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Conserved domains on  [gi|212720630|ref|NP_001074294|]
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transmembrane protein 120B [Homo sapiens]

Protein Classification

TMEM120 family protein( domain architecture ID 10545183)

TMEM120 (transmembrane protein 120) family protein similar to ion channel TACAN that is involved in sensing mechanical pain, contributing to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
9-332 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


:

Pssm-ID: 462288  Cd Length: 324  Bit Score: 539.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630    9 EREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHASREEAELVQQMAANIKERQD 88
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630   89 VFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYY 168
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  169 CTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG 248
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  249 ERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAK 328
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320

                  ....
gi 212720630  329 LQKN 332
Cdd:pfam07851 321 LKRK 324
 
Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
9-332 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


Pssm-ID: 462288  Cd Length: 324  Bit Score: 539.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630    9 EREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHASREEAELVQQMAANIKERQD 88
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630   89 VFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYY 168
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  169 CTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG 248
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  249 ERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAK 328
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320

                  ....
gi 212720630  329 LQKN 332
Cdd:pfam07851 321 LKRK 324
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
4-131 5.79e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 5.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630     4 QLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDL-----KLTLQRCKRHASREE-AELVQ 77
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLerqleELEAQLEELESKLDElAEELA 340
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 212720630    78 QMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEK 131
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
 
Name Accession Description Interval E-value
TMPIT pfam07851
TMPIT-like protein; A number of members of this family are annotated as being transmembrane ...
9-332 0e+00

TMPIT-like protein; A number of members of this family are annotated as being transmembrane proteins induced by tumour necrosis factor alpha, but no literature was found to support this.


Pssm-ID: 462288  Cd Length: 324  Bit Score: 539.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630    9 EREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDLKLTLQRCKRHASREEAELVQQMAANIKERQD 88
Cdd:pfam07851   1 LEEWEELEKEFQQLQETHKEYKQKLEELSSLQTRCKKSIKHQKKRLKELKSSLKRLQRSSIEEDQSLIKELQEEIKERKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630   89 VFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEKFKLYLTIILLLGAVACRFVLHYRVTDEVFNFLLVWYY 168
Cdd:pfam07851  81 QLFEMEALLPKKNGLYLNLILGNVNVSLLNKDEKFKYKDEYEKFKLILTIIFLLLSVLLLFLLNYRFLDALFQFLLVWYY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  169 CTLTIRESILISNGSRIKGWWVSHHYVSTFLSGVMLTWPNGPIYQKFRNQFLAFSIFQSCVQFLQYYYQRGCLYRLRALG 248
Cdd:pfam07851 161 CTLTIRESILIVNGSRIKGWWVFHHYISTALSGVLLTWPDGEQYQSFRPQFLFFSFYQSVVQFLQYYYQRGCLYRLRALG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630  249 ERNHLDLTVEGFQSWMWRGLTFLLPFLFCGHFWQLYNAVTLFELSSHEECREWQVFVLAFTFLILFLGNFLTTLKVVHAK 328
Cdd:pfam07851 241 ERHNMDVTVEGFQSWMWRGLTFLLPFLFFGHFFQLYNAYTLFRLARQPECCEWQVFVLGLLFLILFLGNFFTTLQVVPQK 320

                  ....
gi 212720630  329 LQKN 332
Cdd:pfam07851 321 LKRK 324
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
4-131 5.79e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 5.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212720630     4 QLERCEREWHELEGEFQELQETHRIYKQKLEELAALQTLCSSSISKQKKHLKDL-----KLTLQRCKRHASREE-AELVQ 77
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLerqleELEAQLEELESKLDElAEELA 340
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 212720630    78 QMAANIKERQDVFFDMEAYLPKKNGLYLNLVLGNVNVTLLSNQAKFAYKDEYEK 131
Cdd:TIGR02168  341 ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQ 394
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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