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Conserved domains on  [gi|21759451|sp|Q9WUV2|]
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RecName: Full=Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; AltName: Full=GalNAc alpha-2,6-sialyltransferase III; AltName: Full=ST6GalNAc III; Short=ST6GalNAcIII; AltName: Full=STY; AltName: Full=Sialyltransferase 7C; Short=SIAT7-C

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 77-302 1.08e-171

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23975:

Pssm-ID: 480271  Cd Length: 226  Bit Score: 474.42  E-value: 1.08e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 156
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 236
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759451 237 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 302
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 77-302 1.08e-171

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 474.42  E-value: 1.08e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 156
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 236
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759451 237 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 302
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 77-292 6.09e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.59  E-value: 6.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451    77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 135
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451   136 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 206
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451   207 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 286
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 21759451   287 AKWAKK 292
Cdd:pfam00777 249 QKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 77-302 1.08e-171

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 474.42  E-value: 1.08e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 156
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 236
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759451 237 MINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNW 302
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEPGRDECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 77-300 7.24e-126

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 358.48  E-value: 7.24e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPD-YFFKEASRTIYVIW 155
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAIlLLAGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 156 GPFRNMRKDGNGIvYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVY 235
Cdd:cd23965  81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21759451 236 GMINETYCKTEGYRKVPYHYYEQ-GKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHP 300
Cdd:cd23965 160 GMVPENYCREHPNSKVPYHYYEPgGLKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 77-303 3.87e-119

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 341.46  E-value: 3.87e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 156
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 236
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21759451 237 MINETYCKTEGYRKVPYHYYEQGK-DECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWT 303
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRlDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 77-302 4.65e-90

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 267.88  E-value: 4.65e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWG 156
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYG 236
Cdd:cd23978  81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21759451 237 MINETYC-KTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHPNW 302
Cdd:cd23978 161 MVPPNYCsKRPTPKKMPYHYYEpKGPDECVTYIQNEHGRRGNhHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 63-302 2.31e-86

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 259.03  E-value: 2.31e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  63 GYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDY 142
Cdd:cd23976   1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 143 FFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTF 222
Cdd:cd23976  81 LLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 223 ILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYE-QGKDECNEYLLHEHAPYGG-HRFITEKKVFAKWAKKHRIVFTHP 300
Cdd:cd23976 161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEpSGPDECTMYISHERGRKGShHRFITEKRVFANWARTFNIHFYQP 240


                ..
gi 21759451 301 NW 302
Cdd:cd23976 241 DW 242
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 80-289 1.12e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 155.60  E-value: 1.12e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  80 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFF---KEASRTIYVIWG 156
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGChplPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 PFRNMRKDgngivynmLKKTVDAYPDAQIYVTTEQQ--MTHCDRVFKDETGKDrVQSGSYLSTGWFTFILAMDACYSIHV 234
Cdd:cd19952  81 AAAADFKR--------LKRRKKRHDNAVLLLTDPAPdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 21759451 235 YGMINEtyckTEGYRKVPYHYYEQGKDECneyllhehaPYGGHRFITEKKVFAKW 289
Cdd:cd19952 152 YGFGVD----SGHAPKVPYHYYDLVEAEE---------GTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 77-292 6.09e-21

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 89.59  E-value: 6.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451    77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVP---------------------L 135
Cdd:pfam00777  43 CRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIdskygnlgfshprdpfvefvlV 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451   136 LLKNPDYFF---------KEASRTIYVIWGPFRNMRKDGNGIVYNmlkktvdayPDAQIYVTteqqmthcdRVFKDETGK 206
Cdd:pfam00777 123 PFKGRDLLWlpafltkgnVSRSLRVLYTLKEVKIPVDPDKVLFLH---------PDFLRYVA---------NFWLRSHGL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451   207 DrvqsGSYLSTGWFTFILAMDACYSIHVYGMINEtycktEGYRKVPYHYYEQGKDecneyllHEHAPYGGHRFITEKKVF 286
Cdd:pfam00777 185 K----GRRPSTGLLMLSLALHLCDEVSLYGFGPF-----LDSRGNSHHYYDNVLM-------KKGGFYGVHDMPFEFKLL 248


                  ....*.
gi 21759451   287 AKWAKK 292
Cdd:pfam00777 249 QKLHKE 254
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 72-293 3.98e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 80.18  E-value: 3.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  72 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVS-HTSVPLLLKNPDYFFKEASRT 150
Cdd:cd23973  78 PGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTaHSITSSLMILQKRGFKNIPQD 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 151 IYVIWGPFRNMRKDGNGIVYNMLKKTVDAYP----DAQIYVTTEQQMT-----HCD--RVFKDETGKDRVQSGSYL---- 215
Cdd:cd23973 158 KDIKYILFPEGPRDYQWLEALLKNKTIPSGAyygrRPRSYFSGDFTEDkylvlHPDflRYVKNRFLRSKTLKGKYWaiyr 237

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21759451 216 -STGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGKDECneyllhehAPYGGHRFITEKKVfakWAKKH 293
Cdd:cd23973 238 pTTGAFLLLTALHLCDTVSAYGFI------TEDYRKYPDHYYDKKKTKL--------VFYINHDFRLEKKL---WKRLH 299
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 49-157 1.42e-15

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 75.00  E-value: 1.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  49 PLPYTFRQPLRTHYgyinvrtQEPLQLNCNH---CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMV 125
Cdd:cd23968  21 TSPFKDLLSLRYPF-------PESSLENTKRyntCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTL 93

                        90       100       110
                ....*....|....*....|....*....|....
gi 21759451 126 RVVSHTsvpLLLKNPDYFFKEASRT--IYVIWGP 157
Cdd:cd23968  94 RLINSQ---ILSKPEFNFLTDPLYRnvTLLVWDP 124
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 80-260 4.21e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 73.83  E-value: 4.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  80 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGY----MTMVRVVSHTSVPLLLKNPDY-FFKEASRTI--Y 152
Cdd:cd23963  66 CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRktnlTTLNPSILKRRYNSLKKNRDRdKFLNRLKEYngS 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 153 VIWGPfrnmrKDGNGIVYNMLKKTVDAYPDaqiyVTTEQQMTHCDRVFKDETGK--DRVQSGSYLSTGWFTFILAMDACY 230
Cdd:cd23963 146 ILWYP-----KFSFKSSTNLLLKAARALKK----NGLNLTVVYSNPEHFLAVQKfwKRRGLEKRPSTGLYLVSLALTFCD 216

                       170       180       190
                ....*....|....*....|....*....|....
gi 21759451 231 SIHVYG----MINETycktegYRKVPYHYYEQGK 260
Cdd:cd23963 217 EIHLYGfwpfPTDPN------GRPVPYHYYDDLS 244
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 80-261 1.27e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.56  E-value: 1.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  80 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 156
Cdd:cd23986  52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSSlykDVILVAWD 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 157 P---FRNMRKDGNGIVYNMLKKTVD---AYPDAQIYVTTEQQMTHCDRVFKDETgKDRVQSGSyLSTGWFTFILAMDACY 230
Cdd:cd23986 128 PapySANLHKWYKKPDYNLFTPYVQyrkRNPNQPFYILHPKFIWQLWDIIQENT-QEKIQPNP-PSSGFIGILIMMSMCR 205

                       170       180       190
                ....*....|....*....|....*....|..
gi 21759451 231 SIHVYGMInetycktEGYRKVPY-HYYEQGKD 261
Cdd:cd23986 206 EVHVYEYI-------PSVRQTDLcHYHERYYD 230
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 77-297 4.09e-13

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 68.08  E-value: 4.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---------SHTSVPLL-LKNPDY-FFK 145
Cdd:cd23966  77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMypesavdldPGVHLVLVpFKVLDLqWLI 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 146 EASRTIYVIWGPFRnmrkdgngivynmLKKTVDAYPD-AQIYVTTEQQMTHcDRVFKDEtgkdrvqsGSYLSTGWFTFIL 224
Cdd:cd23966 157 SALTTGEITRTYTP-------------VKRFIKADKDkVLVINPAFIKYVH-DNWTEHH--------GRYPSTGFLALIF 214

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21759451 225 AMDACYSIHVYGMINETYckteGYRkvpYHYYEqgkdecNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVF 297
Cdd:cd23966 215 ALHICDEVSVFGFGADSK----GNW---HHYWE------KNRSAGAFRKTGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 77-294 4.60e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 65.36  E-value: 4.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG-----YMTMVR--VVSHTSVPLLLKNPDYFFkEASR 149
Cdd:cd23964  82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGtktsfYTFFPEslHNSLLKHVPQDKDTKYLF-IPFK 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 150 T---IYVI----WGPFRNMrKDGNGIVYNMLKKTVDA------YPDAQIYVtteqqmtHCDRVfkdetgkdRVQSGSYLS 216
Cdd:cd23964 161 IrdyDYLDavlsGKPVPDG-CDKGKRPPPLFGPKLNAtnvrllHPDFIRYL-------FNRWL--------NSSTSYRPT 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21759451 217 TGWFTFILAMDACYSIHVYGMINEtycktegyRKVPYHYYEQGKdecneyllHEHAP-YGGHRFITEKKVfakWAKKHR 294
Cdd:cd23964 225 TGALMLLTALHTCDQVSVYGFGYD--------PRFSLHYYDKTF--------VKFTVfYANHDFTNERKL---WRKLHE 284
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 77-128 1.70e-11

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 62.31  E-value: 1.70e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV 128
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF 53
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 69-257 2.80e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 62.80  E-value: 2.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  69 TQEPLQLNC-NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRvvshTSVPLLLknpDYFFKEA 147
Cdd:cd23970  59 EVSPFQNKHyNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSIL---EKYYNNL 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 148 SrTIYVIWGPFRNMRKDGNGIVY---------NMLKKTVDAYPDAQIYVTTEQQ------MTHCDRVFKDETGKDRvqsg 212
Cdd:cd23970 132 L-TIQDRNNFFLSLKKLDGAILWipafffhtsATVTRTLVDFFVEHRGQLKVQLawpgniMQHVNRYWKTKHLSPK---- 206

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 21759451 213 sYLSTGWFTFILAMDACYSIHVYGMINETYCKTEgyRKVPYHYYE 257
Cdd:cd23970 207 -RLSTGILMYTLASAICEEIHLYGFWPFGFDPTG--TPLPYHYYD 248
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 80-157 3.20e-11

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 62.42  E-value: 3.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  80 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTsvplLLKNPDYFFKEAS---RTIYVIWG 156
Cdd:cd23985  48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKFLKDSlynEGILIVWD 123


                .
gi 21759451 157 P 157
Cdd:cd23985 124 P 124
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 70-236 3.36e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 62.59  E-value: 3.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  70 QEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSvplllknpdyfFKEASR 149
Cdd:cd23980  74 LEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-----------FRELAQ 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 150 TIYVIWGPFR--NMRKDGNGIVYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMD 227
Cdd:cd23980 143 NVSMILVPFKtlDLEWVISATTTGTISHTYVPVP-RKIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLH 221


                ....*....
gi 21759451 228 ACYSIHVYG 236
Cdd:cd23980 222 VCDEVDLYG 230
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 77-259 5.99e-11

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 60.83  E-value: 5.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVV---SHTSVPLLLKNPDYF-----FKEAS 148
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypeSAQFDPGIENDPDTLlvlvpFKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 149 -RTIYVIWGPFRNMRKDGngivYNMLKKTVDAYPdAQIYVTTEQQMTHCDRVFKDETGKDrvQSGSYLSTGWFTFILAMD 227
Cdd:cd23982  82 fYWLYEILSNEKRVRKGF----WKQPPRIWDANP-KQIRILNPYYTYVAATKLLQVPGQR--KKKQKPTTGLLAITLALH 154

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21759451 228 ACYSIHVYGMinetyckteGY-----RKVPYHYYEQG 259
Cdd:cd23982 155 LCDEVHIAGF---------GYpdngnSNQPIHYYNQI 182
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 68-123 7.10e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 58.73  E-value: 7.10e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 21759451  68 RTQEPLQlnCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 123
Cdd:cd23979  73 RSWDPSR--CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRT 126
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 76-127 6.21e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.93  E-value: 6.21e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 21759451  76 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRV 127
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRI 52
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 77-135 8.00e-09

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 54.74  E-value: 8.00e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPL 135
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPK 60
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 19-260 1.05e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 55.21  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  19 CILLLAMRLVNDATFPLLLNcFGQPKTKW--------------IPLPYTFR--------QPLRTHYGYINVRTQEPLQL- 75
Cdd:cd23972   1 CPHSLHLRIQRDPHFRGLFN-FDIPVLLWgqhftpalwdrlsqRKVPYGWKglshqvvaSTLSLLNDSANAKLFFPRDTp 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  76 -NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT-------------MVRVVSH--TSVPlLLKN 139
Cdd:cd23972  80 gKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygftvntmknsLISYWNLgfTRTP-QGQD 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 140 PDYFFKEASRTIYVI-----------------------WGPFRNMRKdgngivYNMLkktvdaYPDAQIYVTteqqmthc 196
Cdd:cd23972 159 LQYIFIPSDIRDYVMlrsailgvpvpegldkgdrphkyFGPEASAKK------FKLL------HPDFISYLT-------- 218

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21759451 197 DRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMInetyckTEGYRKVPYHYYEQGK 260
Cdd:cd23972 219 DRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFI------TSNYWKFSDHYYERKK 276
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 78-260 1.49e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 54.73  E-value: 1.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  78 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPDY-FFKEASRTIY 152
Cdd:cd23969  65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGtksnLTTMNPSVIPHAYGDLVNATDKeKFVERLRQLG 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 153 --VIWGP-FrnMRKDG-------NGIVYNMLKKTVDAYPDAQIYvtteqqmtHCDRVFKDETgKDRVQSGsylSTGWFTF 222
Cdd:cd23969 145 dsILWIPaF--VSKGGeehvqwtNEIILKHKLNVKTAYPPLRLN--------HAIRGYWLTT-KFRIKRP---STGLLMY 210

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 21759451 223 ILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 260
Cdd:cd23969 211 TLATRFCDEIHLYGFY--PFSEDGNGRAVKYHYYDNRK 246
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 78-260 2.43e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 54.19  E-value: 2.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  78 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNPD---YFFKEASRT 150
Cdd:cd23988  65 KTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdFITMNPSVVQRAFGGFRNESDrekFVHRLSMLN 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 151 IYVIWGPfRNMRKDG-------NGIVYNMLKKTVDAYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFI 223
Cdd:cd23988 145 DSVLWIP-AFMVKGGekhvewvNALILKNKLKVRTAYPSL--------RLIHAVRGYW-LTNKVNIKRP---STGLLMYT 211

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 21759451 224 LAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYEQGK 260
Cdd:cd23988 212 LATRFCDEIHLYGFW--PFPKDANGNPVKYHYYDDLK 246
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 77-126 1.25e-07

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 51.29  E-value: 1.25e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 21759451  77 CNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVR 126
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 76-123 4.58e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 50.52  E-value: 4.58e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 21759451  76 NCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMT 123
Cdd:cd23974  83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRT 130
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 80-257 1.36e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 45.70  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  80 CAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVG----YMTMVRVVSHTSVPLLLKNP--DYFFKE-ASRTIY 152
Cdd:cd23987  67 CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGtktdLVTMNPSVVQRAFEDLVNETwkEKFLQRlQSLNGS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 153 VIWGPfRNMRKDGNGIVY----NMLKKTVD---AYPDAqiyvtteqQMTHCDRVFKdETGKDRVQSGsylSTGWFTFILA 225
Cdd:cd23987 147 ILWIP-AFMAKGGEERVEwvndLILKHHINvrtAYPSL--------RLLHAVRGYW-LTNKVHIKRP---TTGLLMYTLA 213

                       170       180       190
                ....*....|....*....|....*....|..
gi 21759451 226 MDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 257
Cdd:cd23987 214 TRFCNRIHLYGFW--PFPRDQNQNPVKYHYYD 243
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 72-257 3.48e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 3.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451  72 PLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAP-TKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYffkeaSRT 150
Cdd:cd23989  58 PLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSIIDKRFQNLLW-----SRK 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21759451 151 IYViwgpfRNMRKDGNGIVYN---MLKKTVDayPDAQIYVT-----TEQQMTHCDRVFKDETG---KDRVQSGSYLSTGW 219
Cdd:cd23989 133 SFV-----ESMKVYGRSYIYMpafSMKTGTD--PSLRVYYTladvgANQTVLFANPNFLRNVGkfwKSKGVHAKRLSTGL 205

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 21759451 220 FTFILAMDACYSIHVYGMIneTYCKTEGYRKVPYHYYE 257
Cdd:cd23989 206 FLVSAALGLCEEVTIYGFW--PFSVDLDERTISHHYYD 241
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 78-123 3.65e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 41.28  E-value: 3.65e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 21759451  78 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKG-FEEDVGYMT 123
Cdd:cd23991  65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKT 111
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 78-123 9.94e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 39.93  E-value: 9.94e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 21759451  78 NHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKgFEEDVGYMT 123
Cdd:cd23971  65 KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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