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Conserved domains on  [gi|225543251|ref|NP_032248|]
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holocytochrome c-type synthase isoform 1 [Mus musculus]

Protein Classification

holocytochrome c-type synthase( domain architecture ID 6957)

holocytochrome c-type synthase catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome; may be partial

EC:  4.4.1.17
Gene Ontology:  GO:0004408|GO:0046872|GO:0018063
PubMed:  35243551

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Cyto_heme_lyase super family cl03142
Cytochrome c/c1 heme lyase;
5-270 1.54e-92

Cytochrome c/c1 heme lyase;


The actual alignment was detected with superfamily member pfam01265:

Pssm-ID: 426167  Cd Length: 296  Bit Score: 274.97  E-value: 1.54e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251    5 ASSPATAVNASNASDGQPASPPSGCPMHKgqrkgcpvtaaTSDLTSESKAHTVPAHQDRAYDYVECPV-------TGARA 77
Cdd:pfam01265   6 ADSTPSAPPAPSSPASSSASPPPGCPMHH-----------KSKSSSPSSASAPPMPPAPTPSPSACPVppddsppSSSPA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251   78 KDKES----LDPSNLMPPP-NQTPSPDQPFTLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWkwkdDDISQKDMY 152
Cdd:pfam01265  75 SEQQStlskLNPLNYMPSDlSNERAPGQTVDLPTEREISSIPKGDGEGNWEYPSPQQMYNAMLRKGY----TDTPEDAVE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  153 NIIRIHNQNNEQAWKEILKWEALHA-------HECPCG-------------PSLVRFGGKAREYSPRARIRSWMGY---- 208
Cdd:pfam01265 151 SMVAVHNFLNEGAWQEILGWERRFAkglargwEICRRGeenvalelrreeePRLLRFQGRPKELTPKARMLQLLGWlyps 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  209 ----ELPFDRHDWIINRCGT----EVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKvawwRW 270
Cdd:pfam01265 231 kfgtEPPFDRHDWYVLRCTPggqkEVRYVIDYYSGPDEPTGEPVFYLDVRPALDSPTNAAERLM----RW 296
 
Name Accession Description Interval E-value
Cyto_heme_lyase pfam01265
Cytochrome c/c1 heme lyase;
5-270 1.54e-92

Cytochrome c/c1 heme lyase;


Pssm-ID: 426167  Cd Length: 296  Bit Score: 274.97  E-value: 1.54e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251    5 ASSPATAVNASNASDGQPASPPSGCPMHKgqrkgcpvtaaTSDLTSESKAHTVPAHQDRAYDYVECPV-------TGARA 77
Cdd:pfam01265   6 ADSTPSAPPAPSSPASSSASPPPGCPMHH-----------KSKSSSPSSASAPPMPPAPTPSPSACPVppddsppSSSPA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251   78 KDKES----LDPSNLMPPP-NQTPSPDQPFTLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWkwkdDDISQKDMY 152
Cdd:pfam01265  75 SEQQStlskLNPLNYMPSDlSNERAPGQTVDLPTEREISSIPKGDGEGNWEYPSPQQMYNAMLRKGY----TDTPEDAVE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  153 NIIRIHNQNNEQAWKEILKWEALHA-------HECPCG-------------PSLVRFGGKAREYSPRARIRSWMGY---- 208
Cdd:pfam01265 151 SMVAVHNFLNEGAWQEILGWERRFAkglargwEICRRGeenvalelrreeePRLLRFQGRPKELTPKARMLQLLGWlyps 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  209 ----ELPFDRHDWIINRCGT----EVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKvawwRW 270
Cdd:pfam01265 231 kfgtEPPFDRHDWYVLRCTPggqkEVRYVIDYYSGPDEPTGEPVFYLDVRPALDSPTNAAERLM----RW 296
PHA03247 PHA03247
large tegument protein UL36; Provisional
2-121 4.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251    2 GASASSPATAVNASNASDGQPASPPSGCPMHKGQRKGCPVTAATSDLTSESKAHTVPAhqdraydyvecPVTGARAKDKE 81
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA-----------AVLAPAAALPP 2820
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 225543251   82 SLDPSNLMPPPNQT-----PSPDQPFTLSTSREESSIPRADSEKK 121
Cdd:PHA03247 2821 AASPAGPLPPPTSAqptapPPPPGPPPPSLPLGGSVAPGGDVRRR 2865
 
Name Accession Description Interval E-value
Cyto_heme_lyase pfam01265
Cytochrome c/c1 heme lyase;
5-270 1.54e-92

Cytochrome c/c1 heme lyase;


Pssm-ID: 426167  Cd Length: 296  Bit Score: 274.97  E-value: 1.54e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251    5 ASSPATAVNASNASDGQPASPPSGCPMHKgqrkgcpvtaaTSDLTSESKAHTVPAHQDRAYDYVECPV-------TGARA 77
Cdd:pfam01265   6 ADSTPSAPPAPSSPASSSASPPPGCPMHH-----------KSKSSSPSSASAPPMPPAPTPSPSACPVppddsppSSSPA 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251   78 KDKES----LDPSNLMPPP-NQTPSPDQPFTLSTSREESSIPRADSEKKWVYPSEQMFWNAMLRKGWkwkdDDISQKDMY 152
Cdd:pfam01265  75 SEQQStlskLNPLNYMPSDlSNERAPGQTVDLPTEREISSIPKGDGEGNWEYPSPQQMYNAMLRKGY----TDTPEDAVE 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  153 NIIRIHNQNNEQAWKEILKWEALHA-------HECPCG-------------PSLVRFGGKAREYSPRARIRSWMGY---- 208
Cdd:pfam01265 151 SMVAVHNFLNEGAWQEILGWERRFAkglargwEICRRGeenvalelrreeePRLLRFQGRPKELTPKARMLQLLGWlyps 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251  209 ----ELPFDRHDWIINRCGT----EVRYVIDYYDGGEVNKEYQFTILDVRPAFDSFSAVWDRMKvawwRW 270
Cdd:pfam01265 231 kfgtEPPFDRHDWYVLRCTPggqkEVRYVIDYYSGPDEPTGEPVFYLDVRPALDSPTNAAERLM----RW 296
PHA03247 PHA03247
large tegument protein UL36; Provisional
2-121 4.74e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543251    2 GASASSPATAVNASNASDGQPASPPSGCPMHKGQRKGCPVTAATSDLTSESKAHTVPAhqdraydyvecPVTGARAKDKE 81
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA-----------AVLAPAAALPP 2820
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 225543251   82 SLDPSNLMPPPNQT-----PSPDQPFTLSTSREESSIPRADSEKK 121
Cdd:PHA03247 2821 AASPAGPLPPPTSAqptapPPPPGPPPPSLPLGGSVAPGGDVRRR 2865
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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