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Conserved domains on  [gi|20072741|gb|AAH27411|]
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Lrcc33 protein [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-535 7.83e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 7.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 216 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 295
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 296 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 375
Cdd:COG4886  93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 376 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 455
Cdd:COG4886 169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 456 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 535
Cdd:COG4886 221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-354 6.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 6.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  46 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 125
Cdd:COG4886 114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 126 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNNLPCIVDF--SLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHNQ 201
Cdd:COG4886 187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNNQ 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 202 LLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFR 281
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20072741 282 HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 354
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-535 7.83e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 7.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 216 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 295
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 296 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 375
Cdd:COG4886  93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 376 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 455
Cdd:COG4886 169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 456 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 535
Cdd:COG4886 221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-354 6.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 6.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  46 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 125
Cdd:COG4886 114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 126 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNNLPCIVDF--SLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHNQ 201
Cdd:COG4886 187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNNQ 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 202 LLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFR 281
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20072741 282 HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 354
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 42-379 4.21e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741   42 REQGHLRNL---VLADNRLSenyKESAAALHTLLGLRRLDLSGNSLTEDMAAlMLQNLSSLEVVSLARNTLM-RLDDSIF 117
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLS---GEIPYEIGGLTSLNHLDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  118 eGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL----PCIVDfSLTQLRFLNVSYNILEWFLAAREEVAFELE 193
Cdd:PLN00113 282 -SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFtgkiPVALT-SLPRLQVLQLWSNKFSGEIPKNLGKHNNLT 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  194 ILDLSHN-----------------QLLFF---------PLLPQCGKLHTLLLQDNNmgFYRELYNTSSPQEMVAQFLLVD 247
Cdd:PLN00113 360 VLDLSTNnltgeipeglcssgnlfKLILFsnslegeipKSLGACRSLRRVRLQDNS--FSGELPSEFTKLPLVYFLDISN 437

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  248 GNVTNITTVNLWeefsssDLSALRFLDMSQNQFR-HLPDGFlkKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHN 326
Cdd:PLN00113 438 NNLQGRINSRKW------DMPSLQMLSLARNKFFgGLPDSF--GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 20072741  327 QLAelHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQIS 379
Cdd:PLN00113 510 KLS--GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
97-157 5.56e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 5.56e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741    97 SSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL 157
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 249-578 3.13e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  249 NVTNITTVNLWEEFSSSDLSALRF-------LDMSQNQFR-HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPpgALTE 320
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFrlpyiqtINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  321 LDLSHNQLA-ELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISlcpQMVPvdwegppscvdfR 399
Cdd:PLN00113 145 LDLSNNMLSgEI---PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV---GQIP------------R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  400 NMGSLRSLSLDGCGLKALQ-DCPFQ---GTSLTHLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSGAAEMDFSAF 475
Cdd:PLN00113 207 ELGQMKSLKWIYLGYNNLSgEIPYEiggLTSLNHLDLVYN--NLTGPIPSSLGNLKNLQYLFLYQNKL-SGPIPPSIFSL 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  476 GNLRALDLSGNSLT-SFPKFKGSL-ALRTLDLRRNSLTALPQRVVSEQPLrgLQTIYLSQNPYDCCGVEGWGalQQHFKT 553
Cdd:PLN00113 284 QKLISLDLSDNSLSgEIPELVIQLqNLEILHLFSNNFTGKIPVALTSLPR--LQVLQLWSNKFSGEIPKNLG--KHNNLT 359

                        330       340
                 ....*....|....*....|....*
gi 20072741  554 VADLSmvTCNLSSKIvrvvelPEGL 578
Cdd:PLN00113 360 VLDLS--TNNLTGEI------PEGL 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-222 4.65e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  93 LQNLSSLEVVSLARNTLMRLDDsiFEGLEHLVELDLQRNYIFEIEGgaFDGLTELRRLNLAYNNLP-----CIVDFSLT- 166
Cdd:cd21340  42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAa 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20072741 167 ---QLRFLNVSYN---ILEWFLAAREevafeLEILDLSHNQLL----FFPLLPQCGKLHTLLLQDN 222
Cdd:cd21340 118 lsnSLRVLNISGNnidSLEPLAPLRN-----LEQLDASNNQISdleeLLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 273-504 3.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 273 LDMSQNQFRHLPDgfLKKTPSLSHLNLNQNCLKmlHIREHEPPGALTELDLSHNQLAELhlaPGLtGSLRNLRVFNLSSN 352
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKI---ENL-ENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 353 QLlGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdwEGPPSCVDFRNM----GSLRSLSLDGCGLKALQDC-PFqgTSL 427
Cdd:cd21340  79 RI-SVVEGL-ENLTNLEELHIENQRLP----------PGEKLTFDPRSLaalsNSLRVLNISGNNIDSLEPLaPL--RNL 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 428 THLDLSSNwgvlngsisplwavaptlQVLSLRDVglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFK-----GSLALRT 502
Cdd:cd21340 145 EQLDASNN------------------QISDLEEL-------LDLLSSWPSLRELDLTGNPVCKKPKYRdkiilASKSLEV 199


                ..
gi 20072741 503 LD 504
Cdd:cd21340 200 LD 201
LRR_8 pfam13855
Leucine rich repeat;
318-378 4.34e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741   318 LTELDLSHNQLaeLHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQI 378
Cdd:pfam13855   3 LRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-535 7.83e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 7.83e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 216 TLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLS 295
Cdd:COG4886  13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 296 HLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFdNASSITTIDMSH 375
Cdd:COG4886  93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSN 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 376 NQISLCPQmvpvdwegppscvDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaptlqv 455
Cdd:COG4886 169 NQLTDLPE-------------ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN------QLTDL--------- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 456 lslrdvglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPqrvvSEQPLRGLQTIYLSQNP 535
Cdd:COG4886 221 -------------PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP----PLANLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-389 4.30e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 4.30e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  47 LRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLtedmaalmLQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVEL 126
Cdd:COG4886  71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE--------LSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKEL 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 127 DLQRNYIFEIeGGAFDGLTELRRLNLAYNNLPCIVDF--SLTQLRFLNVSYN---ILEWFLAAREEvafeLEILDLSHNQ 201
Cdd:COG4886 142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNqitDLPEPLGNLTN----LEELDLSGNQ 216

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 202 LLFFPL-LPQCGKLHTLLLQDNNmgfyrelyntsspqemvaqfllvdgnVTNITTVnlweefssSDLSALRFLDMSQNQF 280
Cdd:COG4886 217 LTDLPEpLANLTNLETLDLSNNQ--------------------------LTDLPEL--------GNLTNLEELDLSNNQL 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 281 RHLPDgfLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTG 360
Cdd:COG4886 263 TDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                       330       340
                ....*....|....*....|....*....
gi 20072741 361 LFDNASSITTIDMSHNQISLCPQMVPVDW 389
Cdd:COG4886 341 ALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
150-534 2.17e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 150 LNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRE 229
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 230 LYNTSSPQEMvaqfllvdGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDgflkktpSLSHLNlnqnclkmlhi 309
Cdd:COG4886  83 SLLLLGLTDL--------GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-------ELANLT----------- 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 310 reheppgALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdw 389
Cdd:COG4886 137 -------NLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQIT---------- 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 390 EGPPScvdFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLwavaPTLQVLSlrdvglgsgaae 469
Cdd:COG4886 196 DLPEP---LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN------QLTDL----PELGNLT------------ 250

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 20072741 470 mdfsafgNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQN 534
Cdd:COG4886 251 -------NLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-354 6.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 6.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  46 HLRNLVLADNRLSEnykeSAAALHTLLGLRRLDLSGNSLTEDMAALmlQNLSSLEVVSLARNTLMRLDDSIfEGLEHLVE 125
Cdd:COG4886 114 NLESLDLSGNQLTD----LPEELANLTNLKELDLSNNQLTDLPEPL--GNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKE 186

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 126 LDLQRNYIFEIeGGAFDGLTELRRLNLAYNNLPCIVDF--SLTQLRFLNVSYNILEWF--LAAREEvafeLEILDLSHNQ 201
Cdd:COG4886 187 LDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPlaNLTNLETLDLSNNQLTDLpeLGNLTN----LEELDLSNNQ 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 202 LLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFR 281
Cdd:COG4886 262 LTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20072741 282 HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQL 354
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 42-379 4.21e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741   42 REQGHLRNL---VLADNRLSenyKESAAALHTLLGLRRLDLSGNSLTEDMAAlMLQNLSSLEVVSLARNTLM-RLDDSIF 117
Cdd:PLN00113 206 RELGQMKSLkwiYLGYNNLS---GEIPYEIGGLTSLNHLDLVYNNLTGPIPS-SLGNLKNLQYLFLYQNKLSgPIPPSIF 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  118 eGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL----PCIVDfSLTQLRFLNVSYNILEWFLAAREEVAFELE 193
Cdd:PLN00113 282 -SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFtgkiPVALT-SLPRLQVLQLWSNKFSGEIPKNLGKHNNLT 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  194 ILDLSHN-----------------QLLFF---------PLLPQCGKLHTLLLQDNNmgFYRELYNTSSPQEMVAQFLLVD 247
Cdd:PLN00113 360 VLDLSTNnltgeipeglcssgnlfKLILFsnslegeipKSLGACRSLRRVRLQDNS--FSGELPSEFTKLPLVYFLDISN 437

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  248 GNVTNITTVNLWeefsssDLSALRFLDMSQNQFR-HLPDGFlkKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHN 326
Cdd:PLN00113 438 NNLQGRINSRKW------DMPSLQMLSLARNKFFgGLPDSF--GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 20072741  327 QLAelHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQIS 379
Cdd:PLN00113 510 KLS--GEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
97-157 5.56e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 5.56e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741    97 SSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNL 157
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 249-578 3.13e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 3.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  249 NVTNITTVNLWEEFSSSDLSALRF-------LDMSQNQFR-HLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPpgALTE 320
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFrlpyiqtINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLET 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  321 LDLSHNQLA-ELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISlcpQMVPvdwegppscvdfR 399
Cdd:PLN00113 145 LDLSNNMLSgEI---PNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV---GQIP------------R 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  400 NMGSLRSLSLDGCGLKALQ-DCPFQ---GTSLTHLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSGAAEMDFSAF 475
Cdd:PLN00113 207 ELGQMKSLKWIYLGYNNLSgEIPYEiggLTSLNHLDLVYN--NLTGPIPSSLGNLKNLQYLFLYQNKL-SGPIPPSIFSL 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  476 GNLRALDLSGNSLT-SFPKFKGSL-ALRTLDLRRNSLTALPQRVVSEQPLrgLQTIYLSQNPYDCCGVEGWGalQQHFKT 553
Cdd:PLN00113 284 QKLISLDLSDNSLSgEIPELVIQLqNLEILHLFSNNFTGKIPVALTSLPR--LQVLQLWSNKFSGEIPKNLG--KHNNLT 359

                        330       340
                 ....*....|....*....|....*
gi 20072741  554 VADLSmvTCNLSSKIvrvvelPEGL 578
Cdd:PLN00113 360 VLDLS--TNNLTGEI------PEGL 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-222 4.65e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  93 LQNLSSLEVVSLARNTLMRLDDsiFEGLEHLVELDLQRNYIFEIEGgaFDGLTELRRLNLAYNNLP-----CIVDFSLT- 166
Cdd:cd21340  42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPpgeklTFDPRSLAa 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20072741 167 ---QLRFLNVSYN---ILEWFLAAREevafeLEILDLSHNQLL----FFPLLPQCGKLHTLLLQDN 222
Cdd:cd21340 118 lsnSLRVLNISGNnidSLEPLAPLRN-----LEQLDASNNQISdleeLLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 77-311 5.15e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 5.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  77 LDLSGNSLTEdmaalmLQNLS---SLEVVSLARNTLMRLDDsiFEGLEHLVELDLQRNYIFEIEGgaFDGLTELRRLNLA 153
Cdd:cd21340   7 LYLNDKNITK------IDNLSlckNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 154 YNNLPCIVDF-SLTQLRFLNVSYNIlewfLAAREEVAFELEILD-LSHNqllffpllpqcgkLHTLLLQDNNMGFYRELY 231
Cdd:cd21340  77 GNRISVVEGLeNLTNLEELHIENQR----LPPGEKLTFDPRSLAaLSNS-------------LRVLNISGNNIDSLEPLA 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 232 NtsspqemvaqfllvdgnvtnittvnlweefsssdLSALRFLDMSQNQFRHLPD--GFLKKTPSLSHLNLNQNCL-KMLH 308
Cdd:cd21340 140 P----------------------------------LRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVcKKPK 185


                ...
gi 20072741 309 IRE 311
Cdd:cd21340 186 YRD 188
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
298-515 8.72e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 8.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  298 NLNQNCLKMLHIRE--HEPPGALTELDLSHNQLaeLHLAPGLTGSLRNLRVfnlSSNQLLGVPTGLFDN----------- 364
Cdd:PRK15370 179 NKTELRLKILGLTTipACIPEQITTLILDNNEL--KSLPENLQGNIKTLYA---NSNQLTSIPATLPDTiqemelsinri 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  365 -------ASSITTIDMSHNQISLCPQMVPvdwEGppscvdfrnmgsLRSLSLDGCGLKAL-QDCPfqgTSLTHLDLSSNw 436
Cdd:PRK15370 254 telperlPSALQSLDLFHNKISCLPENLP---EE------------LRYLSVYDNSIRTLpAHLP---SGITHLNVQSN- 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  437 gvlngSISPLWAVAP-TLQVLSLRDVGLGSGAAEMDfsafGNLRALDLSGNSLTSFPKfkgSL--ALRTLDLRRNSLTAL 513
Cdd:PRK15370 315 -----SLTALPETLPpGLKTLEAGENALTSLPASLP----PELQVLDVSKNQITVLPE---TLppTITTLDVSRNALTNL 382


                 ..
gi 20072741  514 PQ 515
Cdd:PRK15370 383 PE 384
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
191-386 2.57e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  191 ELEILDLSHNQLLFFPLLPQcGKLHTLLLQDNNMgfyrelynTSSPQEMVAQFLLVDGNVTNITtvnlweEFSSSDLSAL 270
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQ-GNIKTLYANSNQL--------TSIPATLPDTIQEMELSINRIT------ELPERLPSAL 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  271 RFLDMSQNQFRHLPDGFlkkTPSLSHLNLNQNCLKMLhiREHEPPGaLTELDLSHNQLAEL--HLAPGLT---------- 338
Cdd:PRK15370 265 QSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTL--PAHLPSG-ITHLNVQSNSLTALpeTLPPGLKtleagenalt 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20072741  339 ---GSLR-NLRVFNLSSNQLLGVPTGLfdnASSITTIDMSHNQISLCPQMVP 386
Cdd:PRK15370 339 slpASLPpELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPENLP 387
LRR_8 pfam13855
Leucine rich repeat;
122-176 2.81e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20072741   122 HLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVD---FSLTQLRFLNVSYN 176
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-261 3.22e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 3.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741   1 MLILDANPLKDLwNHSLQAYPRLENLSLHSCHLDRISHyAFREQGHLRNLVLADNRLSENykesAAALHTLLGLRRLDLS 80
Cdd:COG4886 163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL----PEPLANLTNLETLDLS 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  81 GNSLTEdmaALMLQNLSSLEVVSLARNTLMRLDDSifEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCI 160
Cdd:COG4886 237 NNQLTD---LPELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 161 VDFSLTQLrFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMV 240
Cdd:COG4886 312 ELLILLLL-LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390

                       250       260
                ....*....|....*....|.
gi 20072741 241 AQFLLVDGNVTNITTVNLWEE 261
Cdd:COG4886 391 LLLLTTTAGVLLLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-511 1.27e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741   21 PRLENLSLHSCHLD-RISHYAFREQGHLRNLVLADNRLSENY-KESAAALHTL------------------LGLRRLDLS 80
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIpRGSIPNLETLdlsnnmlsgeipndigsfSSLKVLDLG 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741   81 GNSLTEDMAAlMLQNLSSLEVVSLARNTL----------MRLDDSIFEGLEHLV-ELDLQrnyifeieggaFDGLTELRR 149
Cdd:PLN00113 173 GNVLVGKIPN-SLTNLTSLEFLTLASNQLvgqiprelgqMKSLKWIYLGYNNLSgEIPYE-----------IGGLTSLNH 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  150 LNLAYNNLPCIVDFS---LTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLlffpllpqCGKLHTLLLQDNNMgf 226
Cdd:PLN00113 241 LDLVYNNLTGPIPSSlgnLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL--------SGEIPELVIQLQNL-- 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  227 yrelyntsspqEMVAQFllvDGNVTNITTVNLweefssSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKM 306
Cdd:PLN00113 311 -----------EILHLF---SNNFTGKIPVAL------TSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTG 370

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  307 LHIREHEPPGALTELDLSHNQLaELHLAPGLtGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISlcPQMVP 386
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSL-EGEIPKSL-GACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ--GRINS 446

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  387 VDWEgppscvdfrnMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNwgVLNGSISPLWAVAPTLQVLSLRDVGLgSG 466
Cdd:PLN00113 447 RKWD----------MPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRN--QFSGAVPRKLGSLSELMQLKLSENKL-SG 513

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 20072741  467 AAEMDFSAFGNLRALDLSGNSLT-----SFPKFKgslALRTLDLRRNSLT 511
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLSgqipaSFSEMP---VLSQLDLSQNQLS 560
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 273-504 3.60e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 273 LDMSQNQFRHLPDgfLKKTPSLSHLNLNQNCLKmlHIREHEPPGALTELDLSHNQLAELhlaPGLtGSLRNLRVFNLSSN 352
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKI---ENL-ENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 353 QLlGVPTGLfDNASSITTIDMSHNQISlcpqmvpvdwEGPPSCVDFRNM----GSLRSLSLDGCGLKALQDC-PFqgTSL 427
Cdd:cd21340  79 RI-SVVEGL-ENLTNLEELHIENQRLP----------PGEKLTFDPRSLaalsNSLRVLNISGNNIDSLEPLaPL--RNL 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 428 THLDLSSNwgvlngsisplwavaptlQVLSLRDVglgsgaaEMDFSAFGNLRALDLSGNSLTSFPKFK-----GSLALRT 502
Cdd:cd21340 145 EQLDASNN------------------QISDLEEL-------LDLLSSWPSLRELDLTGNPVCKKPKYRdkiilASKSLEV 199


                ..
gi 20072741 503 LD 504
Cdd:cd21340 200 LD 201
LRR_8 pfam13855
Leucine rich repeat;
318-378 4.34e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741   318 LTELDLSHNQLaeLHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQI 378
Cdd:pfam13855   3 LRSLDLSNNRL--TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 297-542 4.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 4.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 297 LNLNQNCLKMLHIREHEPP-GALTELDLSHNQLAELHlAPGLTGSLR---NLRVFNLSSNQLLGVPTGL------FDNAS 366
Cdd:cd00116   3 LSLKGELLKTERATELLPKlLCLQVLRLEGNTLGEEA-AKALASALRpqpSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 367 SITTIDMSHNqiSLCPqmvpvdwEGPPSCVDFRNMGSLRSLSLDGCGL---------KALQDCPfqgTSLTHLDLSSNwG 437
Cdd:cd00116  82 GLQELDLSDN--ALGP-------DGCGVLESLLRSSSLQELKLNNNGLgdrglrllaKGLKDLP---PALEKLVLGRN-R 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 438 VLNGSISPLWAVAP---TLQVLSLRDVGLGSGAAEM---DFSAFGNLRALDLSGNSLTSF------PKFKGSLALRTLDL 505
Cdd:cd00116 149 LEGASCEALAKALRanrDLKELNLANNGIGDAGIRAlaeGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNL 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 20072741 506 RRNSLTALPQRVVSEQ---PLRGLQTIYLSQNPYDCCGVE 542
Cdd:cd00116 229 GDNNLTDAGAAALASAllsPNISLLTLSLSCNDITDDGAK 268
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
315-535 4.73e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.78  E-value: 4.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  315 PGALTELDLSHNQLAELhlaPGLTGSLRNLRVFNLSSNQLLGVPTGLfdnassiTTIDMSHNQISLCPQMVPVDWEgppS 394
Cdd:PRK15387 241 PPELRTLEVSGNQLTSL---PVLPPGLLELSIFSNPLTHLPALPSGL-------CKLWIFGNQLTSLPVLPPGLQE---L 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  395 CVDFRNMGSLRSLSLDGCGLKA----LQDCPFQGTSLTHLDLSSN----WGVLNGSISPLWAVAPTLQVLSlrdvGLGSG 466
Cdd:PRK15387 308 SVSDNQLASLPALPSELCKLWAynnqLTSLPTLPSGLQELSVSDNqlasLPTLPSELYKLWAYNNRLTSLP----ALPSG 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741  467 AAEMDFSafGN-----------LRALDLSGNSLTSFPKFKGSLAlrTLDLRRNSLTALPQRVVSeqpLRGLQTIYLSQNP 535
Cdd:PRK15387 384 LKELIVS--GNrltslpvlpseLKELMVSGNRLTSLPMLPSGLL--SLSVYRNQLTRLPESLIH---LSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
73-133 3.62e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741    73 GLRRLDLSGNSLTeDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYI 133
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
270-328 4.40e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 20072741   270 LRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQL 328
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
477-535 6.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 6.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20072741   477 NLRALDLSGNSLTSFPK--FKGSLALRTLDLRRNSLTALPQRVVSeqPLRGLQTIYLSQNP 535
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 318-514 2.27e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 2.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 318 LTELDLSHNQLAELhlapGLTGSLRNLRVFNLSSNQLLGVPTglFDNASSITTIDMSHNQISlcpqmvpvdwegppSCVD 397
Cdd:cd21340   4 ITHLYLNDKNITKI----DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIE--------------KIEN 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 398 FRNMGSLRSLSLDG---CGLKALQDCpfqgTSLTHLDLSsnwgvlNGSISP----------LWAVAPTLQVLSLRDVGLG 464
Cdd:cd21340  64 LENLVNLKKLYLGGnriSVVEGLENL----TNLEELHIE------NQRLPPgekltfdprsLAALSNSLRVLNISGNNID 133

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 20072741 465 SGAaemDFSAFGNLRALDLSGNSLTSFPKFKGSLA----LRTLDLRRNSLTALP 514
Cdd:cd21340 134 SLE---PLAPLRNLEQLDASNNQISDLEELLDLLSswpsLRELDLTGNPVCKKP 184
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 309-567 2.57e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 309 IREHEPPGALTELDLShNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNasSITTIDMSHNQISLCpqmvpvd 388
Cdd:COG5238 126 TLEDSLILYLALPRRI-NLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNN--SVETVYLGCNQIGDE------- 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 389 wegppscvdfrnmgslrslsldgcGLKALQDCPFQGTSLTHLDLSSNwgvlngSISPLWAVA--------PTLQVLSLRD 460
Cdd:COG5238 196 ------------------------GIEELAEALTQNTTVTTLWLKRN------PIGDEGAEIlaealkgnKSLTTLDLSN 245

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 461 VGLGSGAAEMDFSAFGN---LRALDLSGNSLTSfpkfKGSLALRTLdLRRNSltalpqrvvseqplrGLQTIYLSQNPyd 537
Cdd:COG5238 246 NQIGDEGVIALAEALKNnttVETLYLSGNQIGA----EGAIALAKA-LQGNT---------------TLTSLDLSVNR-- 303

                       250       260       270
                ....*....|....*....|....*....|...
gi 20072741 538 cCGVEGWGALQQHF---KTVADLSMVTCNLSSK 567
Cdd:COG5238 304 -IGDEGAIALAEGLqgnKTLHTLNLAYNGIGAQ 335
LRR_8 pfam13855
Leucine rich repeat;
342-414 3.98e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 3.98e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20072741   342 RNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLcpqmvpVDWEgppscvDFRNMGSLRSLSLDGCGL 414
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT------LSPG------AFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
21-84 2.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20072741    21 PRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSEnykESAAALHTLLGLRRLDLSGNSL 84
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT---LSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 192-493 6.68e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 6.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 192 LEILDLSHNQL------LFFPLLPQCGKLHTLLLQDNNMGfyrelyntsspqemvaqfllvdgnvtnittvnlweefsss 265
Cdd:COG5238 182 VETVYLGCNQIgdegieELAEALTQNTTVTTLWLKRNPIG---------------------------------------- 221

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 266 DLSALRFLDMsqnqfrhlpdgfLKKTPSLSHLNLNQNCLK---MLHIREH-EPPGALTELDLSHNQLAELHLApgltgsl 341
Cdd:COG5238 222 DEGAEILAEA------------LKGNKSLTTLDLSNNQIGdegVIALAEAlKNNTTVETLYLSGNQIGAEGAI------- 282

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 342 rnlrvfnlssnqllGVPTGLFDNaSSITTIDMSHNQIslcpqmvpvdweGPPSCVDF----RNMGSLRSLSLDGCGL--- 414
Cdd:COG5238 283 --------------ALAKALQGN-TTLTSLDLSVNRI------------GDEGAIALaeglQGNKTLHTLNLAYNGIgaq 335

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 415 ------KALQdcpfQGTSLTHLDLSSNwgvlngSISPLWAVA--------PTLQVLSLRDVGLGS-GAAEM-DFSAFGNL 478
Cdd:COG5238 336 gaialaKALQ----ENTTLHSLDLSDN------QIGDEGAIAlakylegnTTLRELNLGKNNIGKqGAEALiDALQTNRL 405

                       330
                ....*....|....*
gi 20072741 479 RALDLSGNSLTSFPK 493
Cdd:COG5238 406 HTLILDGNLIGAEAQ 420
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 317-513 9.12e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 9.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 317 ALTELDLSHNQLAELH---LAPGLTGSLRnLRVFNLSSNQL--LGVpTGLFD---NASSITTIDMSHNQIslcpqmvpvD 388
Cdd:COG5238 209 TVTTLWLKRNPIGDEGaeiLAEALKGNKS-LTTLDLSNNQIgdEGV-IALAEalkNNTTVETLYLSGNQI---------G 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 389 WEGppscvdfrnmgsLRSLSldgcglKALQDcpfqGTSLTHLDLSSNWGVLNGSIsplwAVAPTLQVLS-LRDVGLGS-- 465
Cdd:COG5238 278 AEG------------AIALA------KALQG----NTTLTSLDLSVNRIGDEGAI----ALAEGLQGNKtLHTLNLAYng 331

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20072741 466 -GAAEMDFSAFG-----NLRALDLSGNSLT-----SFPKF-KGSLALRTLDLRRNSLTAL 513
Cdd:COG5238 332 iGAQGAIALAKAlqentTLHSLDLSDNQIGdegaiALAKYlEGNTTLRELNLGKNNIGKQ 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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