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Conserved domains on  [gi|19909883|dbj|BAB87120|]
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WD-repeat protein p103 [Mus musculus]

Protein Classification

WD40 and Utp12 domain-containing protein( domain architecture ID 11455513)

protein containing domains WD40, and Utp12

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
322-629 5.10e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 5.10e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 322 LIHSLSISDQRVASVAINSSGDWIAFGCSGmGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 402 TLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSprPTQF-SCVAVDSSGEIVSAGAQDS 480
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWvNSVAFSPDGTFVASSSQDG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 481 FeIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMfDSWRTKETLTLTSDAL-AVTFRPDGAELA 559
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGHENGVnSVAFSPDGYLLA 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 560 VATLNSQITFWDPRMLYRWAPIRGrHDlktgrkeldkitakhsakgKAFTTLCYSADGQSILAGGMSKFV 629
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG-HT-------------------NSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
33-537 5.13e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 109.41  E-value: 5.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  33 VGNRVTVFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFV 112
Cdd:COG2319   2 VDNSSTSSENKSKLLKKSELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDGELLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 113 VTKGN-IAQMYHAPGKKREFNAFvldktYFGPYDETTCIDWT--DDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKD 189
Cdd:COG2319  82 SGSSDgTIKLWDLDNGEKLIKSL-----EGLHDSSVSKLALSspDGNSILLASSSLDGTVKLWDLSTPGKLIRTLEGHSE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 190 AIVA-CFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWkadilqrekeeeeedeeegdrettirgkttpaeqer 268
Cdd:COG2319 157 SVTSlAFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGHTDP------------------------------------ 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 269 VGKVKYSrlakyflnkegdfnnltsaayHKKTHLLVTGFASGIFHLHELPEFNLIHSlSISDQRVASVAINSSGDWIAFG 348
Cdd:COG2319 201 VSSLAFS---------------------PDGGLLIASGSSDGTIRLWDLSTGKLLRS-TLSGHSDSVVSSFSPDGSLLAS 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 349 CSGMGQLLVWEWQSESYVLKQ-QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTE--HSSGVTGVTFTT 425
Cdd:COG2319 259 GSSDGTIRLWDLRSSSSLLRTlSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLkgHEGPVSSLSFSP 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 426 TGHVIVTS-SLDGTVRAFDLHRYRNFRTFtsPRPTQFSCVAVDSSGEIVSAGAQDSFeIFVWSMQTGRLLDVLSGHEGPV 504
Cdd:COG2319 339 DGSLLVSGgSDDGTIRLWDLRTGKPLKTL--EGHSNVLSVSFSPDGRVVSSGSTDGT-VRLWDLSTGSLLRNLDGHTSRV 415
                       490       500       510
                ....*....|....*....|....*....|...
gi 19909883 505 SGLCFNPMKSILASASWDKTVRLWDMFDSWRTK 537
Cdd:COG2319 416 TSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSV 448
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
770-875 2.27e-24

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 427644  Cd Length: 106  Bit Score: 98.38  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883   770 NEKKLAQEALEAVPQNEIEVVSTSLPELYVVKVLEFLAASF-EESRHLEFYLIWTQKLLMSHGQRLKSRAgQLLPVVQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79
                          90       100
                  ....*....|....*....|....*..
gi 19909883   849 QKGLQRHLDDVSKLCDWNRFNIQYVLA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
322-629 5.10e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 5.10e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 322 LIHSLSISDQRVASVAINSSGDWIAFGCSGmGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 402 TLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSprPTQF-SCVAVDSSGEIVSAGAQDS 480
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWvNSVAFSPDGTFVASSSQDG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 481 FeIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMfDSWRTKETLTLTSDAL-AVTFRPDGAELA 559
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGHENGVnSVAFSPDGYLLA 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 560 VATLNSQITFWDPRMLYRWAPIRGrHDlktgrkeldkitakhsakgKAFTTLCYSADGQSILAGGMSKFV 629
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG-HT-------------------NSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
277-643 1.29e-33

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 135.60  E-value: 1.29e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 277 LAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELP-EFNLIHSLSISDQRVASVAINSSGDWIAFGCSGMGQL 355
Cdd:COG2319 101 IKSLEGLHDSSVSKLALSSPDGNSILLASSSLDGTVKLWDLStPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDGTI 180
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 356 LVWEWQSESYVLKQQGHFNSMVALAYSPDGQ-YIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSS 434
Cdd:COG2319 181 KLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS 260
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 435 LDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSfEIFVWSMQTGRLLDVLS--GHEGPVSGLCFNP- 511
Cdd:COG2319 261 SDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDG-TVRLWDLETGKLLSSLTlkGHEGPVSSLSFSPd 339
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 512 MKSILASASWDKTVRLWDMfDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPRMLyrwapirgrhdlktgr 591
Cdd:COG2319 340 GSLLVSGGSDDGTIRLWDL-RTGKPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTG---------------- 402
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 19909883 592 kELDKITAKHSakgKAFTTLCYSADGQSILAGGMSKFVCLYHVREQILVKRF 643
Cdd:COG2319 403 -SLLRNLDGHT---SRVTSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSVSF 450
WD40 COG2319
WD40 repeat [General function prediction only];
33-537 5.13e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 109.41  E-value: 5.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  33 VGNRVTVFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFV 112
Cdd:COG2319   2 VDNSSTSSENKSKLLKKSELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDGELLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 113 VTKGN-IAQMYHAPGKKREFNAFvldktYFGPYDETTCIDWT--DDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKD 189
Cdd:COG2319  82 SGSSDgTIKLWDLDNGEKLIKSL-----EGLHDSSVSKLALSspDGNSILLASSSLDGTVKLWDLSTPGKLIRTLEGHSE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 190 AIVA-CFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWkadilqrekeeeeedeeegdrettirgkttpaeqer 268
Cdd:COG2319 157 SVTSlAFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGHTDP------------------------------------ 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 269 VGKVKYSrlakyflnkegdfnnltsaayHKKTHLLVTGFASGIFHLHELPEFNLIHSlSISDQRVASVAINSSGDWIAFG 348
Cdd:COG2319 201 VSSLAFS---------------------PDGGLLIASGSSDGTIRLWDLSTGKLLRS-TLSGHSDSVVSSFSPDGSLLAS 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 349 CSGMGQLLVWEWQSESYVLKQ-QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTE--HSSGVTGVTFTT 425
Cdd:COG2319 259 GSSDGTIRLWDLRSSSSLLRTlSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLkgHEGPVSSLSFSP 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 426 TGHVIVTS-SLDGTVRAFDLHRYRNFRTFtsPRPTQFSCVAVDSSGEIVSAGAQDSFeIFVWSMQTGRLLDVLSGHEGPV 504
Cdd:COG2319 339 DGSLLVSGgSDDGTIRLWDLRTGKPLKTL--EGHSNVLSVSFSPDGRVVSSGSTDGT-VRLWDLSTGSLLRNLDGHTSRV 415
                       490       500       510
                ....*....|....*....|....*....|...
gi 19909883 505 SGLCFNPMKSILASASWDKTVRLWDMFDSWRTK 537
Cdd:COG2319 416 TSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSV 448
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
770-875 2.27e-24

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 427644  Cd Length: 106  Bit Score: 98.38  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883   770 NEKKLAQEALEAVPQNEIEVVSTSLPELYVVKVLEFLAASF-EESRHLEFYLIWTQKLLMSHGQRLKSRAgQLLPVVQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79
                          90       100
                  ....*....|....*....|....*..
gi 19909883   849 QKGLQRHLDDVSKLCDWNRFNIQYVLA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
490-529 2.37e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 2.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19909883    490 TGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
20-401 8.20e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 8.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  20 LNFTHDGNSVISPVGNR-VTVFDLKNNR-SNTLPLATKyNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFH-FK 96
Cdd:cd00200  15 VAFSPDGKLLATGSGDGtIKVWDLETGElLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  97 GSVHSVSFSPDGRkFVVTKG--NIAQMYhapgkkrEFNAFVLDKTYFGPYDETTCIDWTDDSKcFVVGSKDMST---WVF 171
Cdd:cd00200  94 SYVSSVAFSPDGR-ILSSSSrdKTIKVW-------DVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTiklWDL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 172 GAERwdnlIYYALSGHKDAIvacffesnsldlyslsqdgalcvwqcdtppeglrlkaprgwkadilqrekeeeeedeeeg 251
Cdd:cd00200 165 RTGK----CVATLTGHTGEV------------------------------------------------------------ 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 252 drettirgkttpaeqervgkvkysrlakyflnkegdfnnlTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQ 331
Cdd:cd00200 181 ----------------------------------------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 332 RVASVAINSSGDWIAfGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200 221 GVNSVAFSPDGYLLA-SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
491-529 3.91e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.91e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19909883   491 GRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
322-629 5.10e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.05  E-value: 5.10e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 322 LIHSLSISDQRVASVAINSSGDWIAFGCSGmGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGD-GTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 402 TLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSprPTQF-SCVAVDSSGEIVSAGAQDS 480
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWvNSVAFSPDGTFVASSSQDG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 481 FeIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMfDSWRTKETLTLTSDAL-AVTFRPDGAELA 559
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-STGKCLGTLRGHENGVnSVAFSPDGYLLA 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 560 VATLNSQITFWDPRMLYRWAPIRGrHDlktgrkeldkitakhsakgKAFTTLCYSADGQSILAGGMSKFV 629
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG-HT-------------------NSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
302-529 2.94e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 2.94e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 302 LLVTGFASGIFhLHELPEFNLIHSLSISDQRVASVAINSSGDWIAfGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAY 381
Cdd:cd00200  66 LASGSSDKTIR-LWDLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 382 SPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSpRPTQF 461
Cdd:cd00200 144 SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-HENGV 222
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19909883 462 SCVAVDSSGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:cd00200 223 NSVAFSPDGYLLASGSEDG-TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
277-643 1.29e-33

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 135.60  E-value: 1.29e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 277 LAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELP-EFNLIHSLSISDQRVASVAINSSGDWIAFGCSGMGQL 355
Cdd:COG2319 101 IKSLEGLHDSSVSKLALSSPDGNSILLASSSLDGTVKLWDLStPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDGTI 180
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 356 LVWEWQSESYVLKQQGHFNSMVALAYSPDGQ-YIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSS 434
Cdd:COG2319 181 KLWDLRTGKPLSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGS 260
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 435 LDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSfEIFVWSMQTGRLLDVLS--GHEGPVSGLCFNP- 511
Cdd:COG2319 261 SDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDG-TVRLWDLETGKLLSSLTlkGHEGPVSSLSFSPd 339
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 512 MKSILASASWDKTVRLWDMfDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPRMLyrwapirgrhdlktgr 591
Cdd:COG2319 340 GSLLVSGGSDDGTIRLWDL-RTGKPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTG---------------- 402
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 19909883 592 kELDKITAKHSakgKAFTTLCYSADGQSILAGGMSKFVCLYHVREQILVKRF 643
Cdd:COG2319 403 -SLLRNLDGHT---SRVTSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSVSF 450
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
370-726 1.26e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 1.26e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRN 449
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 450 FRTFTSPRPTqFSCVAVDSSGEIVSAGAQDSfEIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:cd00200  86 VRTLTGHTSY-VSSVAFSPDGRILSSSSRDK-TIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 530 MfDSWRTKETLTLtsdalavtfrpdgaelavatlnsqitfwdprmlyrwapirgrHDlktgrkeldkitakhsakgKAFT 609
Cdd:cd00200 164 L-RTGKCVATLTG------------------------------------------HT-------------------GEVN 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 610 TLCYSADGQSILAGGMSKFVCLYHVREQILVKrfelscnlSLDAMEEFLNRRNMTEFGNLALidqdAGEENGVAVpLPGV 689
Cdd:cd00200 182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG--------TLRGHENGVNSVAFSPDGYLLA----SGSEDGTIR-VWDL 248
                       330       340       350
                ....*....|....*....|....*....|....*..
gi 19909883 690 RKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLL 726
Cdd:cd00200 249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
370-645 1.02e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 111.72  E-value: 1.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGH-----VIVTSSLDGTVRAFDL 444
Cdd:COG2319  62 RGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSLEGLHDSSVSKLALSSPdgnsiLLASSSLDGTVKLWDL 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 445 HRYRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPVSGLCFNP-MKSILASASWDK 523
Cdd:COG2319 142 STPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGHTDPVSSLAFSPdGGLLIASGSSDG 221
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 524 TVRLWDMFDSWRTKETLTLTSDALAVTFRPDGAELAVATLNSQITFWDPRMLyrwapirgrhdlktgrKELDKITAKHSa 603
Cdd:COG2319 222 TIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLRSS----------------SSLLRTLSGHS- 284
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 19909883 604 kgKAFTTLCYSADGQSILAGGMSKFVCLYHVREQILVKRFEL 645
Cdd:COG2319 285 --SSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTL 324
WD40 COG2319
WD40 repeat [General function prediction only];
33-537 5.13e-25

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 109.41  E-value: 5.13e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  33 VGNRVTVFDLKNNRSNTLPLATKYNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFV 112
Cdd:COG2319   2 VDNSSTSSENKSKLLKKSELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDGELLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 113 VTKGN-IAQMYHAPGKKREFNAFvldktYFGPYDETTCIDWT--DDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKD 189
Cdd:COG2319  82 SGSSDgTIKLWDLDNGEKLIKSL-----EGLHDSSVSKLALSspDGNSILLASSSLDGTVKLWDLSTPGKLIRTLEGHSE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 190 AIVA-CFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWkadilqrekeeeeedeeegdrettirgkttpaeqer 268
Cdd:COG2319 157 SVTSlAFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGHTDP------------------------------------ 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 269 VGKVKYSrlakyflnkegdfnnltsaayHKKTHLLVTGFASGIFHLHELPEFNLIHSlSISDQRVASVAINSSGDWIAFG 348
Cdd:COG2319 201 VSSLAFS---------------------PDGGLLIASGSSDGTIRLWDLSTGKLLRS-TLSGHSDSVVSSFSPDGSLLAS 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 349 CSGMGQLLVWEWQSESYVLKQ-QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTE--HSSGVTGVTFTT 425
Cdd:COG2319 259 GSSDGTIRLWDLRSSSSLLRTlSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLkgHEGPVSSLSFSP 338
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 426 TGHVIVTS-SLDGTVRAFDLHRYRNFRTFtsPRPTQFSCVAVDSSGEIVSAGAQDSFeIFVWSMQTGRLLDVLSGHEGPV 504
Cdd:COG2319 339 DGSLLVSGgSDDGTIRLWDLRTGKPLKTL--EGHSNVLSVSFSPDGRVVSSGSTDGT-VRLWDLSTGSLLRNLDGHTSRV 415
                       490       500       510
                ....*....|....*....|....*....|...
gi 19909883 505 SGLCFNPMKSILASASWDKTVRLWDMFDSWRTK 537
Cdd:COG2319 416 TSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSV 448
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
770-875 2.27e-24

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 427644  Cd Length: 106  Bit Score: 98.38  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883   770 NEKKLAQEALEAVPQNEIEVVSTSLPELYVVKVLEFLAASF-EESRHLEFYLIWTQKLLMSHGQRLKSRAgQLLPVVQFL 848
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSNP-DLRPVLRSL 79
                          90       100
                  ....*....|....*....|....*..
gi 19909883   849 QKGLQRHLDDVSKLCDWNRFNIQYVLA 875
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
58-469 2.77e-18

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 88.99  E-value: 2.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  58 IKCVGLSPDGRLAIIVDEGGAALLVSLVC-RSVLHHFHFK--GSVHSVSF-SPDGRKFVVTKGNIaqmyhaPGKKREFN- 132
Cdd:COG2319  68 ITSIAFSPDGELLLSGSSDGTIKLWDLDNgEKLIKSLEGLhdSSVSKLALsSPDGNSILLASSSL------DGTVKLWDl 141
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 133 --AFVLDKTYFGPYDETTCIDWTDDSKCFVVGS-KDMSTWVFGAERWDNLiyYALSGHKDAIVAC-FFESNSLDLYSLSQ 208
Cdd:COG2319 142 stPGKLIRTLEGHSESVTSLAFSPDGKLLASGSsLDGTIKLWDLRTGKPL--STLAGHTDPVSSLaFSPDGGLLIASGSS 219
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 209 DGALCVWQCDTppeGLRLKAPRGWKADILQREKEEEEEDEEEGDRETTIRGKTTpaeqervgKVKYSRLAKYFLNKEGdf 288
Cdd:COG2319 220 DGTIRLWDLST---GKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDL--------RSSSSLLRTLSGHSSS-- 286
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 289 nnLTSAAYHKKTHLLVTGFASGIFHLHEL--PEFNLIHSLSISDQRVASVAINSSGDWIAFGCSGMGQLLVWEWqSESYV 366
Cdd:COG2319 287 --VLSVAFSPDGKLLASGSSDGTVRLWDLetGKLLSSLTLKGHEGPVSSLSFSPDGSLLVSGGSDDGTIRLWDL-RTGKP 363
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 367 LKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHR 446
Cdd:COG2319 364 LKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDLKT 443
                       410       420
                ....*....|....*....|...
gi 19909883 447 YRNFRTFTSPRPTQFSCVAVDSS 469
Cdd:COG2319 444 SLKSVSFSPDGKVLASKSSDLSV 466
WD40 COG2319
WD40 repeat [General function prediction only];
22-413 2.28e-15

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 79.75  E-value: 2.28e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  22 FTHDGNSVISPVG---NRVTVFDLKNNRSNTLPLATKY-NIKCVGLSPDGR-LAIIVDEGGAALLVSLVCRSVLH--HFH 94
Cdd:COG2319 118 SSPDGNSILLASSsldGTVKLWDLSTPGKLIRTLEGHSeSVTSLAFSPDGKlLASGSSLDGTIKLWDLRTGKPLStlAGH 197
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  95 fKGSVHSVSFSPDGRKFVVTKGNIAQMYHapgkkREFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAE 174
Cdd:COG2319 198 -TDPVSSLAFSPDGGLLIASGSSDGTIRL-----WDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIRLWDLR 271
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 175 RWDNLIYYaLSGHKDAIVACFFESNSLDLYSLSQDGALCVWQCDTPPEglrlkaprgwkadilqrekeeeeedeeegdre 254
Cdd:COG2319 272 SSSSLLRT-LSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKL-------------------------------- 318
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 255 ttirgkttpaeqervgkvkysrlaKYFLNKEGDFNNLTSAAYHKKTHLLVTGFAS-GIFHLHELPEFNLIHSLSISDQrV 333
Cdd:COG2319 319 ------------------------LSSLTLKGHEGPVSSLSFSPDGSLLVSGGSDdGTIRLWDLRTGKPLKTLEGHSN-V 373
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 334 ASVAINSSGDWIAFgCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTLTE 413
Cdd:COG2319 374 LSVSFSPDGRVVSS-GSTDGTVRLWDLSTGSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDLKTSLKSVSFSP 452
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
490-529 2.37e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 2.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19909883    490 TGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
20-401 8.20e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 8.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  20 LNFTHDGNSVISPVGNR-VTVFDLKNNR-SNTLPLATKyNIKCVGLSPDGRLAIIVDEGGAALLVSLVCRSVLHHFH-FK 96
Cdd:cd00200  15 VAFSPDGKLLATGSGDGtIKVWDLETGElLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTgHT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  97 GSVHSVSFSPDGRkFVVTKG--NIAQMYhapgkkrEFNAFVLDKTYFGPYDETTCIDWTDDSKcFVVGSKDMST---WVF 171
Cdd:cd00200  94 SYVSSVAFSPDGR-ILSSSSrdKTIKVW-------DVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTiklWDL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 172 GAERwdnlIYYALSGHKDAIvacffesnsldlyslsqdgalcvwqcdtppeglrlkaprgwkadilqrekeeeeedeeeg 251
Cdd:cd00200 165 RTGK----CVATLTGHTGEV------------------------------------------------------------ 180
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 252 drettirgkttpaeqervgkvkysrlakyflnkegdfnnlTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQ 331
Cdd:cd00200 181 ----------------------------------------NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 332 RVASVAINSSGDWIAfGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:cd00200 221 GVNSVAFSPDGYLLA-SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
491-529 3.91e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.91e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19909883   491 GRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
20-397 7.70e-08

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 55.87  E-value: 7.70e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  20 LNFTHDGNSVISPVGNRVTV--FDLKNNRSNTLPLATKYNIKCVGLSPDGRLAII-VDEGGAALLVSLVCRSVLH---HF 93
Cdd:COG2319 161 LAFSPDGKLLASGSSLDGTIklWDLRTGKPLSTLAGHTDPVSSLAFSPDGGLLIAsGSSDGTIRLWDLSTGKLLRstlSG 240
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883  94 HFKGSVHSvsFSPDGRKFVVT-KGNIAQMYHAPGKKREFnafvldKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFG 172
Cdd:COG2319 241 HSDSVVSS--FSPDGSLLASGsSDGTIRLWDLRSSSSLL------RTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWD 312
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 173 AERWDNLIYYALSGHKDAIVACFFESNSLDLY-SLSQDGALCVWQCDTppeglrlkaprgwkadilqrekeeeeedeeeg 251
Cdd:COG2319 313 LETGKLLSSLTLKGHEGPVSSLSFSPDGSLLVsGGSDDGTIRLWDLRT-------------------------------- 360
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 252 drettirgkttpaeqervgkvkysrlaKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQ 331
Cdd:COG2319 361 ---------------------------GKPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGHTS 413
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19909883 332 RVASVAINSSGDWIAFGCSGmGQLLVWEWQSESYVlkqqghfnsmvaLAYSPDGQYIVTGGDDGKV 397
Cdd:COG2319 414 RVTSLDFSPDGKSLASGSSD-NTIRLWDLKTSLKS------------VSFSPDGKVLASKSSDLSV 466
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
362-401 1.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.16e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19909883    362 SESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
370-401 1.78e-06

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.78e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 19909883   370 QGHFNSMVALAYSPDGQYIVTGGDDGKVKVWN 401
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
497-732 2.58e-05

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 47.78  E-value: 2.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 497 LSGHEGPVSGLCFNPMKSILASASWDKTVRLWDMFDSWRTKETLTLTSDALAVTFR---PDGAELAVAT--LNSQITFWD 571
Cdd:COG2319  61 LRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSLEGLHDSSVSKLAlssPDGNSILLASssLDGTVKLWD 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 572 PRMLYrwapirgrhdlktgrkeldKITAKHSAKGKAFTTLCYSADGQSILAGGMSK-FVCLYHVREQILVKrfelscnlS 650
Cdd:COG2319 141 LSTPG-------------------KLIRTLEGHSESVTSLAFSPDGKLLASGSSLDgTIKLWDLRTGKPLS--------T 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19909883 651 LDAMEEFLNRRNMTEFGNLALidqdAGEENGVAVPLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATSTEGLL-IFS 729
Cdd:COG2319 194 LAGHTDPVSSLAFSPDGGLLI----ASGSSDGTIRLWDLSTGKLLRSTLSGHSDSVVSSFSPDGSLLASGSSDGTIrLWD 269

                ...
gi 19909883 730 LDA 732
Cdd:COG2319 270 LRS 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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