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Conserved domains on  [gi|257467533|ref|NP_038694|]
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alpha-2,8-sialyltransferase 8E isoform long [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 135-406 0e+00

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23990:

Pssm-ID: 480271  Cd Length: 273  Bit Score: 536.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 135 EASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGC 214
Cdd:cd23990    2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 215 GKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVS 294
Cdd:cd23990   82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 295 FRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYY 374
Cdd:cd23990  162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 257467533 375 DNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23990  242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 135-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 536.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 135 EASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGC 214
Cdd:cd23990    2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 215 GKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVS 294
Cdd:cd23990   82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 295 FRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYY 374
Cdd:cd23990  162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 257467533 375 DNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23990  242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 4.95e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 272.56  E-value: 4.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  154 FTTQKNTPVETNLRYEvESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPIS 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  234 GiYTTDVGEKTDVVTVNP-SIIIDRFHKL--EKWRRPFFSVLQRYE--NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQ 308
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  309 P---VYFFHPQYLSSVSRYWL-SLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 257467533  382 -GFHAMPSEIFTFLRMHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 135-406 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 536.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 135 EASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGC 214
Cdd:cd23990    2 EANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 215 GKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVS 294
Cdd:cd23990   82 GREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 295 FRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYY 374
Cdd:cd23990  162 IRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYY 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 257467533 375 DNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23990  242 DNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 134-406 1.54e-162

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 457.49  E-value: 1.54e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 134 AEASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSG 213
Cdd:cd23971    1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 214 CGKEINSADFVFRCNLPPISgiYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLV 293
Cdd:cd23971   81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 294 SFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHY 373
Cdd:cd23971  159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                        250       260       270
                 ....*....|....*....|....*....|...
gi 257467533 374 YDNVKPKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23971  239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 134-404 1.08e-124

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 361.76  E-value: 1.08e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 134 AEASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSG 213
Cdd:cd23991    1 EEHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 214 CGKEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLV 293
Cdd:cd23991   81 CGAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 294 SFRVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHY 373
Cdd:cd23991  161 SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHY 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 257467533 374 YDNVKPKPGFHAMPSEIFTFLRMHSRGILRV 404
Cdd:cd23991  241 YDNQLPKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 136-405 3.77e-100

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 299.05  E-value: 3.77e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 136 ASLFKSTLSRCCNAPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRsQFKKCAVVGNGGILKNSGCG 215
Cdd:cd23989    3 VEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSGCG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 216 KEINSADFVFRCNLPPISGIYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSF 295
Cdd:cd23989   82 QQIDRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 296 RVKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYD 375
Cdd:cd23989  162 RVYYTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYD 241

                        250       260       270
                 ....*....|....*....|....*....|
gi 257467533 376 NVKPKPGFHAMPSEIFTFLRMHSRGILRVH 405
Cdd:cd23989  242 NVLPDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 139-406 9.24e-94

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 282.61  E-value: 9.24e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 139 FKSTLSRCCNaPSFLFTTQKNTPVETNLRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEI 218
Cdd:cd23963    6 FRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCGKEI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 219 NSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFR 296
Cdd:cd23963   85 DSHDFVIRCNLPPIKG-FEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 297 VKYMLDDFQSRQPVYFFHPQYLSSVSRYWLSLGVRaRRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDN 376
Cdd:cd23963  164 AARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDD 242

                        250       260       270
                 ....*....|....*....|....*....|..
gi 257467533 377 VKPKP--GFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23963  243 LSPSTknKVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 154-401 4.95e-90

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 272.56  E-value: 4.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  154 FTTQKNTPVETNLRYEvESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPIS 233
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  234 GiYTTDVGEKTDVVTVNP-SIIIDRFHKL--EKWRRPFFSVLQRYE--NASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQ 308
Cdd:pfam00777  80 G-YEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533  309 P---VYFFHPQYLSSVSRYWL-SLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP--- 381
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRG---NSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 257467533  382 -GFHAMPSEIFTFLRMHSRGI 401
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 178-406 1.20e-62

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 203.39  E-value: 1.20e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 178 IDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDR 257
Cdd:cd23970   49 ISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEG-FEKDVGRKTNLTTFNPSILEKY 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 258 FHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNTLVSFRVKYMLDDFQSRQPVYFFHP-QYLSSVSRYWLSLGVRARR 334
Cdd:cd23970  128 YNNLltIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKR 207

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 257467533 335 ISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPK-----PGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23970  208 LSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDKKGTKfttkwQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 166-406 1.16e-60

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 198.02  E-value: 1.16e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 166 LRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD 245
Cdd:cd23969   33 MHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEG-YEKDVGTKSN 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 246 VVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFynVRNTLVSfRVKYMLD-DFQSRQPVYFFHP--QYLSS 320
Cdd:cd23969  112 LTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAF--VSKGGEE-HVQWTNEiILKHKLNVKTAYPplRLNHA 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 321 VSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVK--PKPGFHAMPSEIFTFLRMHS 398
Cdd:cd23969  189 IRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKylTTARPHKMPEEFRALRSLHQ 268


                 ....*...
gi 257467533 399 RGILRVHT 406
Cdd:cd23969  269 RGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 177-406 2.88e-54

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 181.29  E-value: 2.88e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 177 HIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIID 256
Cdd:cd23987   44 NISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGTKTDLVTMNPSVVQR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 257 RFHKL--EKWRRPFFSVLQRYENASVLLPAFYNVRNtlvSFRVKYMLD-DFQSRQPVYFFHP--QYLSSVSRYWLSLGVR 331
Cdd:cd23987  123 AFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGG---EERVEWVNDlILKHHINVRTAYPslRLLHAVRGYWLTNKVH 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 257467533 332 ARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVK----PKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23987  200 IKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 166-406 2.28e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 173.99  E-value: 2.28e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 166 LRYEVESSGLYHIDQEIFKMFPKEMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD 245
Cdd:cd23988   33 IHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGTKSD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 246 VVTVNPSIIIDRFHKL--EKWRRPFFSVLQRYENASVLLPAFYnVRNTL--VSFRVKYMLDDFQSRQPVYffhP--QYLS 319
Cdd:cd23988  112 FITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFM-VKGGEkhVEWVNALILKNKLKVRTAY---PslRLIH 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 320 SVSRYWLSLGVRARRISTGLILVTAALELCEEVHLFGFWAFPMNPSGFFITHHYYDNVKPK----PGFHAMPSEIFTFLR 395
Cdd:cd23988  188 AVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTLNV 267

                        250
                 ....*....|.
gi 257467533 396 MHSRGILRVHT 406
Cdd:cd23988  268 LHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 200-396 7.96e-31

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 116.69  E-value: 7.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 200 CAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIiidrFHKLEKWRRPFFSVLQ-RYENA 278
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKG-FEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPlEEEVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 279 SVLLPAFYNVRNTLVSFRVKYMlddfqsRQPVYFFH--PQYLSSVSRYWLSLGVRA----RRISTGLILVTAALELCEEV 352
Cdd:cd19952   76 LILSRAAAADFKRLKRRKKRHD------NAVLLLTDpaPDLLSYVRKRLEKLGLKSffggNAPSSGLLAVLLALQLCDSV 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 257467533 353 HLFGFWAFPMNPSGFFitHHYYDNVKP--KPGFHAMPSEiFTFLRM 396
Cdd:cd19952  150 DLYGFGVDSGHAPKVP--YHYYDLVEAeeGTAVHSFDLE-AELLRA 192
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 180-405 7.07e-23

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 97.35  E-value: 7.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 180 QEIFKMFPKEMPYYR---SQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKT--------DVVT 248
Cdd:cd23966   57 EKLFQVVPGENPYRTrdpNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKG-FEKDVGSKTthhfmypeSAVD 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 249 VNPSI--IIDRFHKLE-KWrrpffsvlqryenasvLLPAFYNVRNTLVSFRVKYMLDdfQSRQPVYFFHPQYLSSVSRYW 325
Cdd:cd23966  136 LDPGVhlVLVPFKVLDlQW----------------LISALTTGEITRTYTPVKRFIK--ADKDKVLVINPAFIKYVHDNW 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 326 LSLgvRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN-----VKPKPGFHAMPSEIFTFLRMHSRG 400
Cdd:cd23966  198 TEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKnrsagAFRKTGVHDADFESDIIKKLAKEG 270


                 ....*
gi 257467533 401 ILRVH 405
Cdd:cd23966  271 KIRVY 275
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 199-406 7.68e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 97.33  E-value: 7.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 199 KCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGIYtTDVGEKTD--VVTVNPSIIIDRFHklekwrrpffsVLQRYE 276
Cdd:cd23964   84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFE-KDVGTKTSfyTFFPESLHNSLLKH-----------VPQDKD 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 277 NASVLLPAFYN----VRNTLVSFRVKYMLDDFQSRQPVY----------FFHPQYLSSVSRYWLslgvRARRI---STGL 339
Cdd:cd23964  152 TKYLFIPFKIRdydyLDAVLSGKPVPDGCDKGKRPPPLFgpklnatnvrLLHPDFIRYLFNRWL----NSSTSyrpTTGA 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257467533 340 ILVTAALELCEEVHLFGF---WAFPMnpsgffithHYYDN----VKPKPGFHAMPSEIFTFLRMHSRGILRVHT 406
Cdd:cd23964  228 LMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 185-406 1.67e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 91.35  E-value: 1.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 185 MFPKEM-PYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIidrFHKLEK 263
Cdd:cd23974   71 MFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKG-FEKDVGRRTSFYTFSTNTL---MNSLRA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 264 WRRPFFSVL-QRYENASVLLP----AFYNVRNTLVSFRVKYMLDdfQSRQPV-YF-----------FHPQYLSSV-SRYW 325
Cdd:cd23974  147 YAGVGFNGPpQSKETRYIFLPdhdrDYLLVKAALTHTPIDRGRD--KSKRPSkYFgkdvtaekfkiYHPDFIRYLrNRFL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 326 LS--LGVRARRI---STGLILVTAALELCEEVHLFGFwafpMNPSGFFITHHYYDNVKPKPGF---HAMPSEIFTFLRMH 397
Cdd:cd23974  225 WSpiLNTKQRDIyrpSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQKLH 300


                 ....*....
gi 257467533 398 SRGILRVHT 406
Cdd:cd23974  301 KAGLIKLYM 309
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 198-381 1.41e-19

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 86.19  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPsiiidrfhklekwRRPFFSVLQRYEN 277
Cdd:cd23967    3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKG-YEKDVGSKTTFRMFYP-------------ESAFRDPEEYDSD 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 278 ASVLLPAF--------YNV-----RNTLVSF------RVKYMLDDFQsrqpvyFFHPQYLSSVSRYWLSLGVRARRI--- 335
Cdd:cd23967   69 WLLVLVPFksmdllwlQAVikgkkPNGKGGFwkkiatSVPKPPKKIR------ILNPYILQEAAFDLIGLPMNGKQGknv 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 257467533 336 -STGLILVTAALELCEEVHLFGFWAFPMNPSgffITHHYYDNVKPKP 381
Cdd:cd23967  143 pTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLTMKA 186
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 197-397 5.86e-17

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 80.39  E-value: 5.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 197 FKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIiidrfhkLEKWRRPFFSvLQRYE 276
Cdd:cd23968   45 YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKG-FEKDVGSKTTLRLINSQI-------LSKPEFNFLT-DPLYR 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 277 NASVLL--PAFYNVRNTLVSFRVKY-MLDDFQSR------QPVYFFHPQYLssvSRYWLSLGVRARRI------STGLIL 341
Cdd:cd23968  116 NVTLLVwdPSSYNVNLEKWYKKPDFdFFPNYIKYrrrhpeEPFYLIDPRFL---WRLWDILQEYTPEKikpnppSSGFIG 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 257467533 342 VTAALELCEEVHLFGFWafpmnPSgFFITH--HYYDNVKPKP----GFHAMPSEIFTFLRMH 397
Cdd:cd23968  193 IVLMLHLCDWVDVYEYV-----PS-VRQTDrcHYYDVEKDLActlgAWHPLAAEKLLVRHLN 248
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 198-377 4.37e-16

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 76.24  E-value: 4.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVvtvnpsiiidrfhklekwrRPFFSvlqryEN 277
Cdd:cd23982    3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI-------------------RLFYP-----ES 57

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 278 ASVlLPAFYNVRNTL---VSFR------VKYMLDDfQSRQPVYFF-----------------HPQYLSSVSRYWLSLGVR 331
Cdd:cd23982   58 AQF-DPGIENDPDTLlvlVPFKpldfywLYEILSN-EKRVRKGFWkqppriwdanpkqirilNPYYTYVAATKLLQVPGQ 135

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 257467533 332 ---ARRISTGLILVTAALELCEEVHLFGFwAFPMN-PSGFFIthHYYDNV 377
Cdd:cd23982  136 rkkKQKPTTGLLAITLALHLCDEVHIAGF-GYPDNgNSNQPI--HYYNQI 182
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 154-376 5.55e-16

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 77.61  E-value: 5.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 154 FTTQKNTPVETN-------LRYEVESSGLYHIDQEIFKMFPKE---MPYYRS-QFKKCAVVGNGGILKNSGCGKEINSAD 222
Cdd:cd23980   27 LLTAQNAHLEEDtykwwlrLQREKKPKNLNDTIRELFQVVPGNvdpLLEKRLvSCRRCAVVGNSGNLKESYYGPQIDSHD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 223 FVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKLEKWRRPFFSVLQRYEnASVLLPAFYNVRNTLVSFRVKYmld 302
Cdd:cd23980  107 FVLRMNKAPTEG-FEADVGSKTTHHFVYPESFRELAQNVSMILVPFKTLDLEWV-ISATTTGTISHTYVPVPRKIKV--- 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 257467533 303 dfqSRQPVYFFHPQYLSSVSRYWLSlgVRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN 376
Cdd:cd23980  182 ---KKEKILIYHPAFIKYVFDRWLQ--GHGRYPSTGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 176-407 2.17e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 76.33  E-value: 2.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 176 YHIDQEIFKMFPK--------EMPYYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVV 247
Cdd:cd23973   54 YTLVKEVVELIPKpkeqqllaLSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKG-YEEDVGTRTSFY 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 248 TVNPSIIIDRFHKLEKwrRPFFSVLQRYENASVLLPAF---YN-----VRNTLVS----FRV---KYMLDDFqSRQPVYF 312
Cdd:cd23973  133 VHTAHSITSSLMILQK--RGFKNIPQDKDIKYILFPEGprdYQwlealLKNKTIPsgayYGRrprSYFSGDF-TEDKYLV 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 313 FHPQYLSSV-----------SRYWlslgvRARRISTGLILVTAALELCEEVHLFGFwafpMNPSGFFITHHYYDNVKPKP 381
Cdd:cd23973  210 LHPDFLRYVknrflrsktlkGKYW-----AIYRPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKL 280

                        250       260
                 ....*....|....*....|....*....
gi 257467533 382 GF---HAMPSEIFTFLRMHSRGILRVHTG 407
Cdd:cd23973  281 VFyinHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 198-377 2.83e-15

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 74.01  E-value: 2.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNP-SIIIDRFHklekwrrpffsvlqrYE 276
Cdd:cd23984    3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIG-YENDVGKRTTFRLCYPeSIFSDPSH---------------YD 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 277 NASVLLpafynvrntLVSFR---VKYMLDDFQS---------RQP----------VYFFHPQYLSSVSRYWLSLGVR--- 331
Cdd:cd23984   67 PNTTVV---------LIPFKphdLRWLLDLLMGkkvsakgfwKKPalnliykpnqIRILNPFILRIAAYELLHFPKRfpk 137

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 257467533 332 ---ARRISTGLILVTAALELCEEVHLFGfwaFPMNPSGFFITHHYYDNV 377
Cdd:cd23984  138 ekkPKHPTTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 198-380 2.95e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 71.50  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDV-----VTVnPSIIIDRFHKLEKWRRPFFSVL 272
Cdd:cd23965    2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRG-YEKDVGRRTTIrvvshSSL-PRLLRNAILLLAGTRAPTVVVF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 273 QRYENA--SVLLPAFYNVRNTLVSFR-VK-YMLDDFQSRQPVYFFHPQylSSVSRY----WLslgvrarriSTGLILVTA 344
Cdd:cd23965   80 WGPETKmnKDGAGKYNLLRSLSKKYPdVEfYSLTPEKMDYADELFEKE--TGKSRIksgtWL---------STGWFTMLL 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 257467533 345 ALELCEEVHLFGfwafpMNPSGFFITH-------HYYDNVKPK 380
Cdd:cd23965  149 ALDVCDEIKVYG-----MVPENYCREHpnskvpyHYYEPGGLK 186
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 199-405 4.24e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 72.55  E-value: 4.24e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 199 KCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTD-----VVTVNPSIIidrfhklEKWRRPFFSVLQ 273
Cdd:cd23972   84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKG-FEEDVGTKTSfygftVNTMKNSLI-------SYWNLGFTRTPQ 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 274 RYENASVLLPA----FYNVRNTLVSFRVKYMLDdfQSRQPVYFF------------HPQYLSSVSRYWLslgvRARRI-- 335
Cdd:cd23972  156 GQDLQYIFIPSdirdYVMLRSAILGVPVPEGLD--KGDRPHKYFgpeasakkfkllHPDFISYLTDRFL----KSKLLnt 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 336 --------STGLILVTAALELCEEVHLFGF-----WAFpmnpsgffiTHHYYDNVKPKPGF---HAMPSEIFTFLRMHSR 399
Cdd:cd23972  230 hyghlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKA 300


                 ....*.
gi 257467533 400 GILRVH 405
Cdd:cd23972  301 GILQLY 306
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 166-376 1.58e-13

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 70.29  E-value: 1.58e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 166 LRYEVESSGLYHIDQEIFKMFPKEMPYY---RSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGE 242
Cdd:cd23979   46 LQPQFKPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVG-FEADVGS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 243 KT----------DVVTVNPSIIIDRFHKLE-KWRRPFFSVLQ-RYENASVllPAFYNVrntlvsfrvkymlddfqSRQPV 310
Cdd:cd23979  125 RTthhfmypesaKNLPANVSFVLVPFKTLDlLWITSALSTGQiRFTYAPV--KQFLRV-----------------DKDKV 185

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 257467533 311 YFFHPQYLSSVSRYWLSLgvRARRISTGLILVTAALELCEEVHLFGFWAfpmNPSGFFitHHYYDN 376
Cdd:cd23979  186 QIYNPAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 184-357 1.61e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 70.25  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 184 KMFPKeMP---YYRSQFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHK 260
Cdd:cd23986   34 KYVPK-IPlskLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRG-YEKDVGNKTTIRIINSQILTNPNHH 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 261 -----------LEKWRRPFFSV--LQRYENASvllpafYNVRNTLVSFRVKYmlddfqSRQPVYFFHPQYLSSVsryWLS 327
Cdd:cd23986  112 fidsslykdviLVAWDPAPYSAnlHKWYKKPD------YNLFTPYVQYRKRN------PNQPFYILHPKFIWQL---WDI 176

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 257467533 328 L------GVRARRISTGLILVTAALELCEEVHLFGF 357
Cdd:cd23986  177 IqentqeKIQPNPPSSGFIGILIMMSMCREVHVYEY 212
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 196-357 1.17e-12

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 67.81  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 196 QFKKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRFHKlekwrrpfFSVLQRY 275
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAG-FQQDVGTKTTIRLINSQLVTTEKHK--------FLKDSLY 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 276 eNASVLL---PAFYNV------RNTLVSFrvkymLDDFQS------RQPVYFFHPQYLSSVsryWLSL------GVRARR 334
Cdd:cd23985  115 -NEGILIvwdPAPYHSdipewyKNPDYNF-----FENYKTyrrlnpNQPFYILHPQMQWEL---WDIIqenspeEIQPNP 185

                        170       180
                 ....*....|....*....|...
gi 257467533 335 ISTGLILVTAALELCEEVHLFGF 357
Cdd:cd23985  186 PSSGMLGIILMMTLCDQVDVYEF 208
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 198-377 7.73e-11

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 61.29  E-value: 7.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNP----SIIIDRFHK------------- 260
Cdd:cd23983    3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQG-YSQDVGNKTTIRMTYPegapKSEQEYDPTslfvavlfksvdf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 261 -----------LEKWRRPFFsvLQRYENASVLLPAFYNVRNTLVsfrVKYMLDDFQsrqpvyffhpQYLSSVSRYWlslG 329
Cdd:cd23983   82 awlkamvkkepLSFWSRLFF--WKEVADSIPLKPSQFRILNPLI---IKETALDIL----------QYPEPQSRLW---G 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 257467533 330 VRARRISTGLILVTAALELCEEVHLFGFwafpmnpsGFFITH-----HYYDNV 377
Cdd:cd23983  144 WDKNVPTLGVTAVVLATHLCDEVSLAGF--------GYDLSQphaplHYYDSV 188
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 198-378 7.96e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 61.09  E-value: 7.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPSIIIDRfhklekwrrpffsvLQRYEN 277
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQK--------------PEQYEK 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 278 ASVLLPAFYNVRNtlvsFR-VKYML--------DDFQS-------RQP--VYFFHPQYLSSVSRYWLSL----GVRAR-R 334
Cdd:cd23981   68 DSLFVLAGFKWQD----FKwLKYIVykekvsasDGFWKsvatrvpREPheIRILNPYFIQEAAFSFIGLpfnnGLMGRgN 143

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 257467533 335 IST-GLILVTAALELCEEVHLFGFwAFPMN-PSGFFithHYYDNVK 378
Cdd:cd23981  144 IPTlGSVAITMALHNCDEVAVAGF-GYDMNtPNAPL---HYYETIK 185
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 198-375 6.95e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 52.94  E-value: 6.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVN----PSIIIDRFHKLEKWRRPFFSVLQ 273
Cdd:cd23977    2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAG-YEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 274 RYENASVLLPAfyNVRNTLVSFRVKYmlddfqSRQPVYFFHPQYLSSVSRYWLSLGVRARR-----ISTGLILVTAALEL 348
Cdd:cd23977   81 PERNMDRDGGG--KTYRALLTLAKMY------PHLQVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALEL 152

                        170       180
                 ....*....|....*....|....*....
gi 257467533 349 CEEVHLFGFW--AFPMNPSGFFITHHYYD 375
Cdd:cd23977  153 CEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 198-379 1.96e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 48.71  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 198 KKCAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVNPS----IIIDRFHKLEKWRRPFF---- 269
Cdd:cd23976   16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRG-YGKDVGNKTSLRVIAHSsiqrILRNRNELLNVSQGTVFifwg 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 270 --SVLQR------YENASVL------LPAFYNVRNTLVSFRVKYMLDDFQSRQpvyffhpqylssVSRYWLslgvrarri 335
Cdd:cd23976   95 psNYMRRdgkglvYNNLQLMnqilpkLKVYTITRHKMLQFDELFKRETGKDRK------------ISNTWL--------- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 257467533 336 STGLILVTAALELCEEVHLFGFWA--FPMNPSGFFITHHYYDNVKP 379
Cdd:cd23976  154 STGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPSGP 199
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 200-375 1.07e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 40.30  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 200 CAVVGNGGILKNSGCGKEINSADFVFRCNLPPISGiYTTDVGEKTDVVTVN----PSIIIDRFHklekwrrpFFSvlQRY 275
Cdd:cd23975    4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKG-YEEDVGKRTTIRVVShtsvPLLLKNPDY--------FFK--ETN 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 257467533 276 ENASVLLPAFYNVR---NTLVSFRVKYMLDDFQSRQpVYFFHPQYLSSVSRYWLSLGVRAR-----RISTGLILVTAALE 347
Cdd:cd23975   73 ETIYVIWGPFRNMRkdgKGIVYNMLKKAVESYPQAK-IYVTTEKRMSYCDTVFKKETGKDRvqsgsYLSTGWFTLILAMD 151

                        170       180       190
                 ....*....|....*....|....*....|
gi 257467533 348 LCEEVHLFGFWAFPMNPSGFF--ITHHYYD 375
Cdd:cd23975  152 ACYGIHVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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