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Conserved domains on  [gi|194328762|ref|NP_001123655|]
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dnaJ homolog subfamily A member 4 isoform 3 [Homo sapiens]

Protein Classification

J domain-containing protein( domain architecture ID 1002416)

J domain-containing protein similar to the N-terminal conserved domain (called J domain) of DnaJ-like proteins, which is involved in regulating the ATPase activity of heat shock protein 70 (Hsp70) by ATP hydrolysis

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  9585179|23894646|15170475
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00037 super family cl36499
DnaJ_C chaperone protein; Provisional
 17-367 2.38e-118

DnaJ_C chaperone protein; Provisional


The actual alignment was detected with superfamily member PTZ00037:

Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 349.50  E-value: 2.38e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  17 RFKLISQAYEVLSDPKKRDVYDQGGEQAIKeggsGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGV 96
Cdd:PTZ00037  66 KFKEISRAYEVLSDPEKRKIYDEYGEEGLE----GGEQPADASDLFDLIFGGGRKPGGKKRGEDIVSHLKVTLEQIYNGA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  97 TKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPgMVQQIQTVCIECKGQGERINPKDRCESCSGAKVI 176
Cdd:PTZ00037 142 MRKLAINKDVICANCEGHGGPKDAFVDCKLCNGQGIRVQIRQMGS-MIHQTQSTCNSCNGQGKIIPESKKCKNCSGKGVK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 177 REKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDN 256
Cdd:PTZ00037 221 KTRKILEVNIDKGVPNQHKITFHGEADEKPNEIPGNVVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 257 RILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVE 336
Cdd:PTZ00037 301 RKLLVNTPPGEVVKPGDIKVINNEGMPTYKSPFKKGNLYVTFEVIFPVDRKFTNEEKEILKSLFPQNPEEKKDLEDTEIE 380

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 194328762 337 L---KEFCPNEQNWRQHREAYEEDEDGPQAG----VQC 367
Cdd:PTZ00037 381 VvtaQNVDPEEVKDRDQKQQYQEDEDDEHHQegerVAC 418
 
Name Accession Description Interval E-value
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 17-367 2.38e-118

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 349.50  E-value: 2.38e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  17 RFKLISQAYEVLSDPKKRDVYDQGGEQAIKeggsGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGV 96
Cdd:PTZ00037  66 KFKEISRAYEVLSDPEKRKIYDEYGEEGLE----GGEQPADASDLFDLIFGGGRKPGGKKRGEDIVSHLKVTLEQIYNGA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  97 TKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPgMVQQIQTVCIECKGQGERINPKDRCESCSGAKVI 176
Cdd:PTZ00037 142 MRKLAINKDVICANCEGHGGPKDAFVDCKLCNGQGIRVQIRQMGS-MIHQTQSTCNSCNGQGKIIPESKKCKNCSGKGVK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 177 REKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDN 256
Cdd:PTZ00037 221 KTRKILEVNIDKGVPNQHKITFHGEADEKPNEIPGNVVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 257 RILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVE 336
Cdd:PTZ00037 301 RKLLVNTPPGEVVKPGDIKVINNEGMPTYKSPFKKGNLYVTFEVIFPVDRKFTNEEKEILKSLFPQNPEEKKDLEDTEIE 380

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 194328762 337 L---KEFCPNEQNWRQHREAYEEDEDGPQAG----VQC 367
Cdd:PTZ00037 381 VvtaQNVDPEEVKDRDQKQQYQEDEDDEHHQegerVAC 418
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 81-303 1.80e-66

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 209.42  E-value: 1.80e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   81 VVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQqigpgmvQQIQTVCIECKGQGER 160
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTCGGSGAKPGTSPKTCPCCGGGGQVRRQ-------FGFFSTCTCCPCCGGG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  161 INPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQ 239
Cdd:pfam01556  74 GKIIDKCCKCCGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGDAGENgGPPGDLYVVIRVKPHPVFRRDGDDLYCTVPIS 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194328762  240 LSEALCGFKKTIKTLDNRILVitsKAGEVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFP 303
Cdd:pfam01556 154 LTEALLGGTIEVPTLDGKVKL---KIPAGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 14-320 1.06e-63

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 206.68  E-value: 1.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGG---------SGSPSFSSPMDIFDMFFGGGGRMAR-----ERRGK 79
Cdd:TIGR02349  38 AEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGggggggfngFDIGFFGDFGDIFGDFFGGGGGSGRrrrsgPRRGE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   80 NVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQQIGPGMVQQIQTvCIECKGQG 158
Cdd:TIGR02349 118 DLRYDLELTFEEAVFGVEKEIEIPRKESCETCHGTGAKPGTdPKTCPTCGGTGQVRRQQGTPFGFFQQQQT-CPTCGGEG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  159 ERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQ-EPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:TIGR02349 197 KII--KEPCSTCKGKGRVKERKTITVKIPAGVDTGQRLRVSGKGNAgENGGPNGDLYVVIRVKPHKIFERDGNDLYIEVP 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  238 IQLSEALCGFKKTIKTLDnRILVITSKAGevIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFPEKhwLSLEKLPQLE 317
Cdd:TIGR02349 275 ISFTQAILGGEIEVPTLD-GDVKLKIPAG--TQSGTVFRLKGKGVPRLRGN-GRGDLLVTVKVETPKN--LSKEQKELLE 348


                  ...
gi 194328762  318 ALL 320
Cdd:TIGR02349 349 ELA 351
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 79-305 1.20e-43

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 148.34  E-value: 1.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  79 KNVVHQLSVTLEDLYNGVTKKLALQKNVIcekcegvggkkgsvekcplckgrgmqihiqqigpgmvqqiqtvcieckgqg 158
Cdd:cd10747    1 ADLRYDLELTLEEAYFGKEKEIKIPRKVT--------------------------------------------------- 29

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 159 erinpkdrcescsgakVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:cd10747   30 ----------------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNgGPPGDLYVVIRVKPHPVFRRDGNDLYCEVP 93

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194328762 238 IQLSEALCGFKKTIKTLDnRILVITSKAGEviKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFPEK 305
Cdd:cd10747   94 ISLTEALLGGEIEVPTLG-GKVKLKIPPGT--QPGTVLRLKGKGMPRLR-GGGRGDLYVEVKVEFPKK 157
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 14-47 9.63e-09

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 53.55  E-value: 9.63e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 47
Cdd:COG0484   39 AEEKFKEINEAYEVLSDPEKRAAYDRFGHAAELL 72
DnaJ smart00271
DnaJ molecular chaperone homology domain;
9-33 1.75e-03

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 36.44  E-value: 1.75e-03
                           10        20
                   ....*....|....*....|....*
gi 194328762     9 SGQISALTRFKLISQAYEVLSDPKK 33
Cdd:smart00271  36 GDKEEAEEKFKEINEAYEVLSDPEK 60
 
Name Accession Description Interval E-value
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 17-367 2.38e-118

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 349.50  E-value: 2.38e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  17 RFKLISQAYEVLSDPKKRDVYDQGGEQAIKeggsGSPSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGV 96
Cdd:PTZ00037  66 KFKEISRAYEVLSDPEKRKIYDEYGEEGLE----GGEQPADASDLFDLIFGGGRKPGGKKRGEDIVSHLKVTLEQIYNGA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  97 TKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQQIGPgMVQQIQTVCIECKGQGERINPKDRCESCSGAKVI 176
Cdd:PTZ00037 142 MRKLAINKDVICANCEGHGGPKDAFVDCKLCNGQGIRVQIRQMGS-MIHQTQSTCNSCNGQGKIIPESKKCKNCSGKGVK 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 177 REKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDN 256
Cdd:PTZ00037 221 KTRKILEVNIDKGVPNQHKITFHGEADEKPNEIPGNVVFILNEKPHDTFKREGGDLFITKKISLYEALTGFVFYITHLDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 257 RILVITSKAGEVIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFPEKHWLSLEKLPQLEALLPPRQKVRITDDMDQVE 336
Cdd:PTZ00037 301 RKLLVNTPPGEVVKPGDIKVINNEGMPTYKSPFKKGNLYVTFEVIFPVDRKFTNEEKEILKSLFPQNPEEKKDLEDTEIE 380

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 194328762 337 L---KEFCPNEQNWRQHREAYEEDEDGPQAG----VQC 367
Cdd:PTZ00037 381 VvtaQNVDPEEVKDRDQKQQYQEDEDDEHHQegerVAC 418
DnaJ_C pfam01556
DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It ...
 81-303 1.80e-66

DnaJ C terminal domain; This family consists of the C terminal region of the DnaJ protein. It is always found associated with pfam00226 and pfam00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region.


Pssm-ID: 460251 [Multi-domain]  Cd Length: 213  Bit Score: 209.42  E-value: 1.80e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   81 VVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQqigpgmvQQIQTVCIECKGQGER 160
Cdd:pfam01556   1 LEYELELTLEEAYFGCTKKIKITRNVICDTCGGSGAKPGTSPKTCPCCGGGGQVRRQ-------FGFFSTCTCCPCCGGG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  161 INPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQ 239
Cdd:pfam01556  74 GKIIDKCCKCCGGGGVVEKKTLEVKIPAGVDDGQRIRLRGEGDAGENgGPPGDLYVVIRVKPHPVFRRDGDDLYCTVPIS 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194328762  240 LSEALCGFKKTIKTLDNRILVitsKAGEVIKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFP 303
Cdd:pfam01556 154 LTEALLGGTIEVPTLDGKVKL---KIPAGTQPGTVLRLKGKGMPRLK-GGGRGDLYVTVKVEVP 213
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 14-320 1.06e-63

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 206.68  E-value: 1.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGG---------SGSPSFSSPMDIFDMFFGGGGRMAR-----ERRGK 79
Cdd:TIGR02349  38 AEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGGGggggggfngFDIGFFGDFGDIFGDFFGGGGGSGRrrrsgPRRGE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   80 NVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQQIGPGMVQQIQTvCIECKGQG 158
Cdd:TIGR02349 118 DLRYDLELTFEEAVFGVEKEIEIPRKESCETCHGTGAKPGTdPKTCPTCGGTGQVRRQQGTPFGFFQQQQT-CPTCGGEG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  159 ERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQ-EPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:TIGR02349 197 KII--KEPCSTCKGKGRVKERKTITVKIPAGVDTGQRLRVSGKGNAgENGGPNGDLYVVIRVKPHKIFERDGNDLYIEVP 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  238 IQLSEALCGFKKTIKTLDnRILVITSKAGevIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFPEKhwLSLEKLPQLE 317
Cdd:TIGR02349 275 ISFTQAILGGEIEVPTLD-GDVKLKIPAG--TQSGTVFRLKGKGVPRLRGN-GRGDLLVTVKVETPKN--LSKEQKELLE 348


                  ...
gi 194328762  318 ALL 320
Cdd:TIGR02349 349 ELA 351
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 14-283 9.24e-52

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 176.58  E-value: 9.24e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAI-----KEGGSGSPSFSSPMDIFDMFFGGGGRMARE--RRGKNVVHQLS 86
Cdd:PRK14298  43 AEEKFKEISEAYAVLSDAEKRAQYDRFGHAGIdnqysAEDIFRGADFGGFGDIFEMFFGGGGRRGRMgpRRGSDLRYDLY 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  87 VTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRGmQIHIQQIGPGMVQQIQTVCIECKGQGERInpKD 165
Cdd:PRK14298 123 ITLEEAAFGVRKDIDVPRAERCSTCSGTGAKPGTSPKrCPTCGGTG-QVTTTRSTPLGQFVTTTTCSTCHGRGQVI--ES 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 166 RCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQ-EPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEAL 244
Cdd:PRK14298 200 PCPVCSGTGKVRKTRKITVNVPAGADSGLRLKLSGEGEAgSPGAPSGDLYIVLHVKEHDYFERVGDDIISEIPISFTQAA 279

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 194328762 245 CGFKKTIKTLDNRIlVITSKAGeVIKHGDLRcVRDEGMP 283
Cdd:PRK14298 280 LGADIMVPTLYGKV-KMNIPPG-TQTHSVFR-LKDKGMP 315
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 13-305 2.84e-47

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 164.55  E-value: 2.84e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  13 SALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPM------DIFDMFFGG--GGRMARERRGKNVVHQ 84
Cdd:PRK10767  42 EAEEKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGGGGGFGGGGGfgdifgDIFGDIFGGgrGGGRQRARRGADLRYN 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  85 LSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGmQIHIQQiGPGMVQQiqtVCIECKGQGERInp 163
Cdd:PRK10767 122 MEITLEEAVRGVTKEIRIPTLVTCDTCHGSGAKPGtSPKTCPTCHGAG-QVRMQQ-GFFTVQQ---TCPTCHGRGKII-- 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 164 KDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGdqEPELE---PGDVIIVLDQKDHSVFQRRGHDLIMKMKIQL 240
Cdd:PRK10767 195 KDPCKKCHGQGRVEKEKTLSVKIPAGVDTGDRIRLSGEG--EAGERggpAGDLYVQIHVKEHPIFERDGNDLYCEVPISF 272

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194328762 241 SEALCGFKKTIKTLDNRILVitsKAGEVIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFPEK 305
Cdd:PRK10767 273 TTAALGGEIEVPTLDGRVKL---KIPEGTQTGKLFRLRGKGVKSVRSG-ARGDLYCQVVVETPVN 333
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 14-283 2.87e-47

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 164.84  E-value: 2.87e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGG---EQAIKEGGSGSPSFSSPMDIFDMFFGGG----GRMARERRGKNVVHQLS 86
Cdd:PRK14278  41 AQEKFKEISVAYEVLSDPEKRRIVDLGGdplESAGGGGGGFGGGFGGLGDVFEAFFGGGaasrGPRGRVRPGSDSLLRMR 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  87 VTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRGmqiHIQQIGPGMVQQIQTV--CIECKGQGERInp 163
Cdd:PRK14278 121 LDLEECATGVTKQVTVDTAVLCDRCHGKGTAGDSKPVtCDTCGGRG---EVQTVQRSFLGQVMTSrpCPTCRGVGEVI-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 164 KDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSE 242
Cdd:PRK14278 196 PDPCHECAGDGRVRARREITVKIPAGVGDGMRIRLAAQGEVGPGGGPaGDLYVEVHEQPHDVFVRDGDDLHCTVSVPMVD 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 194328762 243 ALCGFKKTIKTLDNRILVITSKAGevIKHGDLRCVRDEGMP 283
Cdd:PRK14278 276 AALGTTVTVEAILDGPSEITIPPG--TQPGSVITLRGRGMP 314
PRK14289 PRK14289
molecular chaperone DnaJ;
10-319 3.80e-46

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 161.92  E-value: 3.80e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  10 GQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPM---DIFDMF----------------FGGGG 70
Cdd:PRK14289  40 GDKEAEEKFKEAAEAYDVLSDPDKRSRYDQFGHAGVGGAAGGGGFSGEGMsmeDIFSMFgdifgghgggfggfggFGGGG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  71 RMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGK-KGSVEKCPLCKGRGMQIHIQQIGPGMVQQiQT 149
Cdd:PRK14289 120 SQQRVFRGSDLRVKVKLNLKEISTGVEKKFKVKKYVPCSHCHGTGAEgNNGSETCPTCKGSGSVTRVQNTILGTMQT-QS 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 150 VCIECKGQGERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELE-PGDVIIVLDQKDHSVFQRR 228
Cdd:PRK14289 199 TCPTCNGEGKII--KKKCKKCGGEGIVYGEEVITVKIPAGVAEGMQLSMNGKGNAGKHGGvNGDLLVVIEEEPHPELIRD 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 229 GHDLIMKMKIQLSEALCGFKKTIKTLDNRILVIT---SKAGEVIKhgdlrcVRDEGMPIYKApLEKGILIIQFLVIFPEK 305
Cdd:PRK14289 277 ENDLIYNLLLSVPTAALGGAVEVPTIDGKAKVKIeagTQPGKVLR------LRNKGLPSVNG-YGTGDLLVNVSVYIPET 349

                        330
                 ....*....|....
gi 194328762 306 hwLSLEKLPQLEAL 319
Cdd:PRK14289 350 --LSKEEKQTLEKM 361
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 13-326 3.64e-45

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 159.16  E-value: 3.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  13 SALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMDIFDM--------------FFGGGGRMA--RER 76
Cdd:PRK14291  40 EAEEKFKEINEAYQVLSDPEKRKLYDQFGHAAFSGSGQQQQGQEGFSDFGGGniediledvfdifgFGDIFGRRRatRER 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  77 R--------GKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRGmqiHIQQigPGMVQQI 147
Cdd:PRK14291 120 RktyqrpvkGEDIYQTVEISLEEAYTGTTVSLEVPRYVPCEACGGTGYDPGSGEKvCPTCGGSG---EIYQ--RGGFFRI 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 148 QTVCIECKGQGERINPkdrCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQ----EPelePGDVIIVLDQKDHS 223
Cdd:PRK14291 195 SQTCPTCGGEGVLREP---CSKCNGRGLVIKKETIKVRIPPGVDNGSKLRVPGKGHAgrfgGP---PGDLYIIVKVKPHP 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 224 VFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGevIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFP 303
Cdd:PRK14291 269 LFERRGDNLYLDVNITVAEAVLGTELEVPLLDGKKEKVKIPPG--TKEGDKIRVPGKGMPRLKGS-GYGDLVVRVHIDVP 345

                        330       340       350
                 ....*....|....*....|....*....|..
gi 194328762 304 EKHWLS--------LEK-LPQLEALLPPRQKV 326
Cdd:PRK14291 346 KISMLSklmgdgkkAKKlLKELDKLLPEPERI 377
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 14-305 1.61e-44

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 157.29  E-value: 1.61e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGE------------QAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERRGKNV 81
Cdd:PRK14283  43 AEEKFKEISEAYAVLSDDEKRQRYDQFGHagmdgfsqedifNNINFEDIFQGFGFGIGNIFDMFGFGGGSRHGPQRGADI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  82 VHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQQIGPGMVQQIQTvCIECKGQGER 160
Cdd:PRK14283 123 YTEVEITLEEAASGVEKDIKVRHTKKCPVCNGSRAEPGSeVKTCPTCGGTGQVKQVRNTILGQMMNVTT-CPDCQGEGKI 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 161 InpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQ-EPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQ 239
Cdd:PRK14283 202 V--EKPCSNCHGKGVVRETKTISVKIPAGVETGSRLRVSGEGEMgDRGGEPGDLYVVIKVKPHKIFRREGANLYYEKPIS 279

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194328762 240 LSEALCGFKKTIKTLDNRI-LVIT--SKAGEVIKhgdlrcVRDEGMPIYKAPlEKGILIIQFLVIFPEK 305
Cdd:PRK14283 280 FVQAALGDTVDVPTIDGPVeLKIPagTQSGTTFR------LKGHGMPSLRWS-GKGNLYVKVKVVVPKK 341
DnaJ_C cd10747
C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 ...
 79-305 1.20e-43

C-terminal substrate binding domain of DnaJ and HSP40; The C-terminal region of the DnaJ/Hsp40 protein mediates oligomerization and binding to denatured polypeptide substrate. DnaJ/Hsp40 is a widely conserved heat-shock protein. It prevents the aggregation of unfolded substrate and forms a ternary complex with both substrate and DnaK/Hsp70; the N-terminal J-domain of DnaJ/Hsp40 stimulates the ATPase activity of DnaK/Hsp70.


Pssm-ID: 199909 [Multi-domain]  Cd Length: 158  Bit Score: 148.34  E-value: 1.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  79 KNVVHQLSVTLEDLYNGVTKKLALQKNVIcekcegvggkkgsvekcplckgrgmqihiqqigpgmvqqiqtvcieckgqg 158
Cdd:cd10747    1 ADLRYDLELTLEEAYFGKEKEIKIPRKVT--------------------------------------------------- 29

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 159 erinpkdrcescsgakVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:cd10747   30 ----------------RVREKKTLTVKIPAGVDDGQRLRLRGEGDAGPNgGPPGDLYVVIRVKPHPVFRRDGNDLYCEVP 93

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194328762 238 IQLSEALCGFKKTIKTLDnRILVITSKAGEviKHGDLRCVRDEGMPIYKaPLEKGILIIQFLVIFPEK 305
Cdd:cd10747   94 ISLTEALLGGEIEVPTLG-GKVKLKIPPGT--QPGTVLRLKGKGMPRLR-GGGRGDLYVEVKVEFPKK 157
PRK14280 PRK14280
molecular chaperone DnaJ;
14-258 3.16e-42

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 151.41  E-value: 3.16e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPM-------DIFDMFFGGGGRMARE---RRGKNVVH 83
Cdd:PRK14280  42 ADEKFKEISEAYEVLSDDQKRAQYDQFGHAGPNQGFGGGGFGGGDFgggfgfeDIFSSFFGGGGRRRDPnapRQGADLQY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  84 QLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGmQIHIQQIGP-GMVQQiQTVCIECKGQGERI 161
Cdd:PRK14280 122 TMTLTFEEAVFGKEKEIEIPKEETCDTCHGSGAKPGtSKETCSHCGGSG-QVSVEQNTPfGRVVN-RQTCPHCNGTGQEI 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 162 npKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGdqEPELE---PGDVIIVLDQKDHSVFQRRGHDLIMKMKI 238
Cdd:PRK14280 200 --KEKCPTCHGKGKVRKRKKINVKIPAGVDNGQQIRVSGEG--EPGVNggpAGDLYVVFRVRPHEFFERDGDDIYCEMPL 275

                        250       260
                 ....*....|....*....|
gi 194328762 239 QLSEALCGFKKTIKTLDNRI 258
Cdd:PRK14280 276 TFAQAALGDEIEVPTLHGKV 295
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 7-354 6.68e-42

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 150.72  E-value: 6.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   7 LDSGQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSP------------------MDIFDMFFGG 68
Cdd:PRK14277  37 LNPGDKEAEQKFKEINEAYEILSDPQKRAQYDQFGHAAFDPGGFGQGGFGQGgfggggfdfdfggfgdifEDIFGDFFGT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  69 GGRMARE--RRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGmQIHIQQIGP-GMV 144
Cdd:PRK14277 117 GRRRAETgpQKGADIRYDLELTFEEAAFGTEKEIEVERFEKCDVCKGSGAKPGSkPVTCPVCHGTG-QVRTRQNTPfGRI 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 145 QQIQTvCIECKGQGERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHS 223
Cdd:PRK14277 196 VNIRT-CDRCHGEGKII--TDPCNKCGGTGRIRRRRKIKVNIPAGIDDGQMITLRGEGEPGIKGGPnGDLYIVIKVKPHP 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 224 VFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSkagEVIKHGDLRCVRDEGMPiYKAPLEKGILIIQFLVIFP 303
Cdd:PRK14277 273 LFKREGYNVYLEMPITFTDAALGGEIEIPTLDGKVKFTIP---EGTQTGTKFRLRGKGIP-HLRGRGRGDQIVKVYIEVP 348

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194328762 304 EKhwLSlEKlpQLEALlppRQKVRITDDMDQVELKEFcpneqnWRQHREAY 354
Cdd:PRK14277 349 KK--LT-EK--QKELL---REFEKLSGEEGTESRKSF------FQRMKDAF 385
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 8-283 5.00e-41

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 148.21  E-value: 5.00e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   8 DSGQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSP---------MDIFDMFFG-------GGGR 71
Cdd:PRK14286  37 NKGNKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVNAGAGGFGQGAYTdfsdifgdfGDIFGDFFGggrgggsGGGR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  72 MARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRGmQIHIQQigpGMVqQIQTV 150
Cdd:PRK14286 117 RSGPQRGSDLRYNLEVSLEDAALGREYKIEIPRLESCVDCNGSGASKGSSPTtCPDCGGSG-QIRRTQ---GFF-SVATT 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 151 CIECKGQGERI-NPkdrCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRR 228
Cdd:PRK14286 192 CPTCRGKGTVIsNP---CKTCGGQGLQEKRRTINIKIPPGVETGSRLKVSGEGEAGPNGGPhGDLYVVTHIKKHELFERQ 268

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194328762 229 GHDLIMKMKIQLSEALCGFKKTIKTLDNRilVITSKAGEVIKHGDLRCVRDEGMP 283
Cdd:PRK14286 269 GNDLILVRKISLAQAILGAEIEVPTIDGK--KAKMKIPEGTESGQVFRLKGHGMP 321
PRK14297 PRK14297
molecular chaperone DnaJ;
10-255 2.68e-40

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 146.47  E-value: 2.68e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  10 GQISALTRFKLISQAYEVLSDPKKRDVYDQ---------GGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARERR--- 77
Cdd:PRK14297  39 GNKEAEEKFKEINEAYQVLSDPQKKAQYDQfgtadfngaGGFGSGGFGGFDFSDMGGFGDIFDSFFGGGFGSSSRRRngp 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  78 --GKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRGmQIHIQQIGPGMVQQIQTVCIEC 154
Cdd:PRK14297 119 qrGADIEYTINLTFEEAVFGVEKEISVTRNENCETCNGTGAKPGTSPKtCDKCGGTG-QIRVQRNTPLGSFVSTTTCDKC 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 155 KGQGERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGdqEPELE---PGDVIIVLDQKDHSVFQRRGHD 231
Cdd:PRK14297 198 GGSGKVI--EDPCNKCHGKGKVRKNRKIKVNVPAGVDTGNVIPLRGQG--EHGKNggpTGDLYINIRVAPHKTFKRKGFD 273

                        250       260
                 ....*....|....*....|....
gi 194328762 232 LIMKMKIQLSEALCGFKKTIKTLD 255
Cdd:PRK14297 274 IYIDKHISFAKAALGTEIKVPTVD 297
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 14-258 5.87e-40

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 145.72  E-value: 5.87e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQ------GGEQAIKEGGSGSPSFSSPMDIF----DMF-----------------F 66
Cdd:PRK14281  42 AEEHFKEVNEAYEVLSNDDKRRRYDQfghagvGSSAASGGGPGYGGGGGDFNDIFsafnDMFgggarrgggspfgfedvF 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  67 GGGGRMARER---RGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGmqiHIQQIGPGM 143
Cdd:PRK14281 122 GGGGRRRRASagiPGTDLKIRLKLTLEEIAKGVEKTLKIKKQVPCKECNGTGSKTGATETCPTCHGSG---EVRQASKTM 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 144 VQQIQ--TVCIECKGQGERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQK 220
Cdd:PRK14281 199 FGQFVniTACPTCGGEGRVV--KDRCPACYGEGIKQGEVTVKVTVPAGVQDGNYLTLRGQGNAGPRgGAPGDLIVVIEEK 276

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 194328762 221 DHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRI 258
Cdd:PRK14281 277 PHELFVRNGDDVIYNLAVSYPDLVLGTKVEVPTLDGAV 314
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 10-257 1.03e-38

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 141.83  E-value: 1.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  10 GQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPM-----DIFDMFFG-GGGRMARE----RRGK 79
Cdd:PRK14294  39 GDKEAEELFKEAAEAYEVLSDPKKRGIYDQYGHEGLSGTGFSGFSGFDDIfssfgDIFEDFFGfGGGRRGRSrtavRAGA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  80 NVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQqigpGMVqQIQTVCIECKGQG 158
Cdd:PRK14294 119 DLRYDLTLPFLEAAFGTEKEIRIQKLETCEECHGSGCEPGTsPTTCPQCGGSGQVTQSQ----GFF-SIRTTCPRCRGMG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 159 ERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEG-DQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:PRK14294 194 KVI--VSPCKTCHGQGRVRVSKTVQVKIPAGVDTGSRLRLRGEGeAGVRGGPPGDLYVFLTVEPHEFFERDGNDVHCKVP 271

                        250       260
                 ....*....|....*....|
gi 194328762 238 IQLSEALCGFKKTIKTLDNR 257
Cdd:PRK14294 272 ISFVQAALGAQIEVPTLEGE 291
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 17-253 8.15e-38

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 139.45  E-value: 8.15e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  17 RFKLISQAYEVLSDPKKRDVYDQ----------GGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMAR---ERRGKNVVH 83
Cdd:PRK14276  45 KYKEVQEAYETLSDPQKRAAYDQygaaganggfGGGAGGFGGFDGSGGFGGFEDIFSSFFGGGGARRNpnaPRQGDDLQY 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  84 QLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGMqIHIQQIGP-GMVQQiQTVCIECKGQGERI 161
Cdd:PRK14276 125 RVNLDFEEAIFGKEKEVSYNREATCHTCNGSGAKPGtSPVTCGKCHGSGV-ITVDTQTPlGMMRR-QVTCDVCHGTGKEI 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 162 npKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRRGHDLIMKMKIQL 240
Cdd:PRK14276 203 --KEPCQTCHGTGHEKQAHTVSVKIPAGVETGQQIRLQGQGEAGFNGGPyGDLYVVFRVEPSKKFERDGSTIYYTLPISF 280

                        250
                 ....*....|...
gi 194328762 241 SEALCGFKKTIKT 253
Cdd:PRK14276 281 VQAALGDTVEVPT 293
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 8-283 1.02e-37

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 139.59  E-value: 1.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   8 DSGQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQA-IKEGGSGSPSFSSPMD-------------------IFDMFFG 67
Cdd:PRK14284  34 NPGDAEAEKRFKEVSEAYEVLSDAQKRESYDRYGKDGpFAGAGGFGGAGMGNMEdalrtfmgafggefggggsFFEGLFG 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  68 G---------GGRMARERRGKNVvhQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGG-KKGSVEKCPLCKGRGmQIhIQ 137
Cdd:PRK14284 114 GlgeafgmrgGPAGARQGASKKV--HITLSFEEAAKGVEKELLVSGYKSCDACSGSGAnSSQGIKVCDRCKGSG-QV-VQ 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 138 QIGpgmVQQIQTVCIECKGQGERINpkDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIV 216
Cdd:PRK14284 190 SRG---FFSMASTCPECGGEGRVIT--DPCSVCRGQGRIKDKRSVHVHIPAGVDSGMRLKMEGYGDAGQNGAPaGDLYVF 264

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194328762 217 LDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTL-DNRILVITSKAGevIKHGDLRCVRDEGMP 283
Cdd:PRK14284 265 IDVEPHPVFERRGDDLILELPIGFVDAALGMKKEIPTLlKEGTCRLTIPEG--IQSGTILKVRGQGFP 330
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 14-327 3.58e-37

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 137.57  E-value: 3.58e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSP------MDIFDMFFG----GGGRMARERRGKNVVH 83
Cdd:PRK14301  43 AEQKFKEAAEAYEVLRDAEKRARYDRFGHAGVNGNGGFGGFSSAEdifshfSDIFGDLFGfsggGSRRGPRPQAGSDLRY 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  84 QLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGmQIHIQQigpGMVQqIQTVCIECKGQGERIn 162
Cdd:PRK14301 123 NLTVSFRQAAKGDEVTLRIPKNVTCDDCGGSGAAPGtSPETCRHCGGSG-QVRQSQ---GFFQ-IAVPCPVCRGEGRVI- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 163 pKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGdqEPELE---PGDVIIVLDQKDHSVFQRRGHDLIMKMKIQ 239
Cdd:PRK14301 197 -THPCPKCKGSGIVQQTRELKVRIPAGVDTGSRLRLRGEG--EPGVHggpPGDLYVVITVEDDKIFQRQGQDLVVTQEIS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 240 LSEALCGFKKTIKTLDNRILVITSK---AGEVIKhgdlrcVRDEGMPiYKAPLEKGILIIQFLVIFPEKHWLSLEK-LPQ 315
Cdd:PRK14301 274 FVQAALGDRIEVPTLDDPVTLDIPKgtqSGEVFR------LRGKGLP-YLGSSQKGDLLVEVSVVTPTKLTKRQEElLRE 346

                        330
                 ....*....|....
gi 194328762 316 LEALLP--PRQKVR 327
Cdd:PRK14301 347 FEALEEekPLEKVK 360
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 8-284 4.53e-36

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 134.73  E-value: 4.53e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   8 DSGQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPM----------DIFDMFFGGGGRMARER- 76
Cdd:PRK14285  36 NKGNKEAESIFKEATEAYEVLIDDNKRAQYDRFGHTAFEGGGGFEGFSGGFSgfsdifedfgDIFDSFFTGNRGQDKNRk 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  77 --RGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGMQIHiqqiGPGMVqQIQTVCIE 153
Cdd:PRK14285 116 heKGQDLTYQIEISLEDAYLGYKNNINITRNMLCESCLGKKSEKGtSPSICNMCNGSGRVMQ----GGGFF-RVTTTCPK 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 154 CKGQGERI-NPkdrCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHD 231
Cdd:PRK14285 191 CYGNGKIIsNP---CKSCKGKGSLKKKETIELKIPAGIDDNQQIKMRGKGSVNPDnQQYGDLYIKILIKPHKIFKRNGKD 267

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194328762 232 LIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGevIKHGDLRCVRDEGMPI 284
Cdd:PRK14285 268 LYATLPISFTQAALGKEIKIQTIASKKIKIKIPKG--TENDEQIIIKNEGMPI 318
PRK14295 PRK14295
molecular chaperone DnaJ;
8-318 1.05e-35

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 134.21  E-value: 1.05e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   8 DSGQISALTRFKLISQAYEVLSDPKKRDVYD-----------------------------------QGGEQAikeggsgs 52
Cdd:PRK14295  42 NKGDAKAEERFKEISEAYDVLSDEKKRKEYDearslfgnggfrpgpgggggggfnfdlgdlfgggaQGGGGA-------- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  53 PSFSSPMDIFDMFFGGGGRMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEK-CPLCKGRG 131
Cdd:PRK14295 114 GGGGGLGDVFGGLFNRGGRRTQPRRGADVESEVTLSFTEAIDGATVPLRLTSQAPCPACSGTGAKNGTTPRvCPTCSGTG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 132 mqiHIQQIGPGMvqQIQTVCIECKGQGerINPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP- 210
Cdd:PRK14295 194 ---QVSRNSGGF--SLSEPCPDCKGRG--LIADDPCLVCKGSGRAKSSRTMQVRIPAGVSDGQRIRLRGKGAPGERGGPa 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 211 GDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKAGEviKHGDLRCVRDEGMPiyKAPLE 290
Cdd:PRK14295 267 GDLYVVVHVDPHPVFGRSGDNLTVTVPVTFPEAALGAEVRVPTLGGPPVTVKLPPGT--PNGRVLRVRGKGAV--RKDGT 342

                        330       340
                 ....*....|....*....|....*...
gi 194328762 291 KGILIIQFLVIFPEKhwLSLEKLPQLEA 318
Cdd:PRK14295 343 RGDLLVTVEVAVPKD--LSGKAREALEA 368
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 14-283 7.61e-34

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 128.51  E-value: 7.61e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGS-----PSFSSPMDIFDMFFGG----------GGRMARERRG 78
Cdd:PRK14290  43 AEEKFKEISEAYEVLSDPQKRRQYDQTGTVDFGAGGSNFnwdnfTHFSDINDIFNQIFGGnfgsdffsgfGNQQSTRNID 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  79 KNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGMQIHIQqiGPGMVQQIQ-TVCIECKGQ 157
Cdd:PRK14290 123 LDIYTNLDISLEDAYYGTEKRIKYRRNAMCPDCSGTGAKNGKLITCPTCHGTGQQRIVR--GQGFFRMVTvTTCRTCGGR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 158 GeRInPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGdQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMK 237
Cdd:PRK14290 201 G-RI-PEEKCPRCNGTGTVVVNEDISVKIPKGATDNLRLRVKGKG-QSYGGRTGDLYVVLRVNNDPNIQRINDDLYVDQK 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 194328762 238 IQLSEALCGFKKTIKTLDNRI-LVIT--SKAGEVIKhgdlrcVRDEGMP 283
Cdd:PRK14290 278 INFPQAALGGEIEIKLFREKYnLKIPegTQPGEVLK------IKGAGMP 320
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 14-258 2.68e-32

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 124.74  E-value: 2.68e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSP--MDIFDMFFGGGGRMARE---RRGKNVVHQLSVT 88
Cdd:PRK14287  42 AEDKFKEVKEAYDTLSDPQKKAHYDQFGHTDPNQGFGGGGAGDFGgfSDIFDMFFGGGGGRRNPnapRQGADLQYTMTLE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  89 LEDLYNGVTKKLALQKNVICEKCEGVGGKKGSV-EKCPLCKGRGmQIHIQQIGP-GMVQQiQTVCIECKGQGERInpKDR 166
Cdd:PRK14287 122 FKEAVFGKETEIEIPREETCGTCHGSGAKPGTKpETCSHCGGSG-QLNVEQNTPfGRVVN-RRVCHHCEGTGKII--KQK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 167 CESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEALC 245
Cdd:PRK14287 198 CATCGGKGKVRKRKKINVKVPAGIDHGQQLRVSGQGEAGVNGGPpGDLYVVFNVKPHEFFERDGDDIYCEMPLTFPQVAL 277

                        250
                 ....*....|...
gi 194328762 246 GFKKTIKTLDNRI 258
Cdd:PRK14287 278 GDEIEVPTLNGKV 290
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 14-318 2.80e-32

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 124.62  E-value: 2.80e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQ---AIKEGGSGSPSFSSPMDIFDMFFGGGGRMA-----RERRGKNVVHQL 85
Cdd:PRK14292  40 AAEKFAQINEAYAVLSDAEKRAHYDRFGTApgaGMPGGDPFGGMGFDPMDIFEQLFGGAGFGGgrgrrGPARGDDLETEA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  86 SVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS--VEKCPLCKGRGmQIHIQQIGPGMVQQIQTVCIECKGQGERInp 163
Cdd:PRK14292 120 RITLEQARAGEEVEVEVDRLTECEHCHGSRTEPGGkpPKTCPTCRGAG-AVRAQARTIFGVVETQQPCPTCRGEGQII-- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 164 KDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPElEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQLSEA 243
Cdd:PRK14292 197 TDPCTVCRGRGRTLKAETVKVKLPRGIDEGYRIRVAGMGNEGPG-GNGDLYVHIEMEPHPELRREQEHLIYEARIGFAKA 275

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194328762 244 LCGFKKTIKTLDNRiLVITSKAGevIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFPEKhwLSLEKLPQLEA 318
Cdd:PRK14292 276 ALGGQITVPTLDGP-QVIEVKPG--TQHGDLHRLRGQGMPRLQGA-GTGDLIVEYEIAVPKQ--LSPEAREALEA 344
PRK14279 PRK14279
molecular chaperone DnaJ;
10-319 1.55e-31

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 122.92  E-value: 1.55e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  10 GQISALTRFKLISQAYEVLSDPKKRDVYDQ-------GGEQAIKEGGSG------SPSFSSPMDIFDMFFGGGG------ 70
Cdd:PRK14279  44 GDPAAEERFKAVSEAHDVLSDPAKRKEYDEtrrlfagGGFGGRRFDGGGgfggfgTGGDGAEFNLNDLFDAAGRgggggi 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  71 ---------------RMARERRGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGMqI 134
Cdd:PRK14279 124 gdlfgglfnrgggsaRPSRPRRGNDLETETTLDFVEAAKGVTMPLRLTSPAPCTTCHGSGARPGtSPKVCPTCNGSGV-I 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 135 HIQQIGPGMVQQiqtvCIECKGQGERINpkDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDV 213
Cdd:PRK14279 203 SRNQGAFGFSEP----CTDCRGTGSIIE--DPCEECKGTGVTTRTRTINVRIPPGVEDGQRIRLAGQGEAGLRGAPsGDL 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 214 IIVLDQKDHSVFQRRGHDLIMKMKIQLSEALCGFKKTIKTLDNRILVITSKA---GEVIKhgdlrcVRDEGMPiyKAPLE 290
Cdd:PRK14279 277 YVTVHVRPDKVFGRDGDDLTVTVPVSFTELALGSTLSVPTLDGPVGVKVPAGtadGRILR------VRGRGVP--KRSGG 348

                        330       340
                 ....*....|....*....|....*....
gi 194328762 291 KGILIIQFLVIFPEKhwlsLEKlPQLEAL 319
Cdd:PRK14279 349 AGDLLVTVKVAVPPN----LDG-AAAEAL 372
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 14-325 4.10e-31

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 121.44  E-value: 4.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQG---GEQAIKEGGSGSPSFSSPM----------DIFDMFFGGGG----RMARER 76
Cdd:PRK14282  44 AEQKFKEIQEAYEVLSDPQKRAMYDRFgyvGEQPPYQETESGGGFFEDIfkdfenifnrDIFDIFFGERRtqeeQREYAR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  77 RGKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMqIHIQQIGPGMVQQIQTVCIECK 155
Cdd:PRK14282 124 RGEDIRYEIEVTLSDLINGAEIPVEYDRYETCPHCGGTGVEPGSgYVTCPKCHGTGR-IREERRSFFGVFVSERTCERCG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 156 GQGeRInPKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRRGHDLIM 234
Cdd:PRK14282 203 GTG-KI-PGEYCHECGGSGRIRRRVRTTVKIPAGVEDGTVLRITGGGNAGYYGGPyGDLYVIVRVRPDPRFKRSGSDLIY 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 235 KMKIQLSEALCGFKKTIKTLDNRILVITSKAGevIKHGDLRCVRDEGMPIYKAPlEKGILIIQFLVIFPEKhwLSLEKLP 314
Cdd:PRK14282 281 DVTIDYLQAILGTTVEVPLPEGGTTMLKIPPG--TQPETVFRLKGKGLPNMRYG-RRGDLIVNVHVEIPKR--LSREERK 355

                        330
                 ....*....|.
gi 194328762 315 QLEALLPPRQK 325
Cdd:PRK14282 356 LLKELAKKRGV 366
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 14-303 2.19e-30

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 119.28  E-value: 2.19e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIK------------EGGSGSPSFSSPMDIFDMF--FGGGGRMARER--R 77
Cdd:PRK14296  42 AHDKMVEINEAADVLLDKDKRKQYDQFGHAAFDgssgfssnfgdfEDLFSNMGSSGFSSFTNIFsdFFGSNKSDYQRstK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  78 GKNVVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQQIGPGMVQQiQTVCIECKG 156
Cdd:PRK14296 122 GQSVSLDIYLTFKELLFGVDKIIELDLLTNCSKCFGSGAESNSdIHICNNCHGTGEVLVQKNMGFFQFQQ-SAKCNVCNG 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 157 QGERInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELE-PGDVIIVLDQKDHSVFQR-RGHDLIM 234
Cdd:PRK14296 201 AGKII--KNKCKNCKGKGKYLERKKIEVNIPKGIRPNQQIKLSQKGHASLNNGvNGDLIIDIYLKESKVFEIiNNNDILM 278

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194328762 235 KMKIQLSEALCGFKKTIKTLDNRILVITSKAgevIKHGDLRCVRDEGMPIYKAPLEKGILIIQFLVIFP 303
Cdd:PRK14296 279 TYNISYLDAILGNEIIIKTLDGDIKYKLPKS---INSNELIIINNKGLYKSINKDKRGDLIIKVNIVVP 344
PRK14293 PRK14293
molecular chaperone DnaJ;
17-255 4.98e-30

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 118.17  E-value: 4.98e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  17 RFKLISQAYEVLSDPKKRDVYDQGGEQAIkeGGSGSPSFSSPM----DIFDMFF------GGGGRMARER---RGKNVVH 83
Cdd:PRK14293  44 RFKEINRAYEVLSDPETRARYDQFGEAGV--SGAAGFPDMGDMggfaDIFETFFsgfggaGGQGGRRRRRgpqRGDDLRY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  84 QLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGS-VEKCPLCKGRGmQIHIQQIGP-GMVQQIqTVCIECKGQGERI 161
Cdd:PRK14293 122 DLKLDFREAIFGGEKEIRIPHLETCETCRGSGAKPGTgPTTCSTCGGAG-QVRRATRTPfGSFTQV-SECPTCNGTGQVI 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 162 npKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEP-GDVIIVLDQKDHSVFQRRGHDLIMKMKIQL 240
Cdd:PRK14293 200 --EDPCDACGGQGVKQVTKKLKINIPAGVDTGTRLRVSGEGDAGLRGGPpGDLYVYLFVKNDPEFRRDGINILSEIKISY 277

                        250
                 ....*....|....*
gi 194328762 241 SEALCGFKKTIKTLD 255
Cdd:PRK14293 278 LQAILGDTLEVDTVD 292
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 14-282 4.89e-27

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 110.10  E-value: 4.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSP---MDIFDMF------FGGGGRMARER----RGKN 80
Cdd:PRK14300  41 AEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFQNQQSRGGGGNHGgfhPDINDIFgdffsdFMGGSRRSRPTsskvRGSD 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  81 VVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKG-SVEKCPLCKGRGMQiHIQQiGPGMVQQiqtVCIECKGQGE 159
Cdd:PRK14300 121 LKYNLTINLEEAFHGIEKNISFSSEVKCDTCHGSGSEKGeTVTTCDACSGVGAT-RMQQ-GFFTIEQ---ACHKCQGNGQ 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 160 RInpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPE-LEPGDVIIVLDQKDHSVFQRRGHDLIMKMKI 238
Cdd:PRK14300 196 II--KNPCKKCHGMGRYHKQRNLSVNIPAGVENGTRIRHTGEGEAGIRgGNSGDLYVDIAIKPHDIYKVDGANLHCKLPI 273

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 194328762 239 QLSEALCGFKKTIKTLDNRILVITSKAGevIKHGDLRCVRDEGM 282
Cdd:PRK14300 274 SFVNAALGGEIEVPVIEGGKVNLTIPAG--TQNGDQLRLRSKGM 315
PRK14288 PRK14288
molecular chaperone DnaJ;
8-319 1.29e-23

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 100.53  E-value: 1.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   8 DSGQISALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGSGSPSFSSPMD----IFDMFFGGGGRMARERRGK---N 80
Cdd:PRK14288  36 NAGDKEAEEKFKLINEAYGVLSDEKKRALYDRYGKKGLNQAGASQSDFSDFFEdlgsFFEDAFGFGARGSKRQKSSiapD 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  81 VVHQLSVTLEDLYNGVTKKLALQKNVICEKCEGVGGKKGSVEKCPLCKGRGmQIHIQQigpGMVQQIQTvCIECKGQGER 160
Cdd:PRK14288 116 YLQTIELSFKEAVFGCKKTIKVQYQSVCESCDGTGAKDKALETCKQCNGQG-QVFMRQ---GFMSFAQT-CGACQGKGKI 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 161 InpKDRCESCSGAKVIREKKIIEVHVEKGMKDGQKILFHGEGDQEPELEPGDVIIVLDQKDHSVFQRRGHDLIMKMKIQL 240
Cdd:PRK14288 191 I--KTPCQACKGKTYILKDEEIDAIIPEGIDDQNRMVLKNKGNEYEKGKRGDLYLEARVKEDEHFKREGCDLFIEAPVFF 268

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194328762 241 SEALCGfkKTIKTLDNRILVITSKAGEVIKHGDLRCVRDEGMPiYKAPLEKGILIIQFLVIFPEKhwLSLEKLPQLEAL 319
Cdd:PRK14288 269 TTIALG--HTIKVPSLKGDELELKIPRNARDRQTFAFRNEGVK-HPESSYRGSLIVELQVIYPKS--LNKEQQELLEKL 342
DnaJ_CXXCXGXG pfam00684
DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four ...
 108-174 8.95e-20

DnaJ central domain; The central cysteine-rich (CR) domain of DnaJ proteins contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found.


Pssm-ID: 459904 [Multi-domain]  Cd Length: 65  Bit Score: 82.22  E-value: 8.95e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194328762  108 CEKCEGVGGKKG-SVEKCPLCKGRGMQIHIQQIGPGMVQQiQTVCIECKGQGERInpKDRCESCSGAK 174
Cdd:pfam00684   1 CPTCNGSGAKPGtKPTTCPTCGGTGQVRRVQQTGPGFFQM-QSTCPTCGGTGKII--KDPCKKCKGKG 65
DnaJ_zf cd10719
Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of ...
 108-174 3.02e-18

Zinc finger domain of DnaJ and HSP40; Central/middle or CxxCxGxG-motif containing domain of DnaJ/Hsp40 (heat shock protein 40). DnaJ proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonin family. Hsp40 proteins are characterized by the presence of an N-terminal J domain, which mediates the interaction with Hsp70. This central domain contains four repeats of a CxxCxGxG motif and binds to two Zinc ions. It has been implicated in substrate binding.


Pssm-ID: 199908 [Multi-domain]  Cd Length: 65  Bit Score: 78.07  E-value: 3.02e-18
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194328762 108 CEKCEGVGGKKGS-VEKCPLCKGRGMQIHIQQIGpGMVQQIQTVCIECKGQGERInpKDRCESCSGAK 174
Cdd:cd10719    1 CPTCNGSGAKPGTkPKTCPTCGGSGQVRQVQGTG-FGFFQTQTTCPTCGGTGKII--KDPCPKCKGKG 65
PRK10266 PRK10266
curved DNA-binding protein;
9-267 2.76e-09

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 57.52  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762   9 SGQISALTRFKLISQAYEVLSDPKKRDVYDQ--------GGEQAIKEGGSGSPSFSSPMDIFDMFFGGGGRMARER---R 77
Cdd:PRK10266  37 SKEPDAEARFKEVAEAWEVLSDEQRRAEYDQlwqhrndpQFNRQFQHGDGQSFNAEDFDDIFSSIFGQHARQSRQRpaaR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  78 GKNVVHQLSVTLEDlyngvtkKLALQKNVICekcegvggkkgsvEKCPLCKGRGMQihiqqigpgmvqqiqtvcieckgq 157
Cdd:PRK10266 117 GHDIEIEVAVFLEE-------TLTEHKRTIS-------------YNLPVYNAFGMI------------------------ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 158 gERINPkdrcescsgakvirekKIIEVHVEKGMKDGQKILFHGEGDQ-EPELEPGDVIIVLDQKDHSVFQRRGHDLIMKM 236
Cdd:PRK10266 153 -EQEIP----------------KTLNVKIPAGVGNGQRIRLKGQGTPgENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVV 215

                        250       260       270
                 ....*....|....*....|....*....|....
gi 194328762 237 KIQLSEALCGFKKTIKTLDNRILVIT---SKAGE 267
Cdd:PRK10266 216 PLAPWEAALGAKVTVPTLKESILLTIppgSQAGQ 249
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 14-47 9.63e-09

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 53.55  E-value: 9.63e-09
                         10        20        30
                 ....*....|....*....|....*....|....
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKE 47
Cdd:COG0484   39 AEEKFKEINEAYEVLSDPEKRAAYDRFGHAAELL 72
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 9-38 1.11e-07

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 48.24  E-value: 1.11e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 194328762    9 SGQISALTRFKLISQAYEVLSDPKKRDVYD 38
Cdd:pfam00226  34 PGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 14-323 2.22e-07

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 51.86  E-value: 2.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  14 ALTRFKLISQAYEVLSDPKKRDVYDQGGEQAIKEGGS------------GSPSFSSPMDIFDMFFGGGGRMA-------- 73
Cdd:PRK14299  42 AEEKFKEINEAYTVLSDPEKRRIYDTYGTTAASAGWQgpppgppgggdfSGFNVGDFSDFFQQLFGGRGGFGgfgdlfgs 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762  74 ---RERRGKNVVHQLSVTLEDLYNGvtkklalqknviCEKCEGVGGKKGSVekcplckgrgmqihiqqigpgmvqqiqtv 150
Cdd:PRK14299 122 vgrRARKGRDLEAELPLTLEEAYRG------------GEKVVEVAGERLSV----------------------------- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 151 cieckgqgeRINPkdrcescsgakvirekkiievhvekGMKDGQKILFHGEGDQEpelepGDVIIVLDQKDHSVFQRRGH 230
Cdd:PRK14299 161 ---------RIPP-------------------------GVREGQVIRLAGKGRQG-----GDLYLVVRLLPHPVFRLEGD 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194328762 231 DLIMKMKIQLSEALCGFKKTIKTLDNRILVIT---SKAGEVIKhgdlrcVRDEGMPiyKAPLEKGILIIQFLVIFPEKHW 307
Cdd:PRK14299 202 DLYATVDVPAPIAVVGGKVRVMTLDGPVEVTIpprTQAGRKLR------LKGKGWP--RGPAGRGDQYAEVRITIPTRPT 273

                        330
                 ....*....|....*..
gi 194328762 308 LSLEKL-PQLEALLPPR 323
Cdd:PRK14299 274 PEEERLyKQLAELYKVR 290
DnaJ smart00271
DnaJ molecular chaperone homology domain;
9-33 1.75e-03

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 36.44  E-value: 1.75e-03
                           10        20
                   ....*....|....*....|....*
gi 194328762     9 SGQISALTRFKLISQAYEVLSDPKK 33
Cdd:smart00271  36 GDKEEAEEKFKEINEAYEVLSDPEK 60
SEC63 COG5407
Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular ...
 17-34 4.01e-03

Preprotein translocase subunit Sec63 [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 444165 [Multi-domain]  Cd Length: 61  Bit Score: 35.36  E-value: 4.01e-03
                         10
                 ....*....|....*...
gi 194328762  17 RFKLISQAYEVLSDPKKR 34
Cdd:COG5407   42 RFKEINEAYELLSDAEKR 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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