TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2047300     394 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 435
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     335 DINECAMPGNVCH--GDCLNNPGSYRCVCPPG 364
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2047300      765 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 805
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2047300      806 DIDECDFPAACI-GGDCINTNGSYRCLCPLGHRlvGGRKCK 845
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 2047300      847 DIDECSqDPGLCLPHA-CENLQGSYVCVCDEGFT 879
Cdd:smart00179    1 DIDECA-SGNPCQNGGtCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 2047300      596 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 639
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     271 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 301
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2047300     394 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 435
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     335 DINECAMPGNVCH--GDCLNNPGSYRCVCPPG 364
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2047300      640 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 672
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|.
gi 2047300      724 DVNECSEGTPCSPG-WCENLPGSYRCTCAQG 753
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPG 31

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2047300      335 DINECAMPGN-VCHGDCLNNPGSYRCVCPPGHSLGP 369
Cdd:smart00179    1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGYTDGR 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 2047300   724 DVNECSEGTPCSP-GWCENLPGSYRCTCAQG 753
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 2047300   806 DIDECDFPAAC-IGGDCINTNGSYRCLCPLGHRL 838
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 2047300      847 DIDECSqDPGLCLPHA-CENLQGSYVCVCDEGFT 879
Cdd:smart00179    1 DIDECA-SGNPCQNGGtCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|
gi 2047300  1016 DVDECLDESNCRN-GVCENTRGGYRCACTP 1044
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2047300   847 DIDECSQdPGLCLPHA-CENLQGSYVCVCDEGFTLT 881
Cdd:cd00054    1 DIDECAS-GNPCQNGGtCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 2047300   683 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 715
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2047300     1186 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1224
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     271 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 301
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2047300     394 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 435
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     335 DINECAMPGNVCH--GDCLNNPGSYRCVCPPG 364
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 2047300      640 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 672
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|.
gi 2047300      724 DVNECSEGTPCSPG-WCENLPGSYRCTCAQG 753
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPG 31

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2047300      335 DINECAMPGN-VCHGDCLNNPGSYRCVCPPGHSLGP 369
Cdd:smart00179    1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGYTDGR 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|.
gi 2047300   724 DVNECSEGTPCSP-GWCENLPGSYRCTCAQG 753
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 2047300   806 DIDECDFPAAC-IGGDCINTNGSYRCLCPLGHRL 838
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 2047300      847 DIDECSqDPGLCLPHA-CENLQGSYVCVCDEGFT 879
Cdd:smart00179    1 DIDECA-SGNPCQNGGtCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|
gi 2047300  1016 DVDECLDESNCRN-GVCENTRGGYRCACTP 1044
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2047300   847 DIDECSQdPGLCLPHA-CENLQGSYVCVCDEGFTLT 881
Cdd:cd00054    1 DIDECAS-GNPCQNGGtCVNTVGSYRCSCPPGYTGR 35

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 2047300   763 CIDVDECEAG-KVCQDgICTNTPGSFQCQCLSGYHLSRD 800
Cdd:cd01475  184 CVVPDLCATLsHVCQQ-VCISTPGSYLCACTEGYALLED 221

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 2047300   596 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 630
Cdd:cd00054    1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 2047300     806 DIDECDFPAA-C-IGGDCINTNGSYRCLCPLG 835
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 2047300   643 ECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 676
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34