGEYS------KLEKINAEQQLKIQELQEKLEK---- 230
Cdd:NF033838   258 QDKPKRRAK---RGVLGEPATPD--KKENDA------KSSDSSVGEETlpspslKPEKKVAEAEKKVEEAKKKAKDqkee 326

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  231 ------AVKASTEATELLQNIRQAKErAERELEKLHNREDSSEgikKKLVEAEERRHSLENKVKRLEtmerrenRLKDDI 304
Cdd:NF033838   327 drrnypTNTYKTLELEIAESDVKVKE-AELELVKEEAKEPRNE---EKIKQAKAKVESKKAEATRLE-------KIKTDR 395

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  305 QTKSEQIQQMADKILELEEKHREAQVSAQHLEVhlkQKEQHYEEKIKVLDNQIKKDlaDKESLENMMQRHEEE 377
Cdd:NF033838   396 KKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQP---EKPAPKPEKPAEQPKAEKPA--DQQAEEDYARRSEEE 463
PH_MRCK cd01243
MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK ...
 1072-1187 9.02e-05

MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain; MRCK is thought to be coincidence detector of signaling by Cdc42 and phosphoinositides. It has been shown to promote cytoskeletal reorganization, which affects many biological processes. There are 2 members of this family: MRCKalpha and MRCKbeta. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. The MRCK PH domain is responsible for its targeting to cell to cell junctions. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 269949  Cd Length: 135  Bit Score: 44.21  E-value: 9.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229 1072 EGWMKVPrnnKRG--QQGWDRKYIVLEGSKVLIYD-NEAREAGQRPVEEFELCLPDGDVSIhGAVGASELANTAKADVPY 1148
Cdd:cd01243     15 EGYVRVP---KPGgvKKGWQRQFAVVCDFKLFLFDiSEDKASQPSQVASQVLDMRDEEFSV-SSVLASDVIHANKKDIPC 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1907160229 1149 ILKME-SHPHTTCWPGRTLyLLAPSFPDKQRWVTALESVV 1187
Cdd:cd01243     91 IFRVSaSQLAPPSLKFSLL-MLADSENEKQKWVDALNELH 129
Filament pfam00038
Intermediate filament protein;
398-694 9.23e-05

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 46.45  E-value: 9.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  398 KIRSLEQRIVEL-SEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKIshqdhsdKSRL 476
Cdd:pfam00038   19 KVRFLEQQNKLLeTKISELRQKKGAEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDF-------RQKY 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  477 lELETRLREvslEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALE-------SQLRQAKTELEETTAEAEEEIQA 549
Cdd:pfam00038   92 -EDELNLRT---SAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKknheeevRELQAQVSDTQVNVEMDAARKLD 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  550 LTAHRDEIQRKFDALRNSCTviTDLEEQLNQLTEdnaELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQ 629
Cdd:pfam00038  168 LTSALAEIRAQYEEIAAKNR--EEAEEWYQSKLE---ELQ----------QAAARNGDALRSAKEEITELRRTIQSLEIE 232

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  630 LTSQKQTMEALKTTCTMLEEQ-VLDLEALNDELLEKERQweawrsvLGDEKSQFECRVRELQRMLD 694
Cdd:pfam00038  233 LQSLKKQKASLERQLAETEERyELQLADYQELISELEAE-------LQETRQEMARQLREYQELLN 291
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
686-940 1.02e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  686 VRELqrMLDtEKQSRARAD------QRITESRQVVELAVKEHKA--EILALQQALKEQKLKAESLSDKLNDLEKKHAMLE 757
Cdd:COG4913    213 VREY--MLE-EPDTFEAADalvehfDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLWFAQRR 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  758 MNArsLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEA-LDRADLLKTERSDLEYQLENIqvlyshekvk 836
Cdd:COG4913    290 LEL--LEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEER---------- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  837 mEGTISQQTKLIDFLQAKMDQPAKkkkGLFSRRKEDPALPTQVPLQYNELKLALekekarcAELEEALQKTRIELRSARE 916
Cdd:COG4913    358 -ERRRARLEALLAALGLPLPASAE---EFAALRAEAAALLEALEEELEALEEAL-------AEAEAALRDLRRELRELEA 426

                          250       260
                   ....*....|....*....|....
gi 1907160229  917 EAAHRKATDHPHPSTPATARQQIA 940
Cdd:COG4913    427 EIASLERRKSNIPARLLALRDALA 450
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 240-578 1.11e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.81  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  240 ELLQNIRQAKERAERELEKLHnrEDSSEGIKKKLVEAEERRHSLENKVKRLETmerrenrlkdDIQTKSEQIQQMADKIL 319
Cdd:pfam07888   30 ELLQNRLEECLQERAELLQAQ--EAANRQREKEKERYKRDREQWERQRRELES----------RVAELKEELRQSREKHE 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  320 ELEEKHREAQVS----AQHLEVHLKQKEQH------YEEKIKVLD---------------------NQIKKDLADKESLE 368
Cdd:pfam07888   98 ELEEKYKELSASseelSEEKDALLAQRAAHearireLEEDIKTLTqrvleretelermkerakkagAQRKEEEAERKQLQ 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  369 NMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSeaNKLAAnsslfTQRNMKAQEEMISELRQQKFYLETQA 448
Cdd:pfam07888  178 AKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLT--QKLTT-----AHRKEAENEALLEELRSLQERLNASE 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  449 GKLEAQNRKLEEQlekISHQDHS----DKSRL--LELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 522
Cdd:pfam07888  251 RKVEGLGEELSSM---AAQRDRTqaelHQARLqaAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAEL 327

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  523 AALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQL 578
Cdd:pfam07888  328 QRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQL 383
C1_nPKC_theta-like_rpt2 cd20837
second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) ...
 988-1036 1.22e-04

second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) theta, delta, and similar proteins; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. Members of this family contain two copies of C1 domain. This model corresponds to the second one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410387  Cd Length: 50  Bit Score: 41.27  E-value: 1.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  988 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20837      1 HRFKVYNYMSPTFCDHC-GSLLWGlfRQGLKCEECGMNVHHKCQKKVANLC 50
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 223-721 1.26e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 47.13  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  223 ELQEKLEKAVKASTEATELlQNIRQAKERAERELEKLHNREDSSEGIKKK--LVEAEERRHSLE---------NKV---- 287
Cdd:PTZ00440  2171 EIIENIKKEIIEINENTEM-NTLENTADKLKELYENLKKKKNIINNIYKKinFIKLQEIENSSEkyndisklfNNVvetq 2249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  288 -KRLETMERRENRLKDDIQTKsEQIQQMADKILELEEKhREAQVSAQHLEVHLKQKEQHYEEKIKVLDN------QIKKD 360
Cdd:PTZ00440  2250 kKKLLDNKNKINNIKDKINDK-EKELINVDSSFTLESI-KTFNEIYDDIKSNIGDLYKLEDTNNDELKKvklyieNITHL 2327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  361 LADKESLENMMQRHEEEahekGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslfTQRNMKAQEEMISELRQQ 440
Cdd:PTZ00440  2328 LNRINTLINDLDNYQDE----NYGKDKNIELNNENNSYIIKTKEKINNLKEEFSK-------LLKNIKRNNTLCNNNNIK 2396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  441 KFYLETqAGKLEAQNRKLEEQLEkishqdhsdksrlleletrLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQA 520
Cdd:PTZ00440  2397 DFISNI-GKSVETIKQRFSSNLP-------------------EKEKLHQIEENLNEIKNIMNETKRISNVDAFTNKILQD 2456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  521 ARAALEsqlrqaKTELEETTAEAEEEIQALTAHRDEIQRKF----DALRNSCTVITDLEEQLNQLTEDNAELNNQ-NFYL 595
Cdd:PTZ00440  2457 IDNEKN------KENNNMNAEKIDDLIENVTSHNEKIKSELliinDALRRVKEKKDEMNKLFNSLTENNNNNNNSaKNIV 2530

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  596 SKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSqkqtmealkttctMLEEQVLDLEALNDELLEKERQweawrsvl 675
Cdd:PTZ00440  2531 DNSTYIINELESHVSKLNELLSYIDNEIKELENEKLK-------------LLEKAKIEESRKERERIESETQ-------- 2589

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1907160229  676 GDEKSQFECRVRELQRMLDTEKQsRARADQRITESRQVVELAVKEH 721
Cdd:PTZ00440  2590 EDNTDEEQINRQQQERLQKEEEQ-KAYSQERLNREVSGTDDTNKNH 2634
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 504-823 1.28e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 46.43  E-value: 1.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  504 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRkfdALRNSCTVITDLEEQLNQLTE 583
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKE---ELRQSREKHEELEEKYKELSA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  584 DNAELNNQNFYLSKQLDEASGandEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLE 663
Cdd:pfam07888  109 SSEELSEEKDALLAQRAAHEA---RIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEE 185

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  664 KERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVvelavkehKAEILALQQALKEQKLKAESLS 743
Cdd:pfam07888  186 ELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEAL--------LEELRSLQERLNASERKVEGLG 257

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  744 DKLNDL--EKKHAMLEMNARSLQ------QKLETE---RELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLL 812
Cdd:pfam07888  258 EELSSMaaQRDRTQAELHQARLQaaqltlQLADASlalREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE 337

                          330
                   ....*....|.
gi 1907160229  813 KTERSDLEYQL 823
Cdd:pfam07888  338 RMEREKLEVEL 348
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 704-861 1.38e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  704 DQRITESRQvvelAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLEterELKQRLLE---- 779
Cdd:COG1579     16 DSELDRLEH----RLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIK---KYEEQLGNvrnn 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  780 -EQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQP 858
Cdd:COG1579     89 kEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168


                   ...
gi 1907160229  859 AKK 861
Cdd:COG1579    169 AAK 171
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 225-519 1.46e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.66  E-value: 1.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  225 QEKLEKAVKasteatellQNIRQAKERAERELEKlhnredssegiKKKLVEAEERRHSlenKVKRLETMERRENRLKDDI 304
Cdd:pfam17380  290 QEKFEKMEQ---------ERLRQEKEEKAREVER-----------RRKLEEAEKARQA---EMDRQAAIYAEQERMAMER 346

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  305 QTKSEQIQQmadkilelEEKHREAQvsaqhlevHLKQKEQHYE-EKIKVLDNqikkdLADKESLENMMQRHEEEAHEKGK 383
Cdd:pfam17380  347 ERELERIRQ--------EERKRELE--------RIRQEEIAMEiSRMRELER-----LQMERQQKNERVRQELEAARKVK 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  384 ILSEQKAminamdskiRSLEQRIVELSEANKLAANSSlftQRNMKAQEEMISElrqqkfylETQAGKLEAQNRklEEQLE 463
Cdd:pfam17380  406 ILEEERQ---------RKIQQQKVEMEQIRAEQEEAR---QREVRRLEEERAR--------EMERVRLEEQER--QQQVE 463

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  464 KISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam17380  464 RLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLE 519
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 491-705 1.53e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  491 EEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRN---- 566
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGErara 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  567 ---SCTVITDLEEQLNQltEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTT 643
Cdd:COG3883     95 lyrSGGSVSYLDVLLGS--ESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAE 172

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  644 ctmLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQ 705
Cdd:COG3883    173 ---LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
mukB PRK04863
chromosome partition protein MukB;
482-809 1.56e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.87  E-value: 1.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  482 RLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEEttaeaeeeIQALTAHRDEIQRKF 561
Cdd:PRK04863   283 VHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNL--------VQTALRQQEKIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  562 DALrnsctviTDLEEQLNQLTEDNAELNNQNFYLSKQLDEAsgaNDEIVQLRSEV-DHLRR--EITEREMQLTSQKQTME 638
Cdd:PRK04863   355 ADL-------EELEERLEEQNEVVEEADEQQEENEARAEAA---EEEVDELKSQLaDYQQAldVQQTRAIQYQQAVQALE 424

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  639 ALKTTC-----------TMLEEQVLDLEALNDELLEKERQWeawrSVLGDEKSQFECRVRELQRMLDTEKQSRAR--ADQ 705
Cdd:PRK04863   425 RAKQLCglpdltadnaeDWLEEFQAKEQEATEELLSLEQKL----SVAQAAHSQFEQAYQLVRKIAGEVSRSEAWdvARE 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  706 RITESRQVVELAVKEH--KAEILALQQALKEQKlKAESLsdkLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 783
Cdd:PRK04863   501 LLRRLREQRHLAEQLQqlRMRLSELEQRLRQQQ-RAERL---LAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSE 576

                          330       340
                   ....*....|....*....|....*.
gi 1907160229  784 LQQQMDLQKNHIFRLTQGLQEALDRA 809
Cdd:PRK04863   577 ARERRMALRQQLEQLQARIQRLAARA 602
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 215-519 1.61e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.96  E-value: 1.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  215 AEQQLKIQELQEKLEKAVKASTEATELLQNIR-QAKERAERElEKLHNREDSSEGIKKKLVEAEERRHSLENKVKRLETM 293
Cdd:pfam15905   52 TARKVKSLELKKKSQKNLKESKDQKELEKEIRaLVQERGEQD-KRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQ 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  294 ERRENRLKDDIQTK-SEQIQQMADKILELEekhreaqVSAQHLEVHLKQKEqhyeekikVLDNQIKKDLADKESLENMMQ 372
Cdd:pfam15905  131 LLELTRVNELLKAKfSEDGTQKKMSSLSME-------LMKLRNKLEAKMKE--------VMAKQEGMEGKLQVTQKNLEH 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  373 RHEEEAHEKGKILSEQKAMINAmDSKIRSLEQRIVELSEANKLAANSSLftqrnmkaqeemisELRQQKFYLETQAGKLE 452
Cdd:pfam15905  196 SKGKVAQLEEKLVSTEKEKIEE-KSETEKLLEYITELSCVSEQVEKYKL--------------DIAQLEELLKEKNDEIE 260

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907160229  453 AQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQ 519
Cdd:pfam15905  261 SLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQ 327
C1_aPKC_iota cd21094
protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) ...
 988-1039 1.63e-04

protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) iota type; PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. Members of this family contain C1 domain found in aPKC isoform iota. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410447  Cd Length: 55  Bit Score: 41.14  E-value: 1.63e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  988 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd21094      3 HTFQAKRFNRRAHCAICTDRIwGLGRQGYKCINCKLLVHKKCHKLVTIECGRH 55
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 569-788 1.79e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  569 TVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASG----ANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEAL---- 640
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEeyneLQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaral 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  641 ---KTTCTMLEeQVLDLEALNDELlekeRQWEAWRSVLGDEKSQFEcRVRELQRMLDTEKQSRARADQRITESRQVVELA 717
Cdd:COG3883     96 yrsGGSVSYLD-VLLGSESFSDFL----DRLSALSKIADADADLLE-ELKADKAELEAKKAELEAKLAELEALKAELEAA 169

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  718 VKEhkaeilaLQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQM 788
Cdd:COG3883    170 KAE-------LEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 435-912 1.79e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.25  E-value: 1.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  435 SELRQQKFYLETQAGKLEAQNRKLEE---QLEKISH------QDHSDKSR-----------LLELETRLREVSLEHEEQK 494
Cdd:pfam05483   99 AELKQKENKLQENRKIIEAQRKAIQElqfENEKVSLkleeeiQENKDLIKennatrhlcnlLKETCARSAEKTKKYEYER 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  495 LELKRQLTELQLSLqerESQLTALQAARAalesQLRQAKTELEETTAEAEEEIQALtahRDEIQRKFDALRNSCTVItdl 574
Cdd:pfam05483  179 EETRQVYMDLNNNI---EKMILAFEELRV----QAENARLEMHFKLKEDHEKIQHL---EEEYKKEINDKEKQVSLL--- 245

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  575 eeqLNQLTEDNAELNNQNFYLSK------QLDEASGANDE-IVQLRSEVDHLRREITEREMQLTSQKQTMEAL------- 640
Cdd:pfam05483  246 ---LIQITEKENKMKDLTFLLEEsrdkanQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQRSMSTQKALeedlqia 322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  641 -KTTCTMLEEQVLDLEALNDE-------LLEKERQWEAWRSVLGDEKSQFECRVRELqRMLDTEKQSRARADQRITESRQ 712
Cdd:pfam05483  323 tKTICQLTEEKEAQMEELNKAkaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKFKN 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  713 VVELAVKEHKaEILALQQALKEQKLKAESLSDKLNDLEKKHAML----EMNARSLQQKLETERELKQRLLEEQAKLQQQM 788
Cdd:pfam05483  402 NKEVELEELK-KILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTEL 480

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  789 DLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQqtklIDFLQAKMDQpakkkkglfsR 868
Cdd:pfam05483  481 EKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQ----IENLEEKEMN----------L 546

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1907160229  869 RKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRIELR 912
Cdd:pfam05483  547 RDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMK 590
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 269-665 1.91e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 46.00  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  269 IKKKLVEAEE--RRHSLeNKVKRleTMERRENRLkDDIQTKSEQIQQMADKILELEEKHREAqvsAQHLEVH-------L 339
Cdd:pfam06160   65 IEELLFEAEElnDKYRF-KKAKK--ALDEIEELL-DDIEEDIKQILEELDELLESEEKNREE---VEELKDKyrelrktL 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  340 KQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE-EEAHEkgkILSEQKAMINAMDSKIRSLEQRIVELseanklaan 418
Cdd:pfam06160  138 LANRFSYGPAIDELEKQLAEIEEEFSQFEELTESGDyLEARE---VLEKLEEETDALEELMEDIPPLYEEL--------- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  419 sslftQRNMKAQ----EEMISELRQQKFYLETQagkleaqnrKLEEQLEKISHQDHSDKSRLLELEtrlrevsLEHEEQK 494
Cdd:pfam06160  206 -----KTELPDQleelKEGYREMEEEGYALEHL---------NVDKEIQQLEEQLEENLALLENLE-------LDEAEEA 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  495 LE-LKRQLTELQLSLqEREsqltalqaaraalesqlrqakteleettaeaeeeIQAltahRDEIQRKFDALRNSctvITD 573
Cdd:pfam06160  265 LEeIEERIDQLYDLL-EKE----------------------------------VDA----KKYVEKNLPEIEDY---LEH 302

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  574 LEEQLNQLTEDNAELnNQNFYLS-KQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVL 652
Cdd:pfam06160  303 AEEQNKELKEELERV-QQSYTLNeNELERVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQE 381

                          410
                   ....*....|....
gi 1907160229  653 DL-EALNDelLEKE 665
Cdd:pfam06160  382 EFkESLQS--LRKD 393
C1_MTMR-like cd20828
protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to ...
 984-1037 1.99e-04

protein kinase C conserved region 1 (C1 domain) found in uncharacterized proteins similar to myotubularin-related proteins; The family includes a group of uncharacterized proteins that show high sequence similarity to vertebrate myotubularin-related proteins (MTMRs), such as MTMR5 and MTMR13. MTMRs may function as guanine nucleotide exchange factors (GEFs). Vertebrate MTMR5 and MTMR13 contain an N-terminal DENN domain, a PH-GRAM domain, an inactive PTP domain, a SET interaction domain, a coiled-coil domain, and a C-terminal PH domain. Members of this family contain these domains and have an additional C1 domain. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410378  Cd Length: 57  Bit Score: 40.89  E-value: 1.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229  984 HNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATCG 1037
Cdd:cd20828      2 FTQPHNFEPHSFVTPTNCDYCLQILwGIVKKGMKCSECGYNCHEKCQPQVPKQCS 56
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 503-862 2.18e-04

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 45.84  E-value: 2.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  503 ELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiqaltahrdEIQRKFDALRNSCTVIT----DLEEQL 578
Cdd:pfam05622   11 ELAQRCHELDQQVSLLQEEKNSLQQENKKLQ----------------------ERLDQLESGDDSGTPGGkkylLLQKQL 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  579 NQLTEDN--------------AELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRrEITER----EMQLTSQKQTMEA- 639
Cdd:pfam05622   69 EQLQEENfrletarddyrikcEELEKEVLELQHRNEELTSLAEEAQALKDEMDILR-ESSDKvkklEATVETYKKKLEDl 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  640 --LKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQfecrVRELQRMLDTE-----------KQSRA----- 701
Cdd:pfam05622  148 gdLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQ----VQELHGKLSEEskkadklefeyKKLEEkleal 223

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  702 -RADQRITESRQVVELAVKE-----------HKAEILALQQALKEQKLKAESLS----DKLNDLEKKHAMLEMNAR---- 761
Cdd:pfam05622  224 qKEKERLIIERDTLRETNEElrcaqlqqaelSQADALLSPSSDPGDNLAAEIMPaeirEKLIRLQHENKMLRLGQEgsyr 303

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  762 ----SLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKvkm 837
Cdd:pfam05622  304 erltELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEDSSLLKQKLEEHLE--KLHEAQSE--- 378

                          410       420
                   ....*....|....*....|....*
gi 1907160229  838 egtISQQTKLIDFLQAKMDQPAKKK 862
Cdd:pfam05622  379 ---LQKKKEQIEELEPKQDSNLAQK 400
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 10-272 2.21e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   10 KELQDSQDKCHKMEQEMTRL-----HRRVSEVEAVLSQKEVELKASETQRSLLEQDLatyitECSSLKRSLEQARMEVSQ 84
Cdd:TIGR02169  765 ARIEELEEDLHKLEEALNDLearlsHSRIPEIQAELSKLEEEVSRIEARLREIEQKL-----NRLTLEKEYLEKEIQELQ 839

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   85 EDDKALQLLHDIREQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKL 164
Cdd:TIGR02169  840 EQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRL 919

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  165 MKvvshppRGDSGGTALDDLhkmqghAGLTSAKDQGKPEVGEYSKLEKINAEQQlKIQELQEKLE----KAVKASTEATE 240
Cdd:TIGR02169  920 SE------LKAKLEALEEEL------SEIEDPKGEDEEIPEEELSLEDVQAELQ-RVEEEIRALEpvnmLAIQEYEEVLK 986

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1907160229  241 LLQNIRQAKERAERELEKLHNREDSSEGIKKK 272
Cdd:TIGR02169  987 RLDELKEKRAKLEEERKAILERIEEYEKKKRE 1018
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 206-383 2.35e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERR----- 280
Cdd:COG4942     35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELlraly 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  281 --------------HSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHY 346
Cdd:COG4942    115 rlgrqpplalllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALK 194

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1907160229  347 EEKIKVLD----------NQIKKDLADKESLENMMQRHEEEAHEKGK 383
Cdd:COG4942    195 AERQKLLArlekelaelaAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 245-398 2.54e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.97  E-value: 2.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  245 IRQAKERAERELEKLhnrEDSSEGIKKKLVEAEERRHSLENKVKRLEtmerrenRLKDDIQTKSEQIQQMADKIL-ELEE 323
Cdd:PRK00409   504 IEEAKKLIGEDKEKL---NELIASLEELERELEQKAEEAEALLKEAE-------KLKEELEEKKEKLQEEEDKLLeEAEK 573

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  324 KHREA-------------QVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKdlADKESLENMMQRHEEEAHEKGKILS-EQK 389
Cdd:PRK00409   574 EAQQAikeakkeadeiikELRQLQKGGYASVKAHELIEARKRLNKANEK--KEKKKKKQKEKQEELKVGDEVKYLSlGQK 651


                   ....*....
gi 1907160229  390 AMINAMDSK 398
Cdd:PRK00409   652 GEVLSIPDD 660
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
291-531 2.55e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.78  E-value: 2.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  291 ETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQvsAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENM 370
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFR--QKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEAR 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  371 MQRHEEEAHEKGKILSEQKAminamDSKIRSLEQRIVELSEanKLAANSSLFTQRN--MKAQEEMISELRQQkfyletqa 448
Cdd:COG3206    242 LAALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEA--ELAELSARYTPNHpdVIALRAQIAALRAQ-------- 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  449 gkLEAQNRKLEEQLEkishqdhsdkSRLLELETRLREVSLEHEEQKLELKRqltelqlsLQERESQLTALQAARAALESQ 528
Cdd:COG3206    307 --LQQEAQRILASLE----------AELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREVEVAREL 366


                   ...
gi 1907160229  529 LRQ 531
Cdd:COG3206    367 YES 369
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 206-533 2.62e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 45.72  E-value: 2.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEqqLKIQELQEKLEKAVKASTEATELLQNIRQAKERAeRELEKLHNREDSSEGIKKKLVEAEERRHsLEN 285
Cdd:COG5185    254 KLEKLVEQNTD--LRLEKLGENAESSKRLNENANNLIKQFENTKEKI-AEYTKSIDIKKATESLEEQLAAAEAEQE-LEE 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  286 KVKRLETMerrenrlkddIQTKSEQIQQMADKILELEEKHREaQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKE 365
Cdd:COG5185    330 SKRETETG----------IQNLTAEIEQGQESLTENLEAIKE-EIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQ 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  366 SLENMMQRHEEEAHEKGKILSEQkamINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLE 445
Cdd:COG5185    399 NQRGYAQEILATLEDTLKAADRQ---IEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRS 475

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  446 tqagkLEAQNRKLEEQLEKIshqdhsdKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQEREsqlTALQAARAAL 525
Cdd:COG5185    476 -----VRSKKEDLNEELTQI-------ESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFM---RARGYAHILA 540


                   ....*...
gi 1907160229  526 ESQLRQAK 533
Cdd:COG5185    541 LENLIPAS 548
C1_PKD2_rpt2 cd20843
second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and ...
 986-1036 2.89e-04

second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins; PKD2, also called PRKD2, HSPC187, or serine/threonine-protein kinase D2 (nPKC-D2), is a serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. PKD2 contains N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410393  Cd Length: 79  Bit Score: 41.11  E-value: 2.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  986 IPHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20843     10 VPHTFVIHSYTRPTVCQFCKKLLKgLFRQGLQCKDCKFNCHKRCATRVPNDC 61
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 65-414 3.77e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 45.43  E-value: 3.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   65 ITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSrKLQEIKEQEYQA----QVEEMRLMMNQLEEDLVSARRRSDLYE 140
Cdd:TIGR01612 1364 IDEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI-NLEECKSKIESTlddkDIDECIKKIKELKNHILSEESNIDTYF 1442

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  141 SELRESR----LAAEEFKRKANECQHkLMKVvshppRGDSGGTALD-DLHKMQGHagltsaKDQGKPEVGEYSKlekiNA 215
Cdd:TIGR01612 1443 KNADENNenvlLLFKNIEMADNKSQH-ILKI-----KKDNATNDHDfNINELKEH------IDKSKGCKDEADK----NA 1506

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  216 EQQLKIQELQEKLEKAVKA---STEATELLQNIRQAKERAE---RELEKLHNRED-SSEGIKKKLVEAEERRHSLENKVK 288
Cdd:TIGR01612 1507 KAIEKNKELFEQYKKDVTEllnKYSALAIKNKFAKTKKDSEiiiKEIKDAHKKFIlEAEKSEQKIKEIKKEKFRIEDDAA 1586

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  289 RletmERRENRLKDDIQTKSEQIQQMADKILELEEKHREAqvsaqhlevhLKQKEQhYEEKIKVLD-NQIKKDLADKESL 367
Cdd:TIGR01612 1587 K----NDKSNKAAIDIQLSLENFENKFLKISDIKKKINDC----------LKETES-IEKKISSFSiDSQDTELKENGDN 1651

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  368 ENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLE---------------QRIVELSEANK 414
Cdd:TIGR01612 1652 LNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEidvdqhkknyeigiiEKIKEIAIANK 1713
C1_Munc13-2-like cd20859
protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar ...
 982-1036 4.24e-04

protein kinase C conserved region 1 (C1 domain) found in Munc13-2, Munc13-3 and similar proteins; Munc13-2, also called protein unc-13 homolog B (Unc13B), plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410409  Cd Length: 82  Bit Score: 40.82  E-value: 4.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  982 MHHNIPHRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20859     14 ISCTTPHNFEVWTATTPTYCYECEGLLwGIARQGMRCSECGVKCHEKCQDLLNADC 69
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 220-378 4.36e-04

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 43.86  E-value: 4.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERE----------------------------LEKLHNREDSSEGIKK 271
Cdd:pfam00261    2 KMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEvaalnrriqlleeelerteerlaealekLEEAEKAADESERGRK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  272 KL----VEAEERRHSLENKVK-----------RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLE 336
Cdd:pfam00261   82 VLenraLKDEEKMEILEAQLKeakeiaeeadrKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSLE 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1907160229  337 VHLK---QKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEA 378
Cdd:pfam00261  162 ASEEkasEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLEKEV 206
PRK12704 PRK12704
phosphodiesterase; Provisional
 198-351 4.43e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.77  E-value: 4.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  198 DQGKPEVGEYSKLEKINAEQqlKIQELQEKLEKAVKAST-EATELLQNIRQAKERAERELEKLHNREDssegikkklvEA 276
Cdd:PRK12704    45 EEAKKEAEAIKKEALLEAKE--EIHKLRNEFEKELRERRnELQKLEKRLLQKEENLDRKLELLEKREE----------EL 112

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  277 EERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQM----ADKILeLEEKHREAQVSAQHLevhLKQKEQHYEEKIK 351
Cdd:PRK12704   113 EKKEKELEQKQQELEKKEEELEELIEEQLQELERISGLtaeeAKEIL-LEKVEEEARHEAAVL---IKEIEEEAKEEAD 187
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 500-717 4.72e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  500 QLTELQLSLQERESQLTALQAARAALESQLRQAKTEleettaeaeeeIQALTAHRDEIQRKFDALRNSctvITDLEEQLN 579
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEE-----------YNELQAELEALQAEIDKLQAE---IAEAEAEIE 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  580 QLTEDNAELNNQNF---YLSKQLDEASGANDeIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEA 656
Cdd:COG3883     83 ERREELGERARALYrsgGSVSYLDVLLGSES-FSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  657 LNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELA 717
Cdd:COG3883    162 LKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAA 222
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 556-856 5.01e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 44.95  E-value: 5.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  556 EIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFY----LSKQLDEasgandEIVQLRSEVDHLRREITERE---- 627
Cdd:COG5185    233 EALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGenaeSSKRLNE------NANNLIKQFENTKEKIAEYTksid 306

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  628 -----MQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQF--ECRVRELQRMLDTEKQSR 700
Cdd:COG5185    307 ikkatESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKEEIENIvgEVELSKSSEELDSFKDTI 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  701 ARADQRITESRQVVELAVKEHKAeilALQQALKEQKLKAESLSDKLNDLEKKhamlemNARSLQQKLETERELKQRLLEE 780
Cdd:COG5185    387 ESTKESLDEIPQNQRGYAQEILA---TLEDTLKAADRQIEELQRQIEQATSS------NEEVSKLLNELISELNKVMREA 457

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  781 QAKLQQQMDLQKNHIFRltqGLQEALDRADLlktERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMD 856
Cdd:COG5185    458 DEESQSRLEEAYDEINR---SVRSKKEDLNE---ELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLK 527
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
594-829 5.57e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 5.57e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  594 YLSKQLDEASGANDEIVQ-LRSEVDHLRREITEREMQLTS--QKQTMEALKTTCTMLEEQVLDLE----ALNDELLEKER 666
Cdd:COG3206    161 YLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQLSELEsqlaEARAELAEAEA 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  667 QWEAWRSVLGDEKSQF-----ECRVRELQRMLDTEKQSRARADQRITE-SRQVVELavkehKAEILALQQALKEQKLKAe 740
Cdd:COG3206    241 RLAALRAQLGSGPDALpellqSPVIQQLRAQLAELEAELAELSARYTPnHPDVIAL-----RAQIAALRAQLQQEAQRI- 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  741 slsdkLNDLEKKHAMLEMNARSLQQKLEterELKQRLLEEQAKLQQQMDLQKNhIFRLTQGLQEALDRADLLKTERSdle 820
Cdd:COG3206    315 -----LASLEAELEALQAREASLQAQLA---QLEARLAELPELEAELRRLERE-VEVARELYESLLQRLEEARLAEA--- 382


                   ....*....
gi 1907160229  821 YQLENIQVL 829
Cdd:COG3206    383 LTVGNVRVI 391
PRK09039 PRK09039
peptidoglycan -binding protein;
614-747 5.79e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.19  E-value: 5.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  614 SEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELlekerqwEAWRSVLGDEKSQFECRVRELQRML 693
Cdd:PRK09039    53 SALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRL-------QALLAELAGAGAAAEGRAGELAQEL 125

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  694 DTEKQSRARADQRITE-SRQVVELavkehKAEILALQQAL-------KEQKLKAESLSDKLN 747
Cdd:PRK09039   126 DSEKQVSARALAQVELlNQQIAAL-----RRQLAALEAALdasekrdRESQAKIADLGRRLN 182
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 372-869 6.33e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.83  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  372 QRHEEEAHEKGKILSEQKAMINAMDS------KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQ-EEMISELRQQKFYL 444
Cdd:pfam12128  234 AGIMKIRPEFTKLQQEFNTLESAELRlshlhfGYKSDETLIASRQEERQETSAELNQLLRTLDDQwKEKRDELNGELSAA 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  445 ETQAGKLEAQNRKLEEQLEKISHQD----HSDKSRLLELETRLREVSLEHE---------EQKLELKRQLTELQL----- 506
Cdd:pfam12128  314 DAAVAKDRSELEALEDQHGAFLDADietaAADQEQLPSWQSELENLEERLKaltgkhqdvTAKYNRRRSKIKEQNnrdia 393

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  507 --------SLQERESQLTALQAARAALESQLRQAKTeleettaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDL---E 575
Cdd:pfam12128  394 gikdklakIREARDRQLAVAEDDLQALESELREQLE-------------AGKLEFNEEEYRLKSRLGELKLRLNQAtatP 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  576 EQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALK--------TTCTML 647
Cdd:pfam12128  461 ELLLQLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELElqlfpqagTLLHFL 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  648 EEQVLDLE-----ALNDELLEK-ERQWEAWRSVLGDEKSQFECRVReLQRM-----LDTEKQSRARADQritesrqvvel 716
Cdd:pfam12128  541 RKEAPDWEqsigkVISPELLHRtDLDPEVWDGSVGGELNLYGVKLD-LKRIdvpewAASEEELRERLDK----------- 608

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  717 aVKEhkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQmdlqknhif 796
Cdd:pfam12128  609 -AEE------ALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKA--------- 672

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  797 rLTQGLQEALDRADLLKTERSDLEYQLEniQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRR 869
Cdd:pfam12128  673 -LAERKDSANERLNSLEAQLKQLDKKHQ--AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAARR 742
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1-152 7.40e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.05  E-value: 7.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    1 MEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELK--ASETQRS---------LLE-QDLATYITEC 68
Cdd:COG3883     42 LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARALYRSggsvsyldvLLGsESFSDFLDRL 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   69 SSLKR----------SLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEqEYQAQVEEMRLMMNQLEEDLVSARRRSDL 138
Cdd:COG3883    122 SALSKiadadadlleELKADKAELEAKKAELEAKLAELEALKAELEAAKA-ELEAQQAEQEALLAQLSAEEAAAEAQLAE 200

                          170
                   ....*....|....
gi 1907160229  139 YESELRESRLAAEE 152
Cdd:COG3883    201 LEAELAAAEAAAAA 214
C1_dGM13116p-like cd20831
protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and ...
 999-1036 7.63e-04

protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins; This group contains uncharacterized proteins including Drosophila melanogaster GM13116p and Caenorhabditis elegans hypothetical protein R11G1.4, both of which contain C2 (a calcium-binding domain) and C1 domains. This model describes the C1 domain, a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410381  Cd Length: 58  Bit Score: 39.25  E-value: 7.63e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907160229  999 TKCAVCLDTV--HFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20831     17 PSCAVCNKLIpgRFGKQGYQCRDCGLICHKRCHVKVETHC 56
46 PHA02562
endonuclease subunit; Provisional
 694-853 8.49e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.85  E-value: 8.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  694 DTEKQSRARADQRITESRQVVELAVKE---HKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQ------ 764
Cdd:PHA02562   202 KNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQkvikmy 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  765 ----------QKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEk 834
Cdd:PHA02562   282 ekggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITL- 356

                          170
                   ....*....|....*....
gi 1907160229  835 vkmEGTISQQTKLIDFLQA 853
Cdd:PHA02562   357 ---VDKAKKVKAAIEELQA 372
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
205-299 9.09e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 9.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  205 GEYSKLEKINAEQQLKIQELQEKLEKAVKAsteatellqniRQAKERAERELEKLHNREDSsegIKKKLVEAEERRHSLE 284
Cdd:COG2433    427 AEVEELEAELEEKDERIERLERELSEARSE-----------ERREIRKDREISRLDREIER---LERELEEERERIEELK 492

                           90
                   ....*....|....*
gi 1907160229  285 NKVKRLETMERRENR 299
Cdd:COG2433    493 RKLERLKELWKLEHS 507
PRK12704 PRK12704
phosphodiesterase; Provisional
 300-468 1.09e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  300 LKDDIQTKSEQIQQMADKIleLEEKHREAqvsaqhlEVHLKQKEQHYEEKIKVLDNQIKKDLADKeslENMMQRHEEEAH 379
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKRI--LEEAKKEA-------EAIKKEALLEAKEEIHKLRNEFEKELRER---RNELQKLEKRLL 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  380 EKGKILSEQKAMINAMDSKIRSLEQRIVELseanklaansslftQRNMKAQEEMISELR-QQKFYLETQAG--KLEAQNR 456
Cdd:PRK12704    93 QKEENLDRKLELLEKREEELEKKEKELEQK--------------QQELEKKEEELEELIeEQLQELERISGltAEEAKEI 158

                          170
                   ....*....|..
gi 1907160229  457 KLEEQLEKISHQ 468
Cdd:PRK12704   159 LLEKVEEEARHE 170
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
473-836 1.12e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  473 KSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTA 552
Cdd:COG4372      5 GEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  553 HRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEasgANDEIVQLRSEVDHLRREITEREMQLTS 632
Cdd:COG4372     85 LNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ---LEAQIAELQSEIAEREEELKELEEQLES 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  633 QKQTMEALKTTCTMLEEQVLDlEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQ 712
Cdd:COG4372    162 LQEELAALEQELQALSEAEAE-QALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  713 VVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmNARSLQQKLETERELKQRLLEEQAKLQQQMDLQK 792
Cdd:COG4372    241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALEL-EALEEAALELKLLALLLNLAALSLIGALEDALLA 319

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1907160229  793 NHIFRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVK 836
Cdd:COG4372    320 ALLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGA 363
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
11-259 1.15e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   11 ELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL--LEQDLATYIT---ECSSLKRSLEQARMEVSQE 85
Cdd:COG4913    625 ELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIaeLEAELERLDAssdDLAALEEQLEELEAELEEL 704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   86 DDKALQLLHDIREQSRKLQEIKEQ--EYQAQVEEMRLMMNQLEEDLVSARRRS---DLYESELRE---SRLAAEefKRKA 157
Cdd:COG4913    705 EEELDELKGEIGRLEKELEQAEEEldELQDRLEAAEDLARLELRALLEERFAAalgDAVERELREnleERIDAL--RARL 782

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  158 NECQHKLMKVVSH-----PPRGDSGGTALDDLHKMQGHagltsakdqgkpevgeYSKLEKINAEqqlkiqELQEKLEKAV 232
Cdd:COG4913    783 NRAEEELERAMRAfnrewPAETADLDADLESLPEYLAL----------------LDRLEEDGLP------EYEERFKELL 840

                          250       260
                   ....*....|....*....|....*....
gi 1907160229  233 KASTEA--TELLQNIRQAKERAERELEKL 259
Cdd:COG4913    841 NENSIEfvADLLSKLRRAIREIKERIDPL 869
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
71-359 1.15e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 42.98  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   71 LKRSLEQARMEVSQEDDKalqlLHDIREQSRKLQEiKEQEYQAQVEEMRLMMNQLEEdlvsarRRSDLYEsELRESRLAA 150
Cdd:COG1340     13 LEEKIEELREEIEELKEK----RDELNEELKELAE-KRDELNAQVKELREEAQELRE------KRDELNE-KVKELKEER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  151 EEFKRKANECQHKLMKVVSHPPRGDSGGTALDDLHKmqghagltsakdqgkpevgEYSKLEK--------INAEQQL--K 220
Cdd:COG1340     81 DELNEKLNELREELDELRKELAELNKAGGSIDKLRK-------------------EIERLEWrqqtevlsPEEEKELveK 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  221 IQELQEKLE---KAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIKKKLVEAEERRHSLenkVKRLETMERRE 297
Cdd:COG1340    142 IKELEKELEkakKALEKNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADEL---RKEADELHKEI 218

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  298 NRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEqhYEEKIKVLDNQIKK 359
Cdd:COG1340    219 VEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE--LEEKAEEIFEKLKK 278
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 571-751 1.18e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.48  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  571 ITDLEEQLNQLTEDNAELNnqnfylskqlDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQ 650
Cdd:pfam05667  337 LEELQEQLEDLESSIQELE----------KEIKKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDLLPDAEENIAKL 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  651 VLDLEALNDELLEKERQWEAWRSVLGDEksqfecrVRELqrmldtekqsRARADQRITESRQVVElAVKEHKAEIlalQQ 730
Cdd:pfam05667  407 QALVDASAQRLVELAGQWEKHRVPLIEE-------YRAL----------KEAKSNKEDESQRKLE-EIKELREKI---KE 465

                          170       180
                   ....*....|....*....|.
gi 1907160229  731 ALKEQKLKAESLSDKLNDLEK 751
Cdd:pfam05667  466 VAEEAKQKEELYKQLVAEYER 486
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 4-255 1.26e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 1.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229    4 KLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLE---QDLATYITECSSLKRSLEQArm 80
Cdd:TIGR02169  778 EEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEkeiQELQEQRIDLKEQIKSIEKE-- 855

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   81 evsQEDDKAlqllhDIREQSRKLQEIKEQEYQ--AQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAN 158
Cdd:TIGR02169  856 ---IENLNG-----KKEELEEELEELEAALRDleSRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLE 927

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  159 ECQHKLMKVVSHPPRGDSGGTALDDLHKMQghagltsAKDQGKPEvgEYSKLEKIN-------AEQQLKIQELQEKLEKA 231
Cdd:TIGR02169  928 ALEEELSEIEDPKGEDEEIPEEELSLEDVQ-------AELQRVEE--EIRALEPVNmlaiqeyEEVLKRLDELKEKRAKL 998

                          250       260
                   ....*....|....*....|....
gi 1907160229  232 VKASTEATELLQNIRQAKERAERE 255
Cdd:TIGR02169  999 EEERKAILERIEEYEKKKREVFME 1022
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 211-411 1.32e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  211 EKINAEQQLKIQELQEKLEKAV---KASTEATELLQNIRQAKEraERELEKLHNREDSS-EGIKKKLVEAEERRHSLENK 286
Cdd:PRK05771    38 EELSNERLRKLRSLLTKLSEALdklRSYLPKLNPLREEKKKVS--VKSLEELIKDVEEElEKIEKEIKELEEEISELENE 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  287 VKRLETMERRENRLKD-DIqtkseqiqqmaDKILELEEKH---REAQVSAQHLEVHLKQKEQHYEEKIKVLDN------- 355
Cdd:PRK05771   116 IKELEQEIERLEPWGNfDL-----------DLSLLLGFKYvsvFVGTVPEDKLEELKLESDVENVEYISTDKGyvyvvvv 184

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907160229  356 QIKKDLADKESLenmMQRHE---EEAHEKGK---ILSEQKAMINAMDSKIRSLEQRIVELSE 411
Cdd:PRK05771   185 VLKELSDEVEEE---LKKLGferLELEEEGTpseLIREIKEELEEIEKERESLLEELKELAK 243
C1_MRCKalpha cd20864
protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related ...
 988-1041 1.42e-03

protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins; MRCK alpha, also called Cdc42-binding protein kinase alpha, DMPK-like alpha, or myotonic dystrophy protein kinase-like alpha, is a serine/threonine-protein kinase expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK alpha is an important downstream effector of Cdc42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410414  Cd Length: 60  Bit Score: 38.46  E-value: 1.42e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229  988 HRFNVGLNMRATKCAVCLD-TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAE 1041
Cdd:cd20864      3 HQFVVKSFTTPTKCNQCTSlMVGLIRQGCTCEVCGFSCHVTCADKAPSVCPIPPE 57
Stathmin pfam00836
Stathmin family; The Stathmin family of proteins play an important role in the regulation of ...
 261-348 1.43e-03

Stathmin family; The Stathmin family of proteins play an important role in the regulation of the microtubule cytoskeleton. They regulate microtubule dynamics by promoting depolymerization of microtubules and/or preventing polymerization of tubulin heterodimers.


Pssm-ID: 459956 [Multi-domain]  Cd Length: 136  Bit Score: 40.41  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  261 NREDSSEGIKKKLVEAEERRHSLE-NKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL----ELEEKHREAQVSAqhL 335
Cdd:pfam00836   39 KKDSSLEEIQKKLEAAEERRKSLEaQKLKQLAEKREKEEEALQKADEENNNFSKMAEEKLkqkmEAYKENREAQIAA--L 116

                           90
                   ....*....|...
gi 1907160229  336 EVHLKQKEQHYEE 348
Cdd:pfam00836  117 KEKLKEKEKHVEE 129
C1_MRCK cd20809
protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related ...
 988-1039 1.47e-03

protein kinase C conserved region 1 (C1 domain) found in the Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) family; MRCK is thought to be a coincidence detector of signaling by the small GTPase Cdc42 and phosphoinositides. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. MRCK has been shown to promote cytoskeletal reorganization, which affects many biological processes. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. MRCK consists of a serine/threonine kinase domain, a cysteine rich (C1) region, a PH domain and a p21 binding motif. This model corresponds to C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410359  Cd Length: 53  Bit Score: 38.02  E-value: 1.47e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  988 HRFNVGLNMRATKCAVClDTVHFG--RQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd20809      1 HKFIVRTFSTPTKCNHC-TSLMVGlvRQGLVCEVCGYACHVSCADKAPQVCPVP 53
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 499-921 1.65e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 43.50  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  499 RQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITD----- 573
Cdd:PRK10929     2 RLIITFLMAWLLSWGAYAATAPDEKQITQELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQQVIDNfpkls 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  574 --LEEQLNQLTED---------NAELNNQNFYLSKQLDEASGandeivQLRSEVDHLrREITEREMQLTsQKQTmEALKt 642
Cdd:PRK10929    82 aeLRQQLNNERDEprsvppnmsTDALEQEILQVSSQLLEKSR------QAQQEQDRA-REISDSLSQLP-QQQT-EARR- 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  643 tctMLEEQVLDLEALNDELLEKErqwEAWRSVLGDEKSQFECRVRELQrmldtekQSRARADQRITESRQVVELAVKEHk 722
Cdd:PRK10929   152 ---QLNEIERRLQTLGTPNTPLA---QAQLTALQAESAALKALVDELE-------LAQLSANNRQELARLRSELAKKRS- 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  723 AEILALQQALKEQklkaeslsdkLNDLEKKHA--------MLEMNA----RSLQQKLETERELKQrLLEEQAklqQQMDL 790
Cdd:PRK10929   218 QQLDAYLQALRNQ----------LNSQRQREAeralesteLLAEQSgdlpKSIVAQFKINRELSQ-ALNQQA---QRMDL 283

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  791 ----QK---NHIFRLTQGLQ----------------EALdRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKL 847
Cdd:PRK10929   284 iasqQRqaaSQTLQVRQALNtlreqsqwlgvsnalgEAL-RAQVARLPEMPKPQQLDTEMAQLRVQRLRYEDLLNKQPQL 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  848 IDFLQAKMDQPAKKKKGLFsrrkeDPALPTQVPL------QYNELKLALEKEKARCAELEEALQKTRielrsareEAAHR 921
Cdd:PRK10929   363 RQIRQADGQPLTAEQNRIL-----DAQLRTQRELlnsllsGGDTLILELTKLKVANSQLEDALKEVN--------EATHR 429
C1_TNS1_v cd20888
protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar ...
 988-1035 1.76e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins; Tensin-1 (TNS1) plays a role in fibrillar adhesion formation. It may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This model corresponds to the C1 domain found in TNS1 variant. Typical TNS1 does not contain C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410438  Cd Length: 57  Bit Score: 38.31  E-value: 1.76e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  988 HRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKC-----STCLPAT 1035
Cdd:cd20888      6 HTFKVKTFKKVKSCGICKQAI--TREGSTCRVCKLSCHKKCeakvaTPCVPAV 56
46 PHA02562
endonuclease subunit; Provisional
 289-588 1.83e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  289 RLETMERREnRLKD--DIQTKSEqiqqMaDKILEleEKHREAQVSAQHLEV---HLKQKEQHYEEKIKVLDNQIKKDLAD 363
Cdd:PHA02562   146 QLSAPARRK-LVEDllDISVLSE----M-DKLNK--DKIRELNQQIQTLDMkidHIQQQIKTYNKNIEEQRKKNGENIAR 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  364 KEsleNMMQRHEEEAhekgkilseqkamiNAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEEMISELRQQKF 442
Cdd:PHA02562   218 KQ---NKYDELVEEA--------------KTIKAEIEELTDELLNLVmDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKM 280

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  443 YLETQAGKLEAQNrkLEEQLEKIShqdhSDKSRLLELETRLREVSlEHEEQKLELKRQLTELQLSLQERESQLTALQAAR 522
Cdd:PHA02562   281 YEKGGVCPTCTQQ--ISEGPDRIT----KIKDKLKELQHSLEKLD-TAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  523 AALESQLRQAKteleettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 588
Cdd:PHA02562   354 ITLVDKAKKVK---------------------AAIEELQAEFVDNAEELAKLQDELDKIVKTKSEL 398
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 206-804 1.83e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 43.20  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  206 EYSKLEKINAEQQLKIQELQEKLEKAVKASTE--------ATELLQNIRQAKERAERELEKLHNREDSSegikkkLVEAE 277
Cdd:pfam07111   87 ETSLQQKMRLEAQAMELDALAVAEKAGQAEAEglraalagAEMVRKNLEEGSQRELEEIQRLHQEQLSS------LTQAH 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  278 ERrhSLENKVKRLETMERRENRLKddiQTKSEQIQQMAdkileleekhrEAQVSAQHLEVHLKQKEQHYEEKIKVLDNqI 357
Cdd:pfam07111  161 EE--ALSSLTSKAEGLEKSLNSLE---TKRAGEAKQLA-----------EAQKEAELLRKQLSKTQEELEAQVTLVES-L 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  358 KKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLaansslftqrnmkaQEEMISEL 437
Cdd:pfam07111  224 RKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQVRVQSLTHMLAL--------------QEEELTRK 289

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  438 RQQKFYLETQAGKleaqnrkleeqleKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTE-------------- 503
Cdd:pfam07111  290 IQPSDSLEPEFPK-------------KCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQVAElqeqvtsqsqeqai 356

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  504 LQLSLQERESQLTALQAARAALESQLRQAKTELEETTaeaeeeiQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTE 583
Cdd:pfam07111  357 LQRALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQ-------QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVA 429

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  584 DNAELNNQNFYLSKQLDEASG---ANDEIVQLRSEVDHLRREITEREMQLTSQkqtMEALKTTCTMLEEQV-LDLEALND 659
Cdd:pfam07111  430 RIPSLSNRLSYAVRKVHTIKGlmaRKVALAQLRQESCPPPPPAPPVDADLSLE---LEQLREERNRLDAELqLSAHLIQQ 506

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  660 ELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKA 739
Cdd:pfam07111  507 EVGRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQALQEKVAEV 586

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  740 ES-----LSD---KLNDLEKKHAMLEMNARSLQQKLETERELKQ---RLLEEQAKLQQQmdlqknhifRLTQGLQE 804
Cdd:pfam07111  587 ETrlreqLSDtkrRLNEARREQAKAVVSLRQIQHRATQEKERNQelrRLQDEARKEEGQ---------RLARRVQE 653
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
109-344 1.89e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.08  E-value: 1.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  109 QEYQAQVEEMRlmMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANecqhklmkVVSHPPRGDSGGTALDDLHKmq 188
Cdd:COG3206    159 EAYLEQNLELR--REEARKALEFLEEQLPELRKELEEAEAALEEFRQKNG--------LVDLSEEAKLLLQQLSELES-- 226

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  189 ghagltsakdqgkpevgEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATE--LLQNIRQAKERAERELEKLHNR--ED 264
Cdd:COG3206    227 -----------------QLAEARAELAEAEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARytPN 289

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  265 SSE--GIKKKLVEAEERRHSLENKVK-----RLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEV 337
Cdd:COG3206    290 HPDviALRAQIAALRAQLQQEAQRILasleaELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYES 369


                   ....*..
gi 1907160229  338 HLKQKEQ 344
Cdd:COG3206    370 LLQRLEE 376
C1_ScPKC1-like_rpt1 cd20822
first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae ...
 983-1036 1.95e-03

first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; ScPKC1 is required for cell growth and for the G2 to M transition of the cell division cycle. It mediates a protein kinase cascade, activating BCK1 which itself activates MKK1/MKK2. The family also includes Schizosaccharomyces pombe PKC1 and PKC2, which are involved in the control of cell shape and act as targets of the inhibitor staurosporine. Members of this family contain two copies of the C1 domain. This model corresponds to the first one. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410372  Cd Length: 52  Bit Score: 37.65  E-value: 1.95e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229  983 HHNIPHRF-NVglnmraTKCAVCLDtvHFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20822      3 HKFVQKQFyQI------MRCAVCGE--FLVNAGYQCEDCKYTCHKKCYEKVVTKC 49
mukB PRK04863
chromosome partition protein MukB;
373-786 1.95e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.02  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  373 RHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELS-EANKLAANSSLFTQRNMKAQEE---MISELRQQKfYLETQA 448
Cdd:PRK04863   276 RHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMArELAELNEAESDLEQDYQAASDHlnlVQTALRQQE-KIERYQ 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  449 GKLEAQNRKLEEQLEKISHQDhsdkSRLLELETRLREVslehEEQKLELKRQLTELQLSLQERESQLTALQAARAALESq 528
Cdd:PRK04863   355 ADLEELEERLEEQNEVVEEAD----EQQEENEARAEAA----EEEVDELKSQLADYQQALDVQQTRAIQYQQAVQALER- 425

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  529 LRQAKTELEETTAEAEEEIQALTAHRDEIQrkfDALRnsctvitDLEEQLNqLTEDNAELNNQNFYLSKQL-------DE 601
Cdd:PRK04863   426 AKQLCGLPDLTADNAEDWLEEFQAKEQEAT---EELL-------SLEQKLS-VAQAAHSQFEQAYQLVRKIagevsrsEA 494

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  602 ASGANDEIVQLRSEVDH------LRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAwrsvL 675
Cdd:PRK04863   495 WDVARELLRRLREQRHLaeqlqqLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLES----L 570

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  676 GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVElavkehkaeilALQQaLKEQKLKAESLSDKLNDLEKKHAM 755
Cdd:PRK04863   571 SESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQD-----------ALAR-LREQSGEEFEDSQDVTEYMQQLLE 638

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1907160229  756 LEmnaRSLQQKLETERELKQRLLEEQAKLQQ 786
Cdd:PRK04863   639 RE---RELTVERDELAARKQALDEEIERLSQ 666
46 PHA02562
endonuclease subunit; Provisional
 552-752 2.19e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 42.69  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  552 AHRDEIQRKFDALRNSctvITDLEEQLNQLTEDNAELNnqnfylsKQLDEASGA----NDEIVQLRSEVDHLRREITERE 627
Cdd:PHA02562   213 ENIARKQNKYDELVEE---AKTIKAEIEELTDELLNLV-------MDIEDPSAAlnklNTAAAKIKSKIEQFQKVIKMYE 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  628 ---------MQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSvlgdeksqfecRVRELQRMLDTEKQ 698
Cdd:PHA02562   283 kggvcptctQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSK-----------KLLELKNKISTNKQ 351

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907160229  699 SRARADQRITESRQVVELAVKE---HKAEILALQQALKEqklkaesLSDKLNDLEKK 752
Cdd:PHA02562   352 SLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDK-------IVKTKSELVKE 401
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 17-664 2.22e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.12  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   17 DKCHKMEQEMTRLHRRVSEVEavlsQKEVELKASETQRSLLEQDLATYITEcsslkrsleqarmEVSQEDDKALQLLHDI 96
Cdd:TIGR01612 1183 DKKKNIYDEIKKLLNEIAEIE----KDKTSLEEVKGINLSYGKNLGKLFLE-------------KIDEEKKKSEHMIKAM 1245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   97 REQSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVsarrrsDLYESELRESRLAAEEFKRKANECQHKLMKVVshppRGDS 176
Cdd:TIGR01612 1246 EAYIEDLDEIKEKSPEIENEMGIEMDIKAEMETF------NISHDDDKDHHIISKKHDENISDIREKSLKII----EDFS 1315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  177 GGTALDDLHKMQGHAGLTSAKDQGkpEVGEYskLEKI-NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERE 255
Cdd:TIGR01612 1316 EESDINDIKKELQKNLLDAQKHNS--DINLY--LNEIaNIYNILKLNKIKKIIDEVKEYTKEIEENNKNIKDELDKSEKL 1391

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  256 LEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHL 335
Cdd:TIGR01612 1392 IKKI--KDDINLEECKSKIESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADENNENVLLLFKNIEMADNKSQHI 1469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  336 evhLKQKEQHYEEKIKVLDNQIKKDLaDKEslenmmQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKL 415
Cdd:TIGR01612 1470 ---LKIKKDNATNDHDFNINELKEHI-DKS------KGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSALAIKNKF 1539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  416 AansslftqRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEqlEKISHQD---HSDKSrlleletrlrevslehee 492
Cdd:TIGR01612 1540 A--------KTKKDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKK--EKFRIEDdaaKNDKS------------------ 1591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  493 qklelKRQLTELQLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqaltahrDEIQRKFDALR--NSCTV 570
Cdd:TIGR01612 1592 -----NKAAIDIQLSLENFENKFLKISDIKKKINDCLKET----------------------ESIEKKISSFSidSQDTE 1644

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  571 ITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRRE----ITEREMQLT-SQKQTMEALKTTCT 645
Cdd:TIGR01612 1645 LKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEIEKIEIDVDQHKKNyeigIIEKIKEIAiANKEEIESIKELIE 1724

                          650       660
                   ....*....|....*....|....*.
gi 1907160229  646 MLEEQVL------DLEALN-DELLEK 664
Cdd:TIGR01612 1725 PTIENLIssfntnDLEGIDpNEKLEE 1750
PRK12704 PRK12704
phosphodiesterase; Provisional
 703-839 2.63e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 2.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  703 ADQRITESRQVVELAVKEHKAEILALQQALKEqklKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQA 782
Cdd:PRK12704    62 AKEEIHKLRNEFEKELRERRNELQKLEKRLLQ---KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  783 KLQQQMDlqknHIFRLTQglQEAldRADLLKTERSDLEYQlenIQVLY--SHEKVKMEG 839
Cdd:PRK12704   139 EQLQELE----RISGLTA--EEA--KEILLEKVEEEARHE---AAVLIkeIEEEAKEEA 186
mukB PRK04863
chromosome partition protein MukB;
601-921 3.24e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  601 EASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEqvlDLEALNDEL---LEKERQWEAWRSVLGD 677
Cdd:PRK04863   280 ERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQ---DYQAASDHLnlvQTALRQQEKIERYQAD 356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  678 eksqfecrVRELQRMLDTEKQSRARADQRITESRQVVELA---VKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHA 754
Cdd:PRK04863   357 --------LEELEERLEEQNEVVEEADEQQEENEARAEAAeeeVDELKSQLADYQQALDVQQTRAIQYQQAVQALERAKQ 428

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  755 ML---EMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQ------------EALDRADLLKTERSDL 819
Cdd:PRK04863   429 LCglpDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQlvrkiagevsrsEAWDVARELLRRLREQ 508

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  820 EYQLENIQVLYSHEKvKMEGTISQQTKLIDFLQAkmdqpAKKKkglFSRRKEDPALPTQVPLQYNELKLALEKEKARCAE 899
Cdd:PRK04863   509 RHLAEQLQQLRMRLS-ELEQRLRQQQRAERLLAE-----FCKR---LGKNLDDEDELEQLQEELEARLESLSESVSEARE 579

                          330       340
                   ....*....|....*....|..
gi 1907160229  900 LEEALQKTRIELRSAREEAAHR 921
Cdd:PRK04863   580 RRMALRQQLEQLQARIQRLAAR 601
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 81-661 3.44e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 42.35  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   81 EVSQEDDKALQLLHDIREQSRKLQEIKEQEyQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKanEC 160
Cdd:TIGR01612 1112 EINKIKDDIKNLDQKIDHHIKALEEIKKKS-ENYIDEIKAQINDLEDVADKAISNDDPEEIEKKIENIVTKIDKKK--NI 1188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  161 QHKLMKVVSHPPRGDSGGTALDDLHKMQghagLTSAKDQGKpevgeySKLEKINAEQqlkiqelqEKLEKAVKASTEATE 240
Cdd:TIGR01612 1189 YDEIKKLLNEIAEIEKDKTSLEEVKGIN----LSYGKNLGK------LFLEKIDEEK--------KKSEHMIKAMEAYIE 1250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  241 LLQNIRQAKERAERELeklhnredSSEGIKKKLVEAEERRHSlenKVKRLETMERRENRLKDDIQTKSEQIQQ------- 313
Cdd:TIGR01612 1251 DLDEIKEKSPEIENEM--------GIEMDIKAEMETFNISHD---DDKDHHIISKKHDENISDIREKSLKIIEdfseesd 1319

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  314 MADKILELEEKHREAQVSAQHLEVHLKQ------------------KEQHYEEKIKVLDNQIKKDLADKESLENMMQRHE 375
Cdd:TIGR01612 1320 INDIKKELQKNLLDAQKHNSDINLYLNEianiynilklnkikkiidEVKEYTKEIEENNKNIKDELDKSEKLIKKIKDDI 1399

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  376 EEAHEKGKILSEQKAM-INAMDSKIRSLEQRIVE-----------LSEANK----------LAANSSLFTQRNMK--AQE 431
Cdd:TIGR01612 1400 NLEECKSKIESTLDDKdIDECIKKIKELKNHILSeesnidtyfknADENNEnvlllfknieMADNKSQHILKIKKdnATN 1479

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  432 EM---ISELRQQKfyleTQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKleLKRQLTELQLSL 508
Cdd:TIGR01612 1480 DHdfnINELKEHI----DKSKGCKDEADKNAKAIEKNKELFEQYKKDVTELLNKYSALAIKNKFAK--TKKDSEIIIKEI 1553

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  509 QERESQLTaLQAARAalESQLRQAKTELEETTAEAEEEIQALTAHRDeIQRKFDALRNSCTVITDLEEQLNQ-LTEDNAe 587
Cdd:TIGR01612 1554 KDAHKKFI-LEAEKS--EQKIKEIKKEKFRIEDDAAKNDKSNKAAID-IQLSLENFENKFLKISDIKKKINDcLKETES- 1628

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907160229  588 lnnqnfyLSKQLDEASgandeivqlrseVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDEL 661
Cdd:TIGR01612 1629 -------IEKKISSFS------------IDSQDTELKENGDNLNSLQEFLESLKDQKKNIEDKKKELDELDSEI 1683
pepcterm_ChnLen TIGR03007
polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this ...
 612-791 4.37e-03

polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Members of this protein family belong to the family of polysaccharide chain length determinant proteins (pfam02706). All are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria, and are found near the epsH homolog that is the putative exosortase gene. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides]


Pssm-ID: 274386 [Multi-domain]  Cd Length: 498  Bit Score: 41.58  E-value: 4.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  612 LRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLE-----EQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFEcRV 686
Cdd:TIGR03007  202 YYSEISEAQEELEAARLELNEAIAQRDALKRQLGGEEpvllaGSSVANSELDGRIEALEKQLDALRLRYTDKHPDVI-AT 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  687 RELQRMLDTEKQSRARADQRITESR-------QVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEmn 759
Cdd:TIGR03007  281 KREIAQLEEQKEEEGSAKNGGPERGeianpvyQQLQIELAEAEAEIASLEARVAELTARIERLESLLRTIPEVEAELT-- 358

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1907160229  760 arSLQQKLETERELKQRLLE--EQAKLQQQMDLQ 791
Cdd:TIGR03007  359 --QLNRDYEVNKSNYEQLLTrrESAEVSKQMEVQ 390
C1_PKD_rpt2 cd20796
second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D ...
 987-1036 4.69e-03

second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD); PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs contain N-terminal tandem cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. This model corresponds to the second C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410346  Cd Length: 54  Bit Score: 36.88  E-value: 4.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  987 PHRFNVGLNMRATKCAVCLDTVH-FGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20796      1 PHTFVVHTYTKPTVCQHCKKLLKgLFRQGLQCKDCKFNCHKKCAEKVPKDC 51
46 PHA02562
endonuclease subunit; Provisional
 300-496 4.80e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.54  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  300 LKDDIQTKS-------EQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQ 372
Cdd:PHA02562   179 LNQQIQTLDmkidhiqQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALN 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  373 R----------------HEEEAHEKGKI-------LSEQKAMINAMDSKIRSLEQRIVELSEA-NKLAANSSLFTQRNMK 428
Cdd:PHA02562   259 KlntaaakikskieqfqKVIKMYEKGGVcptctqqISEGPDRITKIKDKLKELQHSLEKLDTAiDELEEIMDEFNEQSKK 338

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  429 AQeEMISELRQQKfyleTQAGKLEAQNRKLEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLE 496
Cdd:PHA02562   339 LL-ELKNKISTNK----QSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKE 401
C1_TNS2 cd20887
protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; ...
 987-1039 4.80e-03

protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins; Tensin-2 (TNS2), also called C1 domain-containing phosphatase and tensin (C1-TEN), or tensin-like C1 domain-containing phosphatase (TENC1), is an essential component for the maintenance of glomerular basement membrane (GBM) structures. It regulates cell motility and proliferation. It may have phosphatase activity. TNS2 reduces AKT1 phosphorylation, lowers AKT1 kinase activity, and interferes with AKT1 signaling. It contains an N-terminal region with a zinc finger (C1 domain), a protein tyrosine phosphatase (PTP)-like domain and a protein kinase 2 (C2) domain, and a C-terminal region with SH2 and pTyr binding (PTB) domains. This model corresponds to the C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410437  Cd Length: 53  Bit Score: 36.68  E-value: 4.80e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  987 PHRFNVGLNMRATKCAVCLDTVhfGRQASKCLECQVMCHPKCSTCLPATCGLP 1039
Cdd:cd20887      2 PHSFKEKTFKKKRACAVCREPV--GGQGLVCRVCKVASHKKCEAKVTSACQPP 52
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 205-331 5.13e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  205 GEYSKLEKINAEQQLKIQELQEKLEKavkasteATELLQNIRQAKE--RAERELEKLHNREDSSEgikKKLVEAEERRHS 282
Cdd:COG1579     52 TELEDLEKEIKRLELEIEEVEARIKK-------YEEQLGNVRNNKEyeALQKEIESLKRRISDLE---DEILELMERIEE 121

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907160229  283 LENKVKRLET-MERRENRLKDDIQTKSEQIQQMADKILELEEKhREAQVS 331
Cdd:COG1579    122 LEEELAELEAeLAELEAELEEKKAELDEELAELEAELEELEAE-REELAA 170
PRK12704 PRK12704
phosphodiesterase; Provisional
 719-846 5.29e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  719 KEHKAEILAlQQALKEQKLKAESLsdklndleKKHAMLEMNARSLQQKLETERELKQRLLEEQA---KLQQQMDLQKNHI 795
Cdd:PRK12704    32 KIKEAEEEA-KRILEEAKKEAEAI--------KKEALLEAKEEIHKLRNEFEKELRERRNELQKlekRLLQKEENLDRKL 102

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907160229  796 FRLTQGLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEgTISQQTK 846
Cdd:PRK12704   103 ELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELE-RISGLTA 152
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 347-529 5.32e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  347 EEKIKVLDNQIKKDLADKESLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRivelseanklaanssLFTQRN 426
Cdd:COG1579     23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---------------LGNVRN 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  427 MKAQEEMISELRqqkfYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEEQKLELKRQLTELQL 506
Cdd:COG1579     88 NKEYEALQKEIE----SLKRRISDLEDEILELMERIE--------------ELEEELAELEAELAELEAELEEKKAELDE 149

                          170       180
                   ....*....|....*....|...
gi 1907160229  507 SLQERESQLTALQAARAALESQL 529
Cdd:COG1579    150 ELAELEAELEELEAEREELAAKI 172
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 220-349 5.43e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 40.77  E-value: 5.43e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   220 KIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDSSEGIK----KKLVEA-EERRHSLENKVKRLETME 294
Cdd:smart00787  152 NLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCDptelDRAKEKlKKLLQEIMIKVKKLEELE 231

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1907160229   295 RRENRLKDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEK 349
Cdd:smart00787  232 EELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFKEIEKLKEQLKLLQSL 286
PLN03229 PLN03229
acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional
 10-376 5.50e-03

acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Provisional


Pssm-ID: 178768 [Multi-domain]  Cd Length: 762  Bit Score: 41.38  E-value: 5.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   10 KELQDSQDKCHKMEQEMTRLHRRVS--------EVEAVLSQKEVELKASETQRSlleqDLATYITECSSLKRSLEQARME 81
Cdd:PLN03229   376 IAINENMDELGKMDTEELLKHRMLKfrkiggfqEGVPVDPERKVNMKKREAVKT----PVRELEGEVEKLKEQILKAKES 451

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229   82 VSQEDDKALQllhdirEQSRKLQEIKEQEYQAQVEEMRLM--MNQLEEDLVSARRRSDLYESELresrlaAEEFKRKANE 159
Cdd:PLN03229   452 SSKPSELALN------EMIEKLKKEIDLEYTEAVIAMGLQerLENLREEFSKANSQDQLMHPVL------MEKIEKLKDE 519

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  160 CQHKLmkvvSHPPRGDSGGTALDDLHKMQGHAGLTSAKDQG---KPEVGEYSKLEKINAEQQLKIQELQEKLEKAvKAST 236
Cdd:PLN03229   520 FNKRL----SRAPNYLSLKYKLDMLNEFSRAKALSEKKSKAeklKAEINKKFKEVMDRPEIKEKMEALKAEVASS-GASS 594

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  237 EAT---ELLQNIRQAKERAERELEKLHNRED-SSEGIKKKLVEAEERR--HSLENKVKRLetmerrenrlKDDIQTKSEQ 310
Cdd:PLN03229   595 GDElddDLKEKVEKMKKEIELELAGVLKSMGlEVIGVTKKNKDTAEQTppPNLQEKIESL----------NEEINKKIER 664

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  311 IQQMADKILELEEKHREAQVSAQHLEVHLKqkeqhyeEKIKVLDNQIKKDLADKESLENMMQRHEE 376
Cdd:PLN03229   665 VIRSSDLKSKIELLKLEVAKASKTPDVTEK-------EKIEALEQQIKQKIAEALNSSELKEKFEE 723
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
 240-340 5.94e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 41.22  E-value: 5.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  240 ELLQNIRQAKERAERELEKLhnREDSSEGIKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKSEQIQQMADKIL 319
Cdd:COG0542    411 EELDELERRLEQLEIEKEAL--KKEQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYGKIP 488

                           90       100
                   ....*....|....*....|.
gi 1907160229  320 ELEEKHREAQVSAQHLEVHLK 340
Cdd:COG0542    489 ELEKELAELEEELAELAPLLR 509
Filament pfam00038
Intermediate filament protein;
472-789 6.03e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 40.67  E-value: 6.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  472 DKSRLLELETRLREVSL-EHEEQKLELKRQLTEL-QLSLQERESQLTALQAARAALESQLRQAkteleettaeaeeeiqa 549
Cdd:pfam00038   18 DKVRFLEQQNKLLETKIsELRQKKGAEPSRLYSLyEKEIEDLRRQLDTLTVERARLQLELDNL----------------- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  550 ltahRDEIQRkfdaLRNSctvitdLEEQLNQLTEDNAELNNqnfyLSKQLDEASGANDE----IVQLRSEVDHLRR---- 621
Cdd:pfam00038   81 ----RLAAED----FRQK------YEDELNLRTSAENDLVG----LRKDLDEATLARVDleakIESLKEELAFLKKnhee 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  622 EITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQweawrsvlgDEKSQFECRVRELQRMLDTEKQSRA 701
Cdd:pfam00038  143 EVRELQAQVSDTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNRE---------EAEEWYQSKLEELQQAAARNGDALR 213

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  702 RADQRITESRQVVElavkehkaeilALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETE-RELKQRLLEE 780
Cdd:pfam00038  214 SAKEEITELRRTIQ-----------SLEIELQSLKKQKASLERQLAETEERYELQLADYQELISELEAElQETRQEMARQ 282


                   ....*....
gi 1907160229  781 QAKLQQQMD 789
Cdd:pfam00038  283 LREYQELLN 291
C1_Munc13 cd20807
protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene ...
 988-1036 6.30e-03

protein kinase C conserved region 1 (C1 domain) found in the Munc13 family; The Munc13 gene family encodes a family of neuron-specific, synaptic molecules that bind to syntaxin, an essential mediator of neurotransmitter release. Munc13-1 is a component of presynaptic active zones in which it acts as an essential synaptic vesicle priming protein. Munc13-2 is essential for normal release probability at hippocampal mossy fiber synapses. Munc13-3 is almost exclusively expressed in the cerebellum. It acts as a tumor suppressor and plays a critical role in the formation of release sites with calcium channel nanodomains. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.


Pssm-ID: 410357  Cd Length: 53  Bit Score: 36.30  E-value: 6.30e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1907160229  988 HRFNVGLNMRATKCAVCLDTV-HFGRQASKCLECQVMCHPKCSTCLPATC 1036
Cdd:cd20807      1 HNFEVWTATTPTYCYECEGLLwGIARQGVRCTECGVKCHEKCKDLLNADC 50
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 611-931 6.87e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 6.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  611 QLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQvldlealndELLEKERQWEAWRSVLGDEKSQFE------- 683
Cdd:pfam17380  300 RLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQ---------ERMAMERERELERIRQEERKRELErirqeei 370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  684 ----CRVRELQRMLDTEKQSRARADQRITESRQvVELAVKEHkaeilalQQALKEQKLKAESLSDKlndlekkhamlEMN 759
Cdd:pfam17380  371 ameiSRMRELERLQMERQQKNERVRQELEAARK-VKILEEER-------QRKIQQQKVEMEQIRAE-----------QEE 431

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  760 ARSLQ-QKLETERELK-QRLLEEQAKLQQQMDlqknhifRLTQglQEALDRADLLKTERSDLEYQL---ENIQVLYSHEK 834
Cdd:pfam17380  432 ARQREvRRLEEERAREmERVRLEEQERQQQVE-------RLRQ--QEEERKRKKLELEKEKRDRKRaeeQRRKILEKELE 502

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  835 VKMEGTISQQTKLiDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPL----QYNELKLALEKEKARCaeleEALQKTRIE 910
Cdd:pfam17380  503 ERKQAMIEEERKR-KLLEKEMEERQKAIYEEERRREAEEERRKQQEMeerrRIQEQMRKATEERSRL----EAMEREREM 577

                          330       340
                   ....*....|....*....|.
gi 1907160229  911 LRSAREEAAHRKATDHPHPST 931
Cdd:pfam17380  578 MRQIVESEKARAEYEATTPIT 598
COG5022 COG5022
Myosin heavy chain [General function prediction only];
203-822 8.04e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 41.22  E-value: 8.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  203 EVGEYSKLEKINaEQQLKIQELQEKLEKAVKASTEatellqnirqakeraerELEKLHNREDSSEGIKKKLVEAEERRHS 282
Cdd:COG5022    949 EYVKLPELNKLH-EVESKLKETSEEYEDLLKKSTI-----------------LVREGNKANSELKNFKKELAELSKQYGA 1010

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  283 LENKVKRLETMERRENRLKDDIQTKSEqiqqmadkilELEEKHREAQVsaQHLEVHLKQKEQHYEEKIKVLDNQIkkdla 362
Cdd:COG5022   1011 LQESTKQLKELPVEVAELQSASKIISS----------ESTELSILKPL--QKLKGLLLLENNQLQARYKALKLRR----- 1073

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  363 dkeslenmmqrheeeahEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANklAANSSLFTQRNMKAqeemiselrQQKF 442
Cdd:COG5022   1074 -----------------ENSLLDDKQLYQLESTENLLKTINVKDLEVTNRN--LVKPANVLQFIVAQ---------MIKL 1125

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  443 YLETQAGKLEAQNRKLEEQLEKishqdhSDKSRLLELETRLREVSLEHEEQKLELKRQltelqlsLQERESQLTALQAAR 522
Cdd:COG5022   1126 NLLQEISKFLSQLVNTLEPVFQ------KLSVLQLELDGLFWEANLEALPSPPPFAAL-------SEKRLYQSALYDEKS 1192

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  523 AALESQLRQAKTELeettaeaeeeiqaltahrDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEA 602
Cdd:COG5022   1193 KLSSSEVNDLKNEL------------------IALFSKIFSGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPA 1254

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  603 SGANDEIVQLRSEVDHLR----REITEREMQLTSQKQTM-----EALKTTCTMLEEQVLDLEALNDELLEkerQWeawrs 673
Cdd:COG5022   1255 SMSNEKLLSLLNSIDNLLssykLEEEVLPATINSLLQYInvglfNALRTKASSLRWKSATEVNYNSEELD---DW----- 1326

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  674 vlgdeksqfeCRVRELQRmLDTEKQSraradqrITESRQVVELAVK--EHKAEILALQQALKE---QKLKAE-SLSDKLN 747
Cdd:COG5022   1327 ----------CREFEISD-VDEELEE-------LIQAVKVLQLLKDdlNKLDELLDACYSLNPaeiQNLKSRyDPADKEN 1388

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  748 DLEKKHaMLEMNARSLQQKLETERELKQRLleeQAKLQQQMDLQKNHIFRLTQGLQ--EALDR--ADLLKTERSDLEYQ 822
Cdd:COG5022   1389 NLPKEI-LKKIEALLIKQELQLSLEGKDET---EVHLSEIFSEEKSLISLDRNSIYkeEVLSSlsALLTKEKIALLDRK 1463
PRK12704 PRK12704
phosphodiesterase; Provisional
 269-456 8.32e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 8.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  269 IKKKLVEAEERRhslenkVKRLETMERRENRLKDDIqtKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEE 348
Cdd:PRK12704    29 AEAKIKEAEEEA------KRILEEAKKEAEAIKKEA--LLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  349 kikvldnqiKKDLADKEslENMMQRHEEEAHEKGKILSEQKAMInamDSKIRSLEQRIVELSEANKLAANSSLFTQRNMK 428
Cdd:PRK12704   101 ---------KLELLEKR--EEELEKKEKELEQKQQELEKKEEEL---EELIEEQLQELERISGLTAEEAKEILLEKVEEE 166

                          170       180
                   ....*....|....*....|....*...
gi 1907160229  429 AQEEMISELRQqkfyLETQAgKLEAQNR 456
Cdd:PRK12704   167 ARHEAAVLIKE----IEEEA-KEEADKK 189
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
 508-664 8.79e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 39.14  E-value: 8.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  508 LQERESQLTALQAA-RAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTvitDLEEQLNQLTEDNA 586
Cdd:pfam08614   12 LLDRTALLEAENAKlQSEPESVLPSTSSSKLSKASPQSASIQSLEQLLAQLREELAELYRSRG---ELAQRLVDLNEELQ 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907160229  587 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEK 664
Cdd:pfam08614   89 ELEKKLREDERRLAALE---AERAQLEEKLKDREEELREKRKLNQDLQDELVALQLQLNMAEEKLRKLEKENRELVER 163
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 423-630 9.67e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.12  E-value: 9.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  423 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQL---EKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 499
Cdd:pfam15619    2 TQRVLSARLHKIKELQNELAELQSKLEELRKENRLLKRLQkrqEKALGKYEGTESELPQLIARHNEEVRVLRERLRRLQE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  500 QLTELQLSLQERESQLTALQAARAALEsQLRQAKTEleettaeaeeeiqaltAHRDEIQRKFDALRNsctvITDLEEQLN 579
Cdd:pfam15619   82 KERDLERKLKEKEAELLRLRDQLKRLE-KLSEDKNL----------------AEREELQKKLEQLEA----KLEDKDEKI 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1907160229  580 QLTEDNAELNNQNF--YLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQL 630
Cdd:pfam15619  141 QDLERKLELENKSFrrQLAAEKKKHKEAQEEVKILQEEIERLQQKLKEKEREL 193
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 427-789 9.71e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 40.65  E-value: 9.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  427 MKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEkishqdhsdksrllELETRLREVSLEHEEqkleLKRQLTELQL 506
Cdd:pfam07888   47 LQAQEAANRQREKEKERYKRDREQWERQRRELESRVA--------------ELKEELRQSREKHEE----LEEKYKELSA 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  507 SLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNA 586
Cdd:pfam07888  109 SSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELR 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  587 ELNNQNFYLSKQLDEASganDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDEL----- 661
Cdd:pfam07888  189 SLSKEFQELRNSLAQRD---TQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELssmaa 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  662 LEKERQWEAWRSVLgdEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKE-----QK 736
Cdd:pfam07888  266 QRDRTQAELHQARL--QAAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEermerEK 343

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1907160229  737 LKAESLSDKLNDL----EKKHAMLEMNA--RSLQQKLETERELKQRLLEEQAKLQQQMD 789
Cdd:pfam07888  344 LEVELGREKDCNRvqlsESRRELQELKAslRVAQKEKEQLQAEKQELLEYIRQLEQRLE 402
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 492-707 9.81e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.52  E-value: 9.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  492 EQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKteleettaeaeeeiQALTAHRDEIQrkfdalrnsctvi 571
Cdd:COG1579      3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALE--------------ARLEAAKTELE------------- 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  572 tDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGaNDEIVQLRSEVDHLRREITEREMQLtsqKQTMEAlkttctmleeqv 651
Cdd:COG1579     56 -DLEKEIKRLELEIEEVEARIKKYEEQLGNVRN-NKEYEALQKEIESLKRRISDLEDEI---LELMER------------ 118

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907160229  652 ldLEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRI 707
Cdd:COG1579    119 --IEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 732-923 9.89e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 9.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  732 LKEQKLKAE---SLSDKLNDLEKKHAMLEMnaRSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIfrltQGLQEALDR 808
Cdd:COG1196    205 LERQAEKAEryrELKEELKELEAELLLLKL--RELEAELEELEAELEELEAELEELEAELAELEAEL----EELRLELEE 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  809 ADLLKTERSDLEYQLENiqvlyshEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPAlptqvplqynELKL 888
Cdd:COG1196    279 LELELEEAQAEEYELLA-------ELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEE----------ELEE 341

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1907160229  889 ALEKEKARCAELEEAlQKTRIELRSAREEAAHRKA 923
Cdd:COG1196    342 LEEELEEAEEELEEA-EAELAEAEEALLEAEAELA 375
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
301-667 9.91e-03

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 40.48  E-value: 9.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  301 KDDIQTKSEQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQRHEEEAHE 380
Cdd:COG2770    264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLL 343

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  381 KGKILSEQKAMINAMDSKIRSLEQRIVELSEAnklaansslftQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEE 460
Cdd:COG2770    344 LLLAADLLLALALAALLLLLALELLLEAELLV-----------LLALEALALEAELAAVLALLAALAAALLLLELALEEL 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  461 QLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETT 540
Cdd:COG2770    413 VLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLL 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907160229  541 AEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLR 620
Cdd:COG2770    493 EEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAVEAAALLLAALL 572

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 1907160229  621 REITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQ 667
Cdd:COG2770    573 LAAVAALLELAALLLLLLAAAEALAALELELAAAAEAALAEAELLEV 619
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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