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Conserved domains on  [gi|254596554|gb|ACT75561|]
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NADH dehydrogenase subunit 4, partial (mitochondrion) [Dactylopsila trivirgata]

Protein Classification

proton-conducting transporter membrane subunit( domain architecture ID 1562513)

proton-conducting transporter membrane subunit such as NADH dehydrogenase subunit 2, 4, or N, which shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain

EC:  7.1.-.-
Gene Ontology:  GO:0005886

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Proton_antipo_M super family cl39059
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-201 2.02e-116

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


The actual alignment was detected with superfamily member MTH00110:

Pssm-ID: 476862 [Multi-domain]  Cd Length: 459  Bit Score: 338.41  E-value: 2.02e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-201 2.02e-116

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 338.41  E-value: 2.02e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-200 2.34e-30

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 115.95  E-value: 2.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG1008  278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFitsQR---G 159
Cdd:COG1008  358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY---QRvffG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596554 160 KLTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLT 200
Cdd:COG1008  435 PLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-140 4.43e-28

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 106.63  E-value: 4.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554    1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA-NTNYERI 79
Cdd:pfam00361 148 QILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRV 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596554   80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGT 140
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-201 1.07e-26

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 105.79  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554    4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT- 162
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSn 432

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 254596554  163 HHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLTY 201
Cdd:TIGR01972 433 PEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
 
Name Accession Description Interval E-value
ND4 MTH00110
NADH dehydrogenase subunit 4; Provisional
 1-201 2.02e-116

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177172 [Multi-domain]  Cd Length: 459  Bit Score: 338.41  E-value: 2.02e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00110 259 YPFLMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSFMGATALMIAHGLTSSMLFCLANSNYERIH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00110 339 SRTMILARGLQTLLPLMATWWLLASLTNLALPPTINLIGELFVIMSSFSWSNITIILMGLNMLITALYSLYMLITTQRGK 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLTY 201
Cdd:MTH00110 419 LTHHINNIKPSFTRENTLMALHLLPLLLLSLNPKIILGPTY 459
ND4 MTH00124
NADH dehydrogenase subunit 4; Provisional
 1-198 3.28e-88

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214427 [Multi-domain]  Cd Length: 457  Bit Score: 266.68  E-value: 3.28e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00124 259 YPFLTLALWGALMTSLICLRQTDLKSLIAYSSVSHMGLVIAATMIQTPWSLSGAMILMIAHGLTSSMLFCLANTNYERTH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00124 339 SRTLLLTRGLQLLLPLMTTWWLLANLTNMALPPTINLMGELTIMTSLFNWSPTTIILTGLATLITASYTLYMFLSTQRGT 418

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILG 198
Cdd:MTH00124 419 LPTHITTIQPTHTREHLLMTLHIIPLLLLILKPELISG 456
ND4 MTH00068
NADH dehydrogenase subunit 4; Provisional
 1-199 4.87e-85

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214417 [Multi-domain]  Cd Length: 458  Bit Score: 258.31  E-value: 4.87e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00068 259 YPFIILALWGVLMTSLICLRQTDLKSLIAYSSVSHMGLVIAAALIQTPWSFSGAIILMISHGLTSSALFCLANTNYERTH 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00068 339 SRTLLLLRGAQTILPLMATWWLLSNLSNMALPPSPNLWGELTIMVSLFNWSNWTILITGLGTLITAAYTLYMFLMTQRGP 418

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGL 199
Cdd:MTH00068 419 LPNHLKTLFPTYTREHLLLALHILPMLLLILKPELISGM 457
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 1-200 1.23e-70

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 221.37  E-value: 1.23e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00127 260 YPFIILALWGIIMTGSICLRQTDLKSLIAYSSVSHMGLVAGGILIQTPWGFTGALILMIAHGLTSSALFCLANTNYERTH 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00127 340 SRTMLLARGLQMILPLMATWWFIASLANLALPPLPNLMGELMIITSLFNWSPWTLALTGLGTLITAGYSLYMFLMTQRGP 419

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLT 200
Cdd:MTH00127 420 LPDHIIALNPSHTREHLLMALHLLPLLLLILKPELIWGWT 459
ND4 MTH00206
NADH dehydrogenase subunit 4; Provisional
 1-196 2.36e-65

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214458 [Multi-domain]  Cd Length: 450  Bit Score: 207.48  E-value: 2.36e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00206 255 YFFIILGLWGSIMTSSICLRQTDLKSLIAYSSVSHMSLVTAGILSGSPWGFKGALLLMIAHGLVSSALFCLANLLYERSH 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00206 335 TRTILGNRGLQMILPLLSFWWLLFFLANLGLPPFPNLFGELLIITSLFSWSNFTLPLLGLGFLFTAIYSLYMFVMTQHGK 414

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFI 196
Cdd:MTH00206 415 TPNHLLSLSPSSTREHLLLFLHLFPVILLILNPNLI 450
ND4 MTH00044
NADH dehydrogenase subunit 4; Validated
 1-197 1.16e-52

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214411 [Multi-domain]  Cd Length: 458  Bit Score: 174.78  E-value: 1.16e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00044 261 FILIVFCCWGALITSIICLRQTDLKALIAYSSVGHMSLVAAGIFSGTNWGINGALILMIAHGLVSSALFCLANILYERSG 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00044 341 TRTLSITRGFKLITPLLPLWWLIFCAANLGLPPLPNLIGELLIISSIISWSILSFPIIGLATVFGAIYSLLIYQLTNSGS 420

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFIL 197
Cdd:MTH00044 421 FPSWISNVSPISSREHLLIFLHLLPLILIIINPNIIL 457
ND4 MTH00163
NADH dehydrogenase subunit 4; Provisional
 1-199 1.26e-47

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214443 [Multi-domain]  Cd Length: 445  Bit Score: 161.48  E-value: 1.26e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00163 247 YIWISISLVGGVIVSLICLRQVDLKSLIAYSSVAHMGLVLGGLMTFSYWGLMGSLLMMIGHGLCSSGLFCLANIIYERLG 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00163 327 SRSLLINKGLLNFMPSMSLWWFLLSSSNMAAPPSLNLLGEISLINSLISWSKLSMIFLMLLSFFSAAYSLYLYSYSQHGK 406

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGL 199
Cdd:MTH00163 407 YYSGLYSCSSGKVREYLLLFLHWLPLNLLILKSDLFMLW 445
ND4 MTH00150
NADH dehydrogenase subunit 4; Provisional
 3-196 2.27e-45

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214435 [Multi-domain]  Cd Length: 417  Bit Score: 155.00  E-value: 2.27e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00150 220 LISLSLWGGVLTSLICLRQSDVKSLIAYSSVGHMSLVLAGVLSNTSWGWVGALIMMVSHGFCSSGLFCLANYTYEKVHSR 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT 162
Cdd:MTH00150 300 SLFLSKGMLMLYPSLSLWWFLFCIINMAAPPSLNLLSEIMIFPSLISYSPWFFVPLGLMVFLSGLYSLYLYTSIQHGGSS 379

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254596554 163 HHLHTMKPTYTREHILMTLHLTPLLITSISPKFI 196
Cdd:MTH00150 380 SFLKPFNELKSSEMLLLLLHWVPLLLLILKSDLL 413
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 2-196 1.09e-41

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 146.04  E-value: 1.09e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   2 PFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:MTH00014 254 PFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTAGIMSNTSWGWQGALAMMIAHGLCSSALFALANMTYETTHT 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  82 RTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKL 161
Cdd:MTH00014 334 RSLFLTKGLLSLFPTMTMWWFLLSAANMAAPPSINLLSEIMLLTSILSSSLSTAILLAITSFLAAAYSLFLYTSTQHGSP 413

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 254596554 162 THHLHTMKPTYTREHILMTLHLTPLLITSISPKFI 196
Cdd:MTH00014 414 PSFMNPLNLFTPRNHTLMTLHLVPLFILILKPDLI 448
ND4 MTH00205
NADH dehydrogenase subunit 4; Provisional
 3-196 2.61e-41

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214457 [Multi-domain]  Cd Length: 448  Bit Score: 144.74  E-value: 2.61e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00205 253 FFSISLWGGVMTGMICLRQVDLKSLIAYSSVGHMGLMVVGVFSNTSWGMNGAIIMMVAHGLCSSGMFALANVNYERTNSR 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT 162
Cdd:MTH00205 333 SMLMNKGVLNTFPFLVLMWFLLISCNMAAPPSLNLASEILLIMSLLSSSKISGIPLSLISFLSGAYSLYLYSQSQHGKVS 412

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254596554 163 HHLHTMKPTYTREHILMTLHLTPLLITSISPKFI 196
Cdd:MTH00205 413 SQISSFLAISEREYYILILHWFPLNILILKLKIF 446
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 3-200 2.34e-30

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 115.95  E-value: 2.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG1008  278 LAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLLGIFALNPLGLQGAVLQMVSHGLITAALFLLVGVLYDRTHTR 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFitsQR---G 159
Cdd:COG1008  358 DIADLGGLAKRMPVLAALFLLAALASLGLPGTSGFVGEFLVLLGAFQVNPWLAILAALGLILTAAYLLWMY---QRvffG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 254596554 160 KLTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLT 200
Cdd:COG1008  435 PLKEELAELPDLNPRELAVLAPLAALILLLGLYPQPLLDLI 475
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 1-140 4.43e-28

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 106.63  E-value: 4.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554    1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA-NTNYERI 79
Cdd:pfam00361 148 QILLILAIISMLLGSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLFLCAgSVIYRRV 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596554   80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGT 140
Cdd:pfam00361 228 HTRNIRDYGGLAKTMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGV 288
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 4-201 1.07e-26

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 105.79  E-value: 1.07e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554    4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:TIGR01972 273 AALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVLLGIFSFNELGISGAVFQMISHGLITAALFLLVGVLYERAHTRD 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLT- 162
Cdd:TIGR01972 353 IAKYGGLANKMPVLAAFFMLFAMASLGLPGTSGFVGEFLILLGSFKVNPVVAFLAALGIVLAAAYMLTLYKRVFFGELSn 432

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 254596554  163 HHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGLTY 201
Cdd:TIGR01972 433 PEVAEFPDLNGREIAVLAPLVVLILFLGLYPNPLLDLTE 471
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 1-197 3.27e-24

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 98.74  E-value: 3.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:PRK05846 278 PIIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVTLGIFAGNQLGIQGAIFQMISHGLSSAALFLLVGVLYDRLH 357

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:PRK05846 358 TRDIADYGGLAKVMPVLAAFFLFFAMASLGLPGTSGFVGEFLILLGSFQVNPVIAFIATTGLILAAVYSLWLYQRVMFGP 437

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 254596554 161 LTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFIL 197
Cdd:PRK05846 438 VKNEVAKLKDLNGRELLILLPLVALLLLLGVYPKPLL 474
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 1-199 3.42e-21

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 90.12  E-value: 3.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   1 YPFIV-LSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERI 79
Cdd:MTH00204 275 APLIVmLSVIAVIYGSLTTCRQVDFKRLIAYSSVAHMGLVPLGLFTHTIEGLVAAVFLMLAHGFVSSALFIAVTFLYERH 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  80 HSRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRG 159
Cdd:MTH00204 355 HTRLIKYYRGLTLTMPLFVIIMLVLSLANMGFPLSCNFVGEFFSLLAAFEYSLGLGVLVTSGMVWSAAYSLYLYNRISFG 434

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 254596554 160 KLTHHLHTMKPTYTREHILMTLHLTPLLITSISPKFILGL 199
Cdd:MTH00204 435 GGSNYLLFSRDLNRRELLAILPLIIAIFLLGIVPFIIIDL 474
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 4-197 7.36e-21

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 89.21  E-value: 7.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:MTH00226 300 IAMGIVGIVYGSFATCRQIDVKRLVAYSSVAHMGLVSITLVTHDIIGLTGSIFIMLAHGIVSSLLFILVTILYDRHHTRL 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLTH 163
Cdd:MTH00226 380 IKYYRGLSITMPIWGTIMIVTSLANVAVPPSGNFIGEYLSILSSFNWNPIIGVFVCSGVILSAVYSFYFANRVTFGAPGN 459

                        170       180       190
                 ....*....|....*....|....*....|....
gi 254596554 164 HLHTMKPTYTREHILMTLHLTPLLITSISPKFIL 197
Cdd:MTH00226 460 LITFARDVNRREFYITASMVFFAFLIGIYPIFIL 493
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 2-153 1.42e-20

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 88.57  E-value: 1.42e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   2 PFI-VLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:MTH00217 273 PLIqTLSLLAIIYGSLTTCRQVDLKRIIAYSSVAHMGLVTLGIFSHTIQGLVAAIFLMLAHGLVSSALFIAVTFLYERHH 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMF 153
Cdd:MTH00217 353 TRLIKYYRGMVITMPLFGILMLLLVLANASIPLSCNFVGEFLSLLAAFEYSYIVGVLASLGMVLSAGYSIYLY 425
ND4 MTH00094
NADH dehydrogenase subunit 4; Provisional
 3-160 8.13e-17

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177157 [Multi-domain]  Cd Length: 403  Bit Score: 77.25  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:MTH00094 216 WIIFSLLGMILSSFCCVFQSDSKSLAAYSSVTHMSFLLLSLVYMSMSGKLSGLMMMLAHGYTSTLMFYLIGEFYHISKSR 295

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGK 160
Cdd:MTH00094 296 LIYFMNSFFSSSMFFGLIFSLVFLSNSGVPPSLSFFSEFLIISNSFMKNKFSFFFIFFYFLVSFYYSLFLIVSSFMGK 373
PRK06473 PRK06473
NADH-quinone oxidoreductase subunit M;
15-177 1.32e-15

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 235810 [Multi-domain]  Cd Length: 500  Bit Score: 74.35  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  15 SSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL---Q 91
Cdd:PRK06473 286 ASCAIAQKDMKKMVAYSSIGHMGYILLAAAAATPLSILAAVFQMISHGLISALLFLLVGVVYKKTGSRDVDVLRGLlnpE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  92 MILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQRGKLTHHLHTMKPT 171
Cdd:PRK06473 366 RGLPITGSLMILGVMASAGIPGMVGFIAEFLVFRGSFPIFPVQTLLCMIGTGLTAVYFLLLVNRVFFGRLTAELSNLPRV 445


                 ....*.
gi 254596554 172 YTREHI 177
Cdd:PRK06473 446 LWSERL 451
ndhD CHL00011
NADH dehydrogenase subunit 4
 11-152 3.59e-14

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 69.97  E-value: 3.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  11 MIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIhsRTMILAR-- 88
Cdd:CHL00011 288 IIYAASTSLGQRNLKKRIAYSSVSHMGFIIIGIGSITDTGLNGAILQIISHGFIGAALFFLAGTSYDRI--RLVYLDEmg 365

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596554  89 GLQMILPLMCTWWLLASLANLALPPTINFLSELMV---IVSSFSWSNMSIILL----GTNTVITALYSLHM 152
Cdd:CHL00011 366 GIAIPMPKIFTMFSSFSMASLALPGMSGFVAELIVffgIITSQKYLLMPKILItfvmAIGMILTPIYLLSM 436
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 21-194 2.26e-13

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 67.75  E-value: 2.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  21 QTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGLQMILPLMCTW 100
Cdd:PRK12561 272 QDNVKRRLAYSSVSHMGFVLLGIAAFTDLGISGAMLQMISHGLIAAALFFLTGVTYERTHTLSIPNMGGLAKVMPKTFAL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554 101 WLLASLANLALPPTINFLSELMV---IVSSFSWSN----MSIILLGTNTVITALYSLHM----FITSQRGKLTHH--LHT 167
Cdd:PRK12561 352 FTASSMASLALPGMSGFVSELTVflgITSSDVYSStfrtITILLAAVGLILTPIYLLSMlrrvFYGPRSELLPALavVED 431

                        170       180
                 ....*....|....*....|....*..
gi 254596554 168 MKPtytREHILMTLHLTPLLITSISPK 194
Cdd:PRK12561 432 AKP---RELFIALSLLVPIIGIGFYPK 455
PRK02546 PRK02546
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 4-164 3.77e-12

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 235050 [Multi-domain]  Cd Length: 525  Bit Score: 64.34  E-value: 3.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:PRK02546 283 IVLGVVNIIYAALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFTDLGTSGAMLQMISHGLIGASLFFLVGATYDRTHTLM 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVS-------SFSWSNMSIILLGTNTVITALYSLHM---- 152
Cdd:PRK02546 363 LDEMGGVGQKMRKMFAMWTACSLASLALPGMSGFVAELMVFVGfatsdayTLPFRVVVVFLAAVGVILTPIYLLSMlrei 442

                        170
                 ....*....|..
gi 254596554 153 FITSQRGKLTHH 164
Cdd:PRK02546 443 FFGPENKELVSH 454
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 3-157 4.59e-12

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 63.63  E-value: 4.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:COG0651  275 LLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNHALAKALLFLAAGAIERATGTR 354

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGtnTVITALYSLHMFITSQ 157
Cdd:COG0651  355 DLDKLGGLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEagaWLLAAVLLLS--SLLTLAYFVRIFGRAQ 430
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
5-177 5.33e-10

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 57.80  E-value: 5.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   5 VLSMWGMIMT---SSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:PRK07363 273 GLAIIGTISViygALSAIAQKDIKRMVAYSSIGHMGYILVAAAAGTQLSLLGAVAQMISHGLILALLFHLVGIVERKVGT 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  82 RTMILARGLQMI---LPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTVITALYSLHMFITSQR 158
Cdd:PRK07363 353 RDLDVLNGLMNPirgLPLTSALLVLAGMASAGIPGLVGFVAEFIVFQGSFSTFPIPTLLCIVASGLTAVYFVILLNRTCF 432

                        170
                 ....*....|....*....
gi 254596554 159 GKLTHHLHTMKPTYTREHI 177
Cdd:PRK07363 433 GRLDNKLAYYPKVLWSEKI 451
PRK06458 PRK06458
hydrogenase 4 subunit F; Validated
 3-147 1.06e-09

hydrogenase 4 subunit F; Validated


Pssm-ID: 235805 [Multi-domain]  Cd Length: 490  Bit Score: 56.86  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK06458 284 LLIFGLLSVLVAAFFLLRQRDIKRLFAYSSIEHMGLIAFALGIGGPLGIFAALLHMLNHSLTKSAIFFASGNVLQKYGTR 363

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGTNTVITAL 147
Cdd:PRK06458 364 DINVIRGLLKVSPLTGWGLMLGALAIAGMPPFGVFISEFLILTAGLArgpLLIAILLLLLLTLAFAAL 431
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 2-148 4.21e-09

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 55.27  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   2 PFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHS 81
Cdd:PRK08375 273 LLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYILLGLALLTPLALAAGLLHLLHHALMKGALFLAAGAIEVTYGT 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  82 RTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFS---WSNMSIILLGtnTVITALY 148
Cdd:PRK08375 353 RRLSELSGLGRRMPLTAAAFAVASLSLIGVPPTSGFVSKWYLVVGAVEagqWLVLAVLLAS--SLLALLY 420
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-191 1.75e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 50.35  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK12667 298 LIILGAVSAIIGALMMVVQKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINHAIAKSLLFLASGVFIHAAGTR 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMvIVSSFSWSNMSI--ILLGTNTVITALYSLHMFITSQRGK 160
Cdd:PRK12667 378 DIDELAGLGRKMPIASFAFLIGALSLVGIPPLNGFFSKLL-LFNALLESGFYLpaLVLLIASAISLVGYFRAWYSLFFGK 456

                        170       180       190
                 ....*....|....*....|....*....|.
gi 254596554 161 LTHHLHTMKptytREHILMTLHLTPLLITSI 191
Cdd:PRK12667 457 PKSGEEVEH----KESPSMSVVILVLALAVL 483
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 11-191 1.35e-06

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 47.84  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  11 MIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSfmgATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:COG1009  286 ALFAALIALAQTDIKRVLAYSTVSQLGYMFLALGVGAYVA---ALFHLLTHAFFKALLFLGAGSVIHATGTRDIRKMGGL 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  91 QMILPLmcTWWLLA--SLANLALPPTINFLSELMVIVSSFSWSNMSIILLGTNTV---ITALYSLHM----FITSQRGKL 161
Cdd:COG1009  363 RKKMPI--TAITFLigALSLAGIPPFAGFFSKEAILEAALEAGGLGPLLLAVALLgafLTAFYSFRLfflvFFGKPRPKT 440

                        170       180       190
                 ....*....|....*....|....*....|
gi 254596554 162 THHLHtmkptytREHILMTLHLTPLLITSI 191
Cdd:COG1009  441 PKHPH-------ESPWLMTLPLVVLAVLSL 463
PRK06525 PRK06525
hydrogenase 4 subunit D; Validated
 4-139 2.16e-05

hydrogenase 4 subunit D; Validated


Pssm-ID: 180606 [Multi-domain]  Cd Length: 479  Bit Score: 44.19  E-value: 2.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   4 IVLSMWGMIMTssicLRQTBLKSLIAYSSVSHMALVIIA---ALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIH 80
Cdd:PRK06525 280 IVTLLYGFLMY----LPQQDMKRLLAYSTITQLGYMFFGlslAILGSRLALEGSIAYIFNHAFAKSLFFLVAGALSYSCG 355

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 254596554  81 SRTMILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILLG 139
Cdd:PRK06525 356 TRLLPRLRGVLKKLPLVGVGFCVAALAITGVPPFNGFFSKFPIFAAGFELSVEYWILLP 414
PRK08377 PRK08377
NADH dehydrogenase subunit N; Validated
 4-138 1.36e-04

NADH dehydrogenase subunit N; Validated


Pssm-ID: 181406 [Multi-domain]  Cd Length: 494  Bit Score: 41.68  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRT 83
Cdd:PRK08377 277 IIMATLTVFFAELSALRQKNVKRMIAYSSIGQVGMIALALALGTQAGVDAGVFHMINHAIVKALLFLAVGYVGITLGGTE 356

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 254596554  84 MILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSNMSIILL 138
Cdd:PRK08377 357 IEKFEGLGKRMPLTALALTIGALSTVGIPLFNVFWSKFRIILAGLSAGYTWPVAL 411
PRK12662 PRK12662
putative monovalent cation/H+ antiporter subunit D; Reviewed
 3-140 2.27e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 183662 [Multi-domain]  Cd Length: 492  Bit Score: 41.26  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSR 82
Cdd:PRK12662 282 FMILAALAIVFGSVLAILSKDIKRIFAYSSISHIGYIILAVSLNTYYGLAAAVAYIVNHSIVKSALFMVSGSISYHFGTT 361

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254596554  83 TMILARGLQMILPLMCTWWLLASLANLALPPTINFLSE---LMVIVSSFSWSNMSIILLGT 140
Cdd:PRK12662 362 KLEDCLNLWKSMPKITLAFVLLSLSLIGMPPTSGFVAKwyiLDAFIKSNAWIGLVVLLVGS 422
PRK12650 PRK12650
DUF4040 family protein;
4-72 6.80e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.03  E-value: 6.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254596554   4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA 72
Cdd:PRK12650 276 IIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALTAAVVHTLAHALFKSSLFMLI 344
PRK12647 PRK12647
putative monovalent cation/H+ antiporter subunit A; Reviewed
 11-122 7.31e-04

putative monovalent cation/H+ antiporter subunit A; Reviewed


Pssm-ID: 237156 [Multi-domain]  Cd Length: 761  Bit Score: 39.90  E-value: 7.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  11 MIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:PRK12647 270 MLTGALLAVRQTDLKLILAYSTVSALGTLVMLLGLGSELAIKAAVLFLVAHSLYKGALFMVAGIIDHETGTRDITKLGGL 349

                         90       100       110
                 ....*....|....*....|....*....|...
gi 254596554  91 QMILPLMCTWWLLASLANLALPPTINFLS-ELM 122
Cdd:PRK12647 350 RRAMPITAAAALLAALSMAGLPPLFGFLAkELI 382
PRK06589 PRK06589
putative monovalent cation/H+ antiporter subunit D; Reviewed
 11-150 8.51e-04

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 235835 [Multi-domain]  Cd Length: 489  Bit Score: 39.41  E-value: 8.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554  11 MIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLANTNYERIHSRTMILARGL 90
Cdd:PRK06589 291 IFYSSLKALKTDNIKKILAYSTISQLSLALLSAFILTPKALGAAILHLVSHSFAKICLFYSMGSIYSLKKEDQVDKLHGT 370

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254596554  91 QMILPLMCTWWLLASLANLALPPTINFLSELMVIVSSFSWSN------MSIILLGTnTVITALYSL 150
Cdd:PRK06589 371 SKSFPLISFIISISSLSLIGIPIFSGFISKFLILLAASEQNQpwlsiiVMLVVIAS-SILSALYLL 435
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 4-69 2.29e-03

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 38.20  E-value: 2.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254596554   4 IVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLF 69
Cdd:PRK08676 277 IGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHMLAHSLVKSGLF 342
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
3-65 4.21e-03

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 37.49  E-value: 4.21e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTS 65
Cdd:PRK05777 273 LAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEGYSAVLFYLLAYLFMT 335
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 19-65 4.95e-03

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 37.02  E-value: 4.95e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 254596554  19 LRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTS 65
Cdd:COG1007  288 LAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLGVSAALFYLLAYLFMN 334
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 1-69 6.29e-03

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 36.90  E-value: 6.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254596554   1 YPFIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLF 69
Cdd:PRK08668 273 YILAWLGNISIIVGTLMAILQEDIKKLIAYSSVANGGYILVGLGLGTSLGFAGGLFHVFNHALFKGLFF 341
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 3-126 7.93e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 36.55  E-value: 7.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254596554   3 FIVLSMWGMIMTSSICLRQTBLKSLIAYSSVSHMALVIIAALMQSTLSFMGATALMVAHGLTSSMLFCLA---NTNYERI 79
Cdd:MTH00196 155 LLIGGLFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFESIQASLVYLFIYIIMSICVFSIIlalNVYKNLI 234

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 254596554  80 hsrtmILARGLQMILPLMCTWWLLASLANLALPPTINFLSELMVIVS 126
Cdd:MTH00196 235 -----IEFSGLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLS 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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