|
Name |
Accession |
Description |
Interval |
E-value |
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
18-394 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 589.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEQwNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITI 96
Cdd:pfam01053 1 DTLAVHAGQRPDP-QTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAiTAAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 97 THLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVH 176
Cdd:pfam01053 80 LALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 177 KRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCR 256
Cdd:pfam01053 160 KHG-ILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 257 GLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTL 336
Cdd:pfam01053 239 GLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLKLFSL 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 22122387 337 AESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
Cdd:pfam01053 319 AVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
15-396 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 583.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 15 QHFATQAIHVGQEPEqWNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAF 86
Cdd:COG0626 1 MGPATRAVHAGRDPD-PQTGAVSPPIYLTSTFVFPsaealaarFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 87 ASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:COG0626 80 ASGMAAiSAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 166 ADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAV 245
Cdd:COG0626 160 VDIAAIAAIAHAAG-ALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 246 PSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAK 325
Cdd:COG0626 239 LSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGREAAR 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22122387 326 AFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:COG0626 319 RFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
35-394 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 554.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDE 105
Cdd:cd00614 2 AVAPPIYQTSTFVFPspaeaadlFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAiSTVLLALLKAGDH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 106 IICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVV 185
Cdd:cd00614 82 VVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHG-ALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 186 DNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRM 265
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 266 EKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYES 345
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 22122387 346 LAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
12-395 |
8.77e-175 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 492.62 E-value: 8.77e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 12 PSFQHFATQAIHVGQEPEQWNSrAVVLPISLATTFKQDFPGQ-SSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGL 90
Cdd:PRK07811 8 HANQGFATRAIHAGYEPDPATG-AVNPPIYASSTFAQDGVGGlRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSGM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 91 AAT-ITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIG 169
Cdd:PRK07811 87 AATdCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 170 ACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPF 249
Cdd:PRK07811 167 ALAELAHDAG-AKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 250 DCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLK 329
Cdd:PRK07811 246 DAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEAARDFCA 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122387 330 NLKLFTLAESLGGYESLAELPAIMTHASVPEkdrATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK07811 326 RTKVFTLAESLGGVESLIEHPSAMTHASTAG---SQLEVPDDLVRLSVGIEDVADLLADLEQALGQ 388
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
19-394 |
4.35e-157 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 447.25 E-value: 4.35e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 19 TQAIHVGQEPEQwNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITH 98
Cdd:PRK07671 5 TKLIHGGIIGDP-STGAVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 99 LLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVhKR 178
Cdd:PRK07671 84 LFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIA-KE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 179 GDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGL 258
Cdd:PRK07671 163 KGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 259 KTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIkGALQHAKAFLKNLKLFTLAE 338
Cdd:PRK07671 243 KTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQYFTLAE 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 22122387 339 SLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
Cdd:PRK07671 322 SLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
16-395 |
5.21e-146 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 419.30 E-value: 5.21e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHvGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATIT 95
Cdd:PRK06176 2 RMQTKLIH-GGISEDTTTGAVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 96 ITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIV 175
Cdd:PRK06176 81 VFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 176 HKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCC 255
Cdd:PRK06176 161 KDHG-LLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 256 RGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQhAKAFLKNLKLFT 335
Cdd:PRK06176 240 RGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSE-AVAFVESLKLFI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 336 LAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK06176 319 LGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAFAK 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
18-396 |
1.25e-135 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 393.04 E-value: 1.25e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEQWNsrAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITIT 97
Cdd:TIGR01329 2 STLLVNTDNKNDPYD--ASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 98 HLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHK 177
Cdd:TIGR01329 80 RLLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 178 RGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRG 257
Cdd:TIGR01329 160 QN-ALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 258 LKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGcPGMVSFYIKGALQHAKAFLKNLKLFTLA 337
Cdd:TIGR01329 239 IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKG-AGSVLSFETGSVALSKRLVEATKLFSIT 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 22122387 338 ESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:TIGR01329 318 VSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTA 376
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
35-396 |
1.02e-128 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 375.29 E-value: 1.02e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVY 113
Cdd:TIGR02080 21 CVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAiHLVTTALLGPDDLLVAPHDCY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 114 GGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAY 193
Cdd:TIGR02080 101 GGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVG-AVVVVDNTFLSPA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 194 FQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGM 273
Cdd:TIGR02080 180 LQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNAQ 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 274 AVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIM 353
Cdd:TIGR02080 260 AIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPATM 339
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 22122387 354 THASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:TIGR02080 340 THAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGLRAA 382
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
12-396 |
3.93e-127 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 372.83 E-value: 3.93e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 12 PSFQHFATQAIHVGQEPEQ-WNSRAVvlPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKH 82
Cdd:COG2873 3 EKKYGFETLALHAGQEPDPtTGARAV--PIYQTTSYVFDdaehaadlFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 83 SLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNP 161
Cdd:COG2873 81 ALATASGQAAiTLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 162 TLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--SVNSD-DLNSR---- 234
Cdd:COG2873 161 ALDVLDIEAIAEIAHEHG-VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdGGNFDwAANGKfpel 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 235 ---------LRF----------------LQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVV 289
Cdd:COG2873 240 tepdpsyhgLVYteafgnaafitkarvqLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 290 YPGLPSHPQHELAKRQCS-GCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGI 368
Cdd:COG2873 320 YPGLPSHPYHELAQKYLPkGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGV 399
|
410 420
....*....|....*....|....*...
gi 22122387 369 NDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:COG2873 400 TPDLIRLSVGIEDIDDIIADLDQALAAA 427
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
15-395 |
1.44e-126 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 370.37 E-value: 1.44e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 15 QHFATQAIHVGQEP-EQWNsrAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLA 85
Cdd:TIGR01328 2 MTFATRAIHAGYPPkDQFG--ALTPPIYQTSTFVFDsceqggnrFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 86 FASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLK 164
Cdd:TIGR01328 80 TSSGMGAiAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 165 LADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNS-RLRFLQNSLG 243
Cdd:TIGR01328 160 LIDMERVCRDAHSQG-VKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 244 AVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQH 323
Cdd:TIGR01328 239 SVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFAG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 324 AKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:TIGR01328 319 AKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQALDA 390
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
17-393 |
2.68e-126 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 369.93 E-value: 2.68e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 17 FATQAIHVGQEPE-QWNSRAVvlPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFA 87
Cdd:PRK06234 9 FATKAIHGGHIGDkQFGSLAT--PIYQTSTFIFDsaeqggrrFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 88 SGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK06234 87 SGMGAiSSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 167 DIGACAQIVHKRG-DIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNS-RLRFLQNSLGA 244
Cdd:PRK06234 167 DIKAISNIAHENNkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQvKLFGIKDMTGS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 245 VPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHA 324
Cdd:PRK06234 247 VIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGGVEEG 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122387 325 KAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 393
Cdd:PRK06234 327 KVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQAL 395
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
35-396 |
1.20e-124 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 364.41 E-value: 1.20e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYG 114
Cdd:PRK08247 22 TVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVMSLFRSGDELIVSSDLYG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYF 194
Cdd:PRK08247 102 GTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIA-KKHGLLLIVDNTFYTPVL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMA 274
Cdd:PRK08247 181 QRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 275 VARFLETNPRVEKVVYPGlpshpqhelakrqcSGcpGMVSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAELPAIMT 354
Cdd:PRK08247 261 IAAFLNEQPGVTDVLYPG--------------RG--GMLSFRLQDE-EWVNPFLKSLKLITFAESLGGVESFITYPATQT 323
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 22122387 355 HASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08247 324 HADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFKQV 365
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
17-397 |
1.13e-123 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 363.35 E-value: 1.13e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 17 FATQAIHVGQEPEQwNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFAS 88
Cdd:PRK07503 10 FSTRAIHHGYDPLD-HGGALVPPVYLTATFAFPtaeygaecFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALAS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 89 GLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK07503 89 GMGAiTATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 168 IGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNSDDLNSRLRF--LQNSLGAV 245
Cdd:PRK07503 169 IAAVAEIAHGAG-AKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLV-VGGKALADRIRLegLKDMTGAV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 246 PSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAK 325
Cdd:PRK07503 247 MSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFELKGGIAAGR 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 326 AFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAH 397
Cdd:PRK07503 327 RFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALDACA 398
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
35-398 |
1.87e-121 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 357.16 E-value: 1.87e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYG 114
Cdd:PRK08064 24 AVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAISTAFLLLSKGDHVLISEDVYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVhKRGDIILVVDNTFMSAYF 194
Cdd:PRK08064 104 GTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVKLA-KAIGCLTFVDNTFLTPLL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMA 274
Cdd:PRK08064 183 QKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 275 VARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGAlQHAKAFLKNLKLFTLAESLGGYESLAELPAIMT 354
Cdd:PRK08064 263 IALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSE-EAVRQFVSHVKLPVFAVSLGAVESILSYPAKMS 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 22122387 355 HASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP 398
Cdd:PRK08064 342 HAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALSYVEE 385
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
35-398 |
7.51e-121 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 358.19 E-value: 7.51e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYG 114
Cdd:PLN02509 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 115 GTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGDIILVvDNTFMSAYF 194
Cdd:PLN02509 183 GSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLV-DNSIMSPVL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMA 274
Cdd:PLN02509 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 275 VARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFyIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMT 354
Cdd:PLN02509 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 420
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 22122387 355 HASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP 398
Cdd:PLN02509 421 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFRTGPL 464
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
15-394 |
1.44e-115 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 342.21 E-value: 1.44e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 15 QHFATQAIHVGQEPEQwNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAF 86
Cdd:PRK06767 4 KHMETALIHHGYTSEE-HKGSLTPPLFQTSTFTFEtaqqgeasFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 87 ASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:PRK06767 83 GSGMAAiSATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 166 ADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAV 245
Cdd:PRK06767 163 IDLKQVIRVAKRNG-LLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 246 PSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYpglpshPQHELAKRQCSGCPGMVSFYIKGALQHAK 325
Cdd:PRK06767 242 MAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEETQ 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122387 326 AFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
Cdd:PRK06767 316 AFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
18-395 |
8.26e-113 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 335.11 E-value: 8.26e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEQWnsRAVVLPISLATTFKQDFPGQSS--GFE--YSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAAT 93
Cdd:PRK08574 4 GTDAVRGYRGSDPY--GSLQPPIYLTALFRQEGEAYPSdrGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 94 ITI-THLLKAGDEIICMDEVYGGTNRYFRRVaSEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACA 172
Cdd:PRK08574 82 STLfFSLLKAGDRVVLPMEAYGTTLRLLKSL-EKFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 173 QiVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCY 252
Cdd:PRK08574 161 K-AAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 253 LCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRqCSGCP---GMVSFYIKGALQHAKAFLK 329
Cdd:PRK08574 240 LVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKR-LFGKDlygGVVSFRVKGGRDAVLKFLR 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22122387 330 NLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK08574 319 SLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALGS 384
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
16-395 |
1.88e-112 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 334.28 E-value: 1.88e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGQE--PEQWNSRAVVLPISL----ATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASG 89
Cdd:PRK08133 6 GFDTLAVRAGQLrsPFGEHSEALFLTSSFvfesAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 90 LAATITIT-HLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADI 168
Cdd:PRK08133 86 MAAILAVVmALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTELADI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 169 GACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQnSLGAVPSP 248
Cdd:PRK08133 166 AALAEIAHAAG-ALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEVFGFLR-TAGPTLSP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 249 FDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFL 328
Cdd:PRK08133 244 FNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGREAAWRVI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22122387 329 KNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK08133 324 DATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLARGLAA 390
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
16-396 |
3.83e-110 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 328.87 E-value: 3.83e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGQEPEQWNSrAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATIT 95
Cdd:PRK08776 12 SAATAAVRAGIDRDTAYG-AVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 96 ITH-LLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQI 174
Cdd:PRK08776 91 VLNaLLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 175 VHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLC 254
Cdd:PRK08776 171 AHKVGALT-VVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 255 CRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLF 334
Cdd:PRK08776 250 LRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGLRYF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 335 TLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08776 330 TLAESLGGVESLIAHPASMTHAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARA 391
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
18-396 |
1.55e-108 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 324.16 E-value: 1.55e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEQwNSRAVVLPISLATTFkqDFP--GQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TI 94
Cdd:PRK08861 7 ATIAVRTGIESDS-QYHAVVPPIYLSTNY--GFPafGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSAlNL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 95 TITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQI 174
Cdd:PRK08861 84 WVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 175 VHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLC 254
Cdd:PRK08861 164 AKAVGALV-AVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 255 CRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLF 334
Cdd:PRK08861 243 LRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFVKALALF 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 335 TLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08861 323 SLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKA 384
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
16-394 |
9.93e-108 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 323.16 E-value: 9.93e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGQEPE-QWNSRAVvlPISLATTF--------KQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAF 86
Cdd:TIGR01326 1 HFETLQLHAGQEPDpTTGSRAV--PIYQTTSYvfdstehaAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 87 ASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKL 165
Cdd:TIGR01326 79 ASGQAAiTYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 166 ADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSdVVMGLVSVNSDDLN------------- 232
Cdd:TIGR01326 159 LDIEAIAEVAHRHG-IPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHG-TAIGGVIVDGGKFDwnngrfplfttpd 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 233 --------------------SRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPG 292
Cdd:TIGR01326 237 psyhglvftetlgnpafilkARVQLLRD-LGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 293 LPSHPQHELAKRQCSGCPGMV-SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDT 371
Cdd:TIGR01326 316 LASHPHHALAKKYLPKGFGAVlSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPG 395
|
410 420
....*....|....*....|...
gi 22122387 372 LIRLSVGLEDEQDLLEDLDRALK 394
Cdd:TIGR01326 396 LIRLSVGIENIDDIIADLEQALE 418
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
18-396 |
9.94e-108 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 322.23 E-value: 9.94e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVG-QEPEQWNsrAVVLPISLATTFK-QDFpGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAAT-I 94
Cdd:PRK08045 6 ATIAVRSGlNDDEQYG--CVVPPIHLSSTYNfTGF-NEPRAHDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIhL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 95 TITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQI 174
Cdd:PRK08045 83 VTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 175 VHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLC 254
Cdd:PRK08045 163 AREAGAVS-VVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 255 CRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLF 334
Cdd:PRK08045 242 LRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFLGGLSLF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 335 TLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08045 322 TLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
16-396 |
2.05e-106 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 318.99 E-value: 2.05e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGqEPEQWNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFA 87
Cdd:PRK08249 8 GVGTKAVWAG-EKEYLPYGATQVPVVLSVAYGYDdidewydvALGKKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 88 SGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK08249 87 TGMAAiSNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 167 DIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVvMGLVSVNSDDLNSRLRFLQNSLGAVP 246
Cdd:PRK08249 167 DIERLAAAAKKVGALV-VVDNTFATPINQNPLALGADLVIHSATKFLSGHADA-LGGVVCGSKELMEQVYHYREINGATM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 247 SPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKA 326
Cdd:PRK08249 245 DPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMDTVKR 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 327 FLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08249 325 LLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEGLVRISVGIEDTEDLIADLEQAFAHL 394
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
35-395 |
3.82e-103 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 309.44 E-value: 3.82e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYG 114
Cdd:PRK07269 24 ALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFSVFPVGSKVVAVRDLYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 115 GTNRYFRRVASEFglKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYF 194
Cdd:PRK07269 104 GSFRWFNQQEKEG--RFHFTYANTEEELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKG-AKVIVDNTFYSPIY 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 195 QRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMA 274
Cdd:PRK07269 181 QRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 275 VARFLETNPRVEKVVYPGLpshpqhelakrqcsgcPGMVSFYI--KGALQHakaFLKNLKLFTLAESLGGYESLAELPAI 352
Cdd:PRK07269 261 VVAFLKKSPAVKEVLYTGK----------------GGMISFKVadETRIPH---ILNSLKVFTFAESLGGVESLITYPTT 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 22122387 353 MTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK07269 322 QTHADIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQALEG 364
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
14-395 |
9.04e-103 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 309.53 E-value: 9.04e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 14 FQHFATQAIHVGQ--EPEQWNsraVVLPISLATTF------KQDFPGQSSG--FEYSRSGNPTRNCLEKAVAALDGAKHS 83
Cdd:PRK06434 6 LNGFNTRAVQSGElrDPRFGN---VTTPIFETSTFvypnseKEAYMDSTRGmpYIYTRWGNPTVQAFEEKYAVLENAEHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 84 LAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEaaITPQT-KLVWIETPTNP 161
Cdd:PRK06434 83 LSFSSGMGAiTSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 162 TLKLADIGACAQIVHKRgdiILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNS 241
Cdd:PRK06434 161 TLKVPDIKNVSSFCHEN---DVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 242 LGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLpshpqhELAKRQCSGCPGMVSFYIKgAL 321
Cdd:PRK06434 238 LGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELR-SM 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122387 322 QHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK06434 311 EDVHKFIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENALSK 384
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
18-393 |
1.55e-102 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 308.70 E-value: 1.55e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEQWNSRAVVLPISLATTFK------QDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLA 91
Cdd:TIGR01325 1 ATLAVRGGMLRSGFEETAEALYLTSGYVYDsaavaaKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 92 ATIT-ITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGA 170
Cdd:TIGR01325 81 AIFAaLMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 171 CAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFD 250
Cdd:TIGR01325 161 VAELAHAAG-AKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFN 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 251 CYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGAlQHAKAFLKN 330
Cdd:TIGR01325 240 AWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCR-QAAFKVLDA 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22122387 331 LKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 393
Cdd:TIGR01325 319 MRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRAL 381
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
18-393 |
2.58e-94 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 287.50 E-value: 2.58e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEqwnSRAVVLPISLATTFkqDFPGqSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITI 96
Cdd:PRK06460 4 ATRTVREDIDEA---TGAITTPIYQTTAY--HYPE-GEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAiSTTA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 97 THLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVH 176
Cdd:PRK06460 78 LALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 177 KRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNsRLRFLQNSLGAVPSPFDCYLCCR 256
Cdd:PRK06460 158 ENG-SILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGKLLN-VIDQMRRTLGTSLDPHAAYLTLR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 257 GLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTL 336
Cdd:PRK06460 236 GIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIP 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 22122387 337 AESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRAL 393
Cdd:PRK06460 316 AQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
16-396 |
5.31e-91 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 280.40 E-value: 5.31e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGQEPEqWNSRAVVLPISLATTFK-------QDF-----------PGQSSGFEYSRSGNPTRNCLEKAVAAL 77
Cdd:PRK07049 17 HPETQMLNYGYDPE-LSEGAVKPPVFLTSTFVfrsaedgRDFfdyvsgrkeppAGEGAGLVYSRFNHPNSEIVEDRLAVY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 78 DGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLK-ISFVDCSKTKLLEAAITP-----QT 150
Cdd:PRK07049 96 EGAESAALFSSGMSAiATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGaVGFADGLSEAAIGAAAEAaaakgRV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 151 KLVWIETPTNPTLKLADIGA----CAQIVHKRGDI-ILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVs 225
Cdd:PRK07049 176 SLILIETPANPTNSLVDVAAvrrvADAIEARQGHRpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAV- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 226 VNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGL--PSHPQHELAK 303
Cdd:PRK07049 255 LGRKALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYK 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 304 RQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQ 383
Cdd:PRK07049 335 RQCTGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPD 414
|
410
....*....|...
gi 22122387 384 DLLEDLDRALKAA 396
Cdd:PRK07049 415 DLIADLAQALDAA 427
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
19-396 |
6.57e-91 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 280.58 E-value: 6.57e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 19 TQAIHVGQEPEQWN-SRAVVLPISLATTFKQD------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLA 91
Cdd:PRK08248 11 TLAIHAGQEIDPTTgSRAVPIYQTTSYGFRDSehaanlFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 92 A-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGA 170
Cdd:PRK08248 91 AiTYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGNPKGDVLDIEA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 171 CAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNSDD-------------------- 230
Cdd:PRK08248 171 VAAIAHEHG-IPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVI-VDSGKfdwkgsgkfpgltepdpsyh 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 231 --------------LNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSH 296
Cdd:PRK08248 249 glvytdavgeaayiTKARVQLLRD-LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 297 PQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRL 375
Cdd:PRK08248 328 PSYELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGLVRL 407
|
410 420
....*....|....*....|.
gi 22122387 376 SVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08248 408 SVGTEAIDDILDDLRQAIRQS 428
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
50-396 |
8.13e-90 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 276.64 E-value: 8.13e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 50 FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFG 128
Cdd:PRK07504 50 FKGEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAvTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 129 LKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCS 208
Cdd:PRK07504 130 IESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAG-AKLVVDNVFATPLFQKPLELGAHIVVYS 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 209 ATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKV 288
Cdd:PRK07504 209 ATKHIDGQGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 289 VYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGI 368
Cdd:PRK07504 289 IYPGRADHPQADIIAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAELGI 368
|
330 340
....*....|....*....|....*...
gi 22122387 369 NDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK07504 369 SEGFLRLSAGLEDTDDLIEDLAAALKKV 396
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
12-396 |
2.69e-89 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 276.23 E-value: 2.69e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 12 PSFQHFATQAIHVGQEPE-QWNSRAVvlPISLATTFK-QD-------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKH 82
Cdd:PRK08134 4 MSPPGFDTLALHAGAAPDpATGARAV--PIHLTTSFVfRDsdhaaalFNLERAGHVYSRISNPTVAVLEERVAALEGGVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 83 SLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNP 161
Cdd:PRK08134 82 AIATASGQAAlHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 162 TLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV----------------- 224
Cdd:PRK08134 162 GLEVLDIPTVAAIAHEAG-VPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLvdggrfdweasgkfpel 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 225 ----------------SVNSDDLNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKV 288
Cdd:PRK08134 241 tepyagfhgmvfaeesTVAAFLLRARREGLRD-FGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 289 VYPGLPSHPQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLG 367
Cdd:PRK08134 320 AHPELESHPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAG 399
|
410 420
....*....|....*....|....*....
gi 22122387 368 INDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK08134 400 IGEGTIRLSIGLEDADDLIDDLKRALKAA 428
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
18-396 |
2.95e-88 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 271.48 E-value: 2.95e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQePEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAkHSLAFASGLAA-TITI 96
Cdd:PRK07582 5 GTRSVHAGG-PEAVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELEGA-EALVFPSGMAAiTAVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 97 THLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKtkLLEAAITPqTKLVWIETPTNPTLKLADIGACAQIVH 176
Cdd:PRK07582 83 RALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAG--MAEAALAG-ADLVLAETPSNPGLDVCDLAALAAAAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 177 KRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCR 256
Cdd:PRK07582 160 AAG-ALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 257 GLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGAlQHAKAFLKNLKLFTL 336
Cdd:PRK07582 239 SLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELADA-AAAERFVAASRLVVA 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 337 AESLGGYESLAElpaimthasvpekDRATLG--INDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK07582 318 ATSFGGVHTSAD-------------RRARWGdaVPEGFVRLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
16-398 |
8.04e-86 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 267.39 E-value: 8.04e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIHVGQEPE-QWNSRAvvLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAF 86
Cdd:PRK07812 13 SFETKQIHAGQTPDpATNARA--LPIYQTTSYTFDdtdhaaalFGLAEPGNIYTRIMNPTQDVVEQRIAALEGGVAALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 87 ASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFV-DCSKTKLLEAAITPQTKLVWIETPTNPTLK 164
Cdd:PRK07812 91 ASGQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 165 LADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--------------SVNSDD 230
Cdd:PRK07812 171 VLDIPGVAEVAHEAG-VPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpGFTTPD 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 231 -----------------LNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGL 293
Cdd:PRK07812 250 psyhgvvfaelgppayaLKARVQLLRD-LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 294 PSHPQHELAKRQC-SGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTL 372
Cdd:PRK07812 329 PSSPWYERAKRLApKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGL 408
|
410 420
....*....|....*....|....*.
gi 22122387 373 IRLSVGLEDEQDLLEDLDRALKAAHP 398
Cdd:PRK07812 409 VRLAVGIEGIDDILADLEAGFAAAKA 434
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
50-396 |
1.02e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 266.17 E-value: 1.02e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 50 FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVAsEFG 128
Cdd:PRK05939 32 FQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAiAAVFLTLLRAGDHLVSSQFLFGNTNSLFGTLR-GLG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 129 LKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCS 208
Cdd:PRK05939 111 VEVTMVDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERG-LLYVVDNTMTSPWLFRPKDVGASLVINS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 209 ATKYMNGHSDVVMGLVS----------VNSDD------------LNSRLRFLQNsLGAVPSPFDCYLCCRGLKTLQVRME 266
Cdd:PRK05939 190 LSKYIAGHGNALGGAVTdtglfdwsayPNIFPayrkgdpqqwglTQIRKKGLRD-MGATLSSEAAHRIAIGAETLALRVD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 267 KHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQhAKAFLKNLKLFTLAESLGGYESL 346
Cdd:PRK05939 269 RSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGID-CFDFLNRLKLVIKATHLGDTRTL 347
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 22122387 347 AeLPAIMT--HASVPEKdRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK05939 348 V-IPVAPTiyYEMGAER-RASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
17-396 |
1.70e-84 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 263.88 E-value: 1.70e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 17 FATQAIHVGQEPEQwNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFAS 88
Cdd:PRK05994 8 FATLAVHAGAQPDP-TTGARATPIYQTTSFVFNdadhaaslFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 89 GLAATITITH-LLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK05994 87 GHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 168 IGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGL-VSVNSDDLNSRLRF--------- 237
Cdd:PRK05994 167 IAAIAEVAHRAG-LPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIiVDGGTFDWSKSGKYpmlseprpe 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 238 -----LQNS-----------------LGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPS 295
Cdd:PRK05994 246 yhglvLHETfgnfafaiaarvlglrdLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 296 HPQHELAKRQCSGCPGMV-SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIR 374
Cdd:PRK05994 326 DPYHALAQKYSPKGAGAVfTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVR 405
|
410 420
....*....|....*....|..
gi 22122387 375 LSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK05994 406 LSIGIEDVDDIIADLEQALAKA 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-396 |
2.60e-83 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 260.60 E-value: 2.60e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 19 TQAIHVGQEPEQwNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGL 90
Cdd:PRK06084 5 TLAIHAGYSPDP-TTKAVAVPIYQTTSYAFDdtqhgadlFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 91 AA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIG 169
Cdd:PRK06084 84 AAiTYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 170 ACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNSDDL-----NSRLRFLQN---- 240
Cdd:PRK06084 164 ALADAAHRHG-VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIV-VDSGKFpwaehKERFALLNTpdps 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 241 -------------------------SLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPS 295
Cdd:PRK06084 242 yhgvtyteafgpaafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 296 HPQHELAKRQCSGCP-GMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIR 374
Cdd:PRK06084 322 HPEHELARRYMGGKPaSILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVR 401
|
410 420
....*....|....*....|..
gi 22122387 375 LSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK06084 402 LSIGIEHIDDIIADLAQALDAS 423
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
17-396 |
8.01e-83 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 258.47 E-value: 8.01e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 17 FATQAIHVGQEPEQWNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFAS 88
Cdd:PRK05968 7 PFDLAALITAHDEGNAFDAVVPPIFQTSLFTFDsydemedvYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 89 GLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAItPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK05968 87 GMAAiSSTVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQD 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 168 IGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVsVNSDDLNSRLRFLQNS-LGAVP 246
Cdd:PRK05968 166 VAALAALAKRHG-VVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVV-AGSKEHIARINAEAYPyLGAKL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 247 SPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELakrqcSGCPGMVSFYIKGALqHAKA 326
Cdd:PRK05968 244 SPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGL-----SGTSGLFSFIFREGI-DVRA 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22122387 327 FLKNLKLFTLAESLGGYESLAeLPAIMTHASVPEKDR-ATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK05968 318 FADALKLFRLGVSWGGHESLV-VPAEVVLQQKAQPNSaARFGVSPRSVRLHVGLEGTEALWADLEQALAAA 387
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
11-394 |
1.55e-81 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 255.43 E-value: 1.55e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 11 LPSFQHFATQAIHVGQEPEQWNSRAVVLPISLATTF------KQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSL 84
Cdd:PRK07810 10 LPDGVSQATIGVRGGLLRSGFEETAEALYLTSGYVYesaaaaEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 85 AFASGLAATIT-ITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTL 163
Cdd:PRK07810 90 ATASGMSAVFTaLGALLGAGDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQ 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 164 KLADIGACAQIVHKRGDIIlVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLG 243
Cdd:PRK07810 170 SLVDIAAVSELAHAAGAKV-VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 244 AVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKG---- 319
Cdd:PRK07810 249 PALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDApeda 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22122387 320 ALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALK 394
Cdd:PRK07810 329 AKKRAFEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
19-396 |
2.74e-79 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 249.34 E-value: 2.74e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 19 TQAIHVGQEPEQWNSrAVVLPISLATTFKqdFP------GQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA 92
Cdd:PRK05967 15 TRLAHDGNDPGDYHG-FVNPPVVHASTVL--FPdaetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSAGTILVPSGLAA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 93 -TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGAC 171
Cdd:PRK05967 92 vTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 172 AQIVHKRGDIILVvDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLnSRLRFLQNSLGAVPSPFDC 251
Cdd:PRK05967 172 AEAAHRHGAIVMM-DNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSANEKCW-PQLLEAHGTLGLCAGPDDT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 252 YLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGAL----QHAKAF 327
Cdd:PRK05967 250 YQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPekgkAKAHAF 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22122387 328 LKNLKLFTLAESLGGYESLAelpaimTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK05967 330 LDALEIFGLGYSWGGYESLA------LHVKLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGFAAA 392
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
19-396 |
9.35e-78 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 244.79 E-value: 9.35e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 19 TQAIHVGQEPEQWnSRAVVLPISLATTFKQDFPGQSSG----FEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-T 93
Cdd:TIGR01324 1 TRLIHSGRQPRFS-QGSVNPPLQRASTVLFDSHAAQRRakgeLTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLAAvT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 94 ITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQ 173
Cdd:TIGR01324 80 NSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIPAIAK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 174 IVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNsDDLNSRLRFLQNSLGAVPSPFDCYL 253
Cdd:TIGR01324 160 AARNPG-IVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVAN-ARTWDQLREHSYLMGQMVDADDAYT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 254 CCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHA-KAFLKNLK 332
Cdd:TIGR01324 238 TLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQvHAFLDHLQ 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122387 333 LFTLAESLGGYESLAeLPAIMTHASVPEKDRATLGindTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:TIGR01324 318 LFGLGYSWGGYESLA-LCNQPELGHRPNIKRNLEG---PLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
16-396 |
2.29e-77 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 244.25 E-value: 2.29e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 16 HFATQAIH-VGQEPEQWNS------RA--VVLPiSLATTFKQDFpGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAF 86
Cdd:PRK07050 9 ALQTRIVQpDDQIPPGFRSfvtpvaRAstVVFP-DLATMRALDW-RQDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 87 ASGLAAtITITH--LLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLK 164
Cdd:PRK07050 87 PSGLAA-ISLVYfgLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTME 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 165 LADIGACAQIVHKRGdIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGA 244
Cdd:PRK07050 166 VPDVPAITAAARARG-VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 245 VPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKG--ALQ 322
Cdd:PRK07050 245 GVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDErySPA 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122387 323 HAKAFLKNLKLFTLAESLGGYESLAeLPaimthASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAA 396
Cdd:PRK07050 325 QVDAFVEALELFAIGWSWGGACSLA-MP-----YDVASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALEAA 392
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
17-395 |
1.88e-73 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 235.54 E-value: 1.88e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 17 FATQAIHVGQePEQWNSRAVVLPISLATTF--------KQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFAS 88
Cdd:PRK05613 14 FETRSIHAGQ-SVDSDTSARNLPIYQTTSYvfdsaehaKQRFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 89 GLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFV-DCSKTKLLEAAITPQTKLVWIETPTNPTLKLA 166
Cdd:PRK05613 93 GQAAeTAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 167 DIGACAQIVHKRgDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLV--------SVNSDD-------- 230
Cdd:PRK05613 173 DIPAVAEVAHRN-QVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwTVERDGkpvfpyfv 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 231 --------------------LNSRLRFLQNSlGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVY 290
Cdd:PRK05613 252 tpdpayhglkyadlgapafgLKARAGLLRDT-GATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNF 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 291 PGLPSHPQHELAKRQCSGCPGMV-SFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGIN 369
Cdd:PRK05613 331 AGLKDSPWYATKEKLGLKYTGSVlSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGIT 410
|
410 420
....*....|....*....|....*.
gi 22122387 370 DTLIRLSVGLEDEQDLLEDLDRALKA 395
Cdd:PRK05613 411 QATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
59-393 |
5.07e-67 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 217.68 E-value: 5.07e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 59 YSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCS 137
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAiSNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 138 KTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKrGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHS 217
Cdd:PRK09028 135 IGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHE-HDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 218 DVVMGlVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHP 297
Cdd:PRK09028 214 DVMLG-TATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCP 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 298 QHELAKRQCSGCPGMVSFYIK-GALQHAKAFLKNLKLFTLAESLGGYESLaelpaIMTHASVPEKDRAT-LGINDTLIRL 375
Cdd:PRK09028 293 GHEFFKRDFSGSNGLFSFVLKqGDPKAVTALVEGMQHFKMGFSWGGFESL-----ILGVFGINKLRTATnWDFSKPLIRL 367
|
330
....*....|....*...
gi 22122387 376 SVGLEDEQDLLEDLDRAL 393
Cdd:PRK09028 368 HIGLEDVDDLIADLEAGF 385
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
18-393 |
4.41e-58 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 195.66 E-value: 4.41e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 18 ATQAIHVGQEPEqwNSRAVVLPISLATTFKQD--------FPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASG 89
Cdd:PRK06702 8 GTICVQGGYTPK--NGEPRVLPLYQSTTYKYDtsddlaalFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 90 LAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKT-KLLEAAITPQTKLVWIETPTNPTLKLAD 167
Cdd:PRK06702 86 QAAiMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTaDEIVALANDKTKLVYAESLGNPAMNVLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 168 IGACAQIVhKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVS---------------VNSDDLN 232
Cdd:PRK06702 166 FKEFSDAA-KELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 233 SRLRFLQN----------------SLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSH 296
Cdd:PRK06702 245 HGVSYVQNfgaaayivkarvqllrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 297 PQHELAKRQCS-GCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRL 375
Cdd:PRK06702 325 ENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRL 404
|
410
....*....|....*...
gi 22122387 376 SVGLEDEQDLLEDLDRAL 393
Cdd:PRK06702 405 SVGIEDVSDIIADLEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
59-390 |
1.99e-57 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 192.61 E-value: 1.99e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 59 YSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCS 137
Cdd:PRK08114 56 YGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAvANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 138 KTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRG-DIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGH 216
Cdd:PRK08114 136 IGADIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGH 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 217 SDVVMGLVSVNS---DDL--NSRLrflqnsLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYP 291
Cdd:PRK08114 216 SDAMIGTAVANArcwEQLreNSYL------MGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHP 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 292 GLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAK--AFLKNLKLFTLAESLGGYESLaelpaIMthASVPEKDRA----- 364
Cdd:PRK08114 290 ALPGCKGHEFWKRDFTGSSGLFSFVLKKKLTDEQlaNYLDNFSLFSMAYSWGGFESL-----IL--ANQPEEIAAirpag 362
|
330 340
....*....|....*....|....*.
gi 22122387 365 TLGINDTLIRLSVGLEDEQDLLEDLD 390
Cdd:PRK08114 363 EVDFTGTLIRLHIGLEDVDDLIADLA 388
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
35-394 |
6.14e-52 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 178.81 E-value: 6.14e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 35 AVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAA-TITITHLLKAGDEIICMDEVY 113
Cdd:PLN02242 46 TVMEPDTMRRMFSGELGPDRDFYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAiSSVLLQLCSSGGHVVASNTLY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 114 GGTNRYFRR-VASEFGLKISFVDCSKTKLLEAAITP-QTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTFmS 191
Cdd:PLN02242 126 GGTHALLAHfLPRKCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKG-VTVVVDNTF-A 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 192 AYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNS---LGAVPSPFDCYLCCRGLKTLQVRMEKH 268
Cdd:PLN02242 204 PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELVNSMMDLHHGAlmlLGPTMNPKVAFELSERLPHLSLRMKEH 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 269 FKNGMAVARfletnpRVE----KVVYPGLPSHPQHELAKRQ---CSGCPGMVSFYIkGALQHAKAFLKNLKLFT----LA 337
Cdd:PLN02242 284 CRRAMEYAK------RMKelglKVIYPGLEDHPQHALLKSMankGYGFGGLLCLDM-DTEERANRLMRYLQNSTqfgfMA 356
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22122387 338 ESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVG----LEDEQDLLEDLDRALK 394
Cdd:PLN02242 357 VSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGytgtLEQRWSQFEKALSAMK 417
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
70-215 |
9.41e-13 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 65.87 E-value: 9.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAAL--DGAKHSLAFASGLAATITITH-LLKAGDEIICMDEVYGGTNRyfrRVASEFGLKISFVD--------CSK 138
Cdd:cd01494 5 LEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSRYW---VAAELAGAKPVPVPvddagyggLDV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 139 TKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGdIILVVDNTF----MSAYFQRPLALGADICMCSATKYMN 214
Cdd:cd01494 82 AILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYG-ILLLVDAASaggaSPAPGVLIPEGGADVVTFSLHKNLG 160
|
.
gi 22122387 215 G 215
Cdd:cd01494 161 G 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
79-306 |
4.02e-09 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 57.74 E-value: 4.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 79 GAKHSLAFAsglaatitITHLLKAGDEIICMDEVYGGtnryFRRVASEFGLKISFVDCSK-------TKLLEAAITPQTK 151
Cdd:cd00609 67 GAQEALSLL--------LRALLNPGDEVLVPDPTYPG----YEAAARLAGAEVVPVPLDEeggflldLELLEAAKTPKTK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 152 LVWIETPTNPT---LKLADIGACAQIVHKRgDIILVVDNT---FMSAYFQRPLALGAD-----ICMCSATKYMNghsdvV 220
Cdd:cd00609 135 LLYLNNPNNPTgavLSEEELEELAELAKKH-GILIISDEAyaeLVYDGEPPPALALLDayervIVLRSFSKTFG-----L 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 221 MGL----VSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHF----KNGMAVARFLETNPRVEKV---- 288
Cdd:cd00609 209 PGLrigyLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEELReryrRRRDALLEALKELGPLVVVkpsg 288
|
250 260
....*....|....*....|.
gi 22122387 289 ---VYPGLPSHPQHELAKRQC 306
Cdd:cd00609 289 gffLWLDLPEGDDEEFLERLL 309
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
70-240 |
3.27e-08 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 55.08 E-value: 3.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAALDGAKHSLAFASGLAATITITHLL--KAGDEIICmdevyggTNRYFrrVAS-----EFGLKISFVDCSK---- 138
Cdd:COG0399 35 FEEEFAAYLGVKHAVAVSSGTAALHLALRALgiGPGDEVIT-------PAFTF--VATanailYVGATPVFVDIDPdtyn 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 139 --TKLLEAAITPQTKLVwIetPT----NPtlklADIGACAQIVHKRGdIILVVDN--TFMSAYFQRPLALGADICMCS-- 208
Cdd:COG0399 106 idPEALEAAITPRTKAI-I--PVhlygQP----ADMDAIMAIAKKHG-LKVIEDAaqALGATYKGKKVGTFGDAGCFSfy 177
|
170 180 190
....*....|....*....|....*....|....*
gi 22122387 209 ATK---YMNGhsdvvmGLVSVNSDDLNSRLRFLQN 240
Cdd:COG0399 178 PTKnltTGEG------GAVVTNDEELAERARSLRN 206
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
74-187 |
8.26e-08 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 53.60 E-value: 8.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 74 VAALDGAKHSLAFAsgLAAtitithLLKAGDEIICMDEVYGgTNRYFRRVAsefGLKISFVDCSKT-------KLLEAAI 146
Cdd:COG0436 93 ILVTNGAKEALALA--LLA------LLNPGDEVLVPDPGYP-SYRAAVRLA---GGKPVPVPLDEEngflpdpEALEAAI 160
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 22122387 147 TPQTKLVWIETPTNPT---LKLADIGACAQIVHKRgDIILVVDN 187
Cdd:COG0436 161 TPRTKAIVLNSPNNPTgavYSREELEALAELAREH-DLLVISDE 203
|
|
| AHBA_syn |
cd00616 |
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal ... |
70-240 |
3.11e-07 |
|
3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary metabolites. Some well studied proteins in this CD are AHBA_synthase, protein product of pleiotropic regulatory gene degT, Arnb aminotransferase and pilin glycosylation protein. The prototype of this family, the AHBA_synthase, is a dimeric PLP dependent enzyme. AHBA_syn is the terminal enzyme of 3-amino-5-hydroxybenzoic acid (AHBA) formation which is involved in the biosynthesis of ansamycin antibiotics, including rifamycin B. Some members of this CD are involved in 4-amino-6-deoxy-monosaccharide D-perosamine synthesis. Perosamine is an important element in the glycosylation of several cell products, such as antibiotics and lipopolysaccharides of gram-positive and gram-negative bacteria. The pilin glycosylation protein encoded by gene pglA, is a galactosyltransferase involved in pilin glycosylation. Additionally, this CD consists of ArnB (PmrH) aminotransferase, a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. This CD also consists of several predicted pyridoxal phosphate-dependent enzymes apparently involved in regulation of cell wall biogenesis. The catalytic lysine which is present in all characterized PLP dependent enzymes is replaced by histidine in some members of this CD.
Pssm-ID: 99740 [Multi-domain] Cd Length: 352 Bit Score: 51.77 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAALDGAKHSLAFASGLAATITITHLL--KAGDEIICmdevyggTNRYFrrVAS-----EFGLKISFVDCSKT--- 139
Cdd:cd00616 23 FEKAFAEYLGVKYAVAVSSGTAALHLALRALgiGPGDEVIV-------PSFTF--VATanailLLGATPVFVDIDPDtyn 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 140 ---KLLEAAITPQTKLVwieTPTNPTLKLADIGACAQIVHKRGdIILVVDN--TFMSAYFQRPLALGADICMCS--ATK- 211
Cdd:cd00616 94 idpELIEAAITPRTKAI---IPVHLYGNPADMDAIMAIAKRHG-LPVIEDAaqALGATYKGRKVGTFGDAGAFSfhPTKn 169
|
170 180 190
....*....|....*....|....*....|.
gi 22122387 212 --YMNGhsdvvmGLVSVNSDDLNSRLRFLQN 240
Cdd:cd00616 170 ltTGEG------GAVVTNDEELAERARLLRN 194
|
|
| YnbB |
COG4100 |
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ... |
54-205 |
3.13e-07 |
|
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 443276 Cd Length: 409 Bit Score: 52.03 E-value: 3.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 54 SSGFEYSRSGnptRNCLEKAVAALDGAKHSL---AFASGlaatitiTH--------LLKAGDEIIC--------MDEVYG 114
Cdd:COG4100 49 TTGYGYDDIG---RDTLERVYADVFGAEDALvrpQIVSG-------THaialalfgVLRPGDELLSitgkpydtLEEVIG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 115 GTNRYfrrVAS--EFGLKISFVDCSKT-----KLLEAAITPQTKLVWIETPT----NPTLKLADIGACAQIVHK-RGDII 182
Cdd:COG4100 119 IRGEG---QGSlkEFGISYRQVPLTEDgkidlEAIKKAINEKTKMVLIQRSRgyswRPSLTIEEIGEIIKFVKSiNPDVI 195
|
170 180
....*....|....*....|....*...
gi 22122387 183 LVVDNtfmsAY--F---QRPLALGADIC 205
Cdd:COG4100 196 CFVDN----CYgeFvetREPTEVGADLM 219
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
95-186 |
3.47e-07 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 51.84 E-value: 3.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 95 TITHLLKAGDEIICMDEVY----------GGTnryFRRVASEFGlkiSF-VDCSKtklLEAAITPQTKLVWIETPTNPT- 162
Cdd:PRK09082 107 AILALVRPGDEVIVFDPSYdsyapaielaGGR---AVRVALQPP---DFrVDWQR---FAAAISPRTRLIILNTPHNPSg 177
|
90 100
....*....|....*....|....*.
gi 22122387 163 --LKLADIGACAQIVHKRgDIILVVD 186
Cdd:PRK09082 178 tvWSAADMRALWQLIAGT-DIYVLSD 202
|
|
| DegT_DnrJ_EryC1 |
pfam01041 |
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ... |
70-240 |
9.79e-06 |
|
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.
Pssm-ID: 395827 Cd Length: 360 Bit Score: 47.28 E-value: 9.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAALDGAKHSLAFASGLAATITITHLLKA--GDEIICMDEVYGGTNRyfrrVASEFGLKISFVD------CSKTKL 141
Cdd:pfam01041 29 FERAFAAYLGVKHAIAVSSGTAALHLALRALGVgpGDEVITPSFTFVATAN----AALRLGAKPVFVDidpdtyNIDPEA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 142 LEAAITPQTKLVwieTPTNPTLKLADIGACAQIVHKRGdIILVVD--NTFMSAYFQRPLALGADICMCS--ATKYM---N 214
Cdd:pfam01041 105 IEAAITPRTKAI---IPVHLYGQPADMDAIRAIAARHG-LPVIEDaaHALGATYQGKKVGTLGDAATFSfhPTKNLttgE 180
|
170 180
....*....|....*....|....*.
gi 22122387 215 GhsdvvmGLVSVNSDDLNSRLRFLQN 240
Cdd:pfam01041 181 G------GAVVTNDPELAEKARVLRN 200
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
70-186 |
2.89e-05 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 45.76 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAAL--------DGAKHSLAFASGLAATIT--ITHLLKAGDEIICMDEVYGGTNRYFRRVasefGLKISFVDCSKT 139
Cdd:pfam00155 44 LREALAKFlgrspvlkLDREAAVVFGSGAGANIEalIFLLANPGDAILVPAPTYASYIRIARLA----GGEVVRYPLYDS 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 22122387 140 KL-------LEAAITPQTKLVWIETPTNPT---LKLADIGACAQIVHKRGdIILVVD 186
Cdd:pfam00155 120 NDfhldfdaLEAALKEKPKVVLHTSPHNPTgtvATLEELEKLLDLAKEHN-ILLLVD 175
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
142-190 |
1.08e-04 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 43.97 E-value: 1.08e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 22122387 142 LEAAITPQTKLVWIETPTNPT---LKLADIGACAQIVHKrgDIILVVDNTFM 190
Cdd:COG0079 129 LLAAITERTDLVFLCNPNNPTgtlLPREELEALLEALPA--DGLVVVDEAYA 178
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
79-186 |
1.81e-04 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 43.19 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 79 GAKHSL--AFASglaatitithLLKAGDEII-------CMDEV---YGGTNRyFRRVASEFGLKISFVDcsktklLEAAI 146
Cdd:PRK05764 99 GAKQALynAFMA----------LLDPGDEVIipapywvSYPEMvklAGGVPV-FVPTGEENGFKLTVEQ------LEAAI 161
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 22122387 147 TPQTKLVWIETPTNPT------LKLADIGACAqivhKRGDIILVVD 186
Cdd:PRK05764 162 TPKTKALILNSPSNPTgavyspEELEAIADVA----VEHDIWVLSD 203
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
91-199 |
6.02e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.56 E-value: 6.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 91 AATITITHLLKAGDEIICMDEVY----------GGTNRYFRRVASEFGLKISfVDCsktklLEAAITPQTKLVWIETPTN 160
Cdd:PRK07777 97 AIAAAVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD-LDA-----LRAAVTPRTRALIVNSPHN 170
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 22122387 161 PT---LKLADIGACAQIVHKRgDIILVVDNTFMSAYF----QRPLA 199
Cdd:PRK07777 171 PTgtvLTAAELAAIAELAVEH-DLLVITDEVYEHLVFdgarHLPLA 215
|
|
| PRK07683 |
PRK07683 |
aminotransferase A; Validated |
91-162 |
2.30e-03 |
|
aminotransferase A; Validated
Pssm-ID: 236075 Cd Length: 387 Bit Score: 39.71 E-value: 2.30e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22122387 91 AATITITHLLKAGDEIICMDEVYGGTNRYFRRVasefGLKISFVDCSKT------KLLEAAITPQTKLVWIETPTNPT 162
Cdd:PRK07683 101 AIDIAFRTILEPGTEVILPAPIYPGYEPIIRLC----GAKPVFIDTRSTgfrltaEALENAITEKTRCVVLPYPSNPT 174
|
|
| PRK15407 |
PRK15407 |
lipopolysaccharide biosynthesis protein RfbH; Provisional |
71-187 |
3.35e-03 |
|
lipopolysaccharide biosynthesis protein RfbH; Provisional
Pssm-ID: 237960 Cd Length: 438 Bit Score: 39.48 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 71 EKAVAALDGAKHSLAFASG----LAATITIT-HLL-----KAGDEIICmdevyggtnryfrrVASEF----------GLK 130
Cdd:PRK15407 69 EKKLAEFLGVRYALLVNSGssanLLAFSALTsPKLgdralKPGDEVIT--------------VAAGFpttvnpiiqnGLV 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22122387 131 ISFVDCS------KTKLLEAAITPQTKLVWI-ETPTNPTlklaDIGACAQIVhKRGDIILVVDN 187
Cdd:PRK15407 135 PVFVDVElptyniDASLLEAAVSPKTKAIMIaHTLGNPF----DLAAVKAFC-DKHNLWLIEDN 193
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
142-162 |
3.71e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 39.16 E-value: 3.71e-03
|
| PRK06348 |
PRK06348 |
pyridoxal phosphate-dependent aminotransferase; |
140-197 |
4.84e-03 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180537 Cd Length: 384 Bit Score: 38.93 E-value: 4.84e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22122387 140 KLLEAAITPQTKLVWIETPTNPTlkladiGAC---------AQIVhKRGDIILVVDNTFMSAYFQRP 197
Cdd:PRK06348 153 KKLEALITSKTKAIILNSPNNPT------GAVfsketleeiAKIA-IEYDLFIISDEVYDGFSFYED 212
|
|
| PRK08912 |
PRK08912 |
aminotransferase; |
70-186 |
5.28e-03 |
|
aminotransferase;
Pssm-ID: 181580 Cd Length: 387 Bit Score: 38.80 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 70 LEKAVAALDGAKHSLAF--------ASG----LAATITitHLLKAGDEIICMDEVY----------GGTNRYFRRVASEF 127
Cdd:PRK08912 68 LRQAVAAHYARFQGLDLdpetevmvTSGateaLAAALL--ALVEPGDEVVLFQPLYdaylplirraGGVPRLVRLEPPHW 145
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122387 128 GLKisfvdcskTKLLEAAITPQTKLVWIETPTNPTLKL---ADIGACAQIVhKRGDIILVVD 186
Cdd:PRK08912 146 RLP--------RAALAAAFSPRTKAVLLNNPLNPAGKVfprEELALLAEFC-QRHDAVAICD 198
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
72-186 |
8.77e-03 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 37.81 E-value: 8.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 72 KAVAALDGAKHS--LAFASG-------LAATITithLLKAGDEIIcmdevyggTNRY--------FRRVASEFGLKISFV 134
Cdd:COG0520 66 EKVARFIGAASPdeIIFTRGtteainlVAYGLG---RLKPGDEIL--------ITEMehhsnivpWQELAERTGAEVRVI 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22122387 135 DCSKT-----KLLEAAITPQTKLV---WIETPT---NPtlkLADIgacAQIVHKRGdIILVVD 186
Cdd:COG0520 135 PLDEDgeldlEALEALLTPRTKLVavtHVSNVTgtvNP---VKEI---AALAHAHG-ALVLVD 190
|
|
| PRK12414 |
PRK12414 |
putative aminotransferase; Provisional |
67-189 |
9.58e-03 |
|
putative aminotransferase; Provisional
Pssm-ID: 183514 Cd Length: 384 Bit Score: 37.84 E-value: 9.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122387 67 RNCLEKAVAALDGAKHS-------LAFAS-GLAATITIthLLKAGDEIICMDEVYGGTNRYFR-RVASEFGLKISF---- 133
Cdd:PRK12414 72 REALAEKTERLYGARYDpasevtvIASASeGLYAAISA--LVHPGDEVIYFEPSFDSYAPIVRlQGATPVAIKLSPedfr 149
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 22122387 134 VDCSKtklLEAAITPQTKLVWIETPTNPT---LKLADIGACAQIVhKRGDIILVVDNTF 189
Cdd:PRK12414 150 VNWDE---VAAAITPRTRMIIVNTPHNPSatvFSAADLARLAQLT-RNTDIVILSDEVY 204
|
|
| |
