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Conserved domains on  [gi|20140196|sp|Q99K85|]
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RecName: Full=Phosphoserine aminotransferase; Short=PSAT; AltName: Full=Endometrial progesterone-induced protein; Short=EPIP; AltName: Full=Phosphohydroxythreonine aminotransferase

Protein Classification

3-phosphoserine/phosphohydroxythreonine aminotransferase( domain architecture ID 10089690)

3-phosphoserine/phosphohydroxythreonine aminotransferase catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
8-366 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


:

Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 632.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   8 VNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVP 87
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  88 LNLIGLKagRSADYVVTGAWSAKAAEEAKKFGT-VNIVHPKL-GSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFV 165
Cdd:cd00611  81 LNLLGDK--GTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEeGKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 166 PDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPC 245
Cdd:cd00611 159 PDTGGVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPT 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 246 FSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDKAV 325
Cdd:cd00611 239 FAIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAE 314
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 20140196 326 ELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLE 366
Cdd:cd00611 315 AAGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
 
Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
8-366 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 632.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   8 VNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVP 87
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  88 LNLIGLKagRSADYVVTGAWSAKAAEEAKKFGT-VNIVHPKL-GSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFV 165
Cdd:cd00611  81 LNLLGDK--GTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEeGKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 166 PDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPC 245
Cdd:cd00611 159 PDTGGVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPT 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 246 FSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDKAV 325
Cdd:cd00611 239 FAIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAE 314
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 20140196 326 ELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLE 366
Cdd:cd00611 315 AAGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
15-368 0e+00

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 613.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    15 AKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPLNLigLK 94
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNL--LA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    95 AGRSADYVVTGAWSAKAAEEAKKFGTVNIV-HPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFVPDVKGAVL 173
Cdd:TIGR01364  79 EGKVADYIVTGAWSKKAAKEAKKYGVVNVVaSGKEGNYTKIPDPSTWEISEDAAYVHYCANETIHGVEFRELPDVKNAPL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   174 VCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPCFSIYVMGM 253
Cdd:TIGR01364 159 VADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   254 VLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNakgdEALEKRFLDKAVELNMISLK 333
Cdd:TIGR01364 239 VFKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNGFYRNPVDPRNRSRMNVVFTLGN----EELEKRFLKEAEERGLVSLK 314
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 20140196   334 GHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMH 368
Cdd:TIGR01364 315 GHRSVGGMRASIYNAMPLEGVQALVDFMKEFQKKH 349
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
5-364 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 586.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    5 KQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFS 84
Cdd:PRK05355   2 MRVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNIPDNYKVLFLQGGASLQFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   85 AVPLNLigLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHP-KLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFD 163
Cdd:PRK05355  82 MVPMNL--LGGGKKADYVDTGSWSKKAIKEAKKYGEVNVAASsEDDGFTYIPPLDEWQLSDDAAYVHYTSNETIDGTEFH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  164 FVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTP 243
Cdd:PRK05355 160 ELPDTGDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTP 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  244 PCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSqGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDK 323
Cdd:PRK05355 240 PTFAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSS-DFYRNPVAPEDRSRMNVPFTL----ADEELDKKFLAE 314
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 20140196  324 AVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNF 364
Cdd:PRK05355 315 AKAAGLVGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEF 355
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
5-368 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 566.62  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   5 KQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFS 84
Cdd:COG1932   1 MRVYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  85 AVPLNLIGlkAGRSADYVVTGAWSAKAAEEAKKFGTVNIVH-PKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFD 163
Cdd:COG1932  81 MVPMNLLR--GGKKADYLVTGEWSKKAIKEAKKYGEVNVVAsSEDDNFGYIPKPEEWQLSPDADYVHYTSNETITGVEFH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 164 FVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTP 243
Cdd:COG1932 159 ELPDVGDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTP 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 244 PCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSqGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDK 323
Cdd:COG1932 239 PTFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDAS-DFYTNPVDPEDRSRMNVTFDL----ADEELDAAFLAE 313
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 20140196 324 AVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMH 368
Cdd:COG1932 314 AKAAGLVGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERRH 358
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
7-357 5.62e-87

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 267.19  E-value: 5.62e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196     7 VVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISvlEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSgQFSAV 86
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGTTE-AINLV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    87 PLNLI-GLKAGRSADYVVTGAWSAK-AAEEAKKFGTVNIVHPKL---GSYTkiPDPSTWNLNPDASYVYFCANETVHGVE 161
Cdd:pfam00266  78 ALSLGrSLKPGDEIVITEMEHHANLvPWQELAKRTGARVRVLPLdedGLLD--LDELEKLITPKTKLVAITHVSNVTGTI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   162 FDfVPDV------KGAVLVCDMSSNFLSRPVDVSKFGV--IFAGAQKNVGSAGVTVVIVRDDLLGF--------SLRECP 225
Cdd:pfam00266 156 QP-VPEIgklahqYGALVLVDAAQAIGHRPIDVQKLGVdfLAFSGHKLYGPTGIGVLYGRRDLLEKmppllgggGMIETV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   226 SvLDYKVQAGNNSLYN--TPPCFSIYVMGMVLEWIkNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERqNRSRMNI 303
Cdd:pfam00266 235 S-LQESTFADAPWKFEagTPNIAGIIGLGAALEYL-SEIGLEAIEKHEHELAQYLYERLLSLPGIRLYGPER-RASIISF 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20140196   304 PFRIGNAkgdeALEKRFLDK-AVELN------MISLKGHRSVGGIRASLYNAVTTEDVEKL 357
Cdd:pfam00266 312 NFKGVHP----HDVATLLDEsGIAVRsghhcaQPLMVRLGLGGTVRASFYIYNTQEDVDRL 368
 
Name Accession Description Interval E-value
PSAT_like cd00611
Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP) ...
8-366 0e+00

Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as a dimer and catalyzes the conversion of phosphohydroxypyruvate to phosphoserine.


Pssm-ID: 99736 [Multi-domain]  Cd Length: 355  Bit Score: 632.02  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   8 VNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVP 87
Cdd:cd00611   1 INFSAGPAALPEEVLEQAQKELLDFNGLGMSVMEMSHRSKDFEAIVNEAESDLRELLNIPDNYKVLFLQGGATGQFAAVP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  88 LNLIGLKagRSADYVVTGAWSAKAAEEAKKFGT-VNIVHPKL-GSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFV 165
Cdd:cd00611  81 LNLLGDK--GTADYVVTGAWSAKAAKEAKRYGGvVVIVAAKEeGKYTKIPDVETWDLAPDAAYVHYCSNETIHGVEFDEV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 166 PDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPC 245
Cdd:cd00611 159 PDTGGVPLVADMSSNILSRPIDVSKFGVIYAGAQKNLGPAGVTVVIVRKDLLGKARKITPSMLNYKTHADNNSLYNTPPT 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 246 FSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDKAV 325
Cdd:cd00611 239 FAIYMMGLVLKWLKEQGGVEAMEKRNRQKAQLLYDTIDNSNGFYRGPVDKRARSRMNVPFRL----GKEELEKEFLKEAE 314
                       330       340       350       360
                ....*....|....*....|....*....|....*....|.
gi 20140196 326 ELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLE 366
Cdd:cd00611 315 AAGMIGLKGHRSVGGIRASIYNALSLEGVQALADFMKEFQK 355
serC_1 TIGR01364
phosphoserine aminotransferase; This model represents the common form of the phosphoserine ...
15-368 0e+00

phosphoserine aminotransferase; This model represents the common form of the phosphoserine aminotransferase SerC. The phosphoserine aminotransferase of the archaeon Methanosarcina barkeri and putative phosphoserine aminotransferase of Mycobacterium tuberculosis are represented by separate models. All are members of the class V aminotransferases (pfam00266). [Amino acid biosynthesis, Serine family]


Pssm-ID: 130431  Cd Length: 349  Bit Score: 613.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    15 AKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPLNLigLK 94
Cdd:TIGR01364   1 AALPEEVLEQAQKELLNFNGTGMSVMEISHRSKEFEAVANEAESDLRELLNIPDNYEVLFLQGGATGQFAAVPLNL--LA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    95 AGRSADYVVTGAWSAKAAEEAKKFGTVNIV-HPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFVPDVKGAVL 173
Cdd:TIGR01364  79 EGKVADYIVTGAWSKKAAKEAKKYGVVNVVaSGKEGNYTKIPDPSTWEISEDAAYVHYCANETIHGVEFRELPDVKNAPL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   174 VCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPCFSIYVMGM 253
Cdd:TIGR01364 159 VADMSSNILSRPIDVSKFGLIYAGAQKNIGPAGLTVVIVRKDLLGRASRITPSMLNYKIHAENDSMYNTPPTFAIYVSGL 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   254 VLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNakgdEALEKRFLDKAVELNMISLK 333
Cdd:TIGR01364 239 VFKWLKEQGGVKAIEKRNQAKAQLLYDTIDNSNGFYRNPVDPRNRSRMNVVFTLGN----EELEKRFLKEAEERGLVSLK 314
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 20140196   334 GHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMH 368
Cdd:TIGR01364 315 GHRSVGGMRASIYNAMPLEGVQALVDFMKEFQKKH 349
PRK05355 PRK05355
3-phosphoserine/phosphohydroxythreonine transaminase;
5-364 0e+00

3-phosphoserine/phosphohydroxythreonine transaminase;


Pssm-ID: 235428  Cd Length: 360  Bit Score: 586.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    5 KQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFS 84
Cdd:PRK05355   2 MRVYNFSAGPAMLPEEVLEQAQQELLDWNGSGMSVMEISHRSKEFEAVAEEAEADLRELLNIPDNYKVLFLQGGASLQFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   85 AVPLNLigLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHP-KLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFD 163
Cdd:PRK05355  82 MVPMNL--LGGGKKADYVDTGSWSKKAIKEAKKYGEVNVAASsEDDGFTYIPPLDEWQLSDDAAYVHYTSNETIDGTEFH 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  164 FVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTP 243
Cdd:PRK05355 160 ELPDTGDVPLVADMSSDILSRPIDVSKFGLIYAGAQKNIGPAGLTIVIVREDLLGRALPSIPSMLDYKTHADNDSMYNTP 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  244 PCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSqGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDK 323
Cdd:PRK05355 240 PTFAIYLAGLVFKWLKEQGGVAAMEKRNQEKAALLYDAIDSS-DFYRNPVAPEDRSRMNVPFTL----ADEELDKKFLAE 314
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 20140196  324 AVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNF 364
Cdd:PRK05355 315 AKAAGLVGLKGHRSVGGMRASIYNAMPLEGVQALVDFMKEF 355
SerC COG1932
Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and ...
5-368 0e+00

Phosphoserine aminotransferase [Coenzyme transport and metabolism, Amino acid transport and metabolism]; Phosphoserine aminotransferase is part of the Pathway/BioSystem: Serine biosynthesis


Pssm-ID: 441535  Cd Length: 358  Bit Score: 566.62  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   5 KQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFS 84
Cdd:COG1932   1 MRVYNFSAGPAKLPEEVLEQAQAELLDWNGSGMSVMEMSHRSKPFKAIVEEAEADLRELLGIPDGYEVLFLQGGATAQFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  85 AVPLNLIGlkAGRSADYVVTGAWSAKAAEEAKKFGTVNIVH-PKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFD 163
Cdd:COG1932  81 MVPMNLLR--GGKKADYLVTGEWSKKAIKEAKKYGEVNVVAsSEDDNFGYIPKPEEWQLSPDADYVHYTSNETITGVEFH 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 164 FVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTP 243
Cdd:COG1932 159 ELPDVGDVPLVADMSSDILSRPVDVSKFGLIYAGAQKNIGPAGLTVVIVRPDLLGRAERAIPSMLDYKTHADNDSMYNTP 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 244 PCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSqGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRFLDK 323
Cdd:COG1932 239 PTFAIYLAGLVLKWLKEQGGLAAMEKRNAEKAALLYDWIDAS-DFYTNPVDPEDRSRMNVTFDL----ADEELDAAFLAE 313
                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 20140196 324 AVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMH 368
Cdd:COG1932 314 AKAAGLVGLKGHRSVGGMRASIYNAMPLEGVEALVDFMDEFERRH 358
PLN02452 PLN02452
phosphoserine transaminase
2-369 0e+00

phosphoserine transaminase


Pssm-ID: 178071  Cd Length: 365  Bit Score: 516.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    2 EATKQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSG 81
Cdd:PLN02452   3 GSQGRVFNFSAGPATLPANVLAKAQAELYNWEGSGMSVMEMSHRGKEFLSIIQKAEADLRELLDIPDNYEVLFLQGGAST 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   82 QFSAVPLNLIglKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHP-KLGSYTKIPDPSTWNLNPDASYVYFCANETVHGV 160
Cdd:PLN02452  83 QFAAIPLNLC--KPGDKADFVVTGSWSKKAAKEAKKYCKTNVIASgKDEKYTKIPSVSEWELTPDAKFVHICANETIHGV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  161 EFDFVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLY 240
Cdd:PLN02452 161 EFKDYPDVGNVPLVADMSSNFLSKPVDVSKYGVIYAGAQKNVGPSGVTIVIIRKDLIGNARPITPGMLDYKIHAENDSLY 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  241 NTPPCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIgnakGDEALEKRF 320
Cdd:PLN02452 241 NTPPCFGIYMCGLVFEDLLAQGGLKAMEKRNIRKADLLYDAIDESNGFYVCPVEKSVRSLMNVPFTL----GGSELEAEF 316
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 20140196  321 LDKAVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMHQ 369
Cdd:PLN02452 317 VKEAAKAGMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQAKHA 365
PRK12462 PRK12462
phosphoserine aminotransferase; Provisional
8-364 1.67e-127

phosphoserine aminotransferase; Provisional


Pssm-ID: 183540  Cd Length: 364  Bit Score: 370.68  E-value: 1.67e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    8 VNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVP 87
Cdd:PRK12462   6 LNFSGGPGALPDTVLEQVRQAVVELPETGLSVLGMSHRSSWFSSLLAQAEADLRDLLGIPDEYGVVFLQGGSSLQFSMIP 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   88 LNLIgLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIV-HPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFVP 166
Cdd:PRK12462  86 MNFS-RPGAAAPEYVTTGYWSRKAIGEASRVAAMRVVwDGAASGYRTLPSLAELDWDARAPFRHYVSNETVEGLQFPDAA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  167 DVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPCF 246
Cdd:PRK12462 165 GLPDSPLIADMSSDFMSRPFDVEAYGMVYAHAQKNLGPAGVTVAIIRRALLERVPDTLPPMLDFRTHVEHRSNYNTPPVF 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  247 SIYVMGMVLEWIKNN-GGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNAkgdeALEKRFLDKAV 325
Cdd:PRK12462 245 AIYVMALVLRWIRDEiGGVHAMRDINARKAAMLYATLDALNEVIDCHAHRAARSTMNVAFRFRQP----RLDTLFKEQST 320
                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 20140196  326 ELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNF 364
Cdd:PRK12462 321 EAGFCGLSGHRSIGGIRASLYNAVSEQAVSRLCAFLKDF 359
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
7-357 5.62e-87

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 267.19  E-value: 5.62e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196     7 VVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISvlEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSgQFSAV 86
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVHR--GVHTLGKEATQAYEEAREKVAEFINAPSNDEIIFTSGTTE-AINLV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    87 PLNLI-GLKAGRSADYVVTGAWSAK-AAEEAKKFGTVNIVHPKL---GSYTkiPDPSTWNLNPDASYVYFCANETVHGVE 161
Cdd:pfam00266  78 ALSLGrSLKPGDEIVITEMEHHANLvPWQELAKRTGARVRVLPLdedGLLD--LDELEKLITPKTKLVAITHVSNVTGTI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   162 FDfVPDV------KGAVLVCDMSSNFLSRPVDVSKFGV--IFAGAQKNVGSAGVTVVIVRDDLLGF--------SLRECP 225
Cdd:pfam00266 156 QP-VPEIgklahqYGALVLVDAAQAIGHRPIDVQKLGVdfLAFSGHKLYGPTGIGVLYGRRDLLEKmppllgggGMIETV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   226 SvLDYKVQAGNNSLYN--TPPCFSIYVMGMVLEWIkNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERqNRSRMNI 303
Cdd:pfam00266 235 S-LQESTFADAPWKFEagTPNIAGIIGLGAALEYL-SEIGLEAIEKHEHELAQYLYERLLSLPGIRLYGPER-RASIISF 311
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20140196   304 PFRIGNAkgdeALEKRFLDK-AVELN------MISLKGHRSVGGIRASLYNAVTTEDVEKL 357
Cdd:pfam00266 312 NFKGVHP----HDVATLLDEsGIAVRsghhcaQPLMVRLGLGGTVRASFYIYNTQEDVDRL 368
PRK03080 PRK03080
phosphoserine transaminase;
9-285 2.03e-15

phosphoserine transaminase;


Pssm-ID: 235103  Cd Length: 378  Bit Score: 76.76  E-value: 2.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196    9 NFGPGPAKLPHSVLLEiqkqlldyrGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPL 88
Cdd:PRK03080  15 RFSSGPCKKRPGWQLE---------ALADALLGRSHRQKPVKALLKRVIEGTRELLSLPEGYEVGIVPGSDTGAWEMALW 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196   89 NLIGlkaGRSADYVVTGAWSAKAAEEAKKfgtvnivHPKLG-------SYTKIPDPSTwnLNPDASYVyFCANETVHGVE 161
Cdd:PRK03080  86 SLLG---ARRVDHLAWESFGSKWATDVVK-------QLKLEdprvleaDYGSLPDLSA--VDFDRDVV-FTWNGTTTGVR 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  162 ---FDFVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVtvvivrddlLGFSL---------------RE 223
Cdd:PRK03080 153 vpvARWIGADREGLTICDATSAAFALPLDWSKLDVYTFSWQKVLGGEGG---------HGMAIlspraverlesytpaRP 223
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20140196  224 CPSVLDY--KVQAGNNSL----YNTPPCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNS 285
Cdd:PRK03080 224 IPKFFRLtkGGKAIENSFkgqtINTPSMLTVEDYLDQLDWANSIGGLDALIARTAANASVLYDWAEKT 291
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
64-213 2.42e-08

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 53.16  E-value: 2.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  64 LAVPNNYKVIFVqGGGSGQFSAVPLNLigLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHPKLGSYTKIP--DPSTWN 141
Cdd:cd01494  12 LLQPGNDKAVFV-PSGTGANEAALLAL--LGPGDEVIVDANGHGSRYWVAAELAGAKPVPVPVDDAGYGGLDvaILEELK 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196 142 LNPDASYVYFCANETVHGV-----EFDFVPDVKGAVLVCDMSSNFLSRP-----VDVSKFGVIFAGAQKNVGSAGVTVVI 211
Cdd:cd01494  89 AKPNVALIVITPNTTSGGVlvplkEIRKIAKEYGILLLVDAASAGGASPapgvlIPEGGADVVTFSLHKNLGGEGGGVVI 168

                ..
gi 20140196 212 VR 213
Cdd:cd01494 169 VK 170
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
10-210 2.47e-08

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 54.99  E-value: 2.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  10 FGPGPAKLPHSVLleiqkqlldyRGLGISVleMSHRSSDFAKIIGNTENLVRELLAvPNNYKVIFVQGGGSGQFSAVPLN 89
Cdd:cd06451   3 LIPGPSNVPPRVL----------KAMNRPM--LGHRSPEFLALMDEILEGLRYVFQ-TENGLTFLLSGSGTGAMEAALSN 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20140196  90 LigLKAGRSADYVVTGAWSAKAAEEAKKFGT-VNIVHPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDfVPDV 168
Cdd:cd06451  70 L--LEPGDKVLVGVNGVFGDRWADMAERYGAdVDVVEKPWGEAVSPEEIAEALEQHDIKAVTLTHNETSTGVLNP-LEGI 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 20140196 169 KGAV------LVCDMSSNFLSRPVDVSKFGV--IFAGAQKNVGS-AGVTVV 210
Cdd:cd06451 147 GALAkkhdalLIVDAVSSLGGEPFRMDEWGVdvAYTGSQKALGApPGLGPI 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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