NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|223365907]
View 

Chain A, Protein CIAO1

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

PubMed:  10322433

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
17-332 4.83e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.83e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200  162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223365907 257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200  224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
17-332 4.83e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.83e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200  162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223365907 257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200  224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
22-334 2.72e-41

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 150.24  E-value: 2.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  22 LAWNPAGTLLASCGGDRRIRIWgTEGDSWICKSVLSEGHQRTVRKVAW-SPCGNYLASA--SFDATTCIWKKNqDDFECV 98
Cdd:COG2319   71 IAFSPDGELLLSGSSDGTIKLW-DLDNGEKLIKSLEGLHDSSVSKLALsSPDGNSILLAssSLDGTVKLWDLS-TPGKLI 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  99 TTLEGHENEVKSVAWAPSGNLLATCSR-DKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHP-SQELLASASYDDTVKL 176
Cdd:COG2319  149 RTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTG---KPLSTLAGHTDPVSSLAFSPdGGLLIASGSSDGTIRL 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEDDwVCCATLEGHESTVWSlAFDPSGQRLASCSDDRTVRIWRqylpgneqgvacsgSDPSWKCICTLSGfHSRTIY 256
Cdd:COG2319  226 WDLSTGK-LLRSTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLWD--------------LRSSSSLLRTLSG-HSSSVL 288
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223365907 257 DIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFsltahlhQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
Cdd:COG2319  289 SVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTL-------KGHEGPVSSLSFSPDGSLLVSGGSDDGTIRLWDLR 359
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
183-221 3.59e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.59e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 223365907   183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.14e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.14e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 223365907  184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
22-123 6.01e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 6.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  22 LAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159
                         90       100       110
                 ....*....|....*....|....*....|..
gi 223365907  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
17-332 4.83e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.83e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200  162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 223365907 257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200  224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
22-334 2.72e-41

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 150.24  E-value: 2.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  22 LAWNPAGTLLASCGGDRRIRIWgTEGDSWICKSVLSEGHQRTVRKVAW-SPCGNYLASA--SFDATTCIWKKNqDDFECV 98
Cdd:COG2319   71 IAFSPDGELLLSGSSDGTIKLW-DLDNGEKLIKSLEGLHDSSVSKLALsSPDGNSILLAssSLDGTVKLWDLS-TPGKLI 148
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  99 TTLEGHENEVKSVAWAPSGNLLATCSR-DKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHP-SQELLASASYDDTVKL 176
Cdd:COG2319  149 RTLEGHSESVTSLAFSPDGKLLASGSSlDGTIKLWDLRTG---KPLSTLAGHTDPVSSLAFSPdGGLLIASGSSDGTIRL 225
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEDDwVCCATLEGHESTVWSlAFDPSGQRLASCSDDRTVRIWRqylpgneqgvacsgSDPSWKCICTLSGfHSRTIY 256
Cdd:COG2319  226 WDLSTGK-LLRSTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLWD--------------LRSSSSLLRTLSG-HSSSVL 288
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 223365907 257 DIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFsltahlhQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
Cdd:COG2319  289 SVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTL-------KGHEGPVSSLSFSPDGSLLVSGGSDDGTIRLWDLR 359
WD40 COG2319
WD40 repeat [General function prediction only];
2-332 9.79e-37

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 137.91  E-value: 9.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907   2 KDSLVLLGRVPAHPDSrCWFLAWNPAGTLLASCGG-DRRIRIWgtEGDSWICKSVLSeGHQRTVRKVAWSPCGN-YLASA 79
Cdd:COG2319  142 STPGKLIRTLEGHSES-VTSLAFSPDGKLLASGSSlDGTIKLW--DLRTGKPLSTLA-GHTDPVSSLAFSPDGGlLIASG 217
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  80 SFDATTCIWKKNQDDfECVTTLEGHENEVKSvAWAPSGNLLATCSRDKSVWVWevDEEDEYECVSVLNSHTQDVKHVVWH 159
Cdd:COG2319  218 SSDGTIRLWDLSTGK-LLRSTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLW--DLRSSSSLLRTLSGHSSSVLSVAFS 293
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLA-SCSDDRTVRIWrqylpgneqgvacsgSD 238
Cdd:COG2319  294 PDGKLLASGSSDGTVRLWDLETGKLLSSLTLKGHEGPVSSLSFSPDGSLLVsGGSDDGTIRLW---------------DL 358
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 239 PSWKCICTLSGFHSrtIYDIAWCQLTGALATACGDDAIRVfqEDPNSDPQQPTFSltahlhqAHSQDVNCVAWNPkEPGL 318
Cdd:COG2319  359 RTGKPLKTLEGHSN--VLSVSFSPDGRVVSSGSTDGTVRL--WDLSTGSLLRNLD-------GHTSRVTSLDFSP-DGKS 426
                        330
                 ....*....|....
gi 223365907 319 LASCSDDGEVAFWK 332
Cdd:COG2319  427 LASGSSDNTIRLWD 440
WD40 COG2319
WD40 repeat [General function prediction only];
1-221 2.67e-33

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 128.28  E-value: 2.67e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907   1 MKDSLVLLGRVPAHPDSrcWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
Cdd:COG2319  228 LSTGKLLRSTLSGHSDS--VVSSFSPDGSLLASGSSDGTIRLWDLRSSS--SLLRTLSGHSSSVLSVAFSPDGKLLASGS 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLAT-CSRDKSVWVWEVDEEdeyECVSVLNSHTQdVKHVVWH 159
Cdd:COG2319  304 SDGTVRLWDLETGKLLSSLTLKGHEGPVSSLSFSPDGSLLVSgGSDDGTIRLWDLRTG---KPLKTLEGHSN-VLSVSFS 379
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223365907 160 PSQELLASASYDDTVKLYREEEDDwvCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:COG2319  380 PDGRVVSSGSTDGTVRLWDLSTGS--LLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLW 439
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
97-331 8.59e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 8.59e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 177 YREEEDDwvCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpgneqgvacsgsdpswkcictlsgfhsrtiy 256
Cdd:cd00200   78 WDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW----------------------------------- 120
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 223365907 257 DIAWCQLTGALatacgddairvfqedpnsdpqqptfsltahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFW 331
Cdd:cd00200  121 DVETGKCLTTL--------------------------------RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
16-174 5.99e-11

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 63.18  E-value: 5.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  16 DSRCWFLAWNPAGTLLASCGG-DRRIRIWGTEGDswicKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDD 94
Cdd:COG2319  328 EGPVSSLSFSPDGSLLVSGGSdDGTIRLWDLRTG----KPLKTLEGHSNVLSVSFSPDGRVVSSGSTDGTVRLW--DLST 401
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDeedeyecvsvlnshtQDVKHVVWHPSQELLASASYDDTV 174
Cdd:COG2319  402 GSLLRNLDGHTSRVTSLDFSPDGKSLASGSSDNTIRLWDLK---------------TSLKSVSFSPDGKVLASKSSDLSV 466
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
183-221 3.59e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.59e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 223365907   183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.14e-09

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.14e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 223365907  184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
94-133 2.32e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.32e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 223365907    94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.52e-08

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.52e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 223365907   95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
141-177 3.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.91e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 223365907   141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
22-123 6.01e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 6.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  22 LAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159
                         90       100       110
                 ....*....|....*....|....*....|..
gi 223365907  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
PTZ00420 PTZ00420
coronin; Provisional
98-182 1.36e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEY-------ECvsVLNSHTQDVKHVVWHP-SQELLASA 168
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESvkeikdpQC--ILKGHKKKISIIDWNPmNYYIMCSS 144
                         90
                 ....*....|....
gi 223365907 169 SYDDTVKLYREEED 182
Cdd:PTZ00420 145 GFDSFVNIWDIENE 158
PTZ00420 PTZ00420
coronin; Provisional
190-260 1.60e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.60e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223365907 190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRqyLPGNEQGVAcSGSDPswkcICTLSGfHSRTIYDIAW 260
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWE--IPHNDESVK-EIKDP----QCILKG-HKKKISIIDW 133
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
49-89 3.42e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.42e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 223365907    49 SWICKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.65e-05

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 223365907  141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
58-88 1.61e-04

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 223365907   58 EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
103-242 1.75e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 103 GHENEVKSVAWAPSGNL-LATCSRDKSVWVWEVDEEDEYECVSV----LNSHTQDVKHVVWHPS-QELLASASYDDTVKL 176
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNISDpivhLQGHTKKVGIVSFHPSaMNVLASAGADMVVNV 152
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 223365907 177 YREEEDdwVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRqylPGNEQGVACSGSDPSWK 242
Cdd:PTZ00421 153 WDVERG--KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID---PRDGTIVSSVEAHASAK 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
186-337 1.82e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRqyLPGNEqgvacsgsdpswkCICTLSGfHSRTIYDIAWCqltg 265
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD--LETGE-------------LLRTLKG-HTGPVRDVAAS---- 60
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 223365907 266 alatacgddairvfqedpnsdpqqptfsltahlhqAHSQdvncvawnpkepgLLASCSDDGEVAFWKYQRPE 337
Cdd:cd00200   61 -----------------------------------ADGT-------------YLASGSSDKTIRLWDLETGE 84
PTZ00421 PTZ00421
coronin; Provisional
37-165 2.68e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907  37 DRRIRIWG--TEGDSWICKSVLSE--GHQRTVRKVAWSPCG-NYLASASFDATTCIWKKNQDdfECVTTLEGHENEVKSV 111
Cdd:PTZ00421  97 DGTIMGWGipEEGLTQNISDPIVHlqGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG--KAVEVIKCHSDQITSL 174
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 223365907 112 AWAPSGNLLATCSRDKSVWVweVDEEDEYECVSVLNSHTQDVKHVVWHPSQELL 165
Cdd:PTZ00421 175 EWNLDGSLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
300-332 6.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.80e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 223365907   300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFWK 332
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
23-135 1.09e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 400822 [Multi-domain]  Cd Length: 194  Bit Score: 39.56  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223365907   23 AWNPAGTLLASCGG--DRRIRIWGTEGDSwicKSVLSEGHQRTVRkvaWSPCGNYLASASF---DATTCIWkkNQDDFEC 97
Cdd:pfam08662  66 AWSPNGKEFAVIYGymPAKVSFFDLKGNV---IHSFGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFW--DVVNKKK 137
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 223365907   98 VTTLEgHENEVkSVAWAPSGNLLATCSR------DKSVWVWEVD 135
Cdd:pfam08662 138 IATAE-ASNAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
4-43 2.45e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.45e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 223365907     4 SLVLLGRVPAHpDSRCWFLAWNPAGTLLASCGGDRRIRIW 43
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
300-331 5.69e-03

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.69e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 223365907  300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFW 331
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
7-43 7.35e-03

WD domain, G-beta repeat;


Pssm-ID: 425662 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 223365907    7 LLGRVPAHpDSRCWFLAWNPAGTLLASCGGDRRIRIW 43
Cdd:pfam00400   3 LLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH