NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|229091322|ref|NP_001153199|]
View 

putative phospholipase B-like 2 isoform 2 precursor [Homo sapiens]

Protein Classification

phospholipase B family protein( domain architecture ID 10522720)

phospholipase B family protein may catalyze the hydrolytic cleavage of acylester bonds in glycerophospholipids

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


:

Pssm-ID: 428195  Cd Length: 483  Bit Score: 531.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYCER-LKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHWLNTIEAYCKNST---GFCDPkLRAFMETNL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSSMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGT------------------------- 373
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfw 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  374 ------GMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLM 447
Cdd:pfam04916 311 vveqipGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALM 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  448 RYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPP 527
Cdd:pfam04916 391 RYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPP 455
                         490       500
                  ....*....|....*....|....*.
gi 229091322  528 FQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 456 FDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 428195  Cd Length: 483  Bit Score: 531.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYCER-LKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHWLNTIEAYCKNST---GFCDPkLRAFMETNL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSSMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGT------------------------- 373
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfw 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  374 ------GMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLM 447
Cdd:pfam04916 311 vveqipGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALM 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  448 RYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPP 527
Cdd:pfam04916 391 RYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPP 455
                         490       500
                  ....*....|....*....|....*.
gi 229091322  528 FQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 456 FDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Name Accession Description Interval E-value
Phospholip_B pfam04916
Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester ...
85-552 0e+00

Phospholipase B; Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.


Pssm-ID: 428195  Cd Length: 483  Bit Score: 531.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322   85 AWANLTNAIRETGWAFLELGTSGQYNDSLQAYAAGVVEAAVSEELIYMHWMNTVVNYCGPFEyevGYCER-LKSFLEANL 163
Cdd:pfam04916   1 ARAYFNDSVNTTGWGFLEIETNSVYSDTLQAYAAGFLEGYLTAELIYDHWLNTIEAYCKNST---GFCDPkLRAFMETNL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  164 EWMQEEMESNPDSPYWHQVRLTLLQLKGLEDSYEGRVSFPAGKfTIKPLGFLLLQLSGDLEDLELALNKTKIKPSLGS-- 241
Cdd:pfam04916  78 KWMRKQVKENPDDPYWRQVGLVYAQLDGLVAGYNARAASDKRK-PLTFFQILLLNLAGDLEDLVPALTPPKNSSAAKFkm 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  242 ---GSCSALIKLLPGQSDLLVAHNTWNNYQHMLRVIKKYWLQFregpwGDYPLVPGNKLVFSSYPGTIFSCDDFYILGSG 318
Cdd:pfam04916 157 kepGHCSALIKLLPGFEDLLFGHTTWSSYSSMLRIYKHYTFPV-----SDRAVVPGTTVSFSSYPGLLSSLDDFYITSSG 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  319 LVTLETTIGNKNPALWKYVRPRGcVLEWVRNIVANRLASDGATWADIFKRFNSGT------------------------- 373
Cdd:pfam04916 232 LAVMETTNGIFNQTLYKLIKPSS-VLTWQRVMVANRLAHSGREWAEIFSRYNSGTynnqwmvldyklftpgqelpdgtfw 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  374 ------GMVVVADKTSELYQKTYWASYNIPSFETVFNASGLQALVAQYGDWFSYDGSPRAQIFRRNQSLVQDMDSMVRLM 447
Cdd:pfam04916 311 vveqipGYIEASDVTAVLNRTGYWPSYNIPYFPEIYNISGYPAMVEKYGDWFSYDLTPRAKIFRRDQGNVTDLESMKALM 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 229091322  448 RYNDFLHDPLSLCKACnpqpngeNAISARSDLNPANGsypfqalrQRSHGGIDVKVTSMSLARILSLLAASGPTWDQVPP 527
Cdd:pfam04916 391 RYNNYKKDPLSKGSPE-------NAISARGDLNPAGG--------HRAFGAIDTKVTNYALVLSLQARAISGPTTDTQPP 455
                         490       500
                  ....*....|....*....|....*.
gi 229091322  528 FQWSTSP-FSGLLHMGQPDLWKFAPV 552
Cdd:pfam04916 456 FDWSSSPfFNVTRHQGHPDVWNFDFV 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH