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Conserved domains on  [gi|231466|sp|P29699|]
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RecName: Full=Alpha-2-HS-glycoprotein; AltName: Full=Countertrypin; AltName: Full=Fetuin-A; Flags: Precursor

Protein Classification

CY domain-containing protein( domain architecture ID 11249404)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 1.71e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466     149 CPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRAQNVPLPVSTL-VEFVIAATDCTaKEVTDPAKCNLLAEKQH 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 231466     228 GFCKANLMHN 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-133 1.37e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 79.78  E-value: 1.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466       26 GFRELACDDPEAEQVALLAVDYLNNHllQGFKQVLNQIDKVKVWSRRPFGVVYEMEVDTLETTCHALDPTPlANCSVRQL 105
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 231466      106 TehavEGDCDFHILKQDGQ--FRVMHTQCH 133
Cdd:smart00043  82 G----EKFCTAKVWEKPWEnkIKLVEFKCT 107
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 1.71e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466     149 CPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRAQNVPLPVSTL-VEFVIAATDCTaKEVTDPAKCNLLAEKQH 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 231466     228 GFCKANLMHN 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-133 1.37e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 79.78  E-value: 1.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466       26 GFRELACDDPEAEQVALLAVDYLNNHllQGFKQVLNQIDKVKVWSRRPFGVVYEMEVDTLETTCHALDPTPlANCSVRQL 105
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 231466      106 TehavEGDCDFHILKQDGQ--FRVMHTQCH 133
Cdd:smart00043  82 G----EKFCTAKVWEKPWEnkIKLVEFKCT 107
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-248 5.10e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.85  E-value: 5.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466      145 LCPRCPLLTPFNDTNVVHTVNTALAAFNTQNNgTYFKLVEISRA---QNVPLPVSTLVEFVIAATDCTaKEVTDPAKCNL 221
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPF 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 231466      222 LAEKQhGFCKANLMHNLG---GEEVSVACK 248
Cdd:smart00043  79 LDQGE-KFCTAKVWEKPWenkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 149-247 1.56e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 71.35  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466   149 CPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRA--QNVPlpvSTLVEFVIAATDCTAKEV---TDPAKCNLLA 223
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVVA---GTNYYITVEAGDTNCKKSsvpLDCPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 231466   224 EKQHGFCKANLMHNL---GGEEVSVAC 247
Cdd:cd00042  79 EGKKKFCTAKVWEKPwenFKELLSFKC 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-132 2.24e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 65.57  E-value: 2.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466    26 GFRELACDDPEAEQVALLAVDYLNNHLLQG---FKQVLNQidKVKVWSrrpfGVVYEMEVDTLETTCHALDPTPLanCSV 102
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKyleFFKVLSA--KSQVVA----GTNYYITVEAGDTNCKKSSVPLD--CPD 73

                        90       100       110
                ....*....|....*....|....*....|..
gi 231466   103 RQLTEHAVEGDCDFHILKQD--GQFRVMHTQC 132
Cdd:cd00042  74 CKLLEEGKKKFCTAKVWEKPweNFKELLSFKC 105
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 149-237 1.71e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 84.69  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466     149 CPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRAQNVPLPVSTL-VEFVIAATDCTaKEVTDPAKCNLLAEKQH 227
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYfIKVEVGETDCS-KSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|
gi 231466     228 GFCKANLMHN 237
Cdd:pfam00031  81 GLCSAQVYKV 90
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-133 1.37e-18

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 79.78  E-value: 1.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466       26 GFRELACDDPEAEQVALLAVDYLNNHllQGFKQVLNQIDKVKVWSRRPFGVVYEMEVDTLETTCHALDPTPlANCSVRQL 105
Cdd:smart00043   5 GPSDVPPNDPEVQEAADFAVAEYNKK--SNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDL-ENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 231466      106 TehavEGDCDFHILKQDGQ--FRVMHTQCH 133
Cdd:smart00043  82 G----EKFCTAKVWEKPWEnkIKLVEFKCT 107
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 145-248 5.10e-16

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 72.85  E-value: 5.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466      145 LCPRCPLLTPFNDTNVVHTVNTALAAFNTQNNgTYFKLVEISRA---QNVPLPVSTLVEFVIAATDCTaKEVTDPAKCNL 221
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSN-DKYELRVIKVVsakSQVVAGTNYYLKVEVGETNCK-KLSVDLENCPF 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 231466      222 LAEKQhGFCKANLMHNLG---GEEVSVACK 248
Cdd:smart00043  79 LDQGE-KFCTAKVWEKPWenkIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 149-247 1.56e-15

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 71.35  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466   149 CPLLTPFNDTNVVHTVNTALAAFNTQNNGTYFKLVEISRA--QNVPlpvSTLVEFVIAATDCTAKEV---TDPAKCNLLA 223
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAksQVVA---GTNYYITVEAGDTNCKKSsvpLDCPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 231466   224 EKQHGFCKANLMHNL---GGEEVSVAC 247
Cdd:cd00042  79 EGKKKFCTAKVWEKPwenFKELLSFKC 105
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-132 2.24e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 65.57  E-value: 2.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 231466    26 GFRELACDDPEAEQVALLAVDYLNNHLLQG---FKQVLNQidKVKVWSrrpfGVVYEMEVDTLETTCHALDPTPLanCSV 102
Cdd:cd00042   2 GPSDIPANDPEVQELADFAVAEYNKKSNDKyleFFKVLSA--KSQVVA----GTNYYITVEAGDTNCKKSSVPLD--CPD 73

                        90       100       110
                ....*....|....*....|....*....|..
gi 231466   103 RQLTEHAVEGDCDFHILKQD--GQFRVMHTQC 132
Cdd:cd00042  74 CKLLEEGKKKFCTAKVWEKPweNFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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