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Conserved domains on  [gi|254839349]
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Protein Classification

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
63-295 4.57e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 421866 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  63 PNSITSSAVSPgETPYLITGSDQGVIKIWNLKeiivGEVYSSSLTyDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNh 142
Cdd:cd00200    9 TGGVTCVAFSP-DGKLLATGSGDGTIKVWDLE----TGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 143 yqqesevkflNCECIRKinLKNFGKNEYAVrmrAFVNeEKSLLVALTNLSRVIIFDIRTLERLQIIENsprH-GAVSSIC 221
Cdd:cd00200   82 ----------TGECVRT--LTGHTSYVSSV---AFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG---HtDWVNSVA 142
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254839349 222 IDEECCVLILGTTRGIIDIWDIRFNVLIRswSFGDH-APITHVevcQFYGKNSVIVVGGSSKTfLTIWNFVKGHC 295
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHtGEVNSV---AFSPDGEKLLSSSSDGT-IKLWDLSTGKC 211
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
63-295 4.57e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  63 PNSITSSAVSPgETPYLITGSDQGVIKIWNLKeiivGEVYSSSLTyDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNh 142
Cdd:cd00200    9 TGGVTCVAFSP-DGKLLATGSGDGTIKVWDLE----TGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 143 yqqesevkflNCECIRKinLKNFGKNEYAVrmrAFVNeEKSLLVALTNLSRVIIFDIRTLERLQIIENsprH-GAVSSIC 221
Cdd:cd00200   82 ----------TGECVRT--LTGHTSYVSSV---AFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG---HtDWVNSVA 142
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254839349 222 IDEECCVLILGTTRGIIDIWDIRFNVLIRswSFGDH-APITHVevcQFYGKNSVIVVGGSSKTfLTIWNFVKGHC 295
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHtGEVNSV---AFSPDGEKLLSSSSDGT-IKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
52-301 2.09e-06

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.70  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  52 GKLIATLmENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEiivGEVYSSSLTYDCSSTVTQITmiPNFDAFAVSSK 131
Cdd:COG2319  188 GKPLSTL-AGHTDPVSSLAFSPDGGLLIASGSSDGTIRLWDLST---GKLLRSTLSGHSDSVVSSFS--PDGSLLASGSS 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 132 DGQIIVLKVNHYQQESEVKFLNCECIRKINLknfgkneyavrmrafvNEEKSLLVALTNLSRVIIFDIRTLERLQIIENS 211
Cdd:COG2319  262 DGTIRLWDLRSSSSLLRTLSGHSSSVLSVAF----------------SPDGKLLASGSSDGTVRLWDLETGKLLSSLTLK 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 212 PRHGAVSSICIDEECCVLILG-TTRGIIDIWDIRFNVLIRSWSFGDhaPITHVEVCqfygKNSVIVVGGSSKTFLTIWNF 290
Cdd:COG2319  326 GHEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHS--NVLSVSFS----PDGRVVSSGSTDGTVRLWDL 399
                        250
                 ....*....|.
gi 254839349 291 VKGHCQYAFIN 301
Cdd:COG2319  400 STGSLLRNLDG 410
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
63-295 4.57e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.96  E-value: 4.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  63 PNSITSSAVSPgETPYLITGSDQGVIKIWNLKeiivGEVYSSSLTyDCSSTVTQITMIPNFDAFAVSSKDGQIIVLKVNh 142
Cdd:cd00200    9 TGGVTCVAFSP-DGKLLATGSGDGTIKVWDLE----TGELLRTLK-GHTGPVRDVAASADGTYLASGSSDKTIRLWDLE- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 143 yqqesevkflNCECIRKinLKNFGKNEYAVrmrAFVNeEKSLLVALTNLSRVIIFDIRTLERLQIIENsprH-GAVSSIC 221
Cdd:cd00200   82 ----------TGECVRT--LTGHTSYVSSV---AFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG---HtDWVNSVA 142
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254839349 222 IDEECCVLILGTTRGIIDIWDIRFNVLIRswSFGDH-APITHVevcQFYGKNSVIVVGGSSKTfLTIWNFVKGHC 295
Cdd:cd00200  143 FSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHtGEVNSV---AFSPDGEKLLSSSSDGT-IKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
52-301 2.09e-06

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.70  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  52 GKLIATLmENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEiivGEVYSSSLTYDCSSTVTQITmiPNFDAFAVSSK 131
Cdd:COG2319  188 GKPLSTL-AGHTDPVSSLAFSPDGGLLIASGSSDGTIRLWDLST---GKLLRSTLSGHSDSVVSSFS--PDGSLLASGSS 261
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 132 DGQIIVLKVNHYQQESEVKFLNCECIRKINLknfgkneyavrmrafvNEEKSLLVALTNLSRVIIFDIRTLERLQIIENS 211
Cdd:COG2319  262 DGTIRLWDLRSSSSLLRTLSGHSSSVLSVAF----------------SPDGKLLASGSSDGTVRLWDLETGKLLSSLTLK 325
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 212 PRHGAVSSICIDEECCVLILG-TTRGIIDIWDIRFNVLIRSWSFGDhaPITHVEVCqfygKNSVIVVGGSSKTFLTIWNF 290
Cdd:COG2319  326 GHEGPVSSLSFSPDGSLLVSGgSDDGTIRLWDLRTGKPLKTLEGHS--NVLSVSFS----PDGRVVSSGSTDGTVRLWDL 399
                        250
                 ....*....|.
gi 254839349 291 VKGHCQYAFIN 301
Cdd:COG2319  400 STGSLLRNLDG 410
WD40 COG2319
WD40 repeat [General function prediction only];
52-309 2.42e-06

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 49.32  E-value: 2.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  52 GKLIATLmENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSltydcSSTVTQITMIPNFDAFAVS-S 130
Cdd:COG2319  145 GKLIRTL-EGHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGH-----TDPVSSLAFSPDGGLLIASgS 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 131 KDGQIIVLKVNhyqqESEVKFLNCECIRKINLKNFGKNeyavrmrafvneeKSLLVALTNLSRVIIFDIRTLERLqIIEN 210
Cdd:COG2319  219 SDGTIRLWDLS----TGKLLRSTLSGHSDSVVSSFSPD-------------GSLLASGSSDGTIRLWDLRSSSSL-LRTL 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 211 SPRHGAVSSICIDEECCVLILGTTRGIIDIWDIRFNVLIRSWSFGDHAPIthVEVCQFYGKNSVIVVGGSSKTFLTIWNF 290
Cdd:COG2319  281 SGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLETGKLLSSLTLKGHEGP--VSSLSFSPDGSLLVSGGSDDGTIRLWDL 358
                        250
                 ....*....|....*....
gi 254839349 291 VKGHCQYAFINSDEQPSME 309
Cdd:COG2319  359 RTGKPLKTLEGHSNVLSVS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
52-137 2.12e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  52 GKLIATLMENEpNSITSSAVSPGETPYLITGSDqGVIKIWNLKEIIVGEVYSSsltydCSSTVTQITMIPNFDAFAVSSK 131
Cdd:cd00200  167 GKCVATLTGHT-GEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRG-----HENGVNSVAFSPDGYLLASGSE 239

                 ....*.
gi 254839349 132 DGQIIV 137
Cdd:cd00200  240 DGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
64-242 2.82e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  64 NSITSSAVSPGETpYLITGSDQGVIKIWNLKEIIVGEVYSSSltydcSSTVTQITMIPNFDAFAVSSKDGQIIVlkvnhy 143
Cdd:cd00200  136 DWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEKLLSSSSDGTIKL------ 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 144 qqeSEVKFLNCecirkinLKNFGKNEYAVRMRAFvNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPrhGAVSSICID 223
Cdd:cd00200  204 ---WDLSTGKC-------LGTLRGHENGVNSVAF-SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT--NSVTSLAWS 270
                        170
                 ....*....|....*....
gi 254839349 224 EECCVLILGTTRGIIDIWD 242
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
17-436 8.09e-04

WD40 repeat [General function prediction only];


Pssm-ID: 225201 [Multi-domain]  Cd Length: 466  Bit Score: 41.61  E-value: 8.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  17 EKFLSTFKILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATLMENEPNSITSSAVSPGEtPYLITGSDQGVIKIWNLKEi 96
Cdd:COG2319   19 SELGPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDG-ELLLSGSSDGTIKLWDLDN- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349  97 ivGEVYSSSLTYDCSSTVTQITMI-PNFDAFAV--SSKDGQIIVLKVNHyqqesevkflNCECIRKINLKNfgKNEYAVr 173
Cdd:COG2319   97 --GEKLIKSLEGLHDSSVSKLALSsPDGNSILLasSSLDGTVKLWDLST----------PGKLIRTLEGHS--ESVTSL- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 174 mrAFVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHgaVSSICIDEECCVLILGTTR-GIIDIWDIRFNVLIRSW 252
Cdd:COG2319  162 --AFSPDGKLLASGSSLDGTIKLWDLRTGKPLSTLAGHTDP--VSSLAFSPDGGLLIASGSSdGTIRLWDLSTGKLLRST 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 253 SFGDHAPithveVCQFYGKNSVIVVGGSSKTFLTIWNFVKGHCQYAFINSDEQPSME-HFLPIEKGLEELNFCGIRSLNA 331
Cdd:COG2319  238 LSGHSDS-----VVSSFSPDGSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSvAFSPDGKLLASGSSDGTVRLWD 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254839349 332 LSTISVSNDKILLTDEATSSIVMFSLNelsSSKAVISPSRFSDVFIPTqvtanlTMLLRKMKRTSTHSVDDSLYHHDIIN 411
Cdd:COG2319  313 LETGKLLSSLTLKGHEGPVSSLSFSPD---GSLLVSGGSDDGTIRLWD------LRTGKPLKTLEGHSNVLSVSFSPDGR 383
                        410       420
                 ....*....|....*....|....*
gi 254839349 412 SISTCEVDETPLLVACDNSGLIGIF 436
Cdd:COG2319  384 VVSSGSTDGTVRLWDLSTGSLLRNL 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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