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Conserved domains on  [gi|209863004|ref|NP_001129561|]
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annexin A10 isoform 1 [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 1.87e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 1.87e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004   93 YDAHELWHAMKGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.25e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.07  E-value: 1.25e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004  251 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.45  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209863004   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 2.91e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863004  175 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 1.87e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 1.87e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004   93 YDAHELWHAMKGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.25e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.07  E-value: 1.25e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004  251 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.45  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209863004   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 2.91e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863004  175 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 1.69e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.36  E-value: 1.69e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 209863004   268 KTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 2.53e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 209863004    36 NKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 1.31e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 209863004   106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 6.69e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 42.78  E-value: 6.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 209863004   198 ILCNKSYPQLWLVFQEFQNISGQDLVDAIndCYD--GYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 93-158 1.87e-24

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.08  E-value: 1.87e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004   93 YDAHELWHAMKGPGTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 251-316 1.25e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.07  E-value: 1.25e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863004  251 YFAYKLYRAIHDFGFHNKTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 316
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 22-86 6.51e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 84.45  E-value: 6.51e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209863004   22 DAQMLGGALQGFDCNKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 175-241 2.91e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863004  175 QDAMVLWEACQqKTGEHKTMMQMILCNKSYPQLWLVFQEFQNISGQDLVDAINDCYDGYFQELLVAI 241
Cdd:pfam00191   1 YDAELLRKAMK-GLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
268-316 1.69e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.36  E-value: 1.69e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 209863004   268 KTVIRILIARSEIDLMTIRKRYKERFGKSLFHDIKNFASGHYEKALLAI 316
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-86 2.53e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 68.97  E-value: 2.53e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 209863004    36 NKDMLIDILTQRSNAQRQMIAGTYQSMYGRDLISVLKEQLSSHFKEVMVGL 86
Cdd:smart00335   3 DEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
106-158 1.31e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 67.05  E-value: 1.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 209863004   106 GTDENCLIEILASRTNGEIFQMREAYCLQYSNNLQEDIYSETSGHFRDTLMNL 158
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
198-241 6.69e-06

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 42.78  E-value: 6.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 209863004   198 ILCNKSYPQLWLVFQEFQNISGQDLVDAIndCYD--GYFQELLVAI 241
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDI--KSEtsGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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