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Conserved domains on  [gi|2131039079|ref|XP_044897486|]
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ataxin-2 isoform X2 [Felis catus]

Protein Classification

Sm_like and LsmAD domain-containing protein( domain architecture ID 10627809)

protein containing domains Sm_like, LsmAD, PAM2, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.78e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


:

Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.78e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 238-299 8.66e-16

LsmAD domain; This domain is found associated with Lsm domain.


:

Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.66e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079  238 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 299
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 770-1114 1.56e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  770 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 841
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  842 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 920
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  921 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 980
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  981 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1060
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1061 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1114
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 751-766 6.01e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


:

Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 6.01e-03
                           10
                   ....*....|....*.
gi 2131039079  751 RKSTLNPNAKEFNPRS 766
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.78e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.78e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 238-299 8.66e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.66e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079  238 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 299
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 770-1114 1.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  770 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 841
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  842 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 920
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  921 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 980
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  981 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1060
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1061 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1114
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 751-909 3.72e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  751 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 830
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  831 PVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 904
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 2131039079  905 HPHVY 909
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 851-1115 6.23e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 6.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  851 QDQHHQSTMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 925
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  926 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 998
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  999 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 1078
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 2131039079 1079 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1115
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 751-766 6.01e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 6.01e-03
                           10
                   ....*....|....*.
gi 2131039079  751 RKSTLNPNAKEFNPRS 766
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Name Accession Description Interval E-value
SM-ATX pfam14438
Ataxin 2 SM domain; This SM domain is found in Ataxin-2.
 92-165 4.78e-20

Ataxin 2 SM domain; This SM domain is found in Ataxin-2.


Pssm-ID: 464173  Cd Length: 78  Bit Score: 85.30  E-value: 4.78e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079   92 MVHILTSVVGSKCEVQVKNGGIYEGVFKTYSP--KCDLVLDAAHEKSMESSSG--PKREEIMESILFKCSDFVVVQFK 165
Cdd:pfam14438    1 LLFLLTSLVGLVVEVTTKNGEVYEGIFSTASLekDFGVVLKMARRIKKSNGSGlnPVRGEIVDTMIFPAKDIVDIEAK 78
LsmAD pfam06741
LsmAD domain; This domain is found associated with Lsm domain.
 238-299 8.66e-16

LsmAD domain; This domain is found associated with Lsm domain.


Pssm-ID: 461998 [Multi-domain]  Cd Length: 65  Bit Score: 72.60  E-value: 8.66e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2131039079  238 YGVVSTYDSSLssYTVPLERdNSEEFLKREARANQLAEEIESSAQYKARVALENDDR------SEEEK 299
Cdd:pfam06741    1 FGVKSTYDENL--YTTKLDR-SSPDYKEREAEAERIAREIEGSASTNAHVAEERGLDvddsglDEEDK 65
PHA03247 PHA03247
large tegument protein UL36; Provisional
 770-1114 1.56e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  770 PKPSTTPTSPRPQAQPSPsmVG--------HQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPVNQAKTYRAG 841
Cdd:PHA03247  2674 AQASSPPQRPRRRAARPT--VGsltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP 2751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  842 KVPNMPQQRQDQHHQSTMMHPAS-AAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPhyqSQHPHVYSPVIQGNARMM 920
Cdd:PHA03247  2752 GGPARPARPPTTAGPPAPAPPAApAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA---VLAPAAALPPAASPAGPL 2828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  921 APPAHAQP-------GLVSSSATQYGA------------HEQTHAMYACP-KLPYNKETSPSFyfAISTGSLAQQyahPN 980
Cdd:PHA03247  2829 PPPTSAQPtapppppGPPPPSLPLGGSvapggdvrrrppSRSPAAKPAAPaRPPVRRLARPAV--SRSTESFALP---PD 2903

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  981 ATLHPHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNS 1060
Cdd:PHA03247  2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA 2983

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1061 fptaqqtvftihPSHVQPA-YTNPPHMAHVPQAHVQSGMVPSH-PTAHAPMMLMTT 1114
Cdd:PHA03247  2984 ------------PSREAPAsSTPPLTGHSLSRVSSWASSLALHeETDPPPVSLKQT 3027
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 751-909 3.72e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 3.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  751 RKSTLNpnaKEFNPRSFSQPKPSTTptSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGVQPLypiPMTPM 830
Cdd:TIGR01628  367 RRAHLQ---DQFMQLQPRMRQLPMG--SPMGGAMGQPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLR---PNGLA 438

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  831 PVNQaktyrAGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSPQQFPNQPLVQHVPHYQSQ------ 904
Cdd:TIGR01628  439 PMNA-----VRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQvlgerl 513


                   ....*
gi 2131039079  905 HPHVY 909
Cdd:TIGR01628  514 FPLVE 518
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 851-1115 6.23e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 47.34  E-value: 6.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  851 QDQHHQSTMMHPASAAGPPIVATPPAYSTQY-VAYSPQQFPNQPLVQHVPHYQSQHP----HVySPVIQGNARMMAPPAH 925
Cdd:pfam09770   96 EEEQVRFNRQQPAARAAQSSAQPPASSLPQYqYASQQSQQPSKPVRTGYEKYKEPEPipdlQV-DASLWGVAPKKAAAPA 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  926 AQPGLVSSSATQYGAH-------EQTHAMYACPKLPYNKETSPSFYFAistgslaQQYAHPNATLHPHTPHPQPSATPTG 998
Cdd:pfam09770  175 PAPQPAAQPASLPAPSrkmmsleEVEAAMRAQAKKPAQQPAPAPAQPP-------AAPPAQQAQQQQQFPPQIQQQQQPQ 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  999 QQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqNSFPTAQQTVFTIHPSHVQP 1078
Cdd:pfam09770  248 QQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNP-NRLSAARVGYPQNPQPGVQP 326

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 2131039079 1079 AytnPPHMAHvPQAHVQSGMVPSHpTAHAPMMLMTTQ 1115
Cdd:pfam09770  327 A---PAHQAH-RQQGSFGRQAPII-THPQQLAQLSEE 358
PHA03247 PHA03247
large tegument protein UL36; Provisional
 764-1147 1.44e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  764 PRSFSQPKPSTTPTSPRPQAQPSPSmvghqQPAPVYTQPVCFAPNmmyPVPVSPGVQPLYPIPMTPMPVNQAKTYRAGKV 843
Cdd:PHA03247  2593 PQSARPRAPVDDRGDPRGPAPPSPL-----PPDTHAPDPPPPSPS---PAANEPDPHPPPTVPPPERPRDDPAPGRVSRP 2664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  844 PNMPQQRQDQHHQSTMMHPASAAGPPIVATppaystqyVAYSPQQFPNQPLVQHVPHYQSqhPHVYSPVIQGNARMMAPP 923
Cdd:PHA03247  2665 RRARRLGRAAQASSPPQRPRRRAARPTVGS--------LTSLADPPPPPPTPEPAPHALV--SATPLPPGPAAARQASPA 2734

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  924 AHAQP-------GLVSSSATQYGAHEQTHAMYACPKLPYNKETSPS-----FYFAISTGSLAQQYAHPNATLHPHTPHPQ 991
Cdd:PHA03247  2735 LPAAPappavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPrrltrPAVASLSESRESLPSPWDPADPPAAVLAP 2814

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  992 PSATPTGQQQSqhGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPqnSFPTAQQTVfti 1071
Cdd:PHA03247  2815 AAALPPAASPA--GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAP--ARPPVRRLA--- 2887

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1072 hpshvQPAYTNPPHMAHVPQAHVQSGMVPSHPTAhaPMMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPS 1147
Cdd:PHA03247  2888 -----RPAVSRSTESFALPPDQPERPPQPQAPPP--PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 768-1058 2.41e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.46  E-value: 2.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  768 SQPKPSTTPTSPRPQAQPSPsmvGHQQPAPVYT-QPVCFAPNMMYPVPVSPGVQPLypipmtPMPVNQAKTYRAGKVPNM 846
Cdd:PRK10263   345 PVASVDVPPAQPTVAWQPVP---GPQTGEPVIApAPEGYPQQSQYAQPAVQYNEPL------QQPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  847 PQQRQDQHHQSTmmhPASAAGPPIVATPPAYSTQYVAYspqqfPNQPLVQHVPHYQSQHPHVySPVIQgnarmmaPPAHA 926
Cdd:PRK10263   416 AQQPYYAPAPEQ---PAQQPYYAPAPEQPVAGNAWQAE-----EQQSTFAPQSTYQTEQTYQ-QPAAQ-------EPLYQ 479

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  927 QPGLVsssatqygahEQTHAMYACPKLPYNKETSPSFYFaisTGSLAQQYAHPNATLHP-HTPHPQPSATPTGQQQSQHG 1005
Cdd:PRK10263   480 QPQPV----------EQQPVVEPEPVVEETKPARPPLYY---FEEVEEKRAREREQLAAwYQPIPEPVKEPEPIKSSLKA 546

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1006 GSHPAPSPVQHHQHQAAQALHLaspqqQSAIYHAGLAPTP--PSMTPASN-TQSPQ 1058
Cdd:PRK10263   547 PSVAAVPPVEAAAAVSPLASGV-----KKATLATGAAATVaaPVFSLANSgGPRPQ 597
PHA03378 PHA03378
EBNA-3B; Provisional
 753-1108 2.65e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  753 STLNPNAKEFNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVytQPVCFAPNMMYPVPVSPGVQPLYPIPMTPMPV 832
Cdd:PHA03378   583 SQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPL--RPIPMRPLRMQPITFNVLVFPTPHQPPQVEIT 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  833 NQAKTYraGKVPNMPQQRQDQHHqSTMMHPASAagPPIVATPPAYSTQyvAYSPQQFPnqplvqhVPHYQSQHPHVYSPV 912
Cdd:PHA03378   661 PYKPTW--TQIGHIPYQPSPTGA-NTMLPIQWA--PGTMQPPPRAPTP--MRPPAAPP-------GRAQRPAAATGRARP 726

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  913 IQGNARMMAPPAHAqPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQyaHPNATlhpHTPHPQP 992
Cdd:PHA03378   727 PAAAPGRARPPAAA-PGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQ--RPRGA---PTPQPPP 800

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  993 SATPTGQQQS--QHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYH---AGLAPTPPSMTPASNTQSPQnSFPTAQQt 1067
Cdd:PHA03378   801 QAGPTSMQLMprAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERqaaAGPTPSPGSGTSDKIVQAPV-FYPPVLQ- 878

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 2131039079 1068 vftihPSHV--QPAYTNPPHMAHVPQAHVQ-----SGMVPSHPTAHAP 1108
Cdd:PHA03378   879 -----PIQVmrQLGSVRAAAASTVTQAPTEytgerRGVGPMHPTDIPP 921
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 985-1138 1.13e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  985 PHTPHPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHL----------ASPQQQSAIYHAGLAPTPPSMTPASNT 1054
Cdd:PRK07764   610 EEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHhpkhvavpdaSDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079 1055 QSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQA-----HVQSGMVPSHPTAHAPMMLMTT--QPPGGPQAALAQS 1127
Cdd:PRK07764   690 PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGasapsPAADDPVPLPPEPDDPPDPAGApaQPPPPPAPAPAAA 769

                          170
                   ....*....|.
gi 2131039079 1128 ALQPIPVSTTA 1138
Cdd:PRK07764   770 PAAAPPPSPPS 780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 765-1141 1.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  765 RSFSQPKPSTTPTS---PRPQAQPSPsmvGHQQPAPVYTQPVCFA--PNMMY---------------PVPVSP------- 817
Cdd:PHA03247  2487 RFPFAAGAAPDPGGggpPDPDAPPAP---SRLAPAILPDEPVGEPvhPRMLTwirgleelasddagdPPPPLPpaappaa 2563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  818 ---GVQPLYPIPMTPMPVNQAKTYR--------AGKVPNMPQQRQDQHHQSTMMHPASAAGPPIVATPPAYSTQYVAYSP 886
Cdd:PHA03247  2564 pdrSVPPPRPAPRPSEPAVTSRARRpdappqsaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP 2643

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  887 QQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAH----AQPGLVSSSATQYGAHEQthamyacPKLPYNKETSPS 962
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRprrrAARPTVGSLTSLADPPPP-------PPTPEPAPHALV 2716

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  963 FYFAISTGSLAQQYAHPNATLHPHTP----HPQPSATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYH 1038
Cdd:PHA03247  2717 SATPLPPGPAAARQASPALPAAPAPPavpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079 1039 AGLAPTPPSMTPASNTQSPQNSFPTAQQTVFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPG 1118
Cdd:PHA03247  2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876

                          410       420
                   ....*....|....*....|...
gi 2131039079 1119 GPQAALAQSALQPIPVSTTAHFP 1141
Cdd:PHA03247  2877 APARPPVRRLARPAVSRSTESFA 2899
PHA03247 PHA03247
large tegument protein UL36; Provisional
 757-1133 3.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  757 PNAKEFNPRSFSQPKPST------TPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFA--PNMMYPVPVSPGVQPLYPIPMT 828
Cdd:PHA03247  2601 PVDDRGDPRGPAPPSPLPpdthapDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPapGRVSRPRRARRLGRAAQASSPP 2680

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  829 PMPVNQAKTYRAGKVPNMpqqrQDQHHQSTMMHPASAAGPPIVATPPAystqyVAYSPQQFPNQPLVQHVPhyqsqhPHV 908
Cdd:PHA03247  2681 QRPRRRAARPTVGSLTSL----ADPPPPPPTPEPAPHALVSATPLPPG-----PAAARQASPALPAAPAPP------AVP 2745

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  909 YSPVIQGN-ARMMAPPAHAQPGLVSSSATQYGAHEQTHAMYACPKLPYNKETSPSfyfAISTGSLAQQYAHPNATLHPHT 987
Cdd:PHA03247  2746 AGPATPGGpARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS---PWDPADPPAAVLAPAAALPPAA 2822

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2131039079  988 PHPQPSATPTGQQQSqhgGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTPASNTQSPQNSFPTAQqt 1067
Cdd:PHA03247  2823 SPAGPLPPPTSAQPT---APPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES-- 2897

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2131039079 1068 vFTIHPSHVQPAYTNPPHMAHVPQAHVQSGMVPSHPTAHAPMMLMTTQPPGGPQAALAQSALQPIP 1133
Cdd:PHA03247  2898 -FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PAM2 pfam07145
Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various ...
 751-766 6.01e-03

Ataxin-2 C-terminal region; The PABP-interacting motif PAM2 has been identified in various eukaryotic proteins as an important binding site for pfam00658. It has been found in a wide range of eukaryotic proteins. Strikingly, this motif appears to occur solely outside of globular domains.


Pssm-ID: 429316  Cd Length: 17  Bit Score: 35.28  E-value: 6.01e-03
                           10
                   ....*....|....*.
gi 2131039079  751 RKSTLNPNAKEFNPRS 766
Cdd:pfam07145    1 SKSKLNPNAKEFVPSF 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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