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Conserved domains on  [gi|21311891|ref|NP_083042|]
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transmembrane protein 43 [Mus musculus]

Protein Classification

TMEM43 family protein( domain architecture ID 10544559)

TMEM43 (transmembrane 43) family protein similar to human transmembrane protein 43, also called LUMA, that may have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-373 1.17e-107

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


:

Pssm-ID: 462267  Cd Length: 249  Bit Score: 316.94  E-value: 1.17e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   121 MYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKI 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   201 DNFKALSLAKLEDPHV------DIIRRGDFFYHSENPKYPEVGDVRVSFSYAglssddpdlgPAHVVTVIARQRGDQLIP 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYA----------PPGDVTVVAKQKGNTLVP 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   275 YSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFC 354
Cdd:pfam07787 151 YRTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALI 230

                         250
                  ....*....|....*....
gi 21311891   355 VATSLTLLTVAAGWLFYRP 373
Cdd:pfam07787 231 LSISLSLLVIALAWLFYRP 249
 
Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-373 1.17e-107

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


Pssm-ID: 462267  Cd Length: 249  Bit Score: 316.94  E-value: 1.17e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   121 MYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKI 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   201 DNFKALSLAKLEDPHV------DIIRRGDFFYHSENPKYPEVGDVRVSFSYAglssddpdlgPAHVVTVIARQRGDQLIP 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYA----------PPGDVTVVAKQKGNTLVP 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   275 YSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFC 354
Cdd:pfam07787 151 YRTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALI 230

                         250
                  ....*....|....*....
gi 21311891   355 VATSLTLLTVAAGWLFYRP 373
Cdd:pfam07787 231 LSISLSLLVIALAWLFYRP 249
 
Name Accession Description Interval E-value
TMEM43 pfam07787
Transmembrane protein 43; This entry represents the transmembrane protein 43 family of ...
 121-373 1.17e-107

Transmembrane protein 43; This entry represents the transmembrane protein 43 family of proteins, which may function as tetraspanin-like membrane organizers.


Pssm-ID: 462267  Cd Length: 249  Bit Score: 316.94  E-value: 1.17e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   121 MYQWVETEESSEYTEDGQVKKETKYSYNTEWRSEIVNSRNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKI 200
Cdd:pfam07787   1 MYQWVEESESETYKKNGGETTETTYTYTKEWRSELVDSSSFHIPEGHHNPSAMPVESETQVADDVKVGAFSLSPELKEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   201 DNFKALSLAKLEDPHV------DIIRRGDFFYHSENPKYPEVGDVRVSFSYAglssddpdlgPAHVVTVIARQRGDQLIP 274
Cdd:pfam07787  81 NGFTELPLDDRNAQEIagperkNVKLHGGYIYHGQNPGEPEVGDLRISFSYA----------PPGDVTVVAKQKGNTLVP 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   275 YSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFC 354
Cdd:pfam07787 151 YRTKNGDKILLLYEGEFSAEEMFAKEHSENATLTWLLRLVGWLLMFIGFTLLFSPLSTLVSWIPLLGGIVGAGLFLVALI 230

                         250
                  ....*....|....*....
gi 21311891   355 VATSLTLLTVAAGWLFYRP 373
Cdd:pfam07787 231 LSISLSLLVIALAWLFYRP 249
COOH-NH2_lig pfam14395
Phage phiEco32-like COOH.NH2 ligase-type 2; A family of COOH-NH2 ligases/GCS superfamily found ...
 192-267 2.75e-03

Phage phiEco32-like COOH.NH2 ligase-type 2; A family of COOH-NH2 ligases/GCS superfamily found in the neighborhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis.


Pssm-ID: 373045  Cd Length: 253  Bit Score: 39.19  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21311891   192 LSAGLIDKIDNFKALSLAKLEDPHVDIIRRgdffyhsenPKYPEVGDVRVS----FSYAGLSS--DDPDLGPA--HVVTV 263
Cdd:pfam14395 104 LTSRLLRALDNYLALPLALIEDPERARRRR---------PRYGFLGDFRRKphggFEYRTLPSwlVSPAIARAvlHLAKL 174


                  ....
gi 21311891   264 IARQ 267
Cdd:pfam14395 175 IARH 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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