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Conserved domains on  [gi|22901428|gb|AAN09964|]
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CG3592, partial [Drosophila melanogaster]

Protein Classification

Cyt_b561 domain-containing protein( domain architecture ID 10171097)

Cyt_b561 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 36-160 1.55e-18

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


:

Pssm-ID: 176489  Cd Length: 131  Bit Score: 78.09  E-value: 1.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428  36 HAVYAILGLFLCVGESLLVCHSWWlgdFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:cd08554   5 HPLLMVIGFVFLMGEALLVYRVFR---LLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLATV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22901428 116 LLIAGAVASGFALVCFTHLAL---HVIHRLMGLCGFVLLSCSQWFALN 160
Cdd:cd08554  82 LLFLLQFLSGFVLFLLPLLRLsyrSSLLPFHRFFGLAIFVLAIATILL 129
 
Name Accession Description Interval E-value
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 36-160 1.55e-18

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 78.09  E-value: 1.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428  36 HAVYAILGLFLCVGESLLVCHSWWlgdFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:cd08554   5 HPLLMVIGFVFLMGEALLVYRVFR---LLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLATV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22901428 116 LLIAGAVASGFALVCFTHLAL---HVIHRLMGLCGFVLLSCSQWFALN 160
Cdd:cd08554  82 LLFLLQFLSGFVLFLLPLLRLsyrSSLLPFHRFFGLAIFVLAIATILL 129
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 36-159 2.51e-18

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 77.66  E-value: 2.51e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428     36 HAVYAILGLFLCVGESLLVCHswWLGDFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:smart00665   2 HPVLMILGFGFLMGEAILVAR--PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 22901428    116 LLIAGAVASGFALVCF------THLALHVIHRLMGLCGFVLLSCSQWFAL 159
Cdd:smart00665  80 VLAGLQWLSGFLRPLPpglpskYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 36-155 4.41e-07

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 47.60  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428    36 HAVYAILGLFLCVGESLLVcHSWWLGDFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:pfam03188   2 HPVLMVIGFIFLMGEAILV-YRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 22901428   116 LLIAGAVASGFALVCFTHLALHV------IHRLMGLCGFVLLSCSQ 155
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIrplllpLHVFFGLVIFVLAIVTA 126
 
Name Accession Description Interval E-value
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 36-160 1.55e-18

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 78.09  E-value: 1.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428  36 HAVYAILGLFLCVGESLLVCHSWWlgdFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:cd08554   5 HPLLMVIGFVFLMGEALLVYRVFR---LLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLATV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22901428 116 LLIAGAVASGFALVCFTHLAL---HVIHRLMGLCGFVLLSCSQWFALN 160
Cdd:cd08554  82 LLFLLQFLSGFVLFLLPLLRLsyrSSLLPFHRFFGLAIFVLAIATILL 129
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 36-159 2.51e-18

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 77.66  E-value: 2.51e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428     36 HAVYAILGLFLCVGESLLVCHswWLGDFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:smart00665   2 HPVLMILGFGFLMGEAILVAR--PLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAF 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 22901428    116 LLIAGAVASGFALVCF------THLALHVIHRLMGLCGFVLLSCSQWFAL 159
Cdd:smart00665  80 VLAGLQWLSGFLRPLPpglpskYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 36-155 4.41e-07

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 47.60  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22901428    36 HAVYAILGLFLCVGESLLVcHSWWLGDFISENRLNLLHMVLGMVGLWLGLVGIFAKSIFKSRIHEPHFNSKHGLCGLLGF 115
Cdd:pfam03188   2 HPVLMVIGFIFLMGEAILV-YRVNSTRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 22901428   116 LLIAGAVASGFALVCFTHLALHV------IHRLMGLCGFVLLSCSQ 155
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIrplllpLHVFFGLVIFVLAIVTA 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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