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Conserved domains on  [gi|1907194209|ref|XP_036010400|]
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alpha-1,2-mannosyltransferase ALG9 isoform X9 [Mus musculus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 1-270 2.21e-68

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 221.85  E-value: 2.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209   1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGWPFSAALGLPIAFDLL- 71
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLl 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209  72 -ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQNLGHPY----------- 135
Cdd:pfam03901 193 rLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTHPWYFYfsnglpnilgp 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209 136 --------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfvfQRYRLEHYT 195
Cdd:pfam03901 272 fllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS-------RRSWKVRKK 344

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907194209 196 VTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLP 270
Cdd:pfam03901 345 LSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-270 2.21e-68

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 221.85  E-value: 2.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209   1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGWPFSAALGLPIAFDLL- 71
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLl 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209  72 -ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQNLGHPY----------- 135
Cdd:pfam03901 193 rLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTHPWYFYfsnglpnilgp 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209 136 --------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfvfQRYRLEHYT 195
Cdd:pfam03901 272 fllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS-------RRSWKVRKK 344

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907194209 196 VTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLP 270
Cdd:pfam03901 345 LSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPSSFFLH 414
ArnT COG1807
PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA ...
 4-180 2.21e-03

PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441412 [Multi-domain]  Cd Length: 309  Bit Score: 39.61  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209   4 AFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYM-----DKTPIAVLGVAAGAIL---GWPFSAALGLPIAFDLLARKH 75
Cdd:COG1807   119 LLLLTSPLLLLFGRLATPDALLLLFWTLALYALLRalerrRLRWLLLAGLALGLGFltkGPVALLLPGLALLLYLLLTRR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209  76 RWKSFLLWSLVALALFLvpvvvidsyyygkLVVAPLNIVLYNVftsHGPDLYVQNLGHPYWLTlapmyiwFIIFFIQPHK 155
Cdd:COG1807   199 WRRLRRLRLLLGLLLAL-------------LLALPWYIANDWA---TGPAFLEYFFGYENLVP-------LLFFSLSATK 255

                         170       180
                  ....*....|....*....|....*
gi 1907194209 156 EERFLFPVYPLICLCGAVALSALQK 180
Cdd:COG1807   256 LPRYLLPLLPALALLAAAGLARLRR 280
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 1-270 2.21e-68

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 221.85  E-value: 2.21e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209   1 MMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGW--------YMDKTPIAVLGVAAGAILGWPFSAALGLPIAFDLL- 71
Cdd:pfam03901 113 WALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLleygntsvSNYKYLKAVLLIAALAILGRPTSALLWLPLVLYLLl 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209  72 -ARKHRWKSFL--LWSLVALALFLVP--VVVIDSYYYGKLVVAPLNIVLYNVFtSHGPDLYVQNLGHPY----------- 135
Cdd:pfam03901 193 rLRGKRLKLFLflAISLGLLVALLVLgaVILIDSYFYGRFVFTPLNFLKYNVL-SNGSSFYGTHPWYFYfsnglpnilgp 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209 136 --------------------WLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQkcyhfvfQRYRLEHYT 195
Cdd:pfam03901 272 fllafilgplvlllrkvsrlSQLLAPILIWLFIYSLQPHKEERFLYPVYPLILLSAAIALTRLS-------RRSWKVRKK 344

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907194209 196 VTSNWLalgtvFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLP 270
Cdd:pfam03901 345 LSLLFL-----LLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAGPPVNVCIGMECYSTPSSFFLH 414
ArnT COG1807
PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA ...
 4-180 2.21e-03

PMT family glycosyltransferase ArnT/Agl22, involved in glycosylation of proteins and lipid IVA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441412 [Multi-domain]  Cd Length: 309  Bit Score: 39.61  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209   4 AFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYM-----DKTPIAVLGVAAGAIL---GWPFSAALGLPIAFDLLARKH 75
Cdd:COG1807   119 LLLLTSPLLLLFGRLATPDALLLLFWTLALYALLRalerrRLRWLLLAGLALGLGFltkGPVALLLPGLALLLYLLLTRR 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907194209  76 RWKSFLLWSLVALALFLvpvvvidsyyygkLVVAPLNIVLYNVftsHGPDLYVQNLGHPYWLTlapmyiwFIIFFIQPHK 155
Cdd:COG1807   199 WRRLRRLRLLLGLLLAL-------------LLALPWYIANDWA---TGPAFLEYFFGYENLVP-------LLFFSLSATK 255

                         170       180
                  ....*....|....*....|....*
gi 1907194209 156 EERFLFPVYPLICLCGAVALSALQK 180
Cdd:COG1807   256 LPRYLLPLLPALALLAAAGLARLRR 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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