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Conserved domains on  [gi|212506051|gb|EEB10367|]
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transcriptional repressor p66 beta, putative [Pediculus humanus corporis]

Protein Classification

transcriptional repressor p66A/B( domain architecture ID 11244092)

transcriptional repressor p66A and p66B includes the coiled-coil and interaction region (P66-CC) and a GATA zinc finger which uses four cysteine residues to coordinate a zinc ion, and bind to DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 198-236 5.69e-14

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


:

Pssm-ID: 465178  Cd Length: 40  Bit Score: 66.67  E-value: 5.69e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 212506051   198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-MKENIA 236
Cdd:pfam16563    1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQqQKENIV 40
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 198-236 5.69e-14

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 66.67  E-value: 5.69e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 212506051   198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-MKENIA 236
Cdd:pfam16563    1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQqQKENIV 40
 
Name Accession Description Interval E-value
P66_CC pfam16563
Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short ...
 198-236 5.69e-14

Coiled-coil and interaction region of P66A and P66B with MBD2; This family is a short coiled-coil interaction region on the transcriptional repressors P66A and P66B. The P66A and B, or alpha and beta, complex with MBDs or methyl-binding domain-containing proteins via a coiled-coil region on each. This P66-MBD2 complex forms part of an assembly with NuRD, nucleosome remodelling and deacetylation protein. MBD2-NuRD binds methylated DNA and regulates transcription of eg, the foetal beta-globin gene during development.


Pssm-ID: 465178  Cd Length: 40  Bit Score: 66.67  E-value: 5.69e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 212506051   198 DLNEKEKLLRKLREDLRNEEMKLVLLKKLRQSQ-MKENIA 236
Cdd:pfam16563    1 EIEERERMIKKLREELRLEEAKLVLLKKLRQSQqQKENIV 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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