NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907172818|ref|XP_036022100|]
View 

solute carrier organic anion transporter family member 1A4 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
oat super family cl36740
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 16-411 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


The actual alignment was detected with superfamily member TIGR00805:

Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 610.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGITKDFFLFM 95
Cdd:TIGR00805 243 EDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFI 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  96 KSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAY 175
Cdd:TIGR00805 323 KRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAY 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 176 IGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTsyEGVQHPLYVENNVlaDCNTKCSCLTNTWDPVCGDNGLSYMSACLAGC 255
Cdd:TIGR00805 403 FAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGC 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 256 EKSVGTGTNMVFQNCSCIQSSGNASAVLGLCDkgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEEKSLGVG 335
Cdd:TIGR00805 479 RMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLG 556

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 336 LHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRIYLGLPAALRGASFLPALFILILMRK 411
Cdd:TIGR00805 557 LQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 16-411 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 610.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGITKDFFLFM 95
Cdd:TIGR00805 243 EDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFI 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  96 KSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAY 175
Cdd:TIGR00805 323 KRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAY 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 176 IGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTsyEGVQHPLYVENNVlaDCNTKCSCLTNTWDPVCGDNGLSYMSACLAGC 255
Cdd:TIGR00805 403 FAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGC 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 256 EKSVGTGTNMVFQNCSCIQSSGNASAVLGLCDkgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEEKSLGVG 335
Cdd:TIGR00805 479 RMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLG 556

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 336 LHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRIYLGLPAALRGASFLPALFILILMRK 411
Cdd:TIGR00805 557 LQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 16-324 5.67e-166

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 477.81  E-value: 5.67e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAK---EEKHREKIKEENRGITKDFF 92
Cdd:cd17458   213 DDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKEGEENETEPSKTLTvelEENKGQETKQEMYEIAKDFL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  93 LFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKK 172
Cdd:cd17458   293 PFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQ 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 173 AAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACL 252
Cdd:cd17458   373 AAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACL 452

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907172818 253 AGCEKSVGTGTNMVFQNCSCIQSSGNASAV---LGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRC 324
Cdd:cd17458   453 AGCKASVGTGKNMVFQNCSCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 18-383 1.79e-139

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 410.05  E-value: 1.79e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  18 LTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGIT---KDFFLF 94
Cdd:pfam03137 159 ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  95 MKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAA 174
Cdd:pfam03137 239 LKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 175 YIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLyveNNVLADCNTKCSCLTNTWDPVCGDNG-LSYMSACLA 253
Cdd:pfam03137 319 KFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGA 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 254 GCEKSVGTGTNMVFQNCSCI----QSSGNASAVLGLCDkgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEE 329
Cdd:pfam03137 396 GCSSSSGAGKSTYICNCCCScgsqDSGGNGSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPED 473

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907172818 330 KSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTlKCGEPGACRMYDINSF 383
Cdd:pfam03137 474 KSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWGK-TCGGRGNCWLYDNDKL 526
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-187 3.90e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 3.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 101 NPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPIcLGYLIGGLIMKKFKItvKKAAYIGFWL 180
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLL 282


                  ....*..
gi 1907172818 181 SLTEYLL 187
Cdd:COG2814   283 LALGLLL 289
 
Name Accession Description Interval E-value
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 16-411 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 610.58  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGITKDFFLFM 95
Cdd:TIGR00805 243 EDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSRGEDRKKNSGITKDFPKFI 322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  96 KSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAY 175
Cdd:TIGR00805 323 KRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAY 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 176 IGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTsyEGVQHPLYVENNVlaDCNTKCSCLTNTWDPVCGDNGLSYMSACLAGC 255
Cdd:TIGR00805 403 FAICLSTLEYLLYSPKFLITCESAPVAGVNN--PSNDQPLYVENRT--DCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGC 478

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 256 EKSVGTGTNMVFQNCSCIQSSGNASAVLGLCDkgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEEKSLGVG 335
Cdd:TIGR00805 479 RMSVGTGSNMVFTNCSCIQTPGNSSAKKGLCD--PPCATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLG 556

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 336 LHTFCMRILGGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRIYLGLPAALRGASFLPALFILILMRK 411
Cdd:TIGR00805 557 LQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
 16-324 5.67e-166

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 477.81  E-value: 5.67e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAK---EEKHREKIKEENRGITKDFF 92
Cdd:cd17458   213 DDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPFWFLPKSLPKEGEENETEPSKTLTvelEENKGQETKQEMYEIAKDFL 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  93 LFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKK 172
Cdd:cd17458   293 PFLKSLFRNPIYMLFIIVTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQ 372

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 173 AAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACL 252
Cdd:cd17458   373 AAHIGFWVSLLEYLLYFSAFWMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACL 452

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907172818 253 AGCEKSVGTGTNMVFQNCSCIQSSGNASAV---LGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRC 324
Cdd:cd17458   453 AGCKASVGTGKNMVFQNCSCVAASGFPSQNssaVGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 18-383 1.79e-139

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 410.05  E-value: 1.79e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  18 LTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREKIKEENRGIT---KDFFLF 94
Cdd:pfam03137 159 ITLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGpslKDFPKA 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  95 MKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAA 174
Cdd:pfam03137 239 LKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 175 YIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLyveNNVLADCNTKCSCLTNTWDPVCGDNG-LSYMSACLA 253
Cdd:pfam03137 319 KFNVITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGA 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 254 GCEKSVGTGTNMVFQNCSCI----QSSGNASAVLGLCDkgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEE 329
Cdd:pfam03137 396 GCSSSSGAGKSTYICNCCCScgsqDSGGNGSATPGKCP--SDCSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPED 473

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907172818 330 KSLGVGLHTFCMRILGGIPAPIYFGALIDRTCLHWGTlKCGEPGACRMYDINSF 383
Cdd:pfam03137 474 KSFALGLQFLILRLLGFIPGPILFGALIDSTCLLWGK-TCGGRGNCWLYDNDKL 526
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
 12-323 3.80e-114

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 342.58  E-value: 3.80e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  12 FLLCDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPktllkeglqdngdgtenakeekhrekikeenrgitkdf 91
Cdd:cd17400   169 FVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP-------------------------------------- 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  92 flfmkslscnPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVK 171
Cdd:cd17400   211 ----------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVK 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 172 KAAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSAC 251
Cdd:cd17400   281 GAAKIGCWLSVLEYLLYLLSFLMTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSAC 360

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 252 LAGCEKSVGTGTNMVFQNCSCIQSSGNASAVLGLCDKG----PECANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17400   361 LAGCETSIGTGKNIVFYNCSCIQTSGNSSANLSLCDGGcprdPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
 12-324 6.83e-109

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 330.96  E-value: 6.83e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  12 FLLCDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenrgiTKDF 91
Cdd:cd17459   213 FVNLDSITITPKDARWVGAWWLGYLIAGVITLLSAVPFWFLPKSL-------------------------------PKDF 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  92 FLFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVK 171
Cdd:cd17459   262 LPSLKNLLGNPVYFLYLCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVI 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 172 KAAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSAC 251
Cdd:cd17459   342 GAAKLSFGTSFFGYLLLLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPC 421

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907172818 252 LAGCEKSVGTGTNMVFQNCSCI----QSSGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLRC 324
Cdd:cd17459   422 LAGCKASNGSGKNTVFHNCSCIgipsSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIRC 498
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
 12-323 5.80e-89

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 278.26  E-value: 5.80e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  12 FLLCDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPktllkeglqdngdgtenakeekhrekikeenrgitkDF 91
Cdd:cd17457   176 FVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIPFFFLP------------------------------------GF 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  92 FLFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVK 171
Cdd:cd17457   220 FQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTV 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 172 KAAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSAC 251
Cdd:cd17457   300 GAAKFACFTSVMALSFYLLYFFIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISAC 379

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 252 LAGCEKSVGTGTNMVFQNCSCIQSSG----NASAVLGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17457   380 LAGCKSSSGNGKPIVFHNCSCLEVTGsqnrNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 17-323 3.93e-79

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 251.39  E-value: 3.93e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  17 DLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPktllkeglqdngdgtenakeekhrekikeenrgitkdfflfmk 96
Cdd:cd17336   158 PLGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP------------------------------------------- 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  97 slscnPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYI 176
Cdd:cd17336   195 -----PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKF 269

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 177 GFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGvqhplyVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCE 256
Cdd:cd17336   270 VLILSLLSVILYISLFFLGCDNPPIAGVTTPYGS------SSSPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCT 343

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907172818 257 KSVGTGTNMVFQNCSCIQS-SGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17336   344 SSDAGNGTKTYSNCSCINSgTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
 18-323 1.66e-53

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 186.16  E-value: 1.66e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  18 LTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQDNGDGTENAKEEKHREkikeenRGITKDFF----- 92
Cdd:cd17461   175 VELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPREMLVGKKPSPEGDMLRKKEDEKKE------EGSLLDFIkrfpk 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  93 LFMKsLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKK 172
Cdd:cd17461   249 MFVK-LLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRA 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 173 AAYIGFWLSLTEYLLSFVSYIMTCDNFPVAGLTTSYE-GVQHPlyvennvLADCNTKCSCLTNTWDPVCGDNGLSYMSAC 251
Cdd:cd17461   328 IPRFSVVILSISIMLCVPLFFMGCSTQDVAGVYPKTSnSSDGP-------HLSCSANCSCPESAFNPVCGENGIEYISPC 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 252 LAGCEKSV---GTGTNMVFQNCSCIQSSGNASAVlglcdKGPECANKLQYFL-----IISIIGcFIFSLGAIPGYMVLLR 323
Cdd:cd17461   401 HAGCTNSNmdsSTYRQQIYSNCSCIPDLSGEKPA-----KTGSCPNSCSHLLlpvmfLISFAG-LIACLTHNPLYMMVLR 474
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 16-323 1.89e-53

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 184.38  E-value: 1.89e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTllkeglqdngdgtenakeekhrekikeenrgitkdfflFM 95
Cdd:cd17403   162 SELGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFPPT--------------------------------------FM 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  96 kslscnpiymiFILISVIQVNAFINSF-TFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAA 174
Cdd:cd17403   204 -----------FLNLAGASEGMLLAGFaTFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGIL 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 175 YIGFWLSLTEYLLSFvSYIMTCDNFPVAGLTTSYEGvqHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAG 254
Cdd:cd17403   273 KFCIVCSIVAFLFSF-ILLIYCPNAPFAGVTVPYGN--SPLEGTSNLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAG 349

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907172818 255 CEKSVGTGTNMVFQNCSCIQS---SGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFsLGAIPGYMVLLR 323
Cdd:cd17403   350 CTTSHGDDGQKVYSNCSCIQSnssKTSTAATGKACPCETCCQKLYLFLAVFFLLIVFTF-MSSTPALSATLR 420
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 16-323 4.75e-49

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 174.19  E-value: 4.75e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  16 DDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEGLQD----NGDGTENAKEEKHREKIKEE---NRGIT 88
Cdd:cd17460   169 DEISLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPREMPKEVVELqpreKKLAKTMLKKLKSLSDILQNlslLQFIK 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  89 KDFFLFMKSLScNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKI 168
Cdd:cd17460   249 KFPRILLRTLR-NPIYLLVVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQL 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 169 TVKKAA---YIGFWLSLteyLLSFVSYIMTCDNFPVAGLTtsYEGVQHPlyvENNVLADCNTKCSCLTNTWDPVCGDNGL 245
Cdd:cd17460   328 TVRGCGamcVLGMLLCL---FFALPLLFIGCSTQKIAGIT--HRTSSSP---GLELSSQCSEACSCPPEAFNPVCGSDGV 399

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 246 SYMSACLAGCeKSV----GTGTNMVFQNCSCIQSSGNA-SAVLGLCDKGpeCANKLQYFLIISIIGCFIFSLGAIPGYMV 320
Cdd:cd17460   400 EYISPCHAGC-KSVnvqaLDNSVVNYTDCSCVSEGGPVgAASPGTCGSG--CSHLLVPFMLLVSLGGFLASLSHTPSFML 476


                  ...
gi 1907172818 321 LLR 323
Cdd:cd17460   477 ILR 479
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 18-323 5.11e-48

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 170.23  E-value: 5.11e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  18 LTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenrgitkdfFLFMkS 97
Cdd:cd17404   159 PDISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPKMT-----------------------------------FLVV-S 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  98 LSCNPIYMIfilisviqVNAFInsfTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIG 177
Cdd:cd17404   203 LGYCMELAI--------VSGFI---TFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLA 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 178 FWLSLTEYLLSFVSYIMTCDNFPVAGLTTSY-EGVQHPLYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCE 256
Cdd:cd17404   272 LICNFLSLLLFLTLFFLGCESIKLAGITIPYtTGPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCT 351

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907172818 257 KSVGTGTNMV-FQNCSCIQSSGNAS----AVLGLCDKGP--ECANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17404   352 SVGNTSTGIRnYTNCACLQSRSSISpptvGQGSQLQAGPcsRTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
 20-323 7.56e-46

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 164.63  E-value: 7.56e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  20 ITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenrgitKDFFLFMKSLS 99
Cdd:cd17401   173 LVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRFI--------------------------------KRFPCIFLRTL 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 100 CNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFW 179
Cdd:cd17401   221 RNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTT 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 180 LSLTEYLLSFVSYIMTCDNFPVAGLTtsYEGVQHPLYVENnvlADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCE--- 256
Cdd:cd17401   301 IITISMIFCVPLFFIGCSTPTIAGVY--PPSSSSSIHPQS---PACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSnin 375

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907172818 257 -KSVGTGTNMVFQNCSCIqSSGNASAVLGLCDKGpeCANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17401   376 mSTSATSKQVIYTNCSCV-TGGSASAKTGSCPSP--CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 20-323 6.66e-44

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 159.14  E-value: 6.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  20 ITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenRGITKdfflfmksls 99
Cdd:cd17463   165 LTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPKHL----------------------------PGLLK---------- 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 100 cNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFW 179
Cdd:cd17463   207 -NPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAII 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 180 LSLTEYLLSFVSYIMTCDNFPVAGLTTSYEGVQHplyvENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKSV 259
Cdd:cd17463   286 TTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTGK----IGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNEN 361

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907172818 260 GTGTNMVFQNCSCIQS-SGNASAVLGLCDKGPECA---NKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17463   362 LHDKKKVYYNCSCIGNfTEEFSANTTKCEEGKKCEttcKNLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 11-323 4.67e-41

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 152.00  E-value: 4.67e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  11 IFLLCDDLTITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikEENRGITKd 90
Cdd:cd17402   168 VFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFPQSL-------------------------QQLRVIPK- 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  91 fflFMKSLSCNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITV 170
Cdd:cd17402   222 ---VTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSA 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 171 KKAAYIGFWLSLTEyLLSFVSYI-MTCDNFPVAGLTTSYEGVQHPLyVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMS 249
Cdd:cd17402   299 LGAIRMAMLVNLVS-TACYVSFLfLGCDTGPVAGVTVPYGNDTAPG-SSLDPYAPCNSNCECQTDSFSPVCGADGITYLS 376

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907172818 250 ACLAGCEKSVGTGtnmvfqnCSCIQS--SGNASAVLGLCDKgPECANKLQYFLIISIIGCFIFSLGAIPGYMVLLR 323
Cdd:cd17402   377 ACFAGCSSTNLSG-------CACLSSvpAENATVVPGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 20-323 1.20e-36

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 139.58  E-value: 1.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  20 ITPTDTRWVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenRGITKdfflfmksls 99
Cdd:cd17462   163 LTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL----------------------------PGLLK---------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 100 cNPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKItvKKAAYIGFW 179
Cdd:cd17462   205 -NPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKL--RCSGIIKFC 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 180 LSLTEY-LLSFVSYIMTCDNFPVAGLTTSYEGVQHPlYVENNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKS 258
Cdd:cd17462   282 LICTVVsLLAIFIFSLHCPNVPMAGVTASYRGSVLP-EGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEA 360

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907172818 259 VGTGTN--MVFQNCSCI-QSSGNASAVLGLCDKGPECANKLQYFLIISIIGCFIFsLGAIPGYMVLLR 323
Cdd:cd17462   361 YSDIRNgqKVYQDCSCVaGNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILFTF-LCSIPALTATLR 427
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
 27-287 3.28e-23

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 101.46  E-value: 3.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  27 WVGAWWIGFLVCAGVNILTSIPFFFFPKTLlkeglqdngdgtenakeekhrekikeenRGITKdfflfmkslscNPIYMI 106
Cdd:cd17405   170 WQSGWWKTFLIAAAIAWCTSFPLVCFPTSL----------------------------PGLLK-----------NPLLLC 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 107 FILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFWLSLTEYL 186
Cdd:cd17405   211 QAICKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 187 LSFVSYIMTCDNFPVAGLTTSYEGVQHPlyveNNVLADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKSVGTGTNMV 266
Cdd:cd17405   291 LFVLIFFVECQTVTFAGINEDYDGYGQL----GNLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKT 366

                         250       260
                  ....*....|....*....|....*....
gi 1907172818 267 FQNCSCIQSSGNAS--------AVLGLCD 287
Cdd:cd17405   367 YYNCSCIKEGLAAAddegdfidAIAGKCD 395
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
 222-274 1.06e-21

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 87.74  E-value: 1.06e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907172818 222 LADCNTKCSCLTNTWDPVCGDNGLSYMSACLAGCEKSVGTGTNMVFQNCSCIQ 274
Cdd:cd01330     2 TSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
 226-272 7.62e-11

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 57.12  E-value: 7.62e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907172818 226 NTKCSCLTNTWDPVCGDNGLSYMSAC---LAGCEKSVGTGTNMVFQNCSC 272
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 31-181 8.95e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.21  E-value: 8.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  31 WWIGFLVCAGVNILTSIPFFFFPktllkeglqdngdgtenakEEKHREKIKEENRGITKDFFLFMKSLSCNPIYMIFILI 110
Cdd:cd06174   151 WRAVFLIAAALALLAAILLLLVV-------------------PDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLA 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907172818 111 SVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPIcLGYLIGGLIMKKFkITVKKAAYIGFWLS 181
Cdd:cd06174   212 IFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRL-IGRKPLLLIGLLLM 280
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
 233-272 3.20e-07

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 46.49  E-value: 3.20e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1907172818 233 TNTWDPVCGDNGLSYMSACLAGCEKSVGTGTNMVFQNCSC 272
Cdd:cd00104     2 PKEYDPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-187 3.90e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 3.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818 101 NPIYMIFILISVIQVNAFINSFTFMPKYLEQQYGKSTAEIVFLMGLYMLPPIcLGYLIGGLIMKKFKItvKKAAYIGFWL 180
Cdd:COG2814   206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV-LGALLAGRLADRFGR--RRLLLIGLLL 282


                  ....*..
gi 1907172818 181 SLTEYLL 187
Cdd:COG2814   283 LALGLLL 289
MFS_1 pfam07690
Major Facilitator Superfamily;
35-191 4.96e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.94  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907172818  35 FLVCAGVNILTSIPFFFFpktllkeglqdngdgtenakEEKHREKIKEENRGITKDFFLFMKSLSCNPIYMIFILISVIQ 114
Cdd:pfam07690 154 FLILAILSLLAAVLLLLP--------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907172818 115 VNAFInSFTFMPKYLEqQYGKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFWLSLTEYLLSFVS 191
Cdd:pfam07690 214 FAFFG-LLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH