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Conserved domains on  [gi|194376304|dbj|BAG62911|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECM1 super family cl25530
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ...
 11-165 2.22e-89

Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.


The actual alignment was detected with superfamily member pfam05782:

Pssm-ID: 461739  Cd Length: 518  Bit Score: 270.17  E-value: 2.22e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   11 EATPLQQEKLLPAQLPAEKEVGPPLPQEAVPLQKELPSLQHPNEQK------------------EGTPAPFGDQSHPEPE 72
Cdd:pfam05782  42 EAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELPPPQLPIEQKeidppfpqqeeitpskqrEEKPAPLVGQGHPEPE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   73 SWNAAQHCQQDRSQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLPQSSYSHLTRQGETLNFLEIGYSRCCHC 152
Cdd:pfam05782 122 SWNPAQHCQQGRRRGGWGHRLDGFPPGRPSPDNLNQICLPERQHVVYGPWNLPQTGYSHLSRQGETLNLLETGYSRCCRC 201

                         170
                  ....*....|...
gi 194376304  153 RSHTNRLECAKLV 165
Cdd:pfam05782 202 RSHTNRLDCAKLV 214
 
Name Accession Description Interval E-value
ECM1 pfam05782
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ...
 11-165 2.22e-89

Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.


Pssm-ID: 461739  Cd Length: 518  Bit Score: 270.17  E-value: 2.22e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   11 EATPLQQEKLLPAQLPAEKEVGPPLPQEAVPLQKELPSLQHPNEQK------------------EGTPAPFGDQSHPEPE 72
Cdd:pfam05782  42 EAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELPPPQLPIEQKeidppfpqqeeitpskqrEEKPAPLVGQGHPEPE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   73 SWNAAQHCQQDRSQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLPQSSYSHLTRQGETLNFLEIGYSRCCHC 152
Cdd:pfam05782 122 SWNPAQHCQQGRRRGGWGHRLDGFPPGRPSPDNLNQICLPERQHVVYGPWNLPQTGYSHLSRQGETLNLLETGYSRCCRC 201

                         170
                  ....*....|...
gi 194376304  153 RSHTNRLECAKLV 165
Cdd:pfam05782 202 RSHTNRLDCAKLV 214
 
Name Accession Description Interval E-value
ECM1 pfam05782
Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic ...
 11-165 2.22e-89

Extracellular matrix protein 1 (ECM1); This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness.


Pssm-ID: 461739  Cd Length: 518  Bit Score: 270.17  E-value: 2.22e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   11 EATPLQQEKLLPAQLPAEKEVGPPLPQEAVPLQKELPSLQHPNEQK------------------EGTPAPFGDQSHPEPE 72
Cdd:pfam05782  42 EAIPVQEEELPPPQLPVEKKVDPPLPQEAIPLQEELPPPQLPIEQKeidppfpqqeeitpskqrEEKPAPLVGQGHPEPE 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194376304   73 SWNAAQHCQQDRSQGGWGHRLDGFPPGRPSPDNLNQICLPNRQHVVYGPWNLPQSSYSHLTRQGETLNFLEIGYSRCCHC 152
Cdd:pfam05782 122 SWNPAQHCQQGRRRGGWGHRLDGFPPGRPSPDNLNQICLPERQHVVYGPWNLPQTGYSHLSRQGETLNLLETGYSRCCRC 201

                         170
                  ....*....|...
gi 194376304  153 RSHTNRLECAKLV 165
Cdd:pfam05782 202 RSHTNRLDCAKLV 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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