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Conserved domains on  [gi|215599065|ref|NP_001135936|]
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evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 2 precursor [Homo sapiens]

Protein Classification

ECSIT domain-containing protein( domain architecture ID 12069160)

ECSIT domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
73-266 6.49e-119

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


:

Pssm-ID: 461857  Cd Length: 191  Bit Score: 338.95  E-value: 6.49e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065   73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065  153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158
                         170       180       190
                  ....*....|....*....|....*....|....
gi 215599065  233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
73-266 6.49e-119

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 338.95  E-value: 6.49e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065   73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065  153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158
                         170       180       190
                  ....*....|....*....|....*....|....
gi 215599065  233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
 
Name Accession Description Interval E-value
ECSIT pfam06239
Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a ...
73-266 6.49e-119

Evolutionarily conserved signalling intermediate in Toll pathway; Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT plays an important role in signalling to NF-kappaB, functioning as the intermediate in the signaling pathways between TRAF-6 and MEKK-1.


Pssm-ID: 461857  Cd Length: 191  Bit Score: 338.95  E-value: 6.49e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065   73 EDLFGQApgGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFV 152
Cdd:pfam06239   1 EDLFSAA--GKRKKASFLMVVIFFKQRSVRRRGHVDFIYAALKKMPEFGVERDLAVYNLLLDVFPKEVFRPRNFIQRFFH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 215599065  153 HYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLR 232
Cdd:pfam06239  79 HYPRQQECGVAVLEQMENYGVMPNKETEFLLVQIFGRKSHPMRKYRRMMYWFPKFKNSNPFPVPPVLPDDPVDLAKLGLR 158
                         170       180       190
                  ....*....|....*....|....*....|....
gi 215599065  233 HMEPDLSARVTIYQVPLPKDSTGaADPPQPHIVG 266
Cdd:pfam06239 159 RMEPDLSARVTVYQMPVPSDIDD-EDPTQPHIVG 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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