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Conserved domains on  [gi|225006402|dbj|BAH28977|]
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phospholipase C, partial [Clostridium perfringens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnPC_S1P1 super family cl16915
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-119 1.15e-33

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


The actual alignment was detected with superfamily member smart00770:

Pssm-ID: 450122  Cd Length: 241  Bit Score: 116.75  E-value: 1.15e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402     1 MHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGcktneafYTDILKNkdfnawskeyargFAKTGKSIY 80
Cdd:smart00770 141 CHYLGDLSTPYHANNVTAVDSPGHRKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLY 200

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 225006402    81 YSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDV 119
Cdd:smart00770 201 YSHATMSKSEKDWDYAAGEALKNAQKTTAGFLYRFYNEV 239
 
Name Accession Description Interval E-value
Zn_dep_PLPC smart00770
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
 1-119 1.15e-33

Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.


Pssm-ID: 214813  Cd Length: 241  Bit Score: 116.75  E-value: 1.15e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402     1 MHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGcktneafYTDILKNkdfnawskeyargFAKTGKSIY 80
Cdd:smart00770 141 CHYLGDLSTPYHANNVTAVDSPGHRKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLY 200

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 225006402    81 YSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDV 119
Cdd:smart00770 201 YSHATMSKSEKDWDYAAGEALKNAQKTTAGFLYRFYNEV 239
ZnPC_S1P1 cd10981
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-116 1.47e-24

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


Pssm-ID: 211380  Cd Length: 238  Bit Score: 93.28  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402   1 MHYFGDIDTPYHPANVT----AVDSAGHVKFETFAEERKEQYKINTAgcktneAFYTDILKNKDFNAWSKEYARGFAKTG 76
Cdd:cd10981  113 SHYIGDAHVPLHTTQNYngqlTGQDGIHRAWETRIPELYAELYALTD------AFGDPFVGKADYIKWPKEYIWDAAKHA 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 225006402  77 KSIYYSHASM------------SHSWDDWDYAAKVTLANSQKGTAGYIYRFL 116
Cdd:cd10981  187 NALYDTVLSHekelagsrkypyEGRNDVVRKTYSEALAKAYHGLANGLVEAL 238
 
Name Accession Description Interval E-value
Zn_dep_PLPC smart00770
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
 1-119 1.15e-33

Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium. Structure information: PDB 1ca1.


Pssm-ID: 214813  Cd Length: 241  Bit Score: 116.75  E-value: 1.15e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402     1 MHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGcktneafYTDILKNkdfnawskeyargFAKTGKSIY 80
Cdd:smart00770 141 CHYLGDLSTPYHANNVTAVDSPGHRKFENFVQTRKDNYSLNTEG-------EKKFLEN-------------VNKKAKKLY 200

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 225006402    81 YSHASMSHSWDDWDYAAKVTLANSQKGTAGYIYRFLHDV 119
Cdd:smart00770 201 YSHATMSKSEKDWDYAAGEALKNAQKTTAGFLYRFYNEV 239
ZnPC_S1P1 cd10981
Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and ...
 1-116 1.47e-24

Zinc dependent phospholipase C/S1-P1 nuclease; This model describes both the bacterial and archeal zinc-dependent phospholipase C, a domain found in the alpha toxin of Clostridium perfringens, as well as S1/P1 nucleases, which predominantly act on single-stranded DNA and RNA.


Pssm-ID: 211380  Cd Length: 238  Bit Score: 93.28  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402   1 MHYFGDIDTPYHPANVT----AVDSAGHVKFETFAEERKEQYKINTAgcktneAFYTDILKNKDFNAWSKEYARGFAKTG 76
Cdd:cd10981  113 SHYIGDAHVPLHTTQNYngqlTGQDGIHRAWETRIPELYAELYALTD------AFGDPFVGKADYIKWPKEYIWDAAKHA 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 225006402  77 KSIYYSHASM------------SHSWDDWDYAAKVTLANSQKGTAGYIYRFL 116
Cdd:cd10981  187 NALYDTVLSHekelagsrkypyEGRNDVVRKTYSEALAKAYHGLANGLVEAL 238
Zn_dep_PLPC cd11009
Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent ...
 1-118 5.61e-23

Zinc dependent phospholipase C (alpha toxin); This domain conveys a zinc dependent phospholipase C activity (EC 3.1.4.3). It is found in a monomeric phospholipase C of Bacillus cereus as well as in the alpha toxin of Clostridium perfringens and Clostridium bifermentans, which is involved in haemolysis and cell rupture. It is also found in a lecithinase of Listeria monocytogenes, which is involved in breaking the 2-membrane vacuoles that surround the bacterium.


Pssm-ID: 211381  Cd Length: 218  Bit Score: 88.59  E-value: 5.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225006402   1 MHYFGDIDTPYHPANVTAVDSAGHVKFETFAEERKEQYKINTAGCKTNeafytdilkNKDFNAWSKEYARGFAKTGKSIY 80
Cdd:cd11009  109 LHYLQDLTVPHHAANATAVALNGHSAYENYVEDHKDDYKLNTAGIYAN---------KPYLSDSPEEYIKENAKYAKKYY 179

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 225006402  81 YSHASMS-HSWDDWDYAAKVTLANSQKGTAGYIYRFLHD 118
Cdd:cd11009  180 PKIYNEKkGSEEAYDRAAGELLPEAQRTTAGFLLKFLKE 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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