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Conserved domains on  [gi|1945949559|emb|VFQ93809|]
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unnamed protein product [Cuscuta campestris]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 10619601)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
45-98 2.80e-18

EF-hand domain pair;


:

Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 74.66  E-value: 2.80e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1945949559  45 ERGVITFESLKRNSAALGLQDLGDDDLRSMLREGDLDGDGALDQMEFCVLMFRL 98
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
 
Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
45-98 2.80e-18

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 74.66  E-value: 2.80e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1945949559  45 ERGVITFESLKRNSAALGLQDLGDDDLRSMLREGDLDGDGALDQMEFCVLMFRL 98
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00183 PTZ00183
centrin; Provisional
 7-95 2.90e-12

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 62.01  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945949559   7 SGRGKEEFEDMLPEMAEKLGGEGLMRELCNGFSLLMDGERGVITFESLKRNSAALGlQDLGDDDLRSMLREGDLDGDGAL 86
Cdd:PTZ00183   65 DGSGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKELG-ETITDEELQEMIDEADRNGDGEI 143


                  ....*....
gi 1945949559  87 DQMEFCVLM 95
Cdd:PTZ00183  144 SEEEFYRIM 152
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 47-95 5.32e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.14  E-value: 5.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1945949559  47 GVITFESLKRNSAALGLqDLGDDDLRSMLREGDLDGDGALDQMEFCVLM 95
Cdd:cd00051    15 GTISADELKAALKSLGE-GLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
 
Name Accession Description Interval E-value
EF-hand_8 pfam13833
EF-hand domain pair;
45-98 2.80e-18

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 74.66  E-value: 2.80e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1945949559  45 ERGVITFESLKRNSAALGLQDLGDDDLRSMLREGDLDGDGALDQMEFCVLMFRL 98
Cdd:pfam13833   1 EKGVITREELKRALALLGLKDLSEDEVDILFREFDTDGDGYISFDEFCVLLERR 54
PTZ00183 PTZ00183
centrin; Provisional
 7-95 2.90e-12

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 62.01  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945949559   7 SGRGKEEFEDMLPEMAEKLGGEGLMRELCNGFSLLMDGERGVITFESLKRNSAALGlQDLGDDDLRSMLREGDLDGDGAL 86
Cdd:PTZ00183   65 DGSGKIDFEEFLDIMTKKLGERDPREEILKAFRLFDDDKTGKISLKNLKRVAKELG-ETITDEELQEMIDEADRNGDGEI 143


                  ....*....
gi 1945949559  87 DQMEFCVLM 95
Cdd:PTZ00183  144 SEEEFYRIM 152
PTZ00184 PTZ00184
calmodulin; Provisional
 7-97 4.45e-06

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 44.75  E-value: 4.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945949559   7 SGRGKEEFEDMLPEMAEKLGGEGLMRELCNGFSLLMDGERGVITFESLKRNSAALGlQDLGDDDLRSMLREGDLDGDGAL 86
Cdd:PTZ00184   59 DGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLG-EKLTDEEVDEMIREADVDGDGQI 137

                          90
                  ....*....|.
gi 1945949559  87 DQMEFCVLMFR 97
Cdd:PTZ00184  138 NYEEFVKMMMS 148
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 47-95 5.32e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.14  E-value: 5.32e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1945949559  47 GVITFESLKRNSAALGLqDLGDDDLRSMLREGDLDGDGALDQMEFCVLM 95
Cdd:cd00051    15 GTISADELKAALKSLGE-GLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
PTZ00184 PTZ00184
calmodulin; Provisional
 21-107 9.59e-04

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 38.20  E-value: 9.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1945949559  21 MAEKLGGEGLmRELCNGFSLLMDGERGVITFESLKRNSAALGlQDLGDDDLRSMLREGDLDGDGALDQMEFCVLMFRLSP 100
Cdd:PTZ00184    1 MADQLTEEQI-AEFKEAFSLFDKDGDGTITTKELGTVMRSLG-QNPTEAELQDMINEVDADGNGTIDFPEFLTLMARKMK 78


                  ....*..
gi 1945949559 101 DLMRESE 107
Cdd:PTZ00184   79 DTDSEEE 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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