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Conserved domains on  [gi|22507355|ref|NP_683748|]
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sodium/calcium exchanger 2 isoform 1 precursor [Mus musculus]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1650.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355     1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GNGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   633 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 711
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   712 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 791
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   792 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 871
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 22507355   872 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 921
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1650.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355     1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GNGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   633 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 711
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   712 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 791
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   792 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 871
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 22507355   872 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 921
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-368 1.77e-66

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 218.33  E-value: 1.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 22507355   324 QKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVL 368
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNIL 125
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 522-612 8.91e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 124.67  E-value: 8.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEEY 601
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-SDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 22507355    602 EKKDNFFIELG 612
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
748-909 1.84e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 748 GWACFGVCILVIG--VLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 825
Cdd:COG0530 155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 826 VFLGLGvawsVAAVYwavqgRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRpqiggeLGGPRGpklattALFLGLWFL 905
Cdd:COG0530 230 ILLVLG----IGALI-----TPIPVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLA 288


                ....
gi 22507355 906 YILF 909
Cdd:COG0530 289 YLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 770-873 1.25e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355  770 ASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRPFE 849
Cdd:PRK10734  26 ASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLILGLAALI---------RPFT 95

                         90       100
                 ....*....|....*....|....
gi 22507355  850 VRAGTLAFSVTLFTVFAFVCIAVL 873
Cdd:PRK10734  96 VHSDVLRRELPLMLLVSVLAGSVL 119
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1650.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355     1 MAPLALMGVVLLLGVPHCLGEATPTPSLPPptANDSDASPEGCQGSYRCQPGVLLPVWEPEDPSLGDKVARAVVYFVAMV 80
Cdd:TIGR00845   6 LSPLFSVGFHLLTAVSLLFLHVDHARALTE--ASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFVAMV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    81 YMFLGVSIIADRFMASIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGHNFQAGEL 160
Cdd:TIGR00845  84 YMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   161 GPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCV 240
Cdd:TIGR00845 164 GPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   241 VFAWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS---IELDGTFVGTEVPGELGALGTgpAEARELDASRREVIQ 317
Cdd:TIGR00845 244 VFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSkteIEMDGKMVNSHVDNFLDGALV--LEVKEFDEARREMIR 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   318 ILKDLKQKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRRHAADAARRPG--ATDGAPDDEDDGASR 395
Cdd:TIGR00845 322 ILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVsmHEVATDDEENDPVSK 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   396 IFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEED 475
Cdd:TIGR00845 402 IFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEED 481

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   476 EHFFVRLLNLRVGDAQGMFEPDGGGRpKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTV 555
Cdd:TIGR00845 482 EHFYVRLSNLRVGSEDGILEANHVSA-VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTV 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   556 RLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQWLKRGIS-ALLLNQ--GNGD 632
Cdd:TIGR00845 561 IVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKaALLLNEtiTDDD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   633 KKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFIEAVTVSAG-DEEEDED 711
Cdd:TIGR00845 641 QKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGdDDDDDED 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   712 GprEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVAL 791
Cdd:TIGR00845 721 G--EEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVAL 798

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   792 GTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRAGTLAFSVTLFTVFAFVCIA 871
Cdd:TIGR00845 799 GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIG 878

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|
gi 22507355   872 VLLYRRRPQIGGELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHIRGF 921
Cdd:TIGR00845 879 VLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 248-368 1.77e-66

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 218.33  E-value: 1.77e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   248 KRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGTEVPGELGALGTGPAEARELDASRREVIQILKDLK 323
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVMEGGAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 22507355   324 QKHPDKDLEQLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVL 368
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNIL 125
Calx-beta pfam03160
Calx-beta domain;
393-482 3.93e-38

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 137.00  E-value: 3.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   393 ASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIF 472
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|
gi 22507355   473 EEDEHFFVRL 482
Cdd:pfam03160  81 EGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 522-612 8.91e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 124.67  E-value: 8.91e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEEY 601
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAG-SDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 22507355    602 EKKDNFFIELG 612
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 393-483 1.49e-33

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 123.90  E-value: 1.49e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    393 ASRIFFEPSLYHCLENCGSVLLSVACQGGeGNSTFYVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIF 472
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 22507355    473 EEDEHFFVRLL 483
Cdd:smart00237  80 EKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
522-612 3.69e-31

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 117.35  E-value: 3.69e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   522 AGIFSFQDRLLHVSECMGTVDVRVVRSSGA-RGTVRLPYRTVDGTARGGgVHYEDACGELEFGDDETMKTLQVKIVDDEE 600
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 22507355   601 YEKKDNFFIELG 612
Cdd:pfam03160  80 YEGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 748-912 3.05e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 96.52  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   748 GWACFGVCILVIGVLTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVF 827
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   828 LGLGVAWSVAAVYWAVQGRPFEvragtlaFSVTLFTVFAFVCIAVLLYRRRpqiggelggPRGPKLATTALFLGLWFLYI 907
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLD-------LGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 22507355   908 LFSSL 912
Cdd:pfam01699 145 VFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 74-245 2.77e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.35  E-value: 2.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    74 VYFVAMVYMFLGVSIIADRFMASIEVItskekeititkangetsvGTVRIWNETVSNLTLMALGSSAPEILLTVIEVCGH 153
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVL------------------ARVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   154 NfqaGELGPGTIVGSAAFNMFVVIAVCVYVIPA--GESRKIKHLRVFFVTASWSIFAYVWLYLILavfsPGVVQVWEALL 231
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIGPVkvDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 22507355   232 TLIFFPVCVVFAWM 245
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
748-909 1.84e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 748 GWACFGVCILVIG--VLTALIGDLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVN 825
Cdd:COG0530 155 LLLVLGLALLVVGarLLVDGAVEIARALG----VSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 826 VFLGLGvawsVAAVYwavqgRPFEVRAGTLAFSVTLFTVFAFVCIAVLLYRRRpqiggeLGGPRGpklattALFLGLWFL 905
Cdd:COG0530 230 ILLVLG----IGALI-----TPIPVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLA 288


                ....
gi 22507355 906 YILF 909
Cdd:COG0530 289 YLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 73-314 6.79e-12

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 69.64  E-value: 6.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355     73 VVYFVAMVYMFLGVSIIADR-FMASIEVITSKekeititkangetsvgtVRIwNETVSNLTLMALGSSAPEILLTVIEV- 150
Cdd:TIGR00927  458 VLHIFGMMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVf 519

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    151 CGHNfqagELGPGTIVGSAAFNMFVVIAVCvyvipAGESRKIKHLrvffvtASWSIFAYVWLY-----LILAVFSPGVVQ 225
Cdd:TIGR00927  520 ISHS----NVGIGTIVGSAVFNILFVIGTC-----ALFSREILNL------TWWPLFRDVSFYildlmMLILFFLDSLIA 584

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    226 VWEALLTLIFFPVcVVFAWMADKRLlfYKYVYKRYRTDPRSGIIigAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEA 305
Cdd:TIGR00927  585 WWESLLLLLAYAL-YVFTMKWNKQI--ELWVKEQLSRRPVAKVM--ALGDLSKGDVAEAEHTGERTGEEGERPTEAEGEN 659


                   ....*....
gi 22507355    306 RELDASRRE 314
Cdd:TIGR00927  660 GEESGGEAE 668
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
769-910 4.19e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 61.69  E-value: 4.19e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 769 LASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGvawsVAAVYwavqgRPF 848
Cdd:COG0530  11 LARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILG----LAALI-----RPL 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22507355 849 EVRAGTLAFSVTLFTVFAFVCIAVLLYRRRPQIGGelggprgpklattALFLGLWFLYILFS 910
Cdd:COG0530  77 AVDRRVLRRDLPFLLLASLLLLALLLDGTLSRIDG-------------VILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
131-249 4.49e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 55.52  E-value: 4.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 131 LTLMALGSSAPEILLTVIEVCGHNFqagELGPGTIVGSAAFNMFVVIAVCVYVIPAgesrKIKHlRVFFVTASWSIFAYV 210
Cdd:COG0530  24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPL----AVDR-RVLRRDLPFLLLASL 95

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22507355 211 wlyLILAVFSPGVVQVWEALLTLIFFPVCVVFAWMADKR 249
Cdd:COG0530  96 ---LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 749-906 2.38e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 50.40  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   749 WACFGVCILVIGvlTALIGDLASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCaDASIGNVTGSNAVNVFL 828
Cdd:TIGR00367 174 LLIIGLIGLVVG--SRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLG-DIAVGNVIGSNIFNILV 250

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22507355   829 GLGVAWSVAAVywavqgrPFEVRAGTLAFSVTLFTVFAFvciaVLLYRRRPQIGGELGgprgpklattALFLGLWFLY 906
Cdd:TIGR00367 251 GLGVPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG----------ILLLALYIAY 307
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 768-906 1.16e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.47  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   768 DLASHFGctvgLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRP 847
Cdd:TIGR00367  27 RIARHLG----ISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFNILLILGLSAIF---------SP 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22507355   848 FEVRAGTLAFSVTLFTVFAFVCIAVLLYrrrpqiggelgGPRGPKLATTALFLG---LWFLY 906
Cdd:TIGR00367  93 IIVDKDWLRRDILFYLLVSILLLFFGLD-----------GQISRIDGVVLLILYivyLLFLV 143
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 77-244 6.69e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 45.78  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355    77 VAMVYMFLGVSII-ADRFMASIEVITSKEKEITItkangetsvgtvriwnetVSNLTLMALGSSAPEILLTVIEVCGHNf 155
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIARHLGISPL------------------IIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355   156 qaGELGPGTIVGSAAFNMFVVIAVCVYVIPagesrkikhlrvfFVTASWSIF----AYVWLYLILAVFspGVVQVWEALL 231
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdilFYLLVSILLLFF--GLDGQISRID 127

                         170
                  ....*....|...
gi 22507355   232 TLIFFPVCVVFAW 244
Cdd:TIGR00367 128 GVVLLILYIVYLL 140
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 770-873 1.25e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 45.02  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355  770 ASHFGCTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQcADASIGNVTGSNAVNVFLGLGVAWSVaavywavqgRPFE 849
Cdd:PRK10734  26 ASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLILGLAALI---------RPFT 95

                         90       100
                 ....*....|....*....|....
gi 22507355  850 VRAGTLAFSVTLFTVFAFVCIAVL 873
Cdd:PRK10734  96 VHSDVLRRELPLMLLVSVLAGSVL 119
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 127-263 1.62e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 42.06  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355  127 TVSNLTLMALGSSAPEILLTVIEVCGHNfqAGELGPGTIVGSAAFNMFVV---IAVCVyvipAGESRKIKHlRVFFVTAS 203
Cdd:PLN03151 178 TVAGVTLLPLGNGAPDVFASIAAFVGKD--AGEVGLNSVLGGAVFVTCVVvgiVSLCV----ADKEVQIDK-RCFIRDLC 250

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355  204 WSIFAYVWLYLILAVfspGVVQVWEAlltLIFFPVCVVFAWMADKRLLFYKYVyKRYRTD 263
Cdd:PLN03151 251 FFLFTLVSLLVILMV---GKVTVGGA---IAFVSIYVVYAFLVAANEILRKHA-RRLKLD 303
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
124-242 5.11e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 5.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22507355 124 WNETVSNLTLMALGSSAPEILLTVIEVcghnFQ-AGELGPGTIVGSAAFNMFVVIAVCVYVIPagesrkikhLRVFFVTA 202
Cdd:COG0530 184 VSELVIGLTIVAIGTSLPELATSIVAA----RKgEDDLAVGNIIGSNIFNILLVLGIGALITP---------IPVDPAVL 250

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22507355 203 SWSIFAYV--WLYLILAVFSPGVVQVWEALLTLIFFPVCVVF 242
Cdd:COG0530 251 SFDLPVMLaaTLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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