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Conserved domains on  [gi|270267429|ref|YP_003331128|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Proedromys liangshanensis]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.30e-42

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 133.13  E-value: 3.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.30e-42

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 133.13  E-value: 3.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.69e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 62.97  E-value: 1.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429   3 PAVINITLAFTFSLLGtLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 270267429  83 NTYGSDMVHNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 3.65e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 36.19  E-value: 3.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429 12 FTFSLLGtLMFRSHLMSTLLCLEGMMLS---LFIMATITPLNTHSMIMFpipITILVFAACEAAVGLALLAKISNTYGSD 88
Cdd:COG0713  14 FAIGLYG-VLTRRNLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                ....*...
gi 270267429 89 MVHNLNLL 96
Cdd:COG0713  90 DVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 3.30e-42

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 133.13  E-value: 3.30e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.65e-25

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 89.52  E-value: 6.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 7.40e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 86.94  E-value: 7.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 8.60e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 81.57  E-value: 8.60e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 270267429 81 ISNTYGSDMVHNLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.69e-14

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 62.97  E-value: 1.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429   3 PAVINITLAFTFSLLGtLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKIS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYG-LLLRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 270267429  83 NTYGSDMVHNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 6.07e-12

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 56.47  E-value: 6.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  1 MTPAVINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAK 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 270267429 81 ISNTYGSDMVHNLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 1.07e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 53.02  E-value: 1.07e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  9 TLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKISNTYGSD 88
Cdd:MTH00181  6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                ....*...
gi 270267429 89 MVHNLNLL 96
Cdd:MTH00181 86 HLLKFNLL 93
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 2.76e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 52.28  E-value: 2.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  8 ITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNThsMIMFPIPITILVFAACEAAVGLALLAKISNTYGS 87
Cdd:MTH00188  9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYM--EKELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                        90
                ....*....|.
gi 270267429 88 DMVHNLNLLQC 98
Cdd:MTH00188 87 DYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 1.66e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 50.23  E-value: 1.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  9 TLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMatITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKISNTYGSD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 270267429 89 MVHNLNLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 8-98 3.16e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.96  E-value: 3.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  8 ITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFpIPITILVFAACEAAVGLALLAKISNTYGS 87
Cdd:MTH00013  8 LSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNGM-LAIVLLTFGACEASLGLSLLVLMTRSYGN 86

                        90
                ....*....|.
gi 270267429 88 DMVHNLNLLQC 98
Cdd:MTH00013 87 DMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 3.65e-04

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 36.19  E-value: 3.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429 12 FTFSLLGtLMFRSHLMSTLLCLEGMMLS---LFIMATITPLNTHSMIMFpipITILVFAACEAAVGLALLAKISNTYGSD 88
Cdd:COG0713  14 FAIGLYG-VLTRRNLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGLAIIVALYRNRGTI 89


                ....*...
gi 270267429 89 MVHNLNLL 96
Cdd:COG0713  90 DVDDLNEL 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 12-92 5.22e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 35.90  E-value: 5.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429 12 FTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPitILVFAACEAAVGLALLAKISNTYGSDMVH 91
Cdd:MTH00162 11 FFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLLF--FLTFSVCEGALGLSILVSMIRSHGNDYFS 88


                .
gi 270267429 92 N 92
Cdd:MTH00162 89 S 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 12-97 5.79e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 35.78  E-value: 5.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429 12 FTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKISNTYGSDMVH 91
Cdd:MTH00180 13 FILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAVK 92


                ....*.
gi 270267429 92 NLNLLQ 97
Cdd:MTH00180 93 SLNLLR 98
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 5-97 4.52e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 33.50  E-value: 4.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270267429  5 VINITLAFTFSLLGTLMFRSHLMSTLLCLEGMMLSLFIMATITPLNTHSMIMFPIPITILVFAACEAAVGLALLAKISNT 84
Cdd:MTH00001  6 LILVVILFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRI 85

                        90
                ....*....|...
gi 270267429 85 YGSDMVHNLNLLQ 97
Cdd:MTH00001 86 RGTISLKSLNSLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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