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Conserved domains on  [gi|1973497116|ref|NP_001380276|]
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clusterin-like protein 1 precursor [Homo sapiens]

Protein Classification

Clusterin domain-containing protein( domain architecture ID 12014179)

Clusterin domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Clusterin pfam01093
Clusterin;
33-463 0e+00

Clusterin;


:

Pssm-ID: 460061 [Multi-domain]  Cd Length: 418  Bit Score: 638.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  33 NLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLCRESLADS 112
Cdd:pfam01093   1 ELKELSEAGEKYVDEEVKNALIGVKQMKTMMERREEEHKKLMKSLEKSKEKKEEALKLAKEVEEKLEEEEEVCNESMKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 113 WGECRSCLENNCMRIYT-TCQPSWSSVKNKIERFFRKIYQFLFPFHEDNEKDLPISEKLIEEDAQLTQMEDVFSQLTVDV 191
Cdd:pfam01093  81 WEECKPCLESTCMKFYTrTCRSGSGLVGRQLEEFFNRISPFSFWINGDRIDDLLVNEEDQEQDAQLVQMEDSFSQLSSDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 192 NSLFNRSFNVFRQMQQEFDQTFQSHFISDTDLTEPYFFPafSKEPMTKADLEQCWDIPNFFQLFCNFSVSIYESVSETIT 271
Cdd:pfam01093 161 DSLFNRSFKVFKQMQQEFDQAFQSYFMSDLDLTEPYFFP--SKEPTRKSRFLRSWGFPNVFQPFFDFSRSVFESFSAVIT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 272 KMLKaiedlpkqdkaPDHGGLISKMLPGQDRGLCGELDQNLSRCFKFHEKCQKCQAHLSEDCPDVPALHTELDEAIRLVN 351
Cdd:pfam01093 239 ETLD-----------SDPGGLFSKELPGQDRMLCRELRRNSSGCLKFQDRCEKCQEILSVDCPSVPELHEELEEALQLAE 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 352 VSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAPETEIIFNSIQVVPRIHEGNISKQDETmMTDLSILPSSN 431
Cdd:pfam01093 308 VSTQQYDELLQIVQHHMEDTSSLLDQMNEQFGWVSELANQTQGPENIFNVTTVVPKSSEGESSKQGDT-KVEVSILDSPP 386
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1973497116 432 FTLKIPLEESAESSNFIGYVVAKALQHFKEHF 463
Cdd:pfam01093 387 FTLTVPGELSWDDPKFIEYVAQKALQHYKEHF 418
 
Name Accession Description Interval E-value
Clusterin pfam01093
Clusterin;
33-463 0e+00

Clusterin;


Pssm-ID: 460061 [Multi-domain]  Cd Length: 418  Bit Score: 638.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  33 NLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLCRESLADS 112
Cdd:pfam01093   1 ELKELSEAGEKYVDEEVKNALIGVKQMKTMMERREEEHKKLMKSLEKSKEKKEEALKLAKEVEEKLEEEEEVCNESMKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 113 WGECRSCLENNCMRIYT-TCQPSWSSVKNKIERFFRKIYQFLFPFHEDNEKDLPISEKLIEEDAQLTQMEDVFSQLTVDV 191
Cdd:pfam01093  81 WEECKPCLESTCMKFYTrTCRSGSGLVGRQLEEFFNRISPFSFWINGDRIDDLLVNEEDQEQDAQLVQMEDSFSQLSSDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 192 NSLFNRSFNVFRQMQQEFDQTFQSHFISDTDLTEPYFFPafSKEPMTKADLEQCWDIPNFFQLFCNFSVSIYESVSETIT 271
Cdd:pfam01093 161 DSLFNRSFKVFKQMQQEFDQAFQSYFMSDLDLTEPYFFP--SKEPTRKSRFLRSWGFPNVFQPFFDFSRSVFESFSAVIT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 272 KMLKaiedlpkqdkaPDHGGLISKMLPGQDRGLCGELDQNLSRCFKFHEKCQKCQAHLSEDCPDVPALHTELDEAIRLVN 351
Cdd:pfam01093 239 ETLD-----------SDPGGLFSKELPGQDRMLCRELRRNSSGCLKFQDRCEKCQEILSVDCPSVPELHEELEEALQLAE 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 352 VSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAPETEIIFNSIQVVPRIHEGNISKQDETmMTDLSILPSSN 431
Cdd:pfam01093 308 VSTQQYDELLQIVQHHMEDTSSLLDQMNEQFGWVSELANQTQGPENIFNVTTVVPKSSEGESSKQGDT-KVEVSILDSPP 386
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1973497116 432 FTLKIPLEESAESSNFIGYVVAKALQHFKEHF 463
Cdd:pfam01093 387 FTLTVPGELSWDDPKFIEYVAQKALQHYKEHF 418
CLa smart00035
CLUSTERIN alpha chain;
238-460 1.25e-109

CLUSTERIN alpha chain;


Pssm-ID: 128350  Cd Length: 216  Bit Score: 323.27  E-value: 1.25e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  238 TKADLEQCWDIpNFFQLFCNFSVSIYESVSETITKMLKAIEDLPKQDKAPDHGgliskmlpgQDRGLCGELDQNLSRCFK 317
Cdd:smart00035   1 NLMPFPQYWPL-NFHDMFQPFFDMIHQAQQAMDTHLHRPPYQFPKQDFAEEHG---------DDRTVCKEIRHNSTGCLK 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  318 FHEKCQKCQAHLSEDC----PDVPALHTELDEAIRLVNVSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAP 393
Cdd:smart00035  71 MKDQCEKCQEILSVDCstnnPDQPQLRQELDESLQLAERFTQQYDQLLQSYQKKMLNTSSLLEQLNEQFGWVSQLANLTQ 150
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1973497116  394 ETEIIFNSIQVVPrIHEGNISKQDETMMTDLSILPSSNFTLKIPLEESAESSNFIGYVVAKALQHFK 460
Cdd:smart00035 151 GEDQYYLQVTTVP-SHTSDSSVPSGTTKVVVKLFDSDPITLTIPEEVSADNPKFMETVAEKALQHYR 216
 
Name Accession Description Interval E-value
Clusterin pfam01093
Clusterin;
33-463 0e+00

Clusterin;


Pssm-ID: 460061 [Multi-domain]  Cd Length: 418  Bit Score: 638.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  33 NLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLCRESLADS 112
Cdd:pfam01093   1 ELKELSEAGEKYVDEEVKNALIGVKQMKTMMERREEEHKKLMKSLEKSKEKKEEALKLAKEVEEKLEEEEEVCNESMKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 113 WGECRSCLENNCMRIYT-TCQPSWSSVKNKIERFFRKIYQFLFPFHEDNEKDLPISEKLIEEDAQLTQMEDVFSQLTVDV 191
Cdd:pfam01093  81 WEECKPCLESTCMKFYTrTCRSGSGLVGRQLEEFFNRISPFSFWINGDRIDDLLVNEEDQEQDAQLVQMEDSFSQLSSDV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 192 NSLFNRSFNVFRQMQQEFDQTFQSHFISDTDLTEPYFFPafSKEPMTKADLEQCWDIPNFFQLFCNFSVSIYESVSETIT 271
Cdd:pfam01093 161 DSLFNRSFKVFKQMQQEFDQAFQSYFMSDLDLTEPYFFP--SKEPTRKSRFLRSWGFPNVFQPFFDFSRSVFESFSAVIT 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 272 KMLKaiedlpkqdkaPDHGGLISKMLPGQDRGLCGELDQNLSRCFKFHEKCQKCQAHLSEDCPDVPALHTELDEAIRLVN 351
Cdd:pfam01093 239 ETLD-----------SDPGGLFSKELPGQDRMLCRELRRNSSGCLKFQDRCEKCQEILSVDCPSVPELHEELEEALQLAE 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116 352 VSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAPETEIIFNSIQVVPRIHEGNISKQDETmMTDLSILPSSN 431
Cdd:pfam01093 308 VSTQQYDELLQIVQHHMEDTSSLLDQMNEQFGWVSELANQTQGPENIFNVTTVVPKSSEGESSKQGDT-KVEVSILDSPP 386
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1973497116 432 FTLKIPLEESAESSNFIGYVVAKALQHFKEHF 463
Cdd:pfam01093 387 FTLTVPGELSWDDPKFIEYVAQKALQHYKEHF 418
CLa smart00035
CLUSTERIN alpha chain;
238-460 1.25e-109

CLUSTERIN alpha chain;


Pssm-ID: 128350  Cd Length: 216  Bit Score: 323.27  E-value: 1.25e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  238 TKADLEQCWDIpNFFQLFCNFSVSIYESVSETITKMLKAIEDLPKQDKAPDHGgliskmlpgQDRGLCGELDQNLSRCFK 317
Cdd:smart00035   1 NLMPFPQYWPL-NFHDMFQPFFDMIHQAQQAMDTHLHRPPYQFPKQDFAEEHG---------DDRTVCKEIRHNSTGCLK 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  318 FHEKCQKCQAHLSEDC----PDVPALHTELDEAIRLVNVSNQQYGQILQMTRKHLEDTAYLVEKMRGQFGWVSELANQAP 393
Cdd:smart00035  71 MKDQCEKCQEILSVDCstnnPDQPQLRQELDESLQLAERFTQQYDQLLQSYQKKMLNTSSLLEQLNEQFGWVSQLANLTQ 150
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1973497116  394 ETEIIFNSIQVVPrIHEGNISKQDETMMTDLSILPSSNFTLKIPLEESAESSNFIGYVVAKALQHFK 460
Cdd:smart00035 151 GEDQYYLQVTTVP-SHTSDSSVPSGTTKVVVKLFDSDPITLTIPEEVSADNPKFMETVAEKALQHYR 216
CLb smart00030
CLUSTERIN Beta chain;
26-237 9.59e-91

CLUSTERIN Beta chain;


Pssm-ID: 128345  Cd Length: 206  Bit Score: 274.39  E-value: 9.59e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116   26 DKTAISENLKSFSEVGEIDADEEVKKALTGIKQMKIMMERKEKEHTNLMSTLKKCREEKQEALKLLNEVQEHLEEEERLC 105
Cdd:smart00030   1 DKTVSDNELQEMSTQGSKYINKEIKNALKGVKQIKTLIEKTNKERKSLLSTLEEAKKKKEEALKDTRESEEKLKESQGVC 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1973497116  106 RESLADSWGECRSCLENNCMRIYT-TCQPSWSSVKNKIERFFRKIYQFLFPFHEDneKDLPISEKLIEEDAQLTQMEDVF 184
Cdd:smart00030  81 NETMMALWEECKPCLKQTCMKFYArVCRSGSGLVGRQLEEFLNQSSPFYFWMNGD--RIDSLLENDRQQSHVLDVMEDSF 158
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1973497116  185 SQLTVDVNSLFNRSFNVFrqmqQEFDQTFQSHFISDTDLTEPYFFPAfSKEPM 237
Cdd:smart00030 159 SRASSIVDELFQDRFFTR----EPQDTTFYSPFSSPHRRTEPFFFPK-SRLAR 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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