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Conserved domains on  [gi|1951689549]
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Chain B, SRP1 isoform 1

Protein Classification

importin subunit alpha( domain architecture ID 11473712)

importin subunit alpha functions in nuclear protein import as an adapter protein for importin beta nuclear receptors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
8-530 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 897.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549   8 STSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIpptdgaDSDEEDESS-VSADQQFYSqlq 86
Cdd:COG5064     1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLA------DVSEEAESSfIPMEQQFYS--- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  87 qELPQMTQQLNSDDMQEQLSATVKFRQILSQEHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQT 166
Cdd:COG5064    72 -ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 167 KVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKP--SLIRTATWTLSNLCR 244
Cdd:COG5064   151 KVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhiSMLRNATWTLSNLCR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 245 GKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVG 324
Cdd:COG5064   231 GKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 325 NIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEAC 404
Cdd:COG5064   311 NIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEAC 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 405 WAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGME 484
Cdd:COG5064   391 WAISNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMD 470

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1951689549 485 KIFNCQQNENDKIYEKAYKIIETYFGeEEDAVDEtMAPQNAGNTFG 530
Cdd:COG5064   471 AIHGLQDSVNRTIYDKAYSIIEKFFG-EEDAVDE-LAPETAGNTFT 514
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
8-530 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 897.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549   8 STSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIpptdgaDSDEEDESS-VSADQQFYSqlq 86
Cdd:COG5064     1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLA------DVSEEAESSfIPMEQQFYS--- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  87 qELPQMTQQLNSDDMQEQLSATVKFRQILSQEHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQT 166
Cdd:COG5064    72 -ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 167 KVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKP--SLIRTATWTLSNLCR 244
Cdd:COG5064   151 KVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhiSMLRNATWTLSNLCR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 245 GKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVG 324
Cdd:COG5064   231 GKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 325 NIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEAC 404
Cdd:COG5064   311 NIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEAC 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 405 WAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGME 484
Cdd:COG5064   391 WAISNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMD 470

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1951689549 485 KIFNCQQNENDKIYEKAYKIIETYFGeEEDAVDEtMAPQNAGNTFG 530
Cdd:COG5064   471 AIHGLQDSVNRTIYDKAYSIIEKFFG-EEDAVDE-LAPETAGNTFT 514
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 17-108 2.49e-32

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 118.79  E-value: 2.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  17 RRTNFKNKGRfSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTdgadsdeedessvSADQQFYSQLQQELPQMTQQL 96
Cdd:pfam01749   1 RRKSFKNKGK-DADELRRRREEVQVELRKQKREEQLLKRRNVGAPS-------------SSSSSAESQLLESLPEMVQGV 66

                          90
                  ....*....|..
gi 1951689549  97 NSDDMQEQLSAT 108
Cdd:pfam01749  67 NSDDPELQLEAT 78
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 330-370 2.03e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 2.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1951689549  330 NDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITA 370
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 150-465 1.04e-08

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 58.19  E-value: 1.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  150 EAAWALTniASGtsaqtkvvvdadAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKP 229
Cdd:PLN03200   479 ESKWAIT--AAG------------GIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGP 544

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  230 SLIRTATWTLSNLCRgkkpQPDWSVVSQALPTLakliysmdtetlvdacwaisyLSDGPQEAIQaVIDVripkrLVELLS 309
Cdd:PLN03200   545 KGQEIAAKTLTKLVR----TADAATISQLTALL---------------------LGDLPESKVH-VLDV-----LGHVLS 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  310 --HESTLVQTPAlravgnivTGNDlqtqvvinagVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPP 387
Cdd:PLN03200   594 vaSLEDLVREGS--------AAND----------ALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINP 655

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951689549  388 LVKLLEVAEYKTKKEACWAISnASSGGLQRPDIIRYlVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEA 465
Cdd:PLN03200   656 CIKLLTNNTEAVATQSARALA-ALSRSIKENRKVSY-AAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAEA 731
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
8-530 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 897.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549   8 STSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIpptdgaDSDEEDESS-VSADQQFYSqlq 86
Cdd:COG5064     1 STSRFVPEARRYNFKGKGRFSADELRRRREEQQVELRKQKREELLNKRRNLA------DVSEEAESSfIPMEQQFYS--- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  87 qELPQMTQQLNSDDMQEQLSATVKFRQILSQEHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQT 166
Cdd:COG5064    72 -ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 167 KVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKP--SLIRTATWTLSNLCR 244
Cdd:COG5064   151 KVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLLSSAIhiSMLRNATWTLSNLCR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 245 GKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVG 324
Cdd:COG5064   231 GKNPPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVG 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 325 NIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEAC 404
Cdd:COG5064   311 NIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEAC 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 405 WAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGME 484
Cdd:COG5064   391 WAISNATSGGLNRPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMD 470

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 1951689549 485 KIFNCQQNENDKIYEKAYKIIETYFGeEEDAVDEtMAPQNAGNTFG 530
Cdd:COG5064   471 AIHGLQDSVNRTIYDKAYSIIEKFFG-EEDAVDE-LAPETAGNTFT 514
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 17-108 2.49e-32

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 118.79  E-value: 2.49e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  17 RRTNFKNKGRfSADELRRRRDTQQVELRKAKRDEALAKRRNFIPPTdgadsdeedessvSADQQFYSQLQQELPQMTQQL 96
Cdd:pfam01749   1 RRKSFKNKGK-DADELRRRREEVQVELRKQKREEQLLKRRNVGAPS-------------SSSSSAESQLLESLPEMVQGV 66

                          90
                  ....*....|..
gi 1951689549  97 NSDDMQEQLSAT 108
Cdd:pfam01749  67 NSDDPELQLEAT 78
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 475-523 2.09e-20

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 84.56  E-value: 2.09e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1951689549 475 DFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQ 523
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEEDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 330-370 4.44e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 57.85  E-value: 4.44e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951689549 330 NDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITA 370
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 372-412 1.70e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 55.92  E-value: 1.70e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951689549 372 NTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASS 412
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 330-370 2.03e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 52.82  E-value: 2.03e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1951689549  330 NDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITA 370
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 372-412 9.43e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 9.43e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1951689549  372 NTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASS 412
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 150-465 1.04e-08

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 58.19  E-value: 1.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  150 EAAWALTniASGtsaqtkvvvdadAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKP 229
Cdd:PLN03200   479 ESKWAIT--AAG------------GIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGP 544

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  230 SLIRTATWTLSNLCRgkkpQPDWSVVSQALPTLakliysmdtetlvdacwaisyLSDGPQEAIQaVIDVripkrLVELLS 309
Cdd:PLN03200   545 KGQEIAAKTLTKLVR----TADAATISQLTALL---------------------LGDLPESKVH-VLDV-----LGHVLS 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549  310 --HESTLVQTPAlravgnivTGNDlqtqvvinagVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPP 387
Cdd:PLN03200   594 vaSLEDLVREGS--------AAND----------ALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINP 655

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1951689549  388 LVKLLEVAEYKTKKEACWAISnASSGGLQRPDIIRYlVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEA 465
Cdd:PLN03200   656 CIKLLTNNTEAVATQSARALA-ALSRSIKENRKVSY-AAEDAIKPLIKLAKSSSIEVAEQAVCALANLLSDPEVAAEA 731
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 119-160 2.80e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.76  E-value: 2.80e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1951689549 119 HRPPIDVVIQAGVVPRLVEFMReNQPEMLQLEAAWALTNIAS 160
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-201 3.69e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 3.69e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1951689549 162 TSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVA 201
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT COG1413
HEAT repeat [General function prediction only];
147-326 5.98e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 51.55  E-value: 5.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 147 LQLEAAWALTNIAsgtsaqtkvvvDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDStdyrdyvlqcnAMEPILGLFNS 226
Cdd:COG1413     1 VRRAAARALGRLG-----------DPAAVPALIAALADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKD 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 227 NKPSLIRTATWTLSNLcrgKKPqpdwsvvsQALPTLAKLIYSMDTETLVDACWAISYLsdGPQEAIQAvidvripkrLVE 306
Cdd:COG1413    59 PDPEVRAAAAEALGRI---GDP--------EAVPALIAALKDEDPEVRRAAAEALGRL--GDPAAVPA---------LLE 116

                         170       180
                  ....*....|....*....|
gi 1951689549 307 LLSHESTLVQTPALRAVGNI 326
Cdd:COG1413   117 ALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 162-201 2.79e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.04  E-value: 2.79e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1951689549  162 TSAQTKVVVDADAVPLFIQLLYTGSVEVKEQAIWALGNVA 201
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 204-244 5.90e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.90e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951689549 204 STDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCR 244
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 146-200 7.28e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 46.21  E-value: 7.28e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951689549 146 MLQLEAAWALTNIASGTSAQTKVVVDaDAVPLFIQLLYTGSVEVKEQAIWALGNV 200
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
129-265 2.53e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 2.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 129 AGVVPRLVEFMRENQPEmLQLEAAWALTNIAsgtsaqtkvvvDADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDStdyr 208
Cdd:COG1413    15 PAAVPALIAALADEDPD-VRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE---- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1951689549 209 dyvlqcnAMEPILGLFNSNKPSLIRTATWTLSNLcrGKKP----------QPDWSVVSQALPTLAKL 265
Cdd:COG1413    79 -------AVPALIAALKDEDPEVRRAAAEALGRL--GDPAavpallealkDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 121-160 5.51e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 43.19  E-value: 5.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1951689549  121 PPIDVVIQAGVVPRLVEFMRENQPEmLQLEAAWALTNIAS 160
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEE-VVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 248-286 8.93e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 8.93e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1951689549 248 PQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSD 286
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 288-328 9.86e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.44  E-value: 9.86e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1951689549 288 PQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVT 328
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 288-327 1.02e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.42  E-value: 1.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1951689549  288 PQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIV 327
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 204-244 3.81e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.88  E-value: 3.81e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1951689549  204 STDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCR 244
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 418-455 3.86e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.90  E-value: 3.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1951689549 418 PDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENI 455
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 315-368 8.36e-05

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 40.43  E-value: 8.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1951689549 315 VQTPALRAVGNIVTGNDLQTQVVINAgVLPALRLLLSSPKENIKKEACWTISNI 368
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 417-455 1.15e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.15e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1951689549  417 RPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENI 455
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 188-242 4.03e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.50  E-value: 4.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1951689549 188 EVKEQAIWALGNVAGDSTDYRDYVLQcNAMEPILGLFNSNKPSLIRTATWTLSNL 242
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 132-200 3.20e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 3.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1951689549 132 VPRLVEFMRENQPEMLQLEAAWALTNIAsgtsaqtkvvvDADAVPLFIQLLYTGSVEVKEQAIWALGNV 200
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIG-----------DPEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT COG1413
HEAT repeat [General function prediction only];
290-426 4.97e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.30  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1951689549 290 EAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVtgndlqtqvviNAGVLPALRLLLSSPKENIKKEACWTISNIT 369
Cdd:COG1413     7 RALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIG 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1951689549 370 agnteqiqaviDANLIPPLVKLLEVAEYKTKKEACWAIsnassGGLQRPDIIRYLVS 426
Cdd:COG1413    76 -----------DPEAVPALIAALKDEDPEVRRAAAEAL-----GRLGDPAAVPALLE 116
HEAT COG1413
HEAT repeat [General function prediction only];
131-201 7.63e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 36.92  E-value: 7.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1951689549 131 VVPRLVEFMRENQPEmLQLEAAWALTNIAsgtsaqtkvvvDADAVPLFIQLLYTGSVEVKEQAIWALGNVA 201
Cdd:COG1413    79 AVPALIAALKDEDPE-VRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALGRLG 137
NopRA1 pfam16201
Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and ...
 169-226 9.84e-03

Nucleolar pre-ribosomal-associated protein 1; This family is found on the long vertebral and plant nucleolar proteins that also carry Npa1, pfam11707.


Pssm-ID: 465063  Cd Length: 197  Bit Score: 37.51  E-value: 9.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1951689549 169 VVDADAVPLFIQLLYTGSVEVKEQAIWALGN-VAG--DSTDYRdyVLQ-CNAMEPILGLFNS 226
Cdd:pfam16201 101 SLDLNDIPLFYSLLYSSSEEYYKERSWLLELlLDGlrTEDDLE--LLRrRGVFELLLSLYNS 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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