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Conserved domains on  [gi|215490074|ref|NP_033145|]
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histone deacetylase complex subunit SAP18 [Mus musculus]

Protein Classification

SAP18 family protein( domain architecture ID 10534643)

SAP18 (Sin3-associated polypeptide p18) family protein similar to human histone deacetylase complex subunit SAP18, a component of the SIN3-repressing complex that enhances the ability of SIN3-HDAC1-mediated transcriptional repression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP18 pfam06487
Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 ...
 38-156 1.31e-68

Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.


:

Pssm-ID: 461934  Cd Length: 123  Bit Score: 203.92  E-value: 1.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490074   38 PIDREKTCPLLLRVFTtNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEV---YPEARKKGTHFNFAIVFMD 114
Cdd:pfam06487   1 PVDREKTCPFLLRVFY-RTGRHHRLDEFSRGSLPSDELQIYTWKDATLRELSTLLKDVlpsNLPAPRRGTRLSFRLVYPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 215490074  115 lKRPGYRVKEIGSTMSGRKG---TDDSMTLQSQKFQIGDYLDIAI 156
Cdd:pfam06487  80 -TRGRYVSKDLGSVVSGDKGpgaEDDSKTLADLRFVIGDYLDVAI 123
 
Name Accession Description Interval E-value
SAP18 pfam06487
Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 ...
 38-156 1.31e-68

Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.


Pssm-ID: 461934  Cd Length: 123  Bit Score: 203.92  E-value: 1.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490074   38 PIDREKTCPLLLRVFTtNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEV---YPEARKKGTHFNFAIVFMD 114
Cdd:pfam06487   1 PVDREKTCPFLLRVFY-RTGRHHRLDEFSRGSLPSDELQIYTWKDATLRELSTLLKDVlpsNLPAPRRGTRLSFRLVYPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 215490074  115 lKRPGYRVKEIGSTMSGRKG---TDDSMTLQSQKFQIGDYLDIAI 156
Cdd:pfam06487  80 -TRGRYVSKDLGSVVSGDKGpgaEDDSKTLADLRFVIGDYLDVAI 123
 
Name Accession Description Interval E-value
SAP18 pfam06487
Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 ...
 38-156 1.31e-68

Sin3 associated polypeptide p18 (SAP18); This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex which is responsible for the repression of transcription via the modification of histone polypeptides. SAP18 is also present in the ASAP complex which is thought to be involved in the regulation of splicing during the execution of programmed cell death.


Pssm-ID: 461934  Cd Length: 123  Bit Score: 203.92  E-value: 1.31e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215490074   38 PIDREKTCPLLLRVFTtNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEV---YPEARKKGTHFNFAIVFMD 114
Cdd:pfam06487   1 PVDREKTCPFLLRVFY-RTGRHHRLDEFSRGSLPSDELQIYTWKDATLRELSTLLKDVlpsNLPAPRRGTRLSFRLVYPD 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 215490074  115 lKRPGYRVKEIGSTMSGRKG---TDDSMTLQSQKFQIGDYLDIAI 156
Cdd:pfam06487  80 -TRGRYVSKDLGSVVSGDKGpgaEDDSKTLADLRFVIGDYLDVAI 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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