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Conserved domains on  [gi|261825043]
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Chain A, Polycomb protein EED

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-400 2.10e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  70 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 148
Cdd:COG2319   89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 149 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319  160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 229 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 306
Cdd:COG2319  236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 307 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 386
Cdd:COG2319  281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                        330
                 ....*....|....
gi 261825043 387 IAVCDDASIWRWDR 400
Cdd:COG2319  346 ASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-400 2.10e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  70 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 148
Cdd:COG2319   89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 149 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319  160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 229 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 306
Cdd:COG2319  236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 307 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 386
Cdd:COG2319  281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                        330
                 ....*....|....
gi 261825043 387 IAVCDDASIWRWDR 400
Cdd:COG2319  346 ASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-399 2.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 2.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 111 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 190
Cdd:cd00200   15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 191 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 259
Cdd:cd00200   90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 260 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 331
Cdd:cd00200  164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261825043 332 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200  229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-180 8.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 8.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 261825043   140 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-180 4.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 261825043  141 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 128-230 1.09e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 128 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 202
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
gi 261825043 203 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 230
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-400 2.10e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  70 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 148
Cdd:COG2319   89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 149 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319  160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 229 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 306
Cdd:COG2319  236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 307 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 386
Cdd:COG2319  281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                        330
                 ....*....|....
gi 261825043 387 IAVCDDASIWRWDR 400
Cdd:COG2319  346 ASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
123-399 1.46e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 1.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 123 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 202
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLI 280
Cdd:COG2319  252 VAFSPDGRLLASGSADGTVRLWDLATGELL----------------------------RTLTGHSGGVNSVAFSpdGKLL 303

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 281 LSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVedphKA 360
Cdd:COG2319  304 ASGSDDGTVRLW-------DLATGKL-------LRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLAT----GE 363

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 261825043 361 KCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:COG2319  364 LLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 111-399 2.96e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 2.96e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 111 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 190
Cdd:cd00200   15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 191 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 259
Cdd:cd00200   90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 260 FS------TRDIHRNYVDCVRWLGDL--ILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 331
Cdd:cd00200  164 LRtgkcvaTLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 261825043 332 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200  229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
44-353 4.68e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 4.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  44 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 122
Cdd:COG2319  153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 123 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGgveGHRDEVLS 202
Cdd:COG2319  219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNS 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRW--LGDLI 280
Cdd:COG2319  294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------------------------HTGAVRSVAFspDGKTL 345

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 261825043 281 LSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLE 353
Cdd:COG2319  346 ASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
44-228 1.95e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 1.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  44 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 123
Cdd:COG2319  237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 124 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 203
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378

                        170       180
                 ....*....|....*....|....*
gi 261825043 204 DYDLLGEKIMSCGMDHSLKLWRINS 228
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-225 3.13e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 3.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043  42 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 119
Cdd:cd00200  124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 120 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 199
Cdd:cd00200  192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263

                        170       180
                 ....*....|....*....|....*.
gi 261825043 200 VLSADYDLLGEKIMSCGMDHSLKLWR 225
Cdd:cd00200  264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
123-399 2.70e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 123 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 202
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 203 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRWLGDlils 282
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG----------------------------HSGAVTSVAFSPD---- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 283 kscenaivcwkpgkmeddidkikpsesnvtilGRFdysqcdiwymrfsmdfwqkmLALGNQVGKLYVWDLEvedphKAKC 362
Cdd:COG2319  174 --------------------------------GKL--------------------LASGSDDGTVRLWDLA-----TGKL 196

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 261825043 363 -TTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:COG2319  197 lRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 193-399 6.41e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 193 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINskrmmnaikesydynpnkTNRPFISQKIHFPDFSTrdihrnyVDC 272
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE------------------TGELLRTLKGHTGPVRD-------VAA 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 273 VRWlGDLILSKSCENAIVCWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDL 352
Cdd:cd00200   60 SAD-GTYLASGSSDKTIRLWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDV 122

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 261825043 353 EVEDPhkakCTTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 399
Cdd:cd00200  123 ETGKC----LTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWD 163
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 140-180 8.86e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 8.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 261825043   140 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-180 4.05e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.05e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 261825043  141 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 180
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 128-230 1.09e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.09  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 128 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 202
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
gi 261825043 203 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 230
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
PTZ00421 PTZ00421
coronin; Provisional
 144-370 3.24e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 144 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLkl 223
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKL-- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 261825043 224 wRINSKRMMNAIKESYDYNPNKTNRPFISQKihfpdfstrdihrnyVDCVRWLGdliLSKSCENAIVCWKPGKMEDDIDK 303
Cdd:PTZ00421 193 -NIIDPRDGTIVSSVEAHASAKSQRCLWAKR---------------KDLIITLG---CSKSQQRQIMLWDTRKMASPYST 253

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 261825043 304 IKPSESNVTILGRFDySQCDIWYMRFSMDFWQKMLALGNQvGKLYVWDLEVEDPHKAKCT----TLTHHKC 370
Cdd:PTZ00421 254 VDLDQSSALFIPFFD-EDTNLLYIGSKGEGNIRCFELMNE-RLTFCSSYSSVEPHKGLCMmpkwSLDTRKC 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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