|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
106-511 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 756.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKD 265
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 266 PEKLAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAG 345
Cdd:cd17456 161 LDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 346 AFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLW 425
Cdd:cd17456 241 CFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 426 VVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSA 505
Cdd:cd17456 321 VVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTI 400
|
....*.
gi 21703892 506 LTAFIK 511
Cdd:cd17456 401 LTALIK 406
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
106-511 |
0e+00 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 646.60 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKD 265
Cdd:cd17398 81 LGAWLKLFSSSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 266 PEKLAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAG 345
Cdd:cd17398 161 KDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 346 AFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLW 425
Cdd:cd17398 241 VYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 426 VVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSA 505
Cdd:cd17398 321 VVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTI 400
|
....*.
gi 21703892 506 LTAFIK 511
Cdd:cd17398 401 LTAFIK 406
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
106-511 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 564.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKD 265
Cdd:cd17455 81 LGAWVKCASVRPDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 266 PEKL-AYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNA 344
Cdd:cd17455 161 DIDLmGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 345 GAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHL 424
Cdd:cd17455 241 GTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 425 WVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGS 504
Cdd:cd17455 321 IVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGI 400
|
....*..
gi 21703892 505 ALTAFIK 511
Cdd:cd17455 401 ILTALIK 407
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
106-511 |
2.51e-119 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 357.87 E-value: 2.51e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSL-EPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIK 264
Cdd:cd17334 81 LGSVLKCIPLgQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 265 DPEKlayHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNA 344
Cdd:cd17334 161 GTKK---EFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 345 GAFYALSTLLNRMvILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSktyKETTLVVYIMTLVGMVVYTFTLNLNHL 424
Cdd:cd17334 238 GVFAGFSSVLAQI-LLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLVDR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 425 -------WVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLC 497
Cdd:cd17334 314 yglpyvtLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLWF 393
|
410
....*....|....
gi 21703892 498 VFLALGSALTAFIK 511
Cdd:cd17334 394 ILCTVGSCLGALFF 407
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
106-480 |
3.86e-74 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 241.79 E-value: 3.86e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHL-----FPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLV 260
Cdd:cd17399 81 IGAVIRVISSLPFVdpsfrFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 261 pniKDPEKLAYHISIMFyIIGGVATFLfiLVIIVFKEKPKHPPSRAQslsyalATTDASYLSSIVRLFKNLNFVLLVITY 340
Cdd:cd17399 161 ---KSSEDIFLLLSIYT-IPALIAVVL--ATFGVRSSVPPTPPSASA------AHESEPFFVGLKQLFKNKQYLILMLCF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 341 GLNAGAFYALSTLLNRmvILHFPGEEVN-AGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTL 419
Cdd:cd17399 229 GGGIGLFNALSTLLEQ--ILCPSGYSNNfAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21703892 420 NL-NHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQ 480
Cdd:cd17399 307 RFpNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
106-500 |
1.32e-51 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 180.96 E-value: 1.32e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHLFPVTM-VGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVpnik 264
Cdd:cd17397 81 AGTGLRCIPVPNHLATWLIhIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 265 dpeklayhisimFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalaTTDASYLSSIVRLFKNLNFVLLVITYGLNA 344
Cdd:cd17397 157 ------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSAS------TQRLSYKSGILSLLKNKRFWLIALAYGIPT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 345 GAFYALSTLLNrmVILHFPG-EEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTY-KETTLVVYIMTLVGMVVYTFTLNL- 421
Cdd:cd17397 219 GVYAGWSGVLD--VNLTPFGvSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRmKLILLLLFSGATGSFLWFTLICLKl 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 422 --NHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTIsqGQIIDNHGT------MFGN 493
Cdd:cd17397 297 lpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL--ILIIPNIGTswmnwcLLGS 374
|
....*..
gi 21703892 494 IFLCVFL 500
Cdd:cd17397 375 CLLSVPL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
114-509 |
6.37e-31 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 124.08 E-value: 6.37e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 114 FSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVKLG 193
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 194 SlepHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVpnikdpEKLAYHI 273
Cdd:cd06174 81 A---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 274 SIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYAlattdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTL 353
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 354 LNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTykeTTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGT 433
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21703892 434 LGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAF 509
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-520 |
1.29e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.67 E-value: 1.29e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 105 KRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN 184
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 185 CLGAwvkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVpnik 264
Cdd:COG2223 81 GIGL---LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 265 dpekLAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLsyalattdasyLSSIVRLFKNLNFVLLVITYGLNA 344
Cdd:COG2223 154 ----AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 345 GAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnLNHL 424
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALA--LGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 425 WVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGT-MFGNIFLCVFLALG 503
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVA 375
|
410
....*....|....*..
gi 21703892 504 SALTAFIKSDLRRQRAN 520
Cdd:COG2223 376 LVLTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
102-516 |
1.38e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.56 E-value: 1.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 102 KVSKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGS 181
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 182 ALNCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVP 261
Cdd:COG2271 83 LLWGLATL--LFGFATS-FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 262 nikdpeklAYHISIMFYIIGGVATFLFILviivfkekpkhppsraqslsyalattdasylssivrlfknlNFVLLVITYG 341
Cdd:COG2271 160 --------AFGWRAAFLILGLPGLLLALL-----------------------------------------RFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 342 LNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDK-SKTYKETTLVVYIMTLVGMVVYTFtln 420
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLAL--- 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 421 LNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFL 500
Cdd:COG2271 268 LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALA 347
|
410
....*....|....*.
gi 21703892 501 ALGSALTAFIKSDLRR 516
Cdd:COG2271 348 LLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
104-473 |
9.13e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.89 E-value: 9.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 104 SKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAL 183
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 184 NCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPni 263
Cdd:COG2814 85 FALGSL--LCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 264 kdpeklAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAqslsyalattdasyLSSIVRLFKNLNFVLLVITYGLN 343
Cdd:COG2814 160 ------LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL--------------RGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 344 AGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnlNH 423
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALA---GS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 21703892 424 LWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFG 473
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
113-477 |
2.16e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.48 E-value: 2.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 113 VFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVkl 192
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 193 gSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVpnikdpekLAYH 272
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 273 ISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALAttdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALST 352
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI--------VAWKALLRDPVLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 353 LLNRMV-ILHFPgeEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITA 431
Cdd:pfam07690 222 YLPLYQeVLGLS--ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 21703892 432 gTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFT 477
Cdd:pfam07690 300 -LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
139-508 |
1.59e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.20 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 139 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFIL 218
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL--LAALAPS-FALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 219 GMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGflvppVLVPNIkdpekLAYHIS--IMFYIIGGVAtflFILVIIVFK 296
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG-----RPLGGL-----LGQLLGwrAAFLAIAVLA---LLAALLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 297 EKPKHPPSRAQSLsyalattdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNrmVILHFPGEEVNAGRIGLTI 376
Cdd:cd17324 173 LLPSLPPKKPGSL---------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA--PFLTDVPGFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 377 V--IAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTy 454
Cdd:cd17324 242 LfgVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 21703892 455 PESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTA 508
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
232-444 |
5.39e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.09 E-value: 5.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 232 DEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKDPEKLAYHisIMFYIIGGVATFLFILVIIVFKEKPKHPPSRaqslsy 311
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYR--LTALIFAVLGLLAFLLTFFGTKERPVPEEEK------ 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 312 alattdASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWL 391
Cdd:COG2211 215 ------VSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 21703892 392 DK-SKtyKETTLVVYIMTLVGMVVYTFtLNLNHLWVVFITAGTLGFFMTGYLPL 444
Cdd:COG2211 289 KRfGK--KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVL 339
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
104-453 |
5.25e-12 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 67.59 E-value: 5.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 104 SKRRWVVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAL 183
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 184 NCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFILGMPSRIASVWFgADEVSTACSVAVFGNQLGIAIGFLVPPVLVPni 263
Cdd:COG2807 93 LAAGLL--LRSLAPS-VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAA-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 264 kdpeklAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalattdasylSSIVRLFKNLNFVLLVITYGLN 343
Cdd:COG2807 167 ------ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA-------------ASLRSLWRSPLAWLLTLFFGLQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 344 AGAFYALSTLLNRMVI-LHFPGEEvnAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFT-LNL 421
Cdd:COG2807 228 SLLYYAVVAWLPPILRdAGLSAAT--AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSL 305
|
330 340 350
....*....|....*....|....*....|..
gi 21703892 422 NHLWVVFITAGTLGFFmtgylPLGFEFAVELT 453
Cdd:COG2807 306 PWLWAVLLGLGQGGLF-----PLALTLIGLRA 332
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
105-517 |
1.12e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.33 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 105 KRRWVVVLVFSCYSLcNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN 184
Cdd:COG0738 5 NYRRALIAIYLLFFL-WGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 185 CLGAwvkLGSLEPHLFPVTMVGQVICSVAQVFIL-GMPSRIASVwfGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNi 263
Cdd:COG0738 84 ALGL---LLFALAPSYPLLLLALFLLGLGLGLLDvAANPYVAAL--GPETAASRLNLLHAFFSLGALLGPLLGGLLILL- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 264 kdpeKLAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAqslsyalattdASYLSSIVRLFKNLNFVLLVITYGLN 343
Cdd:COG0738 158 ----GLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEA-----------AGSAASLKSLLKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 344 AGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNH 423
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR----LLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 424 LWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLnVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALG 503
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 21703892 504 SALTAFIKSDLRRQ 517
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
139-508 |
1.75e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.64 E-value: 1.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 139 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAlnCLGAWVKLGSLE---PHLFPVTMVGQVICSVAQv 215
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLL--LMGAAALLMALVgsyPVLLVLLFLVGAGYGSVQ- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 216 filGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLvpnikdpeklAYHISI-MFYIIGGVATFLFILVIIV 294
Cdd:cd17475 103 ---PGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL----------ALHYGWrAAFVVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 295 FKEKPKHPPSRAQSLSYALAttdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGL 374
Cdd:cd17475 170 FYREPPAASAATESASTLLR--------SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 375 TIVIAGMFGAMISGIWLDK--SKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVEL 452
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 21703892 453 TYPESEGVSSGLLNVSAQVFGIVFTISQGQIID-NHGTMFGNIFLCVFLALGSALTA 508
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
106-510 |
2.70e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.20 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLcNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRT----IAITGS 181
Cdd:cd17319 1 RWRIIPLLFLAYVI-NYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlavSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 182 ALNCLGAWVklgslephlfpVTMVGQVICSvaqvFILGM------P--SRIASVWFGADEVSTACSVAVFGNQLGIAIGf 253
Cdd:cd17319 80 LFTALTGFA-----------TSLTSLYVLR----FLLGVaeagffPgaIKALAEWFPARERGRATGLFNSGAPLGAAIG- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 254 lvPPVLVPnikdpekLAYHIS--IMFYIIGGVATFLFILVIIVFKekpkhppsraqslsyalattdasylssivrlfknl 331
Cdd:cd17319 144 --PPLSGW-------LLLLFGwrWAFIIEGLLGLLLAVLWWFYLR----------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 332 NFVLLVITYGLNAGAFYALSTLLNRMVI--LHFPGEEVnaGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVyIMTL 409
Cdd:cd17319 180 QVWGLALGYFGINYALYGLLTWLPTYLKqaRGFSLKQV--GLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 410 VGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIID-NHG 488
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGS 336
|
410 420
....*....|....*....|..
gi 21703892 489 TMFGNIFLCVFLALGSALTAFI 510
Cdd:cd17319 337 YTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
108-510 |
5.18e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 58.33 E-value: 5.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 108 WVVVLV-----FSCYSLCNAFqwiqyGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSA 182
Cdd:cd17352 2 WVVVFAsflvnFFTDGILNSF-----GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 183 LNCLGAWvkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFgADEVSTACSVAVFGNQLGiaiGFLVPPVLvpn 262
Cdd:cd17352 77 LAALGLL--LSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVG---TFVFPPLL--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 263 ikdpeklayhiSIMFYIIGGVATFLFILVIIVFkekpkhppsraqslsyalattdASYLSSIVRLFKNLNFVLLVITYGL 342
Cdd:cd17352 148 -----------RYLLDNYGWRGALLILGGLCLN----------------------LCVCGLLLRLLKDPTFVLLALGVSF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 343 NAGAFYALSTLLNRMVILHfpGEEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTLnL 421
Cdd:cd17352 195 AMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGR-LYLYIFTLLILGLSLLAFPL-A 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 422 NHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGT-MFGNIFLCVFL 500
Cdd:cd17352 271 TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyDAAFYFCGACL 350
|
410
....*....|
gi 21703892 501 ALGSALTAFI 510
Cdd:cd17352 351 LLSGVLLFLL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
134-511 |
1.87e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 134 IFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAlncLGAWVKLGSLEPHLFPVTMVGQVICSVA 213
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLL---LLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 214 QVFIlgMPSRIASV--WFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPnikdpeklAYHISIMFYIIGGVATFLFILV 291
Cdd:cd17325 98 SAAV--WPAAMALIadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLALVLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 292 IIVFKEKPKHPPSRAQSlsyalattDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFpgeEVNAGR 371
Cdd:cd17325 168 LLLLPEPRPPPNKRAVS--------AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG---GLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 372 IGLTI---VIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVGMVVYTFTLNlnhLWVVFITAGTLGFFMTGYLPLGFEF 448
Cdd:cd17325 237 IGLLFgaqGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATS---FWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21703892 449 AVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 511
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
232-510 |
2.82e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 56.10 E-value: 2.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 232 DEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKDPEKLAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSY 311
Cdd:cd17313 137 EQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENP 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 312 ALATTDASYLSSIVRLFKNLNFVLLVITYGLNA-GAFYALSTLLNRMVILHFP-------GEEVNAGRIGLTIV-IAGMF 382
Cdd:cd17313 217 SLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAfFPFELFFTDYMGEEVYHGTsaasshyGAGVRMGAWGLLIFsLAFLI 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 383 GAMISGIWLDKSKTyKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGtLGFFMTGYLPlgFEFAVELT--YPESEGV 460
Cdd:cd17313 297 FSLPIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGG-IGWATININP--YPLVSDYHseSGRGQGT 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 21703892 461 SSGLLNVSAQVFGIVFTISQGQIIDNhgtmFGNIFLCVFLALGSALTAFI 510
Cdd:cd17313 373 DTGLLNLAISLAQILVSLLAGPIIDV----KGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
139-509 |
4.35e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 52.25 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 139 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN---CLGAWVKLGSLEPHLfpvtMVGQVICSVAQV 215
Cdd:cd17341 29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLlipLLALALAVSSYWGLL----VLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 216 FILGMPSriASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIK-DPEKLAYHISIMFYIIggVATFLFILVIIV 294
Cdd:cd17341 105 FASGQPW--ASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVfDGGFVGWRNAFFVPGI--LLAIAAVLVLLF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 295 FKEKPKHPPSRAQSLSYALATtdasylssivrlFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGL 374
Cdd:cd17341 181 GDDLPTGKASALEFLKVQLAV------------LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 375 TIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFA-VELT 453
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRR-RLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRmVPFI 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 21703892 454 YPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAF 509
Cdd:cd17341 328 FRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
164-509 |
1.40e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.73 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 164 VAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPHLFPVTMVGQVICSVAqVFILGMPSRIASVWFGAdEVSTACSVAVF 243
Cdd:cd17355 58 VGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAG-TLAAVAFATVAAWWFER-RRGLALGILTA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 244 GNQLGiaiGFLVPPVLVPnikdpekLAYHIS--IMFYIIGGVATFLFILVIIVFKEKPKHPPSRAqslsyALATTDASYL 321
Cdd:cd17355 136 GGGLG---SLVFLPLGAA-------LIEAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALRA-----YDDASPASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 322 SSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLtIVIAGMFGAMISGiWLDKSKTYKETT 401
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSG-WLGDRYSPRRLL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 402 LVVYIMTLVGMVVYTFTLNLNHLWVVFitAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQG 481
Cdd:cd17355 279 AASYALRALGLALLLLLPFPPLALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGG 356
|
330 340
....*....|....*....|....*...
gi 21703892 482 QIIDNHGTMFGNIFLCVFLALGSALTAF 509
Cdd:cd17355 357 LLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
276-508 |
2.32e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.88 E-value: 2.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 276 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalattdASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 355
Cdd:cd17320 155 IFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 356 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYK--ETTLVVYIMTLVGMVVYTFTLNLNHLWVV---FIT 430
Cdd:cd17320 226 FIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVaplFLI 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 431 AGTLGFFMtgylPLGFEFAVELtYPESEGVSSGLLNvSAQVFGIVFTISQGQIIDNHGT--MFGNIFLCVFLALGSALTA 508
Cdd:cd17320 306 FFGFGLIF----PNATSLALEP-FPHVAGTASALLG-FLQFLIGALAGALVGLLPNGTAlpMGLLILVLGLLALLLLILL 379
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
108-300 |
4.01e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 4.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 108 WVVVLVFSCYSLCNAFQWiqygSINNIFMNFY-GVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCL 186
Cdd:COG2211 231 LLLLLAYLLFFLALALVA----ALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 187 GAWVkLGSLEPHLFPVTMVGQVICSVAQVFILGMP-SRIASV------WFGADEVSTACSVAVFGNQLGIAIG-FLVPPV 258
Cdd:COG2211 307 GLLL-LFFLGPGNLWLLLVLAALAGIGLGAILVLPwAMLADVvdydewKTGRRREGLYFGIFTFAIKLGQALAgALAGLL 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 21703892 259 L-----VPNIKDPEKLAYHISIMFYIIGGVATFLFILVIIVFKEKPK 300
Cdd:COG2211 386 LalfgyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
134-509 |
1.03e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 134 IFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALncLGAWVKLGSLEPHLFPVTMVgqvicsva 213
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLL--TGLGLSLLGFAPNYWLLLLL-------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 214 qVFILGMPS--------RIASVWFGADeVSTACSVAVFGNQLGIAIGFLVPPVLVpnikdpEKLAYHISIMFYIIGGVAT 285
Cdd:cd17478 91 -VALAGIGSaafhpegaRLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALV------ALFGGLGLLILLIIPGLAV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 286 FLFILViiVFKEKPKHPPSRAQSLSYALATTDasylssivrlfKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFpGE 365
Cdd:cd17478 163 ALLLLR--LRPLKKPEAKKAAAKSSARSTLKG-----------VWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 366 EVNAGRIGLTIVIAGMFGAMISGIWLDKsktYKETTlvVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLG 445
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRR--VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVT 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21703892 446 FEFAVELTyPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGnIFLCVFLALGSALTAF 509
Cdd:cd17478 304 VVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
232-446 |
5.72e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.67 E-value: 5.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 232 DEVSTACSVAVFGNQLGIAIGFLVPPVLVPNIKDPEKlAYHISIMFYIIGGVATFLFILVIIVFKEKPKHPPSraqslsy 311
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNA-SRGYFLTALIIGIIGIILLLICFFGTRERVVPPEE------- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 312 alATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMV--ILHFPGEEVNAGRIGLTIVIAGMFGAMISGI 389
Cdd:cd17332 204 --EKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFkyVLGGRAELVLLLLLILSGALLALLPWPPLKK 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 21703892 390 WLDKSKTYKeTTLVVYIMTLVGMvvytFTLNLNHLWVVFITAGTLGFFMTGYLPLGF 446
Cdd:cd17332 282 RFGKKKAFF-IGLLLAILGLLLL----FFLPPGNLVLILVLAVLAGIGYGGANLLPW 333
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
89-295 |
1.02e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 89 THHSSLVREDSVIKVSKRRWVVVLvfscySLCNAFQW-IQYG---SINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPV 164
Cdd:cd17490 176 EKKPVLTELKELLSVLKDKKLLFF-----SLLAILQQmITFSttfGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLS 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 165 AWMLE-KFGLRTIAITGSALncLGAWVKLGSLEPHLFpVTMVGQVICSVAQ--VFILGMPSRIASVwfGADEVSTAcsVA 241
Cdd:cd17490 251 GTLFYkKLGERNTIIIGFLL--LGAYCFLIPFAPNLT-LLYLLQALNGFGTgiLFPLLMSLSIEGV--PAEQRSTA--MG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 21703892 242 VFgnQLGIAIGFLVPPVLVPNIKDpeklAYHISIMFYIIGGVATFLFILVIIVF 295
Cdd:cd17490 324 FF--QAIYALGMFLGPVLVGIISE----AFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
332-509 |
1.58e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 332 NFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVG 411
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 412 MVVYTFTLNLNhLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMF 491
Cdd:cd17316 257 ALPLFYLLSGS-PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 21703892 492 GNIFLCVFLALGSALTAF 509
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
106-510 |
1.76e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.14 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 106 RRWVVVLVFSCYSLCNAFQWIqYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 185
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGaWVkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFgADEVSTACSVAVFGNQLGiAIGFLVPPVLVPNikd 265
Cdd:cd17353 80 LG-FI-LSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLG-SLIFSPLIAYLIN--- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 266 peklAYHISIMFYIIGgvATFLFILVI--IVFKEKPKHpPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLN 343
Cdd:cd17353 153 ----TVGVPTTFLILG--IIFLIIIVIgaFLIRDPPKG-WVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLN 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 344 AGAFYALSTLLNRMVIlHFPGEEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKtYKETTLVVYIMTLVGMVvyTFTLNLN 422
Cdd:cd17353 226 ATAGLMLIGQAKPIGQ-EFAGLDAGIAALAVSILsIFNGGGRPFWGWLSDKIG-RKNTLSIAFLIQGVAMF--LLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 423 HLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLAL 502
Cdd:cd17353 302 VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLV 381
|
....*...
gi 21703892 503 GSALTAFI 510
Cdd:cd17353 382 ALALALLL 389
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
279-477 |
1.53e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.07 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 279 IIGGVATFLFILVIIVFKEKPKHPPsraqslsyalattdasylssiVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMV 358
Cdd:cd06179 231 VIGGVLLIAFGLYEWKGTKDGLLPP---------------------RLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQI 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 359 ILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVY-TFTLNLNHLWVVFITAGTLGFF 437
Cdd:cd06179 290 SLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLaLITPDNKALAIAFSVLAGIGIG 369
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 21703892 438 MTGYLPLgfeFAVELTYPESE-GVSSGLLNVSAQVFGIVFT 477
Cdd:cd06179 370 GPLVLAI---VIVQLSVPPEDiGTASGLLGSARALGGAVGT 407
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
142-511 |
1.85e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 142 SAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC-----LGAWVKLGSLEPhlfPVTMVGQVICSVAQVF 216
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAllaavLALLALLGSLSL---WLLLVLAFLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 217 ilGMPSRIASV--WFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVpnikdpekLAYHISIMFYIIggVATFLFILVIIV 294
Cdd:cd06173 109 --FGPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLV--------ALLGPGGAFAIN--ALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 295 FKEKPKHPPSRAQSLSYALATTDAsylssIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGrigl 374
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREG-----LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG---- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 375 TIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTY 454
Cdd:cd06173 248 LLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 21703892 455 PESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGnIFLCVFLALGSALTAFIK 511
Cdd:cd06173 328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV-FLLAGALLLLAALLLLLL 383
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
136-438 |
3.94e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 136 MNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWvkLGSLEPHlFPVTMVGQVICSVAQV 215
Cdd:cd17503 23 MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL--LCGLAPN-LASLIIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 216 FILGMPSRIASVWFGADEVSTACSVAVFGNQLGIAIGFLVPPVLVPNikdpeklaYHISIMFYIIGGVATFLFILVIIVf 295
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDN--------LSWRWIFYINLPIGILALLLAPLL- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 296 kekpkhppsraqslsyalattdasylssIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMV--ILHFPGEEvnAGRIG 373
Cdd:cd17503 171 ----------------------------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLqnVLGYSAFE--SGLVL 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21703892 374 LTIVIAGMFGAMISGIWLDKSkTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGFFM 438
Cdd:cd17503 221 APGGLASAILSPLVGRLLDKF-GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGM 284
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
107-502 |
4.62e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.32 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 107 RWVVVLVFSCYS-LCNAFQWIqYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAlnC 185
Cdd:cd17314 1 RWFVLYVSFLLSaMSTGFILS-WSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGI--M 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 186 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFgADEVSTACSVAVFGNQLGIaigFLVPPVLvpnikd 265
Cdd:cd17314 78 VLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGL---VLGSPLL------ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 266 peklayHISIMFYIIGGVATFLFILVIIVFK----EKPKHPPsRAQslsyALATTDASYLSSIVRLFKNLNFVLLVITYG 341
Cdd:cd17314 148 ------RILWVFYGLALVYTILGILAAIVLSvvslLGFKEPP-DNQ----ARLHVQKKKTQTMGEIFRDKVFWILFIAIF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 342 LNAGAFYALSTLLNRMVILhfpGEEVNAGRIGLTIVIAGMF---GAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFT 418
Cdd:cd17314 217 LVLIGGFLFIANMASLVRS---LQLDAPSFVTKLMSIYGLFnafGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703892 419 LNLNHLWvVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCV 498
Cdd:cd17314 294 LKMTPVG-LVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYA 372
|
....
gi 21703892 499 FLAL 502
Cdd:cd17314 373 VIVF 376
|
|
| |
