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Conserved domains on  [gi|2612795|emb|CAA05364|]
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annexin VIII [Mus musculus]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.83e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2612795     26 DAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 8.27e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795     97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 3.09e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 3.09e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795    257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFRKMYGKTLSSMIMADTSGYYKTALLNL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 9.00e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 9.00e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2612795    181 QDAQALHEAgEKIMGTDEMKFITILCTRSLTHLMRVFEEYEKIADKCIEDSFKSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.83e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2612795     26 DAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 8.27e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795     97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 3.09e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 3.09e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795    257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFRKMYGKTLSSMIMADTSGYYKTALLNL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
38-90 2.64e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.64e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795      38 GTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
110-162 6.15e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 6.15e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     110 GTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCL 162
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 9.00e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 9.00e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2612795    181 QDAQALHEAgEKIMGTDEMKFITILCTRSLTHLMRVFEEYEKIADKCIEDSFKSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
270-322 1.47e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.74  E-value: 1.47e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     270 GTRDGTLIRNIVSRSEIDLNLIKGQFRKMYGKTLSSMIMADTSGYYKTALLNL 322
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
195-247 7.94e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 62.04  E-value: 7.94e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     195 GTDEMKFITILCTRSLTHLMRVFEEYEKIADKCIEDSFKSETHGSLEEAMLTV 247
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 26-90 1.83e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 1.83e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2612795     26 DAETLYKAMKGIGTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 97-162 8.27e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.27e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795     97 YEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCL 162
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 257-322 3.09e-21

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 85.60  E-value: 3.09e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2612795    257 YFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKGQFRKMYGKTLSSMIMADTSGYYKTALLNL 322
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
38-90 2.64e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 82.46  E-value: 2.64e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795      38 GTNEQAIIDVLTKRSNVQRQQIAKSFKAQFGKDLTETLKSELSGKFERLIVAL 90
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
110-162 6.15e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 76.29  E-value: 6.15e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     110 GTKEGVIIEILASRTKNQLREIMKAYEEDYGSTLEEDIQGDTSGYLERILVCL 162
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 181-247 9.00e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 75.97  E-value: 9.00e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2612795    181 QDAQALHEAgEKIMGTDEMKFITILCTRSLTHLMRVFEEYEKIADKCIEDSFKSETHGSLEEAMLTV 247
Cdd:pfam00191   1 YDAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
270-322 1.47e-15

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 69.74  E-value: 1.47e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     270 GTRDGTLIRNIVSRSEIDLNLIKGQFRKMYGKTLSSMIMADTSGYYKTALLNL 322
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
195-247 7.94e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 62.04  E-value: 7.94e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2612795     195 GTDEMKFITILCTRSLTHLMRVFEEYEKIADKCIEDSFKSETHGSLEEAMLTV 247
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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