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Conserved domains on  [gi|26333271|dbj|BAC30353|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

BTB_POZ_KLHL16_gigaxonin and BACK_KLHL16_gigaxonin domain-containing protein( domain architecture ID 13033063)

protein containing domains BTB_POZ_KLHL16_gigaxonin, PHA03098, and BACK_KLHL16_gigaxonin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 2.89e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 187.55  E-value: 2.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQI 94
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271  95 RLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 129-225 4.76e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


:

Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 184.06  E-value: 4.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 129 AAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEM 208
Cdd:cd18455   1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                        90
                ....*....|....*..
gi 26333271 209 RKVHMKDVMSALWVSGL 225
Cdd:cd18455  81 RKVHLKDLMSSCWRSGL 97
PHA03098 super family cl33709
kelch-like protein; Provisional
 27-501 4.81e-45

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 167.64  E-value: 4.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   27 RFCDAHLVL--DGEEIPVQKNILAAASPYIRTKLnynppKDDGSTYKIELEgISVMVMREILDYIFSGQIRLNEDTIQDV 104
Cdd:PHA03098   8 KFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMF-----KNNFKENEINLN-IDYDSFNEVIKYIYTGKINITSNNVKDI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  105 VQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLE 184
Cdd:PHA03098  82 LSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  185 KLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSAL-WvsgldsSYLREQML-----------------NEPLVREIVKE 246
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLrI------TFLSEEGIkklkrwklrikkkkivfNKRCIKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  247 CSN--------------IPLSQPQQGEAMLA--------------------SFKPRGYSECIVTIGG---EERVSRKPTA 289
Cdd:PHA03098 236 KYNlnkilprsstfgsiIYIHITMSIFTYNYitnysplseintiidihyvyCFGSVVLNNVIYFIGGmnkNNLSVNSVVS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  290 amrcmcplYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDeNKQTLSSGEKYDPDANTWTALPPMHEARHNFGIV 369
Cdd:PHA03098 316 --------YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIY-NSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  370 EIDGMLYILGG-EDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSY---GKLFESVECYDPRTQ 445
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYidnIKVYNIVESYNPVTN 466

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271  446 QWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMvtcksefYHDEFKRW 501
Cdd:PHA03098 467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEV-------YDDKTNTW 515
 
Name Accession Description Interval E-value
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 2.89e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 187.55  E-value: 2.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQI 94
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271  95 RLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 129-225 4.76e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 184.06  E-value: 4.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 129 AAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEM 208
Cdd:cd18455   1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                        90
                ....*....|....*..
gi 26333271 209 RKVHMKDVMSALWVSGL 225
Cdd:cd18455  81 RKVHLKDLMSSCWRSGL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 27-501 4.81e-45

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 167.64  E-value: 4.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   27 RFCDAHLVL--DGEEIPVQKNILAAASPYIRTKLnynppKDDGSTYKIELEgISVMVMREILDYIFSGQIRLNEDTIQDV 104
Cdd:PHA03098   8 KFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMF-----KNNFKENEINLN-IDYDSFNEVIKYIYTGKINITSNNVKDI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  105 VQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLE 184
Cdd:PHA03098  82 LSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  185 KLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSAL-WvsgldsSYLREQML-----------------NEPLVREIVKE 246
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLrI------TFLSEEGIkklkrwklrikkkkivfNKRCIKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  247 CSN--------------IPLSQPQQGEAMLA--------------------SFKPRGYSECIVTIGG---EERVSRKPTA 289
Cdd:PHA03098 236 KYNlnkilprsstfgsiIYIHITMSIFTYNYitnysplseintiidihyvyCFGSVVLNNVIYFIGGmnkNNLSVNSVVS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  290 amrcmcplYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDeNKQTLSSGEKYDPDANTWTALPPMHEARHNFGIV 369
Cdd:PHA03098 316 --------YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIY-NSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  370 EIDGMLYILGG-EDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSY---GKLFESVECYDPRTQ 445
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYidnIKVYNIVESYNPVTN 466

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271  446 QWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMvtcksefYHDEFKRW 501
Cdd:PHA03098 467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEV-------YDDKTNTW 515
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-234 2.84e-34

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 125.35  E-value: 2.84e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   133 CIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVH 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 26333271   213 MKDVMSALWVSGLDSSYLREQM 234
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
297-474 6.19e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 130.28  E-value: 6.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 297 LYDPNRQLWIELAPLSMPRINH-GVLSAEGFLFVLGGQDENK---QTLSSGEKYDPDANTWTALPPMHEARHNFGIVEID 372
Cdd:COG3055  42 VYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLD 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 373 GMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVR-KIGCYAAMKKKIYAMGG------------------------ 427
Cdd:COG3055 122 GKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVIGGrngsgfsntwttlaplptaragha 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271 428 -----------GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 474
Cdd:COG3055 202 aavlggkilvfGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-233 2.73e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 111.28  E-value: 2.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271    133 CIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVH 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 26333271    213 MKDVMSALWVSGLDSSYLREQ 233
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-124 9.50e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 76.14  E-value: 9.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271    19 LSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIrLNE 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE--ITLDDVSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|....*.
gi 26333271    99 DTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 30-125 3.39e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.79  E-value: 3.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271     30 DAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAAD 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE--IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*.
gi 26333271    110 LLLLTDLKTLCCEFLE 125
Cdd:smart00225  79 YLQIPGLVELCEEFLL 94
Kelch smart00612
Kelch domain;
327-373 1.17e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.17e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 26333271    327 LFVLGGQDeNKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDG 373
Cdd:smart00612   2 IYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 305-475 2.74e-09

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 59.03  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   305 WIELAPLSMPrINHGV-LSAEGFLFVLGGQDENKQ---TLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGG 380
Cdd:TIGR03548  54 WVKAGQLPYE-IAYGAsVSTPYGIYYVGGSPSSESfsdVLLLSLDDTKEALIIETLPSLPVAFDNGSATYKDGKIYVGGG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   381 EDGDRELISMECYDI--YSKTWTKQPDL---TMVRKIGcyAAMKKKIYAMGGGSYGK---LFESVECYDPRTQQWTAIC- 451
Cdd:TIGR03548 133 NANGKPSNKFYCLDLsnDTSGWEELPEFpgeARVQPVC--QALHGKLYVFGGFQLGGdaiIYTDGYAYSPKTNTWQTVAd 210

                         170       180       190
                  ....*....|....*....|....*....|
gi 26333271   452 PLK---ERRFGAVACGVAM---ELYVFGGV 475
Cdd:TIGR03548 211 PVLsdgEPITLLGGNSVKLgdsLMLVIGGV 240
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 362-407 2.92e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.00  E-value: 2.92e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 26333271   362 ARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLT 407
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
 
Name Accession Description Interval E-value
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-125 2.89e-57

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 187.55  E-value: 2.89e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQI 94
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271  95 RLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 129-225 4.76e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 184.06  E-value: 4.76e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 129 AAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEM 208
Cdd:cd18455   1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEE 80

                        90
                ....*....|....*..
gi 26333271 209 RKVHMKDVMSALWVSGL 225
Cdd:cd18455  81 RKVHLKDLMSSCWRSGL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 27-501 4.81e-45

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 167.64  E-value: 4.81e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   27 RFCDAHLVL--DGEEIPVQKNILAAASPYIRTKLnynppKDDGSTYKIELEgISVMVMREILDYIFSGQIRLNEDTIQDV 104
Cdd:PHA03098   8 KFCDESIIIvnGGGIIKVHKIILSSSSEYFKKMF-----KNNFKENEINLN-IDYDSFNEVIKYIYTGKINITSNNVKDI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  105 VQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLE 184
Cdd:PHA03098  82 LSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  185 KLNVGNERYVFEAVIRWIAHDVEMRKVHMKDVMSAL-WvsgldsSYLREQML-----------------NEPLVREIVKE 246
Cdd:PHA03098 162 KLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLrI------TFLSEEGIkklkrwklrikkkkivfNKRCIKIIYSK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  247 CSN--------------IPLSQPQQGEAMLA--------------------SFKPRGYSECIVTIGG---EERVSRKPTA 289
Cdd:PHA03098 236 KYNlnkilprsstfgsiIYIHITMSIFTYNYitnysplseintiidihyvyCFGSVVLNNVIYFIGGmnkNNLSVNSVVS 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  290 amrcmcplYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDeNKQTLSSGEKYDPDANTWTALPPMHEARHNFGIV 369
Cdd:PHA03098 316 --------YDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIY-NSISLNTVESWKPGESKWREEPPLIFPRYNPCVV 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  370 EIDGMLYILGG-EDGDRELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSY---GKLFESVECYDPRTQ 445
Cdd:PHA03098 387 NVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYidnIKVYNIVESYNPVTN 466

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271  446 QWTAICPLKERRFGAVACGVAMELYVFGGVRSREDIQGSEMvtcksefYHDEFKRW 501
Cdd:PHA03098 467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEV-------YDDKTNTW 515
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-234 2.84e-34

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 125.35  E-value: 2.84e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   133 CIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVH 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 26333271   213 MKDVMSALWVSGLDSSYLREQM 234
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
297-474 6.19e-34

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 130.28  E-value: 6.19e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 297 LYDPNRQLWIELAPLSMPRINH-GVLSAEGFLFVLGGQDENK---QTLSSGEKYDPDANTWTALPPMHEARHNFGIVEID 372
Cdd:COG3055  42 VYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLD 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 373 GMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVR-KIGCYAAMKKKIYAMGG------------------------ 427
Cdd:COG3055 122 GKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRdHLAAAVLPDGKILVIGGrngsgfsntwttlaplptaragha 201

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271 428 -----------GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 474
Cdd:COG3055 202 aavlggkilvfGGESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
305-559 1.41e-33

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 129.51  E-value: 1.41e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 305 WIELAPLSMPRINHGVLSAEGFLFVLGGQDENKqTLSSGEKYDPDANTWTALPPM-HEARHNFGIVEIDGMLYILGGEDG 383
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGS-ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 384 D----RELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFG 459
Cdd:COG3055  82 AnpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 460 -AVACGVAMELYVFGGVRSrediqgsemvtcksefyHDEFKRWIYLNDqnlciPASSSFVYGAVPIGASIYVIGdlDTGT 538
Cdd:COG3055 162 lAAAVLPDGKILVIGGRNG-----------------SGFSNTWTTLAP-----LPTARAGHAAAVLGGKILVFG--GESG 217

                       250       260
                ....*....|....*....|.
gi 26333271 539 NYDYVREFKRSTGTWHHTKPL 559
Cdd:COG3055 218 FSDEVEAYDPATNTWTALGEL 238
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-233 2.73e-29

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 111.28  E-value: 2.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271    133 CIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKVH 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 26333271    213 MKDVMSALWVSGLDSSYLREQ 233
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 132-241 9.80e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 107.70  E-value: 9.80e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYCLHHVHYlATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18445   5 NCLGIRAFAdLHSCTDLLKY-AQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPENRK 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271 211 VHMKDVMSALWVSGLDSSYLREQMLNEPLVR 241
Cdd:cd18445  84 EHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
352-572 2.57e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.01  E-value: 2.57e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 352 TWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRKIG-CYAAMKKKIYAMGG--- 427
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGftg 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 428 -GSYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRsrediqgSEMVTCKSEFYHDEFKRWIYLND 506
Cdd:COG3055  82 aNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWD-------DGGNVAWVEVYDPATGTWTQLAP 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271 507 qnlcIPASSSFVYGAVPIGASIYVIGdldtGTNydyvreFKRSTGTWhHTKPLLPSDLRRTGCAAL 572
Cdd:COG3055 155 ----LPTPRDHLAAAVLPDGKILVIG----GRN------GSGFSNTW-TTLAPLPTARAGHAAAVL 205
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 132-241 1.07e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 90.86  E-value: 1.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYCLHHVHyLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18512   5 NCLGIRAFAdMHACTELLN-QANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQ 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271 211 VHMKDVMSALWVSGLDSSYLREQMLNEPLVR 241
Cdd:cd18512  84 EHMAHLMEHVRLPLLSREYLVQRVEEETLVK 114
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 132-219 3.24e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 88.90  E-value: 3.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18457   5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREE 84


                ....*...
gi 26333271 212 HMKDVMSA 219
Cdd:cd18457  85 YLPELLSK 92
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 132-218 4.69e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 88.13  E-value: 4.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALhycLHHVHYL---ATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEM 208
Cdd:cd18448   6 NCLGVRTFAE---QHNRVDLmkmADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQH 82

                        90
                ....*....|
gi 26333271 209 RKVHMKDVMS 218
Cdd:cd18448  83 RKRHLDDLLS 92
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 132-241 7.76e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 88.59  E-value: 7.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYCLHHVHYlATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18513   5 NCLGIRAFAdVHTCTELLQQ-ANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARL 83

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271 211 VHMKDVMSALWVSGLDSSYLREQMLNEPLVR 241
Cdd:cd18513  84 EHMAKLMEHVRLPLLPRDYLVQTVEEEALIK 114
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 132-217 8.14e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 86.96  E-value: 8.14e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18458   6 NCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDEENRRQ 85


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18458  86 YLEALL 91
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 130-205 1.85e-20

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 85.54  E-value: 1.85e-20
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26333271 130 AENCIGIRDFA-LHYCLHHVHYlATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHD 205
Cdd:cd18508   2 ATNCLGIHEFAdAHSCVELEEA-AQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-108 5.97e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 81.45  E-value: 5.97e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKLnyNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQA 107
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMF--SSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAA 78


                .
gi 26333271 108 A 108
Cdd:cd18186  79 A 79
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
297-441 7.69e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.75  E-value: 7.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 297 LYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENKqTLSSGEKYDPDANTWTALPPMHEARHNF-GIVEIDGML 375
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKI 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 376 YILGGEDGD------RELISM-----------------------------ECYDIYSKTWTKQPDLTMVRKIGCYAAMKK 420
Cdd:COG3055 173 LVIGGRNGSgfsntwTTLAPLptaraghaaavlggkilvfggesgfsdevEAYDPATNTWTALGELPTPRHGHAAVLTDG 252

                       170       180
                ....*....|....*....|....*
gi 26333271 421 KIYAMGG----GSYGKLFESVECYD 441
Cdd:COG3055 253 KVYVIGGetkpGVRTPLVTSAEVYD 277
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 132-217 1.44e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 81.15  E-value: 1.44e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18467   5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQERQK 84


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18467  85 YLAQLL 90
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 2.34e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 81.29  E-value: 2.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynppkdDG----STYKIELEGISVMVMREIL 86
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFT------GGmresSQDEIELKGVSAKGLKHIL 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18255  75 DFAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-135 7.97e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 79.82  E-value: 7.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   7 SDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREIL 86
Cdd:cd18265   2 SGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAV--VEIQKVSAAAMEVLL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18265  80 DYMYGGGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-133 1.38e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 78.91  E-value: 1.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  23 REEARFCDAHLVLDGEEIPVQKNILAAASPYIRT--KLNYNPPKDdgSTYKIEleGISVMVMREILDYIFSGQIRLNEDT 100
Cdd:cd18240  12 RLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRAlfTNGWNETEK--KVYKIP--GVSPEMMELIIEYAYTRTVPITAEN 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 26333271 101 IQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18240  88 VEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 131-205 1.71e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 77.27  E-value: 1.71e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271 131 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSS-TEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHD 205
Cdd:cd18450   4 ENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 130-230 3.84e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 77.07  E-value: 3.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 130 AENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMR 209
Cdd:cd18468   2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNR 81

                        90       100
                ....*....|....*....|.
gi 26333271 210 KVHMKDVMSALWVSGLDSSYL 230
Cdd:cd18468  82 KQHIAELLAVVRLPFIHPSYL 102
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 5.75e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 77.52  E-value: 5.75e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYIFSGQI 94
Cdd:cd18268  10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNN--FRESSQAKVDLKGIDSDVLDQIVDYVYTGEI 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 26333271  95 RLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18268  88 LITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-209 8.84e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 75.44  E-value: 8.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 131 ENCIGIRDFALHY---CLHHVhylATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18480   4 SNCLQLLSFAESYgstRLLDH---ALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLE 80


                ..
gi 26333271 208 MR 209
Cdd:cd18480  81 AR 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 19-124 9.50e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 76.14  E-value: 9.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271    19 LSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIrLNE 98
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE--ITLDDVSPEDFEALLEFMYTGKL-ISE 77

                          90       100
                  ....*....|....*....|....*.
gi 26333271    99 DTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:pfam00651  78 ENVDDLLAAADKLQIPSLVDKCEEFL 103
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-133 1.22e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 76.35  E-value: 1.22e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILD 87
Cdd:cd18250   1 DPAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAM--FAGELRESRADRVVLHGVSAEILGLLLD 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  88 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18250  79 FSYTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 1.45e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 75.93  E-value: 1.45e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAM--FTGDLSESRANRVTLQDVDGKALLLLIDY 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18235  80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFLQ 116
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-135 1.48e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 76.29  E-value: 1.48e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynPPKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18256   2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFA--GGMSESSKDVVQIHGVEPDIFHILLDFI 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18256  80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 132-220 1.69e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 75.45  E-value: 1.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYCLHhVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18444   6 NCLGIRSFAdAQGCTD-LLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLPERK 84

                        90
                ....*....|
gi 26333271 211 VHMKDVMSAL 220
Cdd:cd18444  85 KHLAKLLALI 94
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-136 1.93e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 75.76  E-value: 1.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTklNYNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFE--LFSSDSDGESILTVKLDGLDPDAVEVLVNYAY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18306  79 TSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-135 2.01e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 75.99  E-value: 2.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18237   3 KLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSN--MTESKSSEVELKDAEPDIIELLVEFA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18237  81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 132-242 2.75e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 75.90  E-value: 2.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18452   5 NCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKEERED 84

                        90       100       110
                ....*....|....*....|....*....|.
gi 26333271 212 HMKDVMSALWVSGLDSSYLREQMLNEPLVRE 242
Cdd:cd18452  85 YLPELLQYVRLPLLSPRYITDVVDAEPLIRC 115
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 5.51e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 74.40  E-value: 5.51e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNyNPPKDDGSTYkIELEGISVMVMREILDYIF 90
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFT-SEMSEKGKSE-VELQGLTASTMEILLDFVY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18242  82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-134 6.58e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 71.38  E-value: 6.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnynppKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNIL-----KKDPSLQRVELNDISPLGLATVITYAY 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 134
Cdd:cd18260  76 TGKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-136 8.72e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 71.78  E-value: 8.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   7 SDPQHAARLLRALSSFREEARFCDAHLVLDGEE--------IPVQKNILAAASPYIRTKLNynppkddGSTY-----KIE 73
Cdd:cd18273   5 EDAAHARALLAQLKSFYDARLLTDVTIEVNGPGsgpgsgrlFPCNRNVLAAASPYFKSMFT-------GGLYeskqeTVT 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26333271  74 LEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18273  78 IHDVDSESMALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 131-230 1.09e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 70.15  E-value: 1.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 131 ENCIGIRDFA-LHYClHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMR 209
Cdd:cd18462   4 DNCLGMHSFAeFHVC-PELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKR 82

                        90       100
                ....*....|....*....|.
gi 26333271 210 KVHMKDVMSALWVSgLDSSYL 230
Cdd:cd18462  83 IECAYDLLSSIKLD-LDEIYL 102
PHA02713 PHA02713
hypothetical protein; Provisional
 6-427 1.58e-14

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 76.59  E-value: 1.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271    6 VSDPQHAARLLRALSSFREEARFCDAHLVL-DGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTyKIELEGISVMVMRE 84
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVT-RVNLQMFDKDAVKN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   85 ILDYIFSGQIrlNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIgirdFALHYCLHHVHYLATEYLE----THF 160
Cdd:PHA02713  82 IVQYLYNRHI--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCI----YMYHRLYEMSHIPIVKYIKrmlmSNI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  161 RDVSSTEEFLELSPQKLKEVISL-EKLNVGNERYVFEAVIRWIAHDVeMRKVHMKDVMSALWVSGLDSSylREQMLNEPL 239
Cdd:PHA02713 156 PTLITTDAFKKTVFEILFDIISTnDNVYLYREGYKVTILLKWLEYNY-ITEEQLLCILSCIDIQNLDKK--SRLLLYSNK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  240 VREIVKECSNIPLSQPQQGEAMlasfkPRGYseCIVTIGGEERVSRKptaamrCMCpLYDPNRQLWIELAPLSMPRINHG 319
Cdd:PHA02713 233 TINMYPSCIQFLLDNKQNRNII-----PRQL--CLVCHDTKYNVCNP------CIL-VYNINTMEYSVISTIPNHIINYA 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  320 VLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKT 399
Cdd:PHA02713 299 SAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDK 378

                        410       420
                 ....*....|....*....|....*...
gi 26333271  400 WTKQPDLTMVRKIGCYAAMKKKIYAMGG 427
Cdd:PHA02713 379 WKMLPDMPIALSSYGMCVLDQYIYIIGG 406
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 132-204 2.51e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 68.19  E-value: 2.51e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAH 204
Cdd:cd18463   6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
PHA02790 PHA02790
Kelch-like protein; Provisional
 37-447 4.39e-14

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 74.69  E-value: 4.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   37 GEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEgISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDL 116
Cdd:PHA02790  30 GGNIIVNSTILKKLSPYFRTHLRQKYTKNKDPVTRVCLD-LDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFI 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  117 KTLCCEFLEGCIAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSS--TEEFLELSpqkLKEVISLEKLNVGNERYV 194
Cdd:PHA02790 109 IYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDdiIDNFDYLS---MKLILESDELNVPDEDYV 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  195 FEAVIRWIahdveMRKVHMKDVMSALWVSGLDSSYLREQMLNEplVREIVK-----ECSNIP--------LSQPQQGEAM 261
Cdd:PHA02790 186 VDFVIKWY-----MKRRNRLGNLLLLIKNVIRSNYLSPRGINN--VKWILDctkifHCDKQPrksykypfIEYPMNMDQI 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  262 LASF---KPRGYSECIVTIGG-EERVSRKPTAAMRCMcplydpnRQLWIELAPLSMPRINHGVLSAEGFLFVLGGQDENk 337
Cdd:PHA02790 259 IDIFhmcTSTHVGEVVYLIGGwMNNEIHNNAIAVNYI-------SNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNP- 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  338 qtlSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGGED----------------------------------G 383
Cdd:PHA02790 331 ---TSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSetdttteyllpnhdqwqfgpstyyphykscalvfG 407

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26333271  384 DRELI---SMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQW 447
Cdd:PHA02790 408 RRLFLvgrNAEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSW 474
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 132-217 6.49e-14

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 67.89  E-value: 6.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18466   5 NCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKRKK 84


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18466  85 HVVEVL 90
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 132-217 1.11e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 67.33  E-value: 1.11e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18456   5 NCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVDGRRQ 84


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18456  85 HVPRLM 90
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-140 1.16e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 68.38  E-value: 1.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIG--MREAHQKEVELVGASYIGLKAVIDFLY 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFA 140
Cdd:cd18266  86 SSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-137 1.24e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 67.76  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18336   2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAM--FTNDVREAKQEEIKMEGVDPDALKALVHYAY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIR 137
Cdd:cd18336  80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-126 1.70e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 67.18  E-value: 1.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDYIF 90
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENS--EVEFQCIDETALQAIVEYAY 78

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 126
Cdd:cd18257  79 TGTVFISQATVESLLPAANLLQIKLVLKECCDFLES 114
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 132-218 2.26e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 66.30  E-value: 2.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18459   6 NCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQERRP 85


                ....*..
gi 26333271 212 HMKDVMS 218
Cdd:cd18459  86 HLPQVLQ 92
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 3.14e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 66.75  E-value: 3.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVL-DGEEI-PVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILD 87
Cdd:cd18239   5 THSSVVLQGFDQLRGEGLLCDVTLVPgDGDETfPVHRAMMASASDYFKAMFTGGMKEQELMC--IKLHGVSKIGLKNIID 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  88 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18239  83 FIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 30-125 3.39e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 65.79  E-value: 3.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271     30 DAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAAD 109
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSE--IYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELAD 78

                           90
                   ....*....|....*.
gi 26333271    110 LLLLTDLKTLCCEFLE 125
Cdd:smart00225  79 YLQIPGLVELCEEFLL 94
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-217 4.00e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 65.52  E-value: 4.00e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 130 AENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMR 209
Cdd:cd18485   3 ASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSR 82


                ....*...
gi 26333271 210 KVHMKDVM 217
Cdd:cd18485  83 VQHLVELL 90
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-125 4.42e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 66.28  E-value: 4.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILD 87
Cdd:cd18339   1 NPAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAM--FTGDMSESKAKKIEIKDVDGQTLSKLID 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26333271  88 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18339  79 YIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQ 116
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-218 5.23e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 65.27  E-value: 5.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 131 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18483   4 QNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKRE 83


                ....*...
gi 26333271 211 VHMKDVMS 218
Cdd:cd18483  84 MHLPEIFA 91
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-125 5.83e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 65.86  E-value: 5.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILD 87
Cdd:cd18338   1 NPRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAM--FTGEMSESRAKRVRIKEVDGWTLKMLID 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26333271  88 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18338  79 YVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 116
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 130-182 1.44e-12

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 62.29  E-value: 1.44e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 26333271 130 AENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVIS 182
Cdd:cd14733   2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLS 54
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 128-216 1.65e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 63.64  E-value: 1.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80


                ....*....
gi 26333271 208 MRKVHMKDV 216
Cdd:cd18517  81 NRVKSLGEI 89
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-134 1.69e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 64.82  E-value: 1.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTkLNYNPPKDDGSTYkIELEGISVMVMREILDYIF 90
Cdd:cd18264  11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRA-LFKDYTQESKARV-IHLPVVSAAGLQRVLDFIY 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 134
Cdd:cd18264  89 TSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENCC 132
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-136 1.77e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 64.62  E-value: 1.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLD-GEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREIL 86
Cdd:cd18274   2 DPLHACSILQQLKAMYDEGQLTDIVVEVDhGKTFSCHRNVLAAISPYFRSM--FTSGLTESTQKEVRIVGVEAESMHLVL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18274  80 DYAYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 132-217 1.79e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 63.67  E-value: 1.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18464   4 NCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHE 83


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18464  84 VLPELL 89
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 128-229 2.03e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 63.62  E-value: 2.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18469   3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                        90       100
                ....*....|....*....|..
gi 26333271 208 MRKVHMKDVMSALWVSGLDSSY 229
Cdd:cd18469  83 ARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 132-230 2.40e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 63.55  E-value: 2.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18511   6 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVEQRRK 85

                        90
                ....*....|....*....
gi 26333271 212 HMKDVMSALWVSGLDSSYL 230
Cdd:cd18511  86 DLSKLLAYIRLPLLAPQFL 104
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-108 3.60e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 63.66  E-value: 3.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDdGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQA 107
Cdd:cd18293  15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPA-GQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAA 93


                .
gi 26333271 108 A 108
Cdd:cd18293  94 A 94
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-137 4.37e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 63.53  E-value: 4.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18335   1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAM--FTSDVCEAKQEEIKMEGIDPNALWDLVQFA 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIR 137
Cdd:cd18335  79 YTGCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126
Kelch smart00612
Kelch domain;
327-373 1.17e-11

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 59.49  E-value: 1.17e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 26333271    327 LFVLGGQDeNKQTLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDG 373
Cdd:smart00612   2 IYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-108 1.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 60.64  E-value: 1.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKL-NYNPPKDDgstyKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQ 106
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLkETPPDEHP----VIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLK 76


                ..
gi 26333271 107 AA 108
Cdd:cd18315  77 LA 78
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-136 1.37e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 62.16  E-value: 1.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYN-PPKDDGStykIELEGISVMVMREILDYI 89
Cdd:cd18271   7 HGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNmKERDDGS---VTISNLSPKAVKAFLDYA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18271  84 YTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-135 1.79e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 62.15  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDY 88
Cdd:cd18259  13 PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISA--RVEIKDVDPAVMESLIDF 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18259  91 AYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 128-218 2.45e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 60.45  E-value: 2.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRdfALHYCLH--HVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHD 205
Cdd:cd18447   2 VDASNCLGIS--VLAECLDcpELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYD 79

                        90
                ....*....|...
gi 26333271 206 VEMRKVHMKDVMS 218
Cdd:cd18447  80 EPNRQPYMVDILA 92
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 128-216 3.06e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 60.24  E-value: 3.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80


                ....*....
gi 26333271 208 MRKVHMKDV 216
Cdd:cd18477  81 NRQKALPTV 89
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-135 3.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 60.76  E-value: 3.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTYKIEL--EGISVMVMREILDYIFSG 92
Cdd:cd18258   4 MLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFK-DLIKRSSRDSGGGEKLELtmSNINADVLELLLEFVYTG 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  93 QIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18258  83 SLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 3.56e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 60.61  E-value: 3.56e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNpPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18329   4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQN-AKETGQPTVATFDVFSPDTFTIILDFVY 82

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNEDTIQDVVQAA 108
Cdd:cd18329  83 SGKLSLTSQNVIEVMSAA 100
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 6.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 60.26  E-value: 6.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYK-----IELEGISVMVMREI 85
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVLVSPagkcvLDLHHVTVTGFAPL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  86 LDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCI 128
Cdd:cd18228  82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 6.50e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 59.85  E-value: 6.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNyNPPKDDGSTyKIELEGISVMVMREILDYIF 90
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC-NDHRESREM-LVEINGILAEAMDCFLQYVY 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18253  79 TGKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-136 1.80e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 58.96  E-value: 1.80e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  24 EEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQD 103
Cdd:cd18269  23 DENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAM--FLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQD 100

                        90       100       110
                ....*....|....*....|....*....|...
gi 26333271 104 VVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18269 101 IFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-135 1.90e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 58.68  E-value: 1.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVL-DGEEIPVQKNILAAASPYIrtKLNYNPPKDDGSTYKIELEGISVMVMREIL 86
Cdd:cd18252   1 DSSHPADFLDAFRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYF--KVMFTADMKEKSNNVIKLSGIDHDILEALV 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18252  79 NYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-134 2.28e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 58.86  E-value: 2.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18270   8 EYAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAM--FMSGLSESKQTHVHLRNVDAATLQIIITYA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 134
Cdd:cd18270  86 YTGNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-136 2.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 58.69  E-value: 2.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  24 EEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQD 103
Cdd:cd18340  23 DHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAM--FLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQD 100

                        90       100       110
                ....*....|....*....|....*....|...
gi 26333271 104 VVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18340 101 IFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 128-220 2.65e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 57.37  E-value: 2.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18479   1 INAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTE 80

                        90
                ....*....|...
gi 26333271 208 MRKVHMKDVMSAL 220
Cdd:cd18479  81 SRSQYLSSVLSQI 93
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-136 2.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 58.28  E-value: 2.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18276   3 KHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAM--FTCGLMECSQREVVLHDITAESVSIILNYM 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18276  81 YSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 132-218 2.90e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 57.62  E-value: 2.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18510   6 NCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQNRQK 85


                ....*..
gi 26333271 212 HMKDVMS 218
Cdd:cd18510  86 DLGMLLS 92
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 132-217 3.01e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 57.16  E-value: 3.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYClHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18514   5 NCLGMMLLSdAHQC-RRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLEKRK 83


                ....*..
gi 26333271 211 VHMKDVM 217
Cdd:cd18514  84 DYLPELL 90
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-135 3.46e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 57.68  E-value: 3.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  19 LSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKddgSTYK-IELEGISVMVMREILDYIFSGQIRLN 97
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAE---SKQDsITIKDIDEEAVELLVDFAYTGKLTLT 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26333271  98 EDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18238  83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 131-232 5.62e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 56.71  E-value: 5.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 131 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18446   4 ENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERL 83

                        90       100
                ....*....|....*....|..
gi 26333271 211 VHMKDVMSALWVSGLDSSYLRE 232
Cdd:cd18446  84 PLLPRVLENVRLPLLDPWYFVE 105
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-132 5.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 57.36  E-value: 5.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgstyKIELEGISVMVMREILD 87
Cdd:cd18243  12 DPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN---------NLVLQGCSSIGLRLVLE 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26333271  88 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 132
Cdd:cd18243  83 YLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-136 7.42e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 57.16  E-value: 7.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  19 LSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDYIFSGQIRLNE 98
Cdd:cd18341  18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKK--EVVLDNVDPNIMDMILKYLYSAEIDLND 95

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26333271  99 DTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18341  96 GNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-135 8.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 56.78  E-value: 8.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnYNPPKDDGSTyKIELEGISVMVMREILDYIFSGQI 94
Cdd:cd18236  11 LQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMF-CNDLKEKYEE-KIIIKGVDAETMQILLDYTYTSKV 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 26333271  95 RLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18236  89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-125 1.00e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 56.62  E-value: 1.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDG----EEIPVQKNILAAASPYIRTKLNyNPPKDDGSTyKIELEGISVMVMREI 85
Cdd:cd18248   3 DHTKEAFQIMNELRLSQQLCDVTLKVKYqdpkEEFMAHKVVLASSSPYFKAMFT-SGLRECGME-VVPIEGVHPCVMSRL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 26333271  86 LDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18248  81 IEFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLE 120
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-132 1.55e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 55.98  E-value: 1.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDYI 89
Cdd:cd18251   5 AHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQT--EVLIHGVSYNAMCKILDFI 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 132
Cdd:cd18251  83 YTSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 132-217 1.85e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 55.15  E-value: 1.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18516   5 NCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERTK 84


                ....*.
gi 26333271 212 HMKDVM 217
Cdd:cd18516  85 ALPVLL 90
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-136 1.87e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 56.12  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  20 SSFR---EEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDYIFSGQIRL 96
Cdd:cd18244  19 AGFRalyEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQD--KIHLKGLTATGFSHVLQFMYYGTIEL 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 26333271  97 NEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18244  97 SMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 1.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 55.51  E-value: 1.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNpPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHY-IQDTGRPSTASFDVFSSDAFSIILDFVY 79

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNEDTIQDVVQAA 108
Cdd:cd18199  80 SGKLSLTSQNVIEVMSAA 97
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 2.20e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 55.15  E-value: 2.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynppkdDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYG------DGTSGSVVLPESFAEVFGLLLDFFY 74

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNEDTIQDVVQAA 108
Cdd:cd18232  75 TGELALTRENRDRVLLAA 92
mutarot_permut TIGR03548
cyclically-permuted mutarotase family protein; Members of this protein family show essentially ...
 305-475 2.74e-09

cyclically-permuted mutarotase family protein; Members of this protein family show essentially full-length homology, cyclically permuted, to YjhT from Escherichia coli. YjhT was shown to act as a mutarotase for sialic acid, and by this ability to be able to act as a virulence factor. Members of the YjhT family (TIGR03547) and this cyclically-permuted family have multiple repeats of the beta-propeller-forming Kelch repeat.


Pssm-ID: 274642 [Multi-domain]  Cd Length: 331  Bit Score: 59.03  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   305 WIELAPLSMPrINHGV-LSAEGFLFVLGGQDENKQ---TLSSGEKYDPDANTWTALPPMHEARHNFGIVEIDGMLYILGG 380
Cdd:TIGR03548  54 WVKAGQLPYE-IAYGAsVSTPYGIYYVGGSPSSESfsdVLLLSLDDTKEALIIETLPSLPVAFDNGSATYKDGKIYVGGG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   381 EDGDRELISMECYDI--YSKTWTKQPDL---TMVRKIGcyAAMKKKIYAMGGGSYGK---LFESVECYDPRTQQWTAIC- 451
Cdd:TIGR03548 133 NANGKPSNKFYCLDLsnDTSGWEELPEFpgeARVQPVC--QALHGKLYVFGGFQLGGdaiIYTDGYAYSPKTNTWQTVAd 210

                         170       180       190
                  ....*....|....*....|....*....|
gi 26333271   452 PLK---ERRFGAVACGVAM---ELYVFGGV 475
Cdd:TIGR03548 211 PVLsdgEPITLLGGNSVKLgdsLMLVIGGV 240
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 362-407 2.92e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 53.00  E-value: 2.92e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 26333271   362 ARHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTWTKQPDLT 407
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-108 3.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 55.36  E-value: 3.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEA-RFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNyNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18207   8 QHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFS-AQEGDGGTPRELEMHTISSKVFGDILDF 86

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18207  87 AYTSRIVVRLESFPELMTAA 106
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 3.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 55.36  E-value: 3.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGStyKIELEGISVMVMREILDYIF 90
Cdd:cd18261  11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEAD--EVNLHGVTSLGLKQALDFAY 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18261  89 TGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 131-204 4.13e-09

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 53.51  E-value: 4.13e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26333271 131 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAH 204
Cdd:cd18503   4 DNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 132-209 6.18e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 53.87  E-value: 6.18e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26333271 132 NCIGIRDFA-LHYCLHHVHyLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMR 209
Cdd:cd18509   6 NCLGIRAFAdAQGCIELMK-VAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRR 83
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-137 6.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 54.30  E-value: 6.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18337   6 HAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAM--FTNDVREAKQEEIKMEGVEPNALWALVQYAY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIR 137
Cdd:cd18337  84 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-125 1.16e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 53.36  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTkLNYNPPKDDGSTYKIELEGISvmVMREILDYIF 90
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRS-LFQNSSSQKNDVFHLDIKNVG--GIGQILDFMY 77

                        90       100       110
                ....*....|....*....|....*....|....*
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18233  78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 1.30e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 53.40  E-value: 1.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELegISVMVMREILDY 88
Cdd:cd18326   6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDF--VSAEALTALLDF 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18326  84 AYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-136 1.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 53.74  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   7 SDPQHAARLLRALSSF-REEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREI 85
Cdd:cd18272  10 TDRSHSSRVAQSIMDLcLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSN--LKEARNRVIELKDVSESVFQLL 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 26333271  86 LDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18272  88 VDYIYHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 314-359 1.36e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.07  E-value: 1.36e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 26333271   314 PRINHGVLSAEGFLFVLGGQDENkQTLSSGEKYDPDANTWTALPPM 359
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-135 1.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 53.48  E-value: 1.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIElEGISVMVMREILDY 88
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFH-DSLHPEVLELLLDF 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18254  82 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-135 1.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 53.22  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIELEGISVMVMREILDYI 89
Cdd:cd18249   5 KHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAM--FTGELAESRQTEVTIRDIDERAMELLIDFA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIG 135
Cdd:cd18249  83 YTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-96 2.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 52.97  E-value: 2.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYK-----------IELEGISV 79
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLPLGAAAVAAapgatqspervLELPGVKA 80

                        90
                ....*....|....*..
gi 26333271  80 MVMREILDYIFSGQIRL 96
Cdd:cd18195  81 GVFSDVLNFIYSSRVAL 97
Kelch smart00612
Kelch domain;
421-463 2.20e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 26333271    421 KIYAMGGGSYGKLFESVECYDPRTQQWTAICPLKERRFGAVAC 463
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 132-217 3.74e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 51.51  E-value: 3.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFA-LHYCLHhVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18515   4 NCLGMLLLSdAHQCTK-LYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKKRH 82


                ....*..
gi 26333271 211 VHMKDVM 217
Cdd:cd18515  83 CYLSELL 89
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-123 3.88e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 51.34  E-value: 3.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPK-DDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQ 106
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKaTDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                        90
                ....*....|....*..
gi 26333271 107 AADLLLLTDLKTLCCEF 123
Cdd:cd18307  81 GAKYFNIPRLKDHCVDF 97
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 128-205 7.57e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 49.81  E-value: 7.57e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHD 205
Cdd:cd18474   1 IGANNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-125 9.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 50.72  E-value: 9.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  14 RLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQ 93
Cdd:cd18201   7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVVAVQGFSVILDFMYSGN 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 26333271  94 IRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18201  87 LVLTSQNAIEVMSVASYLQMTEVVQSCRNFIK 118
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 1.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 50.31  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDdgstyKIELEGISVMVMREILDY 88
Cdd:cd18206   3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRML--FVDQKD-----VVHLDISNAAGLGQVLEF 75

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18206  76 MYTAKLSLSPENVDDVLAVA 95
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-107 1.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 50.21  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   8 DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYnppkddgSTYKIELEGISVMVMREILD 87
Cdd:cd18219   1 DTQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV-------AGQVVELNFIRADIFAEILN 73

                        90       100
                ....*....|....*....|.
gi 26333271  88 YIFSGQI-RLNEDTIQDVVQA 107
Cdd:cd18219  74 YIYSSKIvRVRSDLLEELIKS 94
PLN02153 PLN02153
epithiospecifier protein
 314-532 1.36e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 53.84  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  314 PRINHGVLSAEGFLFVLGGQ-DENKQTLSSGEKYDPDANTWTALPPMHEARH--NFGI--VEIDGMLYILGGEDGDRELI 388
Cdd:PLN02153  22 PRCSHGIAVVGDKLYSFGGElKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRisCLGVrmVAVGTKLYIFGGRDEKREFS 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  389 SMECYDIYSKTWTKQPDLTMV-----RKIGCYAAMKKKIYAMGGGSYGKL------FESVECYDPRTQQWTAIC-PLK-- 454
Cdd:PLN02153 102 DFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLmktperFRTIEAYNIADGKWVQLPdPGEnf 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26333271  455 ERRFGAVACGVAMELYVFGGVRSREDIQG-SEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVpiGASIYVIG 532
Cdd:PLN02153 182 EKRGGAGFAVVQGKIWVVYGFATSILPGGkSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVV--GKYIIIFG 258
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-136 1.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 51.14  E-value: 1.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIElEGISVMVMREILDY 88
Cdd:cd18267  21 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFH-DSIHPEVLELLLDY 99

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGI 136
Cdd:cd18267 100 AYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
Kelch_6 pfam13964
Kelch motif;
314-363 1.56e-07

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 48.10  E-value: 1.56e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 26333271   314 PRINHGVLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPMHEAR 363
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 1.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 50.59  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtkLNYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18194   4 PEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFH--LFYRDRLDKRDLVRLNSDIVTAPAFGLLLDF 81

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18194  82 MYEGRLALRDLPVEDVLAAA 101
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-125 2.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 49.47  E-value: 2.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgSTYKIELEG-ISVMVMREILDYI 89
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLN------DTNCLVLPSvIEAAAFENLLQLI 74

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 26333271  90 FSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18200  75 YSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-128 2.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 50.06  E-value: 2.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTkLNYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKT-LYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCI 128
Cdd:cd18230  81 MYSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-108 2.53e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 49.54  E-value: 2.53e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  13 ARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNpPKDDGSTYKIELEGISVMVMREILDYIFSG 92
Cdd:cd18330   3 TKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHY-IQDSGRHSTASLDIVTSEAFSIILDFLYSG 81

                        90
                ....*....|....*.
gi 26333271  93 QIRLNEDTIQDVVQAA 108
Cdd:cd18330  82 KLDLCSENVIEVMSAA 97
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 2.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 49.52  E-value: 2.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgSTYKIELEGISVMVMREILDY 88
Cdd:cd18333   2 PSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHD------NLINLDHEMVSPGIFRLILDY 75

                        90       100
                ....*....|....*....|....
gi 26333271  89 IFSGQI----RLNEDTIQDVVQAA 108
Cdd:cd18333  76 IYTGRLsegdPGSEQNLGAVLAAA 99
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-108 3.48e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 48.78  E-value: 3.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  27 RFCDAHLVL--DGEEIPVQKNILAAASPYIRTKLNYNPPKDDgSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDV 104
Cdd:cd18294  13 EFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKES-TQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEV 91


                ....
gi 26333271 105 VQAA 108
Cdd:cd18294  92 LAAA 95
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-124 4.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 48.82  E-value: 4.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  19 LSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYN--PPKDDgstyKIELEGISVMVMREILDYIFSGQIRL 96
Cdd:cd18247  10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDmvESKQD----EITMQGIEPSALEALINFAYSGRIAI 85

                        90       100
                ....*....|....*....|....*...
gi 26333271  97 NEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18247  86 DTSNVQSLLVGASFLQLQSVKDACCEFL 113
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-108 4.27e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 47.66  E-value: 4.27e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26333271  33 LVLDGEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTyKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAA 108
Cdd:cd01165   3 LVVEGEKFHVNKELLAQSSEYFR-ALFRGGFRESGQA-EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 131-219 4.72e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 48.20  E-value: 4.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 131 ENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLnVGNERYVFEAVIRWIAHDVEMRK 210
Cdd:cd18476   4 SNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPKARK 82


                ....*....
gi 26333271 211 VHMKDVMSA 219
Cdd:cd18476  83 GYIHDLFKK 91
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-94 5.51e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 48.81  E-value: 5.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgSTYKIELEGISVMVMREILDY 88
Cdd:cd18334   2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD------NLINLDTDMVNPTVFRQILDF 75


                ....*.
gi 26333271  89 IFSGQI 94
Cdd:cd18334  76 IYTGKL 81
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 128-201 5.68e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 47.38  E-value: 5.68e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRW 201
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRW 74
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 6.03e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 48.46  E-value: 6.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIrtklnYNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFF-----YKFFQDFTQEPLVEIEGVSNMAFRHLIEFTY 75

                        90
                ....*....|....*....
gi 26333271  91 SGQIRLN-EDTIQDVVQAA 108
Cdd:cd18221  76 TAKLMVQgEEEANDVWKAA 94
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-126 6.84e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 48.50  E-value: 6.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgstykiELEGISVMVMR----- 83
Cdd:cd18222   6 PDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN-----------EMSTVSISVIKnptvf 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 26333271  84 -EILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 126
Cdd:cd18222  75 eQLLSFCYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILEG 118
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-62 7.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 48.34  E-value: 7.57e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNP 62
Cdd:cd18203   6 PGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNP 59
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 132-215 1.03e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 46.88  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18451   5 NCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAEERER 84


                ....
gi 26333271 212 HMKD 215
Cdd:cd18451  85 YFEE 88
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 1.73e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 47.17  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYkiELEGISVMVMREILDY 88
Cdd:cd18198   6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVY--EIDFVSPEALTALLEF 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18198  84 AYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 416-448 2.45e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.53  E-value: 2.45e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 26333271   416 AAMKKKIYAMGGGSYGKLFESVECYDPRTQQWT 448
Cdd:pfam01344   8 VVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWS 40
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-108 2.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 46.85  E-value: 2.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKLnYNPPKDDGSTyKIELEGISVMVMREILDYIFSGQIRL---NEDTIQDV 104
Cdd:cd18287  22 YSDVTFVVEEKRFPAHRVILAARSEYFRALL-YGGMRESQQS-EIELKDTNAEAFKALLKYIYTGRLTLtdlKEDVLLDV 99


                ....
gi 26333271 105 VQAA 108
Cdd:cd18287 100 LGLA 103
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 130-213 3.07e-06

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 46.07  E-value: 3.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 130 AENCIGIRDFAlhyCLHHVHYLAT---EYLETHFRDVSSTEEFLELSPQKLkEVISLEK--LNVGNERYVFEAVIRWIAH 204
Cdd:cd18502   3 PENCIGIRSFA---GRMNDSELLQkvdSYIQENIEEVAESKEFLKLPRLQI-EVILESNqeLESINERKLCQLVLEWVQR 78

                        90
                ....*....|....*...
gi 26333271 205 DVE---------MRKVHM 213
Cdd:cd18502  79 SIEeggldlddlTEKVHM 96
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 132-209 3.73e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 45.57  E-value: 3.73e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVS-STEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMR 209
Cdd:cd18482   5 NCAGILKFADAFDNRELKSKALAFIARNFQQLLaKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83
PLN02193 PLN02193
nitrile-specifier protein
 363-482 4.12e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.57  E-value: 4.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  363 RHNFGIVEIDGMLYILGGEDGDRELISMECY--DIYSKTWTKQPDLTMVRKIGCYA----AMKKKIYAMGGGSYGKLFES 436
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFTPNQPIDKHLYvfDLETRTWSISPATGDVPHLSCLGvrmvSIGSTLYVFGGRDASRQYNG 245

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 26333271  437 VECYDPRTQQWTAICPLKE----RRFGAVACGvAMELYVFGGVRSREDIQ 482
Cdd:PLN02193 246 FYSFDTTTNEWKLLTPVEEgptpRSFHSMAAD-EENVYVFGGVSATARLK 294
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-134 4.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 45.82  E-value: 4.19e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  29 CDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTND--VREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATA 79

                        90       100
                ....*....|....*....|....*.
gi 26333271 109 DLLLLTDLKTLCCEFLEGCIAAENCI 134
Cdd:cd18234  80 CLLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 4.34e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 46.03  E-value: 4.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELegISVMVMREILDY 88
Cdd:cd18328   6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDF--VTPEALSAILEF 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26333271  89 IFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18328  84 AYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-108 4.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 45.95  E-value: 4.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFR-EEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPpkddgSTYKIELEGISVMVMREILDY 88
Cdd:cd18226   3 QYNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNP-----NTDAVTLDHVSYSVFQHLLEF 77

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18226  78 LYTSEFFVYENEIPLVLEAA 97
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-94 4.81e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 45.63  E-value: 4.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynpPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFT---EKENESQSVFQLDFCEPDAFENVLNYIY 77


                ....
gi 26333271  91 SGQI 94
Cdd:cd18209  78 SSSL 81
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 5.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 45.70  E-value: 5.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPkddgsTYKIELEGISVMVMREILDYIF 90
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNP-----GQWCLGEGISPSTFKQLLDFVY 75

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNEDTIQDVVQAA 108
Cdd:cd18218  76 GESVEVQPGELRPLLEAA 93
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 28-108 5.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 45.03  E-value: 5.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQA 107
Cdd:cd18314   6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLT--GSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLML 83


                .
gi 26333271 108 A 108
Cdd:cd18314  84 A 84
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-132 8.67e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.38  E-value: 8.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  14 RLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYnpPKDDGSTYKIELEGISVMVMREILDYIFSGQ 93
Cdd:cd18343   7 RLAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEH--EMEESKKNRVEINDVDPEVFKEMMRFIYTGK 84

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26333271  94 IRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 132
Cdd:cd18343  85 APNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-132 8.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 45.22  E-value: 8.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  14 RLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYIFSGQ 93
Cdd:cd18345   4 RLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHE--MEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26333271  94 IRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 132
Cdd:cd18345  82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
PLN02193 PLN02193
nitrile-specifier protein
 327-474 9.65e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.41  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  327 LFVLGGQDENKQtLSSGEKYDPDANTWTALPPMHEA---RHNFGIVEIDGMLYILGGEDGDRELISMECYDIYSKTW--- 400
Cdd:PLN02193 231 LYVFGGRDASRQ-YNGFYSFDTTTNEWKLLTPVEEGptpRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhc 309

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26333271  401 TKQPDLTMVRKIGCYAAMKKKIYAMGGGSyGKLFESVECYDPRTQQWT-----AICPLKERRFGAVACGvaMELYVFGG 474
Cdd:PLN02193 310 STPGDSFSIRGGAGLEVVQGKVWVVYGFN-GCEVDDVHYYDPVQDKWTqvetfGVRPSERSVFASAAVG--KHIVIFGG 385
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 9.69e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 44.74  E-value: 9.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNynppKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYK----DTEDNIVFLDQSQVSADGFQKLLEFIY 76

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNEDTIQDVVQAA 108
Cdd:cd18217  77 TGNLNLDSWNVAEIHQAA 94
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 1.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 45.23  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVL---DGEEIPVQKNILAAASPYIRTKLNynPPKDDGSTYKIELE------GISVMV 81
Cdd:cd18241   6 HCSELSWRQNEQRKQGLFCDITLAFggaGGREFRAHRSVLAAATEYFTPLLS--GQFSESRSGRVEMRkwssepGPDPDT 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 26333271  82 MREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 133
Cdd:cd18241  84 VEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-107 1.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 44.39  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnyNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF--SSQEIWISSHVLELPDLKAEVFAEILNFIY 78

                        90
                ....*....|....*...
gi 26333271  91 SGQIRLNE-DTIQDVVQA 107
Cdd:cd18223  79 SSKVVVKRqETVTDLVAA 96
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-124 1.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 45.02  E-value: 1.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   2 EGSAVS--DPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNyNPPKDDGSTYkIELEGISV 79
Cdd:cd18246  11 DGHSIShnSKRHYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFT-NEMSESRQTH-VTLHDIDP 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26333271  80 MVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18246  89 QALEQLVQYAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFL 133
Kelch smart00612
Kelch domain;
375-418 1.70e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.16  E-value: 1.70e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 26333271    375 LYILGGEDGDRELISMECYDIYSKTWTKQPDLTMVRkigCYAAM 418
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPR---SGHGV 42
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-93 2.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 44.18  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   5 AVSDPQHAarLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMRE 84
Cdd:cd18344   2 AIKDPRHM--LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHE--MEERLKNPIEIHDLDPQVFKE 77


                ....*....
gi 26333271  85 ILDYIFSGQ 93
Cdd:cd18344  78 MMGFIYTGK 86
Kelch_4 pfam13418
Galactose oxidase, central domain;
314-359 2.43e-05

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 41.83  E-value: 2.43e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26333271   314 PRINHG-VLSAEGFLFVLGGQDENKQTLSSGEKYDPDANTWTALPPM 359
Cdd:pfam13418   1 PRAYHTsTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-108 2.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.63  E-value: 2.46e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271  33 LVLD--GEEIPVQKNILAAASPYIRTKLnynppkddgSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18275   7 LVIEvsGQRIRAHKSVLAAKSDYFRARL---------SRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGA 75
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 128-218 3.03e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 42.94  E-value: 3.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDvE 207
Cdd:cd18470   1 INVENCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-Q 79

                        90
                ....*....|.
gi 26333271 208 MRKVHMKDVMS 218
Cdd:cd18470  80 KRVKYAADLLS 90
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-132 4.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 43.55  E-value: 4.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  14 RLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDYIFSGQ 93
Cdd:cd18342   8 RLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHE--MEESKKNRVEINDVEPEVFKEMMCFIYTGK 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26333271  94 IRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAEN 132
Cdd:cd18342  86 APNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 128-205 4.19e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 42.41  E-value: 4.19e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHD 205
Cdd:cd18449   1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE 78
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 154-220 5.24e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 42.60  E-value: 5.24e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26333271 154 EYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVgNERYVFEAVIRWIAHDVEMrKVHMKDVMSAL 220
Cdd:cd14822  27 QFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEHNPDS-KEDAKEILEAV 91
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 5.38e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 43.28  E-value: 5.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDgsTYKIELEGISVMVMREILDY 88
Cdd:cd18323   4 PDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRD--LVCINNEIVTAPAFSLLLEF 81

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18323  82 MYEGRLSFNDTPVEDVLAAA 101
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-126 5.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 43.09  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtklnynppkDDGSTYKIELEGISVM----VMRE 84
Cdd:cd18220   6 PEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFR---------DHSALSTMSGLSISVIknpnVFEQ 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 26333271  85 ILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEG 126
Cdd:cd18220  77 LLSFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILES 118
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-94 7.15e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 42.52  E-value: 7.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgSTYKIELEGISVMVMREILDY 88
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD------NLIHLDQDMVSPTVFQQILDF 74


                ....*.
gi 26333271  89 IFSGQI 94
Cdd:cd18216  75 IYTGKL 80
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 128-209 8.79e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 41.82  E-value: 8.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVE 207
Cdd:cd18465   1 MSVETCLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPS 80


                ..
gi 26333271 208 MR 209
Cdd:cd18465  81 RR 82
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-125 8.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 42.52  E-value: 8.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTYK------IELEGISVMVM 82
Cdd:cd18327   6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFR-KLFTGGGGGSGDLGAgggqdvCELDFVGPEAL 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 26333271  83 REILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLE 125
Cdd:cd18327  85 GALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-94 1.07e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 42.38  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEAR--FCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18309   1 IGTTLEQDMEAFLESVGgdFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRY 80


                ....*.
gi 26333271  89 IFSGQI 94
Cdd:cd18309  81 IYYGDV 86
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-104 1.17e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.16  E-value: 1.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26333271  28 FC-DAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDV 104
Cdd:cd18283   1 YCtDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNL 78
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 1.60e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 41.72  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPkddGSTYKIELEG--ISVMVMREIL 86
Cdd:cd18956   4 PEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPA---GGRDTVRLNGdiVTAPAFGRLL 80

                        90       100
                ....*....|....*....|..
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18956  81 DFMYEGRLDLRSLPVEDVLAAA 102
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-65 1.71e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 41.73  E-value: 1.71e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKD 65
Cdd:cd18214   8 YGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSRE 62
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-108 1.82e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.04  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYnppkddGSTYKIELEGISVMVMRE-ILDYI 89
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLG------SNGPLPPLSLEVTPVGWEaVLTFA 74

                        90
                ....*....|....*....
gi 26333271  90 FSGQIRLNEDTIQDVVQAA 108
Cdd:cd18262  75 YTGVLGRNPATVGDILVAA 93
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-108 1.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 41.20  E-value: 1.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTK--LNYNppkddgstyKIELEG-ISVMVMREILDYIFS 91
Cdd:cd18208  12 VLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKllLGYS---------DIEIPSvVSVQSVQKLIDFMYS 82

                        90
                ....*....|....*..
gi 26333271  92 GQIRLNEDTIQDVVQAA 108
Cdd:cd18208  83 GVLRVSQSEALQILTAA 99
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 132-220 2.26e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 40.55  E-value: 2.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 132 NCIGIRDFALHYCLHHVHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDVEMRKV 211
Cdd:cd18460   5 NCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPKHRQH 84


                ....*....
gi 26333271 212 HMKDVMSAL 220
Cdd:cd18460  85 FWPELLQHV 93
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-100 2.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 41.12  E-value: 2.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnYNPPKDDGSTYKIEL--EGISVMVMREILDYIFSG 92
Cdd:cd18292   4 FLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVML-SNDWWSESKQSEIELveDPECAAVFEKFLRYLYTG 82


                ....*...
gi 26333271  93 QIRLNEDT 100
Cdd:cd18292  83 QISVNLET 90
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-97 2.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 41.18  E-value: 2.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKddgstyKIELEG-ISVMVMREILD 87
Cdd:cd18290   8 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA------VVELPAaVQPQSFQQILS 81

                        90
                ....*....|
gi 26333271  88 YIFSGQIRLN 97
Cdd:cd18290  82 FCYTGRLSMN 91
BACK_KLHL34 cd18473
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...
 128-218 2.94e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.


Pssm-ID: 350548  Cd Length: 106  Bit Score: 40.49  E-value: 2.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271 128 IAAENCIGIRDFALHYCLHHVHYLATEYLETHF-----RDVSSTeEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWI 202
Cdd:cd18473   1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLwrllaSDADDA-GLLELNLESLQAVLEADDIPRVKESRLLTLVLEWL 79

                        90
                ....*....|....*.
gi 26333271 203 AHDvEMRKVHMKDVMS 218
Cdd:cd18473  80 NQD-ESRLAYANALLS 94
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-101 3.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 40.41  E-value: 3.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTykIELEGISVMVMREILDYIF 90
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFK-KLFKKLEVDSSSV--IEIDFLRSDIFEEVLNYMY 77

                        90
                ....*....|.
gi 26333271  91 SGQIRLNEDTI 101
Cdd:cd18204  78 TAKISVKKEDV 88
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-124 3.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 40.29  E-value: 3.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  28 FCDAHLVLDGEE--IPVQKNILAAASPYIRTKLNYNppkDDGSTYKIELEGISVMVMREILDYIFSGQIRLNEDTIQDVV 105
Cdd:cd18231  14 LCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQN---KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVL 90

                        90
                ....*....|....*....
gi 26333271 106 QAADLLLLTDLKTLCCEFL 124
Cdd:cd18231  91 NAAAVLQMNDIAASCQELI 109
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 4.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 40.43  E-value: 4.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnynPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18277  10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRI---VGQADAELNITLPEEVTVKGFEPLIQFAY 86

                        90       100       110
                ....*....|....*....|....*....|....
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18277  87 TAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 16-134 4.71e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 40.18  E-value: 4.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  16 LRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIR 95
Cdd:cd18263   1 LQSIEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSV--VQLPTIPAKDLRLLISFAYSGILH 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 26333271  96 LNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCI 134
Cdd:cd18263  79 LSWENLFEATCTALQLQISGALALCLDFLQREISPARCL 117
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-55 4.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 40.22  E-value: 4.72e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIR 55
Cdd:cd18202   1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFR 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
324-369 4.75e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 38.04  E-value: 4.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26333271   324 EGFLFVLGGQDENKQTLSSG-EKYDPDANTWTALPPMHEARHNFGIV 369
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDlYVYDLDTNTWTQIGDLPPPRSGHSAT 47
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-108 5.92e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 39.94  E-value: 5.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  30 DAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIRL-NEDTIQDVVQAA 108
Cdd:cd18286  19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSE--ITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELLSLA 96
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-94 7.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 39.82  E-value: 7.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTYKIELegISVMVMREILDYIF 90
Cdd:cd18224   9 HPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQ-KLFLSTELDVARTYVVDF--ITPANFEKVLSFIY 85


                ....
gi 26333271  91 SGQI 94
Cdd:cd18224  86 TSEL 89
Kelch_6 pfam13964
Kelch motif;
410-457 7.80e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 7.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 26333271   410 RKIGCYAAMKKKIYAMGGGS-YGKLFESVECYDPRTQQWTAICPLKERR 457
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTnASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 8.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 39.63  E-value: 8.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtkLNYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18325   4 PDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH--LFYRDQLDKRDIVHLNSDIVTAPAFSLLLEF 81

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18325  82 MYEGKLEFSSLPVEDVLAAA 101
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 1.13e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 39.64  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRtkLNYNPPKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18324   4 PDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFH--LFYKDQLDKRDIVHLNSDIVTAPAFALLLEF 81

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18324  82 MYEGKLQFKDLPIEDVLAAA 101
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-101 1.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.39  E-value: 1.40e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26333271  30 DAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTykIELEGISVMVMREILDYIFSGQIRLN-EDTI 101
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNV--IEIDQYSYPVYYAFLRYLYTDQVDLPpEDAI 84
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 15-96 1.43e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 39.21  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSfrEEARFCDAHLVLD-GEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELE------GISVMVMREILD 87
Cdd:cd18310   7 LENLLDS--PDLFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRelipggIVGYDAFMLVLS 84


                ....*....
gi 26333271  88 YIFSGQIRL 96
Cdd:cd18310  85 YLYSGRLRL 93
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-124 1.46e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 38.88  E-value: 1.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKlnYNPPKDDGSTYKIEL--EGISVMVMREIL 86
Cdd:cd18196   2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRAL--FTVAEGDQTMNMIQLdsEVVTAEAFAALI 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 26333271  87 DYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18196  80 DMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 38.66  E-value: 1.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHaaRLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppKDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18279   1 PEC--RLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHE--MEESKKNRVEINDVDPEVFKEMMRF 76

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18279  77 IYTGKAPNLDKMADDLLAAA 96
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-108 2.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 38.27  E-value: 2.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLnynppkDDGSTYKIELEGISVMVMREILDY 88
Cdd:cd18225   4 PNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLL------DSTDTISIDASVVSPEEFALLLEM 77

                        90       100
                ....*....|....*....|
gi 26333271  89 IFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18225  78 VYTGKLPPGKHNFTKIISVA 97
Kelch_6 pfam13964
Kelch motif;
362-407 2.35e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.16  E-value: 2.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 26333271   362 ARHNFGIVEIDGMLYILGG-EDGDRELISMECYDIYSKTWTKQPDLT 407
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLP 47
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-108 2.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 37.93  E-value: 2.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  10 QHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIrtklnYNPPKDDGS--------TYKIELEGISVMv 81
Cdd:cd18215   1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLF-----YSIFTDQLKnnvsvinlDPEIEPEGFRIL- 74

                        90       100
                ....*....|....*....|....*..
gi 26333271  82 mreiLDYIFSGQIRLNEDTIQDVVQAA 108
Cdd:cd18215  75 ----LDFMYTSRLNLREGNIMAVMATA 97
PLN02193 PLN02193
nitrile-specifier protein
 314-447 2.74e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 40.71  E-value: 2.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  314 PRINHGVLSAEGFLFVLGGQDENKQTLSSG-EKYDPDANTWTALPPMHEARH----NFGIVEIDGMLYILGGEDGDRELI 388
Cdd:PLN02193 165 LRCSHGIAQVGNKIYSFGGEFTPNQPIDKHlYVFDLETRTWSISPATGDVPHlsclGVRMVSIGSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 26333271  389 SMECYDIYSKTW---TKQPDLTMVRKIGCYAAMKKKIYAMGGGSYGKLFESVECYDPRTQQW 447
Cdd:PLN02193 245 GFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-127 3.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 38.00  E-value: 3.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271   6 VSDPQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNppkddgSTYKIELEgiSVM---VM 82
Cdd:cd18227   3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLK------NSRRIVLP--DVMnprVF 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 26333271  83 REILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGC 127
Cdd:cd18227  75 ENILLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGN 119
Kelch smart00612
Kelch domain;
273-325 3.35e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 3.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 26333271    273 CIVTIGGeeRVSRKPTAAMRCmcplYDPNRQLWIELAPLSMPRINHGVLSAEG 325
Cdd:smart00612   1 KIYVVGG--FDGGQRLKSVEV----YDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 4.00e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 37.91  E-value: 4.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHLVLD----GEEIPVQKNILAAASPYIRtKLNYNPPKDDGSTYKIELEGISVMVMREILDYIF 90
Cdd:cd18211  12 LLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFK-EVFLNEKISDGKNTNVMLNEIYTADFASFLEFVY 90

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 26333271  91 SGQIRLNEDTIQDVVQAAdlllltdLKTLCCEFLEGC 127
Cdd:cd18211  91 TAKVEVEEDRVQRMLEIA-------EKLKCLDLSETC 120
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-124 6.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 37.23  E-value: 6.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKielEGISVMVMREILDYIF 90
Cdd:cd18278  14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLP---EEVTARGFGPLLQFAY 90

                        90       100       110
                ....*....|....*....|....*....|....
gi 26333271  91 SGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFL 124
Cdd:cd18278  91 TAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 165-201 7.02e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 36.19  E-value: 7.02e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 26333271 165 STEEFLELSPQKLKEVISLEKLNVgNERYVFEAVIRW 201
Cdd:cd18488  38 KSEGFTEIDYKTLESILRRETLNA-KESVVFEAALRW 73
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-53 8.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 36.36  E-value: 8.48e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 26333271   9 PQHAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPY 53
Cdd:cd18210   2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPY 46
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-108 8.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 36.70  E-value: 8.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  11 HAARLLRALSSFREEARFCDAHLVLDGEEIPVQKNILAAASPYIrtKLNYNPPKDDG-STYKieLEGISVMVMREILDYI 89
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYF--SMMFADEGEVGqSIYM--LEGMVAETFGALLEFI 81

                        90
                ....*....|....*....
gi 26333271  90 FSGQIRLNEDTIQDVVQAA 108
Cdd:cd18212  82 YTGCLQVGEKSLEQILATA 100
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 15-108 9.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 36.41  E-value: 9.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26333271  15 LLRALSSFREEARFCDAHL-VLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEgisVMVMREILDYIFSGQ 93
Cdd:cd18311   1 FLQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMPNELQ---ADAVVPVINFMYTGQ 77

                        90
                ....*....|....*
gi 26333271  94 IRLNEDTIQDVVQAA 108
Cdd:cd18311  78 LEFEEKSYGKLLRTA 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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