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Conserved domains on  [gi|219115978|ref|XP_002178784|]
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predicted protein, partial [Phaeodactylum tricornutum CCAP 1055/1]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03032 PLN03032
serine decarboxylase; Provisional
 1-364 0e+00

serine decarboxylase; Provisional


:

Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 733.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   1 SDILHAYDQLLQSKSSVHFGYPYNLMFDYTELAQFMKYSINNLGDPFVPSNYGVHSRQFEVAVIDFFAKLWKMETDSYWG 80
Cdd:PLN03032   9 ADILASYDKLLAEKSSVHFGYPYNLDFDYGELSQLMKYSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWELEKDEYWG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  81 YVTTSGTEGNLHGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPMGEIDYDCLSEAIARNRDKPVILNVN 160
Cdd:PLN03032  89 YITTCGTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTLPSGEIDYDDLERALAKNRDKPAILNVN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 161 IGTTVKGAVDNLDRILRILQSLQIPREQFYIHCDGALFALMMPFVEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSR 240
Cdd:PLN03032 169 IGTTVKGAVDDLDRILRILKELGYTEDRFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 241 KEHVKNLEQHIDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKGLTCRLNDLSSTVV 320
Cdd:PLN03032 249 KKHVKALSQNVEYLNSRDATIMGSRNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAGLTCRLNELSSTVV 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 219115978 321 LERPMDDDLVKRWQLACEEDIAHVVVMPNVTRYKIDLFVEELMQ 364
Cdd:PLN03032 329 FERPMDEAFIKKWQLACEGDIAHVVVMPNVTVEKLDEFVEELVE 372
 
Name Accession Description Interval E-value
PLN03032 PLN03032
serine decarboxylase; Provisional
 1-364 0e+00

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 733.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   1 SDILHAYDQLLQSKSSVHFGYPYNLMFDYTELAQFMKYSINNLGDPFVPSNYGVHSRQFEVAVIDFFAKLWKMETDSYWG 80
Cdd:PLN03032   9 ADILASYDKLLAEKSSVHFGYPYNLDFDYGELSQLMKYSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWELEKDEYWG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  81 YVTTSGTEGNLHGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPMGEIDYDCLSEAIARNRDKPVILNVN 160
Cdd:PLN03032  89 YITTCGTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTLPSGEIDYDDLERALAKNRDKPAILNVN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 161 IGTTVKGAVDNLDRILRILQSLQIPREQFYIHCDGALFALMMPFVEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSR 240
Cdd:PLN03032 169 IGTTVKGAVDDLDRILRILKELGYTEDRFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 241 KEHVKNLEQHIDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKGLTCRLNDLSSTVV 320
Cdd:PLN03032 249 KKHVKALSQNVEYLNSRDATIMGSRNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAGLTCRLNELSSTVV 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 219115978 321 LERPMDDDLVKRWQLACEEDIAHVVVMPNVTRYKIDLFVEELMQ 364
Cdd:PLN03032 329 FERPMDEAFIKKWQLACEGDIAHVVVMPNVTVEKLDEFVEELVE 372
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 60-362 4.83e-47

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 165.78  E-value: 4.83e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  60 EVAVIDFFAKLWKMEtDSYWGYVTTSGTEGNLHGILLAREKF-------------PDGILYTSQETHYSVFKAARYYRME 126
Cdd:COG0076  109 EREVVRWLADLLGLP-EGAGGVFTSGGTEANLLALLAARDRAlarrvraeglpgaPRPRIVVSEEAHSSVDKAARLLGLG 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 127 CQS---IPTLPMGEIDYDCLSEAIARNR---DKPVILNVNIGTTVKGAVDNLDRILRILQslqipREQFYIHCDGA--LF 198
Cdd:COG0076  188 RDAlrkVPVDEDGRMDPDALEAAIDEDRaagLNPIAVVATAGTTNTGAIDPLAEIADIAR-----EHGLWLHVDAAygGF 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 199 ALmmpfveFAPEvsFRKPI------DSIAVSGHKMLGCPMPCGVALSRKE--HVKNLEQHIDYLNS--------VDTTIM 262
Cdd:COG0076  263 AL------PSPE--LRHLLdgieraDSITVDPHKWLYVPYGCGAVLVRDPelLREAFSFHASYLGPaddgvpnlGDYTLE 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 263 GSRNGQaALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTA-KGLTcRLNDLSSTVVL------ERPMDDDLVKRWQL 335
Cdd:COG0076  335 LSRRFR-ALKLWATLRALGREGYRELIERCIDLARYLAEGIAAlPGFE-LLAPPELNIVCfrykpaGLDEEDALNYALRD 412

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 219115978 336 ACEED--------------IAHVVVMPNVTRYK-IDLFVEEL 362
Cdd:COG0076  413 RLRARgraflsptkldgrvVLRLVVLNPRTTEDdVDALLDDL 454
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 57-362 2.29e-38

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 140.03  E-value: 2.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  57 RQFEVAVIDFFAKLWKMETDSYWGYVTTSGTEGNLHGILLAREKF--------PDGI----LYTSQETHYSVFKAARYYR 124
Cdd:cd06450   37 TEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDRArkrlkaggGRGIdklvIVCSDQAHVSVEKAAAYLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 125 MECQSIPTLPMGEIDYDCLSEAIARNRDK---PVILNVNIGTTVKGAVDNLDRILRILQSLQIPreqfyIHCDGALFALM 201
Cdd:cd06450  117 VKVRLVPVDEDGRMDPEALEAAIDEDKAEglnPIMVVATAGTTDTGAIDPLEEIADLAEKYDLW-----LHVDAAYGGFL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 202 MPFVEFAPEVsFRKP-IDSIAVSGHKMLGCPMPCGVALSRkehvknleqhidylnsvdttimgsrngqaALYLWYSLRKK 280
Cdd:cd06450  192 LPFPEPRHLD-FGIErVDSISVDPHKYGLVPLGCSAVLVR-----------------------------ALKLWATLRRF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 281 GIGGIKRDVMHCMETARYLKDALTAKG-----------LTC-RLNDLSSTVVLERPMDDDLVKR--WQLA--CEEDIAH- 343
Cdd:cd06450  242 GRDGYGEHIDRIVDLAKYLAELIRADPgfellgepnlsLVCfRLKPSVKLDELNYDLSDRLNERggWHVPatTLGGPNVl 321

                        330       340
                 ....*....|....*....|.
gi 219115978 344 --VVVMPNVTRYKIDLFVEEL 362
Cdd:cd06450  322 rfVVTNPLTTRDDADALLEDI 342
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
60-307 4.79e-26

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 107.12  E-value: 4.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   60 EVAVIDFFAKLW-----KMETDSYwGYVTTSGTEGNLHGILLAREKF------------PDGI-----LYTSQETHYSVF 117
Cdd:pfam00282  81 ENVVMNWLGEMLglpaeFLGQEGG-GVLQPGSSESNLLALLAARTKWikrmkaagkpadSSGIlaklvAYTSDQAHSSIE 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  118 KAARYYRMECQSIPTLPMGEIDYDCLSEAIAR---NRDKPVILNVNIGTTVKGAVDNLDRILRILQslqipREQFYIHCD 194
Cdd:pfam00282 160 KAALYGGVKLREIPSDDNGKMRGMDLEKAIEEdkeNGLIPFFVVATLGTTGSGAFDDLQELGDICA-----KHNLWLHVD 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  195 GAL--FALMMPfvEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSRKEH--VKNLEQHIDYL----NSVDT---TIMG 263
Cdd:pfam00282 235 AAYggSAFICP--EFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEalQQAFQFNPLYLghtdSAYDTghkQIPL 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 219115978  264 SRnGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKG 307
Cdd:pfam00282 313 SR-RFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG 355
 
Name Accession Description Interval E-value
PLN03032 PLN03032
serine decarboxylase; Provisional
 1-364 0e+00

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 733.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   1 SDILHAYDQLLQSKSSVHFGYPYNLMFDYTELAQFMKYSINNLGDPFVPSNYGVHSRQFEVAVIDFFAKLWKMETDSYWG 80
Cdd:PLN03032   9 ADILASYDKLLAEKSSVHFGYPYNLDFDYGELSQLMKYSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWELEKDEYWG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  81 YVTTSGTEGNLHGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPMGEIDYDCLSEAIARNRDKPVILNVN 160
Cdd:PLN03032  89 YITTCGTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTLPSGEIDYDDLERALAKNRDKPAILNVN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 161 IGTTVKGAVDNLDRILRILQSLQIPREQFYIHCDGALFALMMPFVEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSR 240
Cdd:PLN03032 169 IGTTVKGAVDDLDRILRILKELGYTEDRFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTR 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 241 KEHVKNLEQHIDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKGLTCRLNDLSSTVV 320
Cdd:PLN03032 249 KKHVKALSQNVEYLNSRDATIMGSRNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAGLTCRLNELSSTVV 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 219115978 321 LERPMDDDLVKRWQLACEEDIAHVVVMPNVTRYKIDLFVEELMQ 364
Cdd:PLN03032 329 FERPMDEAFIKKWQLACEGDIAHVVVMPNVTVEKLDEFVEELVE 372
PLN02263 PLN02263
serine decarboxylase
 3-364 0e+00

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 574.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   3 ILHAYDQLLQSKSSVHFGYPYNLMFDYTELAQFMKYSINNLGDPFVPSNYGVHSRQFEVAVIDFFAKLWKMETDSYWGYV 82
Cdd:PLN02263  78 VLARYRKTLVERTKHHLGYPYNLDFDYGALGQLQHFSINNLGDPFIESNYGVHSRQFEVGVLDWFARLWEIEKNEYWGYI 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  83 TTSGTEGNLHGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPMGEIDYDCLSEAIARNRDKPVILNVNIG 162
Cdd:PLN02263 158 TNCGTEGNLHGILVGREVFPDGILYASRESHYSVFKAARMYRMECVKVDTLVSGEIDCADFKAKLLANKDKPAIINVNIG 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 163 TTVKGAVDNLDRILRILQSLQIPREQFYIHCDGALFALMMPFVEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSRKE 242
Cdd:PLN02263 238 TTVKGAVDDLDLVIKTLEECGFSQDRFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRME 317

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 243 HVKNLEQHIDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKGLTCRLNDLSSTVVLE 322
Cdd:PLN02263 318 HINVLSSNVEYLASRDATIMGSRNGHAPIFLWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLREAGISAMLNELSSTVVFE 397

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 219115978 323 RPMDDDLVKRWQLACEEDIAHVVVMPNVTRYKIDLFVEELMQ 364
Cdd:PLN02263 398 RPKDEEFVRRWQLACQGNIAHVVVMPSVTIEKLDYFLKELVE 439
PRK02769 PRK02769
histidine decarboxylase; Provisional
 11-362 3.09e-166

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 469.14  E-value: 3.09e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  11 LQSKSSVHFGYPYNLMFDYTELAQFMKYSINNLGDPFVPSNYGVHSRQFEVAVIDFFAKLWKMETDSYWGYVTTSGTEGN 90
Cdd:PRK02769  18 LRHNQYFNVGYPEAADFDYSALKRFFSFSINNCGDPYSKSNYPLNSFDFERDVMNFFAELFKIPFNESWGYITNGGTEGN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  91 LHGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPMGEIDYDCLSEAIARNRDKPVILNVNIGTTVKGAVD 170
Cdd:PRK02769  98 LYGCYLARELFPDGTLYYSKDTHYSVSKIARLLRIKSRVITSLPNGEIDYDDLISKIKENKNQPPIIFANIGTTMTGAID 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 171 NLDRILRILQSLQIprEQFYIHCDGALFALMMPFVEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSRKEHVKNLEQH 250
Cdd:PRK02769 178 NIKEIQEILKKIGI--DDYYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFIGSPMPCGIVLAKKKYVERISVD 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 251 IDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKGLTCRLNDLSSTVVLERPmDDDLV 330
Cdd:PRK02769 256 VDYIGSRDQTISGSRNGHTALLLWAAIRSLGSKGLRQRVQHCLDMAQYAVDRLQANGIPAWRNPNSITVVFPCP-SERIW 334

                        330       340       350
                 ....*....|....*....|....*....|..
gi 219115978 331 KRWQLACEEDIAHVVVMPNVTRYKIDLFVEEL 362
Cdd:PRK02769 335 KKWHLATSGNQAHIITMPHHNKQQIDSLIDEL 366
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 60-362 4.83e-47

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 165.78  E-value: 4.83e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  60 EVAVIDFFAKLWKMEtDSYWGYVTTSGTEGNLHGILLAREKF-------------PDGILYTSQETHYSVFKAARYYRME 126
Cdd:COG0076  109 EREVVRWLADLLGLP-EGAGGVFTSGGTEANLLALLAARDRAlarrvraeglpgaPRPRIVVSEEAHSSVDKAARLLGLG 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 127 CQS---IPTLPMGEIDYDCLSEAIARNR---DKPVILNVNIGTTVKGAVDNLDRILRILQslqipREQFYIHCDGA--LF 198
Cdd:COG0076  188 RDAlrkVPVDEDGRMDPDALEAAIDEDRaagLNPIAVVATAGTTNTGAIDPLAEIADIAR-----EHGLWLHVDAAygGF 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 199 ALmmpfveFAPEvsFRKPI------DSIAVSGHKMLGCPMPCGVALSRKE--HVKNLEQHIDYLNS--------VDTTIM 262
Cdd:COG0076  263 AL------PSPE--LRHLLdgieraDSITVDPHKWLYVPYGCGAVLVRDPelLREAFSFHASYLGPaddgvpnlGDYTLE 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 263 GSRNGQaALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTA-KGLTcRLNDLSSTVVL------ERPMDDDLVKRWQL 335
Cdd:COG0076  335 LSRRFR-ALKLWATLRALGREGYRELIERCIDLARYLAEGIAAlPGFE-LLAPPELNIVCfrykpaGLDEEDALNYALRD 412

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 219115978 336 ACEED--------------IAHVVVMPNVTRYK-IDLFVEEL 362
Cdd:COG0076  413 RLRARgraflsptkldgrvVLRLVVLNPRTTEDdVDALLDDL 454
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 57-362 2.29e-38

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 140.03  E-value: 2.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  57 RQFEVAVIDFFAKLWKMETDSYWGYVTTSGTEGNLHGILLAREKF--------PDGI----LYTSQETHYSVFKAARYYR 124
Cdd:cd06450   37 TEMEAEVVNWLAKLFGLPSEDADGVFTSGGSESNLLALLAARDRArkrlkaggGRGIdklvIVCSDQAHVSVEKAAAYLD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 125 MECQSIPTLPMGEIDYDCLSEAIARNRDK---PVILNVNIGTTVKGAVDNLDRILRILQSLQIPreqfyIHCDGALFALM 201
Cdd:cd06450  117 VKVRLVPVDEDGRMDPEALEAAIDEDKAEglnPIMVVATAGTTDTGAIDPLEEIADLAEKYDLW-----LHVDAAYGGFL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 202 MPFVEFAPEVsFRKP-IDSIAVSGHKMLGCPMPCGVALSRkehvknleqhidylnsvdttimgsrngqaALYLWYSLRKK 280
Cdd:cd06450  192 LPFPEPRHLD-FGIErVDSISVDPHKYGLVPLGCSAVLVR-----------------------------ALKLWATLRRF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 281 GIGGIKRDVMHCMETARYLKDALTAKG-----------LTC-RLNDLSSTVVLERPMDDDLVKR--WQLA--CEEDIAH- 343
Cdd:cd06450  242 GRDGYGEHIDRIVDLAKYLAELIRADPgfellgepnlsLVCfRLKPSVKLDELNYDLSDRLNERggWHVPatTLGGPNVl 321

                        330       340
                 ....*....|....*....|.
gi 219115978 344 --VVVMPNVTRYKIDLFVEEL 362
Cdd:cd06450  322 rfVVTNPLTTRDDADALLEDI 342
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
60-307 4.79e-26

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 107.12  E-value: 4.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   60 EVAVIDFFAKLW-----KMETDSYwGYVTTSGTEGNLHGILLAREKF------------PDGI-----LYTSQETHYSVF 117
Cdd:pfam00282  81 ENVVMNWLGEMLglpaeFLGQEGG-GVLQPGSSESNLLALLAARTKWikrmkaagkpadSSGIlaklvAYTSDQAHSSIE 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  118 KAARYYRMECQSIPTLPMGEIDYDCLSEAIAR---NRDKPVILNVNIGTTVKGAVDNLDRILRILQslqipREQFYIHCD 194
Cdd:pfam00282 160 KAALYGGVKLREIPSDDNGKMRGMDLEKAIEEdkeNGLIPFFVVATLGTTGSGAFDDLQELGDICA-----KHNLWLHVD 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  195 GAL--FALMMPfvEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGVALSRKEH--VKNLEQHIDYL----NSVDT---TIMG 263
Cdd:pfam00282 235 AAYggSAFICP--EFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEalQQAFQFNPLYLghtdSAYDTghkQIPL 312

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 219115978  264 SRnGQAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTAKG 307
Cdd:pfam00282 313 SR-RFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDG 355
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 81-248 3.17e-06

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 48.40  E-value: 3.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   81 YVTTSGTEGN---LHGILLAREKfPDGILYTSQEtHYSVF----KAARYYRMECQSIPTLPMGEIDYDCLSEAIarnRDK 153
Cdd:pfam00266  65 IFTSGTTEAInlvALSLGRSLKP-GDEIVITEME-HHANLvpwqELAKRTGARVRVLPLDEDGLLDLDELEKLI---TPK 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  154 PVILNVNIGTTVKGAVDNLDRILRILQSLQIpreqfYIHCDGALFALMMPfvefapeVSFRK-PIDSIAVSGHKMLGcPM 232
Cdd:pfam00266 140 TKLVAITHVSNVTGTIQPVPEIGKLAHQYGA-----LVLVDAAQAIGHRP-------IDVQKlGVDFLAFSGHKLYG-PT 206

                         170
                  ....*....|....*.
gi 219115978  233 PCGVALSRKEHVKNLE 248
Cdd:pfam00266 207 GIGVLYGRRDLLEKMP 222
PRK02948 PRK02948
IscS subfamily cysteine desulfurase;
81-236 9.25e-04

IscS subfamily cysteine desulfurase;


Pssm-ID: 179511 [Multi-domain]  Cd Length: 381  Bit Score: 40.87  E-value: 9.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  81 YVTTSGTEGN---LHGILLAREKFPDGILYTSQEtHYSVFKAARYYRMECQSIPTLPM---GEIDYDCLSEAIarnRDKP 154
Cdd:PRK02948  64 YFTSGGTESNylaIQSLLNALPQNKKHIITTPME-HASIHSYFQSLESQGYTVTEIPVdksGLIRLVDLERAI---TPDT 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 155 VILNVNIGTTVKGAVDNLDRILRILQSLQIpreqfYIHCDgalfaLMMPFVEFAPEVsFRKPIDSIAVSGHKMLGcpmPC 234
Cdd:PRK02948 140 VLASIQHANSEIGTIQPIAEIGALLKKYNV-----LFHSD-----CVQTFGKLPIDV-FEMGIDSLSVSAHKIYG---PK 205


                 ..
gi 219115978 235 GV 236
Cdd:PRK02948 206 GV 207
PLN02880 PLN02880
tyrosine decarboxylase
 58-305 9.90e-04

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 41.05  E-value: 9.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  58 QFEVAVIDFFAKLWK-----METDSYWGYVTTSGTEGNLHGILLAREK---------FPDGILYTSQETHYSVFKAARYY 123
Cdd:PLN02880 122 ELEMIVLDWLAKLLNlpeqfLSTGNGGGVIQGTASEAVLVVLLAARDRvlrkvgknaLEKLVVYASDQTHSALQKACQIA 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 124 RMECQSIPTLPMG-----EIDYDCLSEAIARNRDK---PVILNVNIGTTVKGAVDNLDRILRILQSLQIpreqfYIHCDG 195
Cdd:PLN02880 202 GIHPENCRLLKTDsstnyALAPELLSEAISTDLSSgliPFFLCATVGTTSSTAVDPLLELGKIAKSNGM-----WFHVDA 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978 196 ALF--ALMMPfvEFAPEVSFRKPIDSIAVSGHKMLGCPMPCGV--ALSRKEHVKNLEQHIDYL-------NSV----DTT 260
Cdd:PLN02880 277 AYAgsACICP--EYRHYIDGVEEADSFNMNAHKWFLTNFDCSLlwVKDRNALIQSLSTNPEFLknkasqaNSVvdykDWQ 354

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 219115978 261 I-MGSRNgqAALYLWYSLRKKGIGGIKRDVMHCMETARYLKDALTA 305
Cdd:PLN02880 355 IpLGRRF--RSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQ 398
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
59-349 1.21e-03

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 40.37  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978   59 FEVAVIDFFAKLWKMETDSYWGYVTTSGTEGNLhGILLAREKFPDGILYTSQETHYSVFKAARYYRMECQSIPTLPM--G 136
Cdd:pfam00155  44 LREALAKFLGRSPVLKLDREAAVVFGSGAGANI-EALIFLLANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSndF 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  137 EIDYDCLSEAIarnRDKPVIL---NVNIGTtvkGAVDNLDRILRILQSLQipREQFYIHCDGALFALMMPFVEFAPEVSF 213
Cdd:pfam00155 123 HLDFDALEAAL---KEKPKVVlhtSPHNPT---GTVATLEELEKLLDLAK--EHNILLLVDEAYAGFVFGSPDAVATRAL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  214 RKPIDSIAVSG--HKMLGCP-MPCGVALSRKEhVknleqhIDYLNSVDTTIMGSRNGQAALYLWYSLRKKGIGGIKRDVM 290
Cdd:pfam00155 195 LAEGPNLLVVGsfSKAFGLAgWRVGYILGNAA-V------ISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQ 267

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 219115978  291 HCMETARYLKDALTAKGLTCRLND--LSSTVVLERPMDDDLvkrWQLACEEdiAHVVVMPN 349
Cdd:pfam00155 268 RIKERRDYLRDGLQAAGLSVLPSQagFFLLTGLDPETAKEL---AQVLLEE--VGVYVTPG 323
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 80-232 1.72e-03

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 38.90  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 219115978  80 GYVTTSGTEGNLHGILLAREKfPDGILYTSQETHYSVFKAARyyRMECQSIPT----LPMGEIDYDCLSEAIARNRDKPV 155
Cdd:cd01494   20 AVFVPSGTGANEAALLALLGP-GDEVIVDANGHGSRYWVAAE--LAGAKPVPVpvddAGYGGLDVAILEELKAKPNVALI 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 219115978 156 ILNVNIGTTvkGAVDNLDRILRILQSLQIpreqfYIHCDGALFALMMPFVEFAPEVSFrkpIDSIAVSGHKMLGCPM 232
Cdd:cd01494   97 VITPNTTSG--GVLVPLKEIRKIAKEYGI-----LLLVDAASAGGASPAPGVLIPEGG---ADVVTFSLHKNLGGEG 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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