|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
557-1109 |
1.40e-119 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 390.21 E-value: 1.40e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPShvsnIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR----IGMLEPRRLAARAAAERMAEELGEPVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVM-VLRPDLKIILMSAT 715
Cdd:COG1643 86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSAT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 716 LNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiakTRYvledgspyqrsskqLPGPDSARgkkgnsynelldELEQQIS 795
Cdd:COG1643 166 LDAERFARLLGDAPVIESSGRTYPVE----------VRY--------------RPLPADER------------DLEDAVA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 796 SSLRiqdskivkdsvpdqqlnvkelsvryngisksviktlssmdldkinldliEALLEwivngdhsyPPGAVLVFLPGLA 875
Cdd:COG1643 210 DAVR-------------------------------------------------EALAE---------EPGDILVFLPGER 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 876 EIKTLYDQLQsnalfnNRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMREKR 955
Cdd:COG1643 232 EIRRTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPR 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 956 YDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQyQLLDQQLPEIQR------IpLEQLCLRIKILEMF 1029
Cdd:COG1643 306 YDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRadlaslI-LELAAWGLGDPEDL 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1030 secrldlvfaRLIEPPRMESLHASKIRLQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLA 1109
Cdd:COG1643 384 ----------PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS 453
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
557-733 |
1.86e-117 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 361.08 E-value: 1.86e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATL 716
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 281427338 717 NAELFSCYFQDCPVLHI 733
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
555-1176 |
4.58e-87 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 308.62 E-value: 4.58e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 555 QKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASL--KGPPSHvsniicTQPRRISAISVAERVAQERAE 632
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRgsHGLIGH------TQPRRLAARTVAQRIAEELGT 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 633 RVGISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILM 712
Cdd:TIGR01967 138 PLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIIT 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 713 SATLNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiaktryvledgspyqrsskqlpgpdsargkkgnsynelldeleq 792
Cdd:TIGR01967 218 SATIDPERFSRHFNNAPIIEVSGRTYPVE--------------------------------------------------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 793 qissslriqdskivkdsvpdqqlnvkelsVRYNGISKsviktlssmDLDKINLDLIEALLEwIVNGDHSYPPGAVLVFLP 872
Cdd:TIGR01967 247 -----------------------------VRYRPLVE---------EQEDDDLDQLEAILD-AVDELFAEGPGDILIFLP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 873 GLAEIKTLYDQLqsnalfNNRRSKRCVIYPLHSSLSSDEQQSVFlKPPPGvTKIIISTNIAETSITIDDVVYVIDSGKMR 952
Cdd:TIGR01967 288 GEREIRDAAEIL------RKRNLRHTEILPLYARLSNKEQQRVF-QPHSG-RRIVLATNVAETSLTVPGIHYVIDTGTAR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 953 EKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQYQLLDQQlPEIQRIPLEQLCLRIKILemfsec 1032
Cdd:TIGR01967 360 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTD-PEILRTNLASVILQMLAL------ 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1033 RL-DLVFARLIEPPRMESLHASKIRLQDLGALTKEE---KLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASL 1108
Cdd:TIGR01967 433 RLgDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASAL 512
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281427338 1109 AFKSPFVCPWDKKEEANKKKQEFATANSDHLALLQAYQAWSSVIKESSRAAYQ-YCRDNFLS---VRVLQEI 1176
Cdd:TIGR01967 513 SIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQALSANQFRnACRKQYLNylrVREWQDI 584
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
557-1176 |
2.05e-79 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 285.80 E-value: 2.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDAS--LKGPPSHvsniicTQPRRISAISVAERVAQERAERV 634
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgVKGLIGH------TQPRRLAARTVANRIAEELETEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 635 GISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:PRK11131 147 GGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSA 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 715 TLNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiakTRY--VLEDGSPYQRsskqlpgpdsargkkgnsynellDELEq 792
Cdd:PRK11131 227 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRYrpIVEEADDTER-----------------------DQLQ- 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 793 qissslriqdskivkdsvpdqqlnvkelsvrynGIsksviktlssmdldkinLDLIEALlewivnGDHSypPGAVLVFLP 872
Cdd:PRK11131 273 ---------------------------------AI-----------------FDAVDEL------GREG--PGDILIFMS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 873 GLAEIKTLYDQLQSNALfnnrrsKRCVIYPLHSSLSSDEQQSVFlkPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMR 952
Cdd:PRK11131 295 GEREIRDTADALNKLNL------RHTEILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTAR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 953 EKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHY--QYQLLDqqlPEIQRIPLEQLclrikILEMFS 1030
Cdd:PRK11131 367 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFlsRPEFTD---PEILRTNLASV-----ILQMTA 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1031 ECRLDLVFARLIEPPRMESLHASKIRLQDLGALTKEE-----KLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIA 1105
Cdd:PRK11131 439 LGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIIT 518
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281427338 1106 ASLAFKSPFVCPWDKKEEANKKKQEFATANSDHLALLQAYQAWSSVIKESSRAAY-QYCRDNFLS---VRVLQEI 1176
Cdd:PRK11131 519 SALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKALSSNQFrRLCRTDYLNylrVREWQDI 593
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
246-424 |
2.66e-49 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 170.07 E-value: 2.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 246 EECLERRQEEAFVLQSICGEKFVERIPNKVWTVGLEMDYLtkrlqkpkkkdsdkdlfqqmprnickyymkgencrfgskc 325
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL---------------------------------------- 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 326 rfkheapkqnfkdeshlcangnnnCLYELEVRFPKDNKYPYQAPLLAFYSVNENLSMGCRLHITEYLYEKALNIAQTSDP 405
Cdd:cd23825 41 ------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALELAEDGEP 96
|
170
....*....|....*....
gi 281427338 406 AVYTLVSCLEDEDEIVKLL 424
Cdd:cd23825 97 VVFSLVSLLEDEEEILELL 115
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
563-743 |
1.72e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 105.27 E-value: 1.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 563 QDQILE-LLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVsniICTQPRRISAISVAERVAQERAERVGISVGY- 640
Cdd:smart00487 13 QKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRV---LVLVPTRELAEQWAEELKKLGPSLGLKVVGLy 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 641 -----QIRLESVKSAATRLLYCTTGVLLRRLE-GDTTLQNVTHVVVDEVHeRTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:smart00487 90 ggdskREQLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKNVQLLLLSA 168
|
170 180 190
....*....|....*....|....*....|...
gi 281427338 715 TL--NAELFSCYFQDCPVLHIPGRT--FPVDQY 743
Cdd:smart00487 169 TPpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1057-1141 |
1.72e-23 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 96.15 E-value: 1.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1057 LQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLAFKSPFV-------------CPWDKKEE 1123
Cdd:pfam04408 5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVqpnfldprsaakaARRRRRAA 84
|
90 100
....*....|....*....|
gi 281427338 1124 ANKKKQEFA--TANSDHLAL 1141
Cdd:pfam04408 85 DEKARAKFArlDLEGDHLTL 104
|
|
| UBA_DHX57 |
cd14317 |
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ... |
185-222 |
1.44e-16 |
|
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.
Pssm-ID: 270502 Cd Length: 38 Bit Score: 74.27 E-value: 1.44e-16
10 20 30
....*....|....*....|....*....|....*...
gi 281427338 185 ISPFAVGKLSRYGFDKERCMNTLRSHDSDVGVSLEYLL 222
Cdd:cd14317 1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
|
|
| zf-CCCH_4 |
pfam18044 |
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ... |
308-329 |
2.24e-05 |
|
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.
Pssm-ID: 465626 Cd Length: 22 Bit Score: 42.19 E-value: 2.24e-05
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
309-329 |
1.39e-04 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 39.92 E-value: 1.39e-04
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
345-417 |
4.44e-04 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 41.16 E-value: 4.44e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281427338 345 NGNNNCLYELEVRFPKDnkYPYQAPLLAFySVNENLSMGCRLHITEYLYEKAlnIAQTSDPAVYTLVSCLEDE 417
Cdd:pfam05773 43 DSSHLPPLVLKFTLPED--YPDEPPKISL-SSPWNLSDEQVLSLLEELEELA--EENLGEVMIFELIEWLQEN 110
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
557-1109 |
1.40e-119 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 390.21 E-value: 1.40e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPShvsnIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGR----IGMLEPRRLAARAAAERMAEELGEPVGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVM-VLRPDLKIILMSAT 715
Cdd:COG1643 86 TVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSAT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 716 LNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiakTRYvledgspyqrsskqLPGPDSARgkkgnsynelldELEQQIS 795
Cdd:COG1643 166 LDAERFARLLGDAPVIESSGRTYPVE----------VRY--------------RPLPADER------------DLEDAVA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 796 SSLRiqdskivkdsvpdqqlnvkelsvryngisksviktlssmdldkinldliEALLEwivngdhsyPPGAVLVFLPGLA 875
Cdd:COG1643 210 DAVR-------------------------------------------------EALAE---------EPGDILVFLPGER 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 876 EIKTLYDQLQsnalfnNRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMREKR 955
Cdd:COG1643 232 EIRRTAEALR------GRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPR 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 956 YDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQyQLLDQQLPEIQR------IpLEQLCLRIKILEMF 1029
Cdd:COG1643 306 YDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRadlaslI-LELAAWGLGDPEDL 383
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1030 secrldlvfaRLIEPPRMESLHASKIRLQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLA 1109
Cdd:COG1643 384 ----------PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLS 453
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
557-733 |
1.86e-117 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 361.08 E-value: 1.86e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATL 716
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 281427338 717 NAELFSCYFQDCPVLHI 733
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
574-733 |
1.21e-87 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 279.73 E-value: 1.21e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 574 QVLVVSGMTGCGKTTQIPQFILDASLKGPPSHvsNIICTQPRRISAISVAERVAQERAERVGISVGYQIRLESVKSAATR 653
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKG--RIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 654 LLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17917 80 IKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
555-1176 |
4.58e-87 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 308.62 E-value: 4.58e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 555 QKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASL--KGPPSHvsniicTQPRRISAISVAERVAQERAE 632
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRgsHGLIGH------TQPRRLAARTVAQRIAEELGT 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 633 RVGISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILM 712
Cdd:TIGR01967 138 PLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIIT 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 713 SATLNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiaktryvledgspyqrsskqlpgpdsargkkgnsynelldeleq 792
Cdd:TIGR01967 218 SATIDPERFSRHFNNAPIIEVSGRTYPVE--------------------------------------------------- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 793 qissslriqdskivkdsvpdqqlnvkelsVRYNGISKsviktlssmDLDKINLDLIEALLEwIVNGDHSYPPGAVLVFLP 872
Cdd:TIGR01967 247 -----------------------------VRYRPLVE---------EQEDDDLDQLEAILD-AVDELFAEGPGDILIFLP 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 873 GLAEIKTLYDQLqsnalfNNRRSKRCVIYPLHSSLSSDEQQSVFlKPPPGvTKIIISTNIAETSITIDDVVYVIDSGKMR 952
Cdd:TIGR01967 288 GEREIRDAAEIL------RKRNLRHTEILPLYARLSNKEQQRVF-QPHSG-RRIVLATNVAETSLTVPGIHYVIDTGTAR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 953 EKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQYQLLDQQlPEIQRIPLEQLCLRIKILemfsec 1032
Cdd:TIGR01967 360 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTD-PEILRTNLASVILQMLAL------ 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1033 RL-DLVFARLIEPPRMESLHASKIRLQDLGALTKEE---KLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASL 1108
Cdd:TIGR01967 433 RLgDIAAFPFIEAPDPRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASAL 512
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281427338 1109 AFKSPFVCPWDKKEEANKKKQEFATANSDHLALLQAYQAWSSVIKESSRAAYQ-YCRDNFLS---VRVLQEI 1176
Cdd:TIGR01967 513 SIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIEEQRQALSANQFRnACRKQYLNylrVREWQDI 584
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
557-1176 |
2.05e-79 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 285.80 E-value: 2.05e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDAS--LKGPPSHvsniicTQPRRISAISVAERVAQERAERV 634
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGrgVKGLIGH------TQPRRLAARTVANRIAEELETEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 635 GISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:PRK11131 147 GGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSA 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 715 TLNAELFSCYFQDCPVLHIPGRTFPVDqyfledaiakTRY--VLEDGSPYQRsskqlpgpdsargkkgnsynellDELEq 792
Cdd:PRK11131 227 TIDPERFSRHFNNAPIIEVSGRTYPVE----------VRYrpIVEEADDTER-----------------------DQLQ- 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 793 qissslriqdskivkdsvpdqqlnvkelsvrynGIsksviktlssmdldkinLDLIEALlewivnGDHSypPGAVLVFLP 872
Cdd:PRK11131 273 ---------------------------------AI-----------------FDAVDEL------GREG--PGDILIFMS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 873 GLAEIKTLYDQLQSNALfnnrrsKRCVIYPLHSSLSSDEQQSVFlkPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMR 952
Cdd:PRK11131 295 GEREIRDTADALNKLNL------RHTEILPLYARLSNSEQNRVF--QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTAR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 953 EKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHY--QYQLLDqqlPEIQRIPLEQLclrikILEMFS 1030
Cdd:PRK11131 367 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFlsRPEFTD---PEILRTNLASV-----ILQMTA 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1031 ECRLDLVFARLIEPPRMESLHASKIRLQDLGALTKEE-----KLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIA 1105
Cdd:PRK11131 439 LGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIIT 518
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 281427338 1106 ASLAFKSPFVCPWDKKEEANKKKQEFATANSDHLALLQAYQAWSSVIKESSRAAY-QYCRDNFLS---VRVLQEI 1176
Cdd:PRK11131 519 SALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKALSSNQFrRLCRTDYLNylrVREWQDI 593
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
565-1165 |
1.30e-78 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 276.65 E-value: 1.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 565 QILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGppshvSNIICTQPRRISAISVAERVAQERAERVGISVGYQIRL 644
Cdd:TIGR01970 9 ALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAPGIG-----GKIIMLEPRRLAARSAAQRLASQLGEAVGQTVGYRVRG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 645 ESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVM-VLRPDLKIILMSATLNAELFSC 723
Cdd:TIGR01970 84 ENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQsSLREDLKILAMSATLDGERLSS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 724 YFQDCPVLHIPGRTFPVDqyfledaiakTRYvledgspyqrsskqLPGPDSARgkkgnsyneLLDELEQQISSSLRIQds 803
Cdd:TIGR01970 164 LLPDAPVVESEGRSFPVE----------IRY--------------LPLRGDQR---------LEDAVSRAVEHALASE-- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 804 kivkdsvpdqqlnvkelsvryngisksviktlssmdldkinldlieallewivngdhsypPGAVLVFLPGLAEIKTLYDQ 883
Cdd:TIGR01970 209 ------------------------------------------------------------TGSILVFLPGQAEIRRVQEQ 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 884 LQSnalfnnRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMREKRYDPGKSME 963
Cdd:TIGR01970 229 LAE------RLDSDVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGIT 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 964 SLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQyQLLDQQLPEIQRIPLEQLCLriKILEMFSECRLDLvfaRLIE 1043
Cdd:TIGR01970 303 RLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQ-RLPAQDEPEILQADLSGLAL--ELAQWGAKDPSDL---RWLD 376
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1044 PPRMESLHASKIRLQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLafkspfvcpwdkkEE 1123
Cdd:TIGR01970 377 APPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALL-------------EE 443
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 281427338 1124 ANKKKQefatANSD-HLALLQAYQAWSSVIKESSRAAYQYCRD 1165
Cdd:TIGR01970 444 RGLPRQ----GGADlMNRLHRLQQGRQGRGQRAQQLAKKLRRR 482
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
836-994 |
4.12e-76 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 248.60 E-value: 4.12e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 836 SSMDLDKINLDLIEALLEWIvngDHSYPPGAVLVFLPGLAEIKTLYDQLQSNALFNNrrSKRCVIYPLHSSLSSDEQQSV 915
Cdd:cd18791 18 SSEKEDPDYVDAAVRLILQI---HRTEEPGDILVFLPGQEEIERLCELLREELLSPD--LGKLLVLPLHSSLPPEEQQRV 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281427338 916 FLKPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMREKRYDPGKSMESLEDTWVSRANAMQRKGRAGRVASGVCFHLF 994
Cdd:cd18791 93 FEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
557-733 |
3.95e-69 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 229.34 E-value: 3.95e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 --SVGYQIRLESVKS-AATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMS 713
Cdd:cd17981 81 gnSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 281427338 714 ATLNAELFSCYFQDCPVLHI 733
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
557-733 |
8.10e-67 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 222.78 E-value: 8.10e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLK-GPPSHvsnIICTQPRRISAISVAERVAQERAERVG 635
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYAnGIPCR---IFCTQPRRLAAIAVAERVAAERGEKIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 636 ISVGYQIRLESVKSAATRLLYCTTGVLLRRL-EGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:cd17987 78 QTVGYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157
|
170
....*....|....*....
gi 281427338 715 TLNAELFSCYFQDCPVLHI 733
Cdd:cd17987 158 ALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
557-733 |
9.42e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 219.79 E-value: 9.42e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFIL-DASLKGPPSHVSNIICTQPRRISAISVAERVAQERAERVG 635
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLeDLLLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 636 IS-----VGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKII 710
Cdd:cd17975 81 PGgknslCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 281427338 711 LMSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
546-733 |
1.14e-64 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 218.94 E-value: 1.14e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 546 NYQSMLEERQKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIICTQPRRISAISVAER 625
Cdd:cd17972 48 NLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECNIVVTQPRRISAVSVAER 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 626 VAQERAERVGISVGYQIRLESV-KSAATRLLYCTTGVLLRRLEgdTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLR 704
Cdd:cd17972 128 VAFERGEEVGKSCGYSVRFESVlPRPHASILFCTVGVLLRKLE--AGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAY 205
|
170 180
....*....|....*....|....*....
gi 281427338 705 PDLKIILMSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17972 206 PDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
568-1109 |
5.17e-63 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 230.58 E-value: 5.17e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 568 ELLSKY----QVLVvSGMTGCGKTTQIP-QFILDASLKGppshvsNIICTQPRRISAISVAERVAQERAERVGISVGYQI 642
Cdd:PRK11664 12 ELLTALktapQVLL-KAPTGAGKSTWLPlQLLQHGGING------KIIMLEPRRLAARNVAQRLAEQLGEKPGETVGYRM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 643 RLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVM-VLRPDLKIILMSATLNAELF 721
Cdd:PRK11664 85 RAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQqGLRDDLKLLIMSATLDNDRL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 722 SCYFQDCPVLHIPGRTFPVDqyfledaiakTRYvledgspyqrsskqlpgpdsargkkgnsynelldeleQQISSSLRIQ 801
Cdd:PRK11664 165 QQLLPDAPVIVSEGRSFPVE----------RRY-------------------------------------QPLPAHQRFD 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 802 DSkivkdsvpdqqlnvkelsvryngisksVIKTLSSMdLDKinldlieallewivngdhsyPPGAVLVFLPGLAEIKTLY 881
Cdd:PRK11664 198 EA---------------------------VARATAEL-LRQ--------------------ESGSLLLFLPGVGEIQRVQ 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 882 DQLQsnalfnNRRSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNIAETSITIDDVVYVIDSGKMREKRYDPGKS 961
Cdd:PRK11664 230 EQLA------SRVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTG 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 962 MESLEDTWVSRANAMQRKGRAGRVASGVCFHLFTSHHYQyQLLDQQLPEIQRIPLEQLclrikILEMFS-ECRlDLVFAR 1040
Cdd:PRK11664 304 LTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAE-RAAAQSEPEILHSDLSGL-----LLELLQwGCH-DPAQLS 376
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 281427338 1041 LIEPPRMESLHASKIRLQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRclDPALTIAASLA 1109
Cdd:PRK11664 377 WLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLA 443
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
557-733 |
3.91e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 206.14 E-value: 3.91e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLkgppshvSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGF-------RHIACTQPRRIACISLAKRVAFESLNQYGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATL 716
Cdd:cd17979 74 KVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATI 153
|
170
....*....|....*..
gi 281427338 717 NAELFSCYFQDCPVLHI 733
Cdd:cd17979 154 NIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
557-733 |
5.19e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 206.18 E-value: 5.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLES-VKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSAT 715
Cdd:cd17976 81 NVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 281427338 716 LNAELFSCYFQDCPVLHI 733
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
546-733 |
4.05e-59 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 201.10 E-value: 4.05e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 546 NYQSMLEERQKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPShvSNIICTQPRRISAISVAER 625
Cdd:cd17973 2 RYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPK--KLVACTQPRRVAAMSVAQR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 626 VAQERAERVGISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRP 705
Cdd:cd17973 80 VAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRP 159
|
170 180
....*....|....*....|....*...
gi 281427338 706 DLKIILMSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17973 160 DLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
557-733 |
2.76e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 187.18 E-value: 2.76e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGppshVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFAR----GGMIGITQPRRVAAVSVAKRVAEEMGVELGQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLR-----PDLKIIL 711
Cdd:cd17978 77 LVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVII 156
|
170 180
....*....|....*....|..
gi 281427338 712 MSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17978 157 MSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
557-725 |
8.94e-53 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 182.70 E-value: 8.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKgpPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDvmVLRPD---LKIILMS 713
Cdd:cd17988 79 LVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRR--LLRTNsrhVKIILMS 156
|
170
....*....|..
gi 281427338 714 ATLNAELFSCYF 725
Cdd:cd17988 157 ATISCKEFADYF 168
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
557-733 |
1.01e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 179.62 E-value: 1.01e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDAslkGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEA---GYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATL 716
Cdd:cd17974 78 EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATM 157
|
170
....*....|....*..
gi 281427338 717 NAELFSCYFQDCPVLHI 733
Cdd:cd17974 158 DAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
552-734 |
1.28e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 176.52 E-value: 1.28e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 552 EERQKLPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLkgppSHVSNIICTQPRRISAISVAERVAQERA 631
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGY----TSRGKIGCTQPRRVAAMSVAKRVAEEFG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 632 ERVGISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIIL 711
Cdd:cd17971 77 CCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIV 156
|
170 180
....*....|....*....|...
gi 281427338 712 MSATLNAELFSCYFQDCPVLHIP 734
Cdd:cd17971 157 TSATLDAVKFSQYFYEAPIFTIP 179
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
246-424 |
2.66e-49 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 170.07 E-value: 2.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 246 EECLERRQEEAFVLQSICGEKFVERIPNKVWTVGLEMDYLtkrlqkpkkkdsdkdlfqqmprnickyymkgencrfgskc 325
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYL---------------------------------------- 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 326 rfkheapkqnfkdeshlcangnnnCLYELEVRFPKDNKYPYQAPLLAFYSVNENLSMGCRLHITEYLYEKALNIAQTSDP 405
Cdd:cd23825 41 ------------------------PWFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITERLMEEALELAEDGEP 96
|
170
....*....|....*....
gi 281427338 406 AVYTLVSCLEDEDEIVKLL 424
Cdd:cd23825 97 VVFSLVSLLEDEEEILELL 115
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
557-726 |
6.07e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 171.88 E-value: 6.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDAslkGPPSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEA---GWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLES-VKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSAT 715
Cdd:cd17980 78 EVGYCIRFDDcTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASAT 157
|
170
....*....|.
gi 281427338 716 LNAELFSCYFQ 726
Cdd:cd17980 158 LDAEKFRDFFN 168
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
557-733 |
1.20e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 159.16 E-value: 1.20e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLkgppsHVSNII-CTQPRRISAISVAERVAQERAERVG 635
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGY-----TDYGMIgCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 636 ISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSAT 715
Cdd:cd17983 76 EEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155
|
170
....*....|....*...
gi 281427338 716 LNAELFSCYFQDCPVLHI 733
Cdd:cd17983 156 MDADKFADFFGNVPIFTI 173
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
557-733 |
6.82e-44 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 157.23 E-value: 6.82e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASL--KGPPSHvsniicTQPRRISAISVAERVAQERAERV 634
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRgiRGLIGH------TQPRRLAARSVAERIAEELKTEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 635 GISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:cd17989 75 GGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSA 154
|
170
....*....|....*....
gi 281427338 715 TLNAELFSCYFQDCPVLHI 733
Cdd:cd17989 155 TIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
564-731 |
2.42e-42 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 152.49 E-value: 2.42e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 564 DQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPpshvSNIICTQPRRISAISVAERVAQERAERVGISVGYQIR 643
Cdd:cd17990 8 PALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAG----GKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 644 LESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVM-VLRPDLKIILMSATLNAELFS 722
Cdd:cd17990 84 GESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQqLLRDDLRLLAMSATLDGDGLA 163
|
....*....
gi 281427338 723 CYFQDCPVL 731
Cdd:cd17990 164 ALLPEAPVV 172
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
557-722 |
5.92e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 143.65 E-value: 5.92e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSNII-CTQPRRISAISVAERVAQERAErVG 635
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 636 ISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPD--------- 706
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170
....*....|....*..
gi 281427338 707 -LKIILMSATLNAELFS 722
Cdd:cd17982 160 pLKLVIMSATLRVEDFT 176
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
557-733 |
2.00e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 141.53 E-value: 2.00e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLkgppSHVSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGF----SQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRP-----DLKIIL 711
Cdd:cd17984 77 KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLKVVV 156
|
170 180
....*....|....*....|..
gi 281427338 712 MSATLNAELFSCYFQDCPVLHI 733
Cdd:cd17984 157 MSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
557-733 |
2.37e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 124.17 E-value: 2.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHvSNIICTQPRRISAISVAERVAQERAERVGI 636
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQH-GVVVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 637 SVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSATL 716
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159
|
170
....*....|....*..
gi 281427338 717 NAELFSCYFQDCPVLHI 733
Cdd:cd17977 160 LSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
557-733 |
3.27e-28 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 112.30 E-value: 3.27e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 557 LPAWQKQDQILELL-SKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVSnIICTQPRRISAISVAERVAQERAERVG 635
Cdd:cd17986 1 LPIWAAKFTFLEQLeSPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQKGQ-VTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 636 ISVGYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHERTEESDFLLLVLKDVMVLRPDLKIILMSAT 715
Cdd:cd17986 80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSP 159
|
170
....*....|....*...
gi 281427338 716 LNAELFSCYFQDCPVLHI 733
Cdd:cd17986 160 ALEPKLRAFWGNPPVVHV 177
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
563-743 |
1.72e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 105.27 E-value: 1.72e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 563 QDQILE-LLSKYQVLVVSGMTGCGKTTQIPQFILDASLKGPPSHVsniICTQPRRISAISVAERVAQERAERVGISVGY- 640
Cdd:smart00487 13 QKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRV---LVLVPTRELAEQWAEELKKLGPSLGLKVVGLy 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 641 -----QIRLESVKSAATRLLYCTTGVLLRRLE-GDTTLQNVTHVVVDEVHeRTEESDFLLLVLKDVMVLRPDLKIILMSA 714
Cdd:smart00487 90 ggdskREQLRKLESGKTDILVTTPGRLLDLLEnDKLSLSNVDLVILDEAH-RLLDGGFGDQLEKLLKLLPKNVQLLLLSA 168
|
170 180 190
....*....|....*....|....*....|...
gi 281427338 715 TL--NAELFSCYFQDCPVLHIPGRT--FPVDQY 743
Cdd:smart00487 169 TPpeEIENLLELFLNDPVFIDVGFTplEPIEQF 201
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
1060-1142 |
8.12e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 99.26 E-value: 8.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1060 LGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLAFKSPFvcPWDKKEEANKKKQEFATANSDHL 1139
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHL 79
|
...
gi 281427338 1140 ALL 1142
Cdd:smart00847 80 TLL 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
1057-1141 |
1.72e-23 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 96.15 E-value: 1.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 1057 LQDLGALTKEEKLTPLGYHLASLPVDVRIGKLMLFGAIFRCLDPALTIAASLAFKSPFV-------------CPWDKKEE 1123
Cdd:pfam04408 5 LYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVqpnfldprsaakaARRRRRAA 84
|
90 100
....*....|....*....|
gi 281427338 1124 ANKKKQEFA--TANSDHLAL 1141
Cdd:pfam04408 85 DEKARAKFArlDLEGDHLTL 104
|
|
| UBA_DHX57 |
cd14317 |
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, ... |
185-222 |
1.44e-16 |
|
UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins; DHX57, also called DEAH box protein 57, is a multi-domain protein with an N-terminal ubiquitin-association (UBA) domain, a Zinc finger domain, a RWD domain, a DEAD-like helicase domain and two C-terminal helicase associated domains. Although the precise biological function of DHX57 remains unclear, it may function as a putative ATP-dependent RNA helicase.
Pssm-ID: 270502 Cd Length: 38 Bit Score: 74.27 E-value: 1.44e-16
10 20 30
....*....|....*....|....*....|....*...
gi 281427338 185 ISPFAVGKLSRYGFDKERCMNTLRSHDSDVGVSLEYLL 222
Cdd:cd14317 1 VSPFAVGKLSRYGFDKERCIQALRSNDGDIGAALEHLL 38
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
563-988 |
2.80e-15 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 80.79 E-value: 2.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 563 QDQILELLSKYQVLVVSGMTGCGKTTQIPQFIL----------DASLKGPPSHVSNIICTQPR----RISAISVAERVAQ 628
Cdd:PHA02653 169 QLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfdNLDKIDPNFIERPIVLSLPRvalvRLHSITLLKSLGF 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 629 ERAERVGISVGY-QIRLESVKSA--ATRLLYCTTGVLLrrlegdTTLQNVTHVVVDEVHERTEESDFLLLVL-KDVMVLR 704
Cdd:PHA02653 249 DEIDGSPISLKYgSIPDELINTNpkPYGLVFSTHKLTL------NKLFDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIR 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 705 pdlKIILMSATL--NAELFSCYFQDCPVLHIPGRT-FPVdqyfledaiaKTRYVLEDGSPYQRSSkqlpgpdsargkkgn 781
Cdd:PHA02653 323 ---SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPI----------SEVYVKNKYNPKNKRA--------------- 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 782 sYNElldELEQQISSSLriqdskivKDSVPDQQlnvkelsvryngisKSVIktlssmdldkinldlieallewivngdhs 861
Cdd:PHA02653 375 -YIE---EEKKNIVTAL--------KKYTPPKG--------------SSGI----------------------------- 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 862 yppgavlVFLPGLAEIkTLYDQLQSnalfnnRRSKRCVIYPLHSSLSSDEQ--QSVFLKPPPgvtKIIISTNIAETSITI 939
Cdd:PHA02653 400 -------VFVASVSQC-EEYKKYLE------KRLPIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTPYLESSVTI 462
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 281427338 940 DDVVYVIDSGKMREKRYDPGKSMesledtWVSRANAMQRKGRAGRVASG 988
Cdd:PHA02653 463 RNATHVYDTGRVYVPEPFGGKEM------FISKSMRTQRKGRVGRVSPG 505
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
894-984 |
1.24e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 69.93 E-value: 1.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 894 RSKRCVIYPLHSSLSSDEQQSVFLKPPPGVTKIIISTNIAETSITIDDVVYVIDSgkmrekrydpgksmesleDTWVSRA 973
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIY------------------DLPWSPA 69
|
90
....*....|.
gi 281427338 974 NAMQRKGRAGR 984
Cdd:smart00490 70 SYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
846-985 |
2.62e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 69.93 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 846 DLIEALLEWIvngdHSYPPGAVLVFLPGlaeiktlYDQLQSNALFNNRRSKrcvIYPLHSSLSSDEQQSVFLKPPPGVTK 925
Cdd:pfam00271 1 EKLEALLELL----KKERGGKVLIFSQT-------KKTLEAELLLEKEGIK---VARLHGDLSQEEREEILEDFRKGKID 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 926 IIISTNIAETSITIDDVVYVIDsgkmrekrYDPGKSMESLedtwvsranaMQRKGRAGRV 985
Cdd:pfam00271 67 VLVATDVAERGLDLPDVDLVIN--------YDLPWNPASY----------IQRIGRAGRA 108
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
582-715 |
5.72e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 67.43 E-value: 5.72e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 582 TGCGKTTQIPQFILDASL-KGPPSHVsniicTQPRRISAISVAERVAQERAE--RVGISVGYQiRLESVKSAATR---LL 655
Cdd:cd00046 10 TGSGKTLAALLAALLLLLkKGKKVLV-----LVPTKALALQTAERLRELFGPgiRVAVLVGGS-SAEEREKNKLGdadII 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281427338 656 YCTTGVLLRRLEGDT--TLQNVTHVVVDEVHERTEESDFLLLVLKDVMVL-RPDLKIILMSAT 715
Cdd:cd00046 84 IATPDMLLNLLLREDrlFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
563-720 |
1.08e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 67.27 E-value: 1.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 563 QDQILELLSKYQVLVVSGMTGCGKTT--QIPqfILDAsLKGPPSHVSnIICTQPRRISAISVAERvAQERAERVGISV-- 638
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEA-LDKLDNGPQ-ALVLAPTRELAEQIYEE-LKKLGKGLGLKVas 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 639 ---GYQIRLESVKSAATRLLYCTTGVLLRRLEGDTTLQNVTHVVVDEVHeRTEESDFLLLVLKDVMVLRPDLKIILMSAT 715
Cdd:pfam00270 79 llgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKRQILLLSAT 157
|
....*
gi 281427338 716 LNAEL 720
Cdd:pfam00270 158 LPRNL 162
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
576-734 |
2.29e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 54.96 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 576 LVVSGMTGCGKTTQIPQFILDASLKGPpshvSNIICTQPRRisAIsVAERVA--QERAERVGISVGYQIRLESV---KSA 650
Cdd:cd17921 20 VLVSAPTSSGKTLIAELAILRALATSG----GKAVYIAPTR--AL-VNQKEAdlRERFGPLGKNVGLLTGDPSVnklLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 651 ATRLLYCTT---GVLLRRLEGDTtLQNVTHVVVDEVH--ERTEESDFLLLVLKDVMVLRPDLKIILMSATL-NAELFSCY 724
Cdd:cd17921 93 EADILVATPeklDLLLRNGGERL-IQDVRLVVVDEAHliGDGERGVVLELLLSRLLRINKNARFVGLSATLpNAEDLAEW 171
|
170
....*....|
gi 281427338 725 FQDCPVLHIP 734
Cdd:cd17921 172 LGVEDLIRFD 181
|
|
| zf-CCCH_4 |
pfam18044 |
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ... |
308-329 |
2.24e-05 |
|
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.
Pssm-ID: 465626 Cd Length: 22 Bit Score: 42.19 E-value: 2.24e-05
|
| zf_CCCH_4 |
pfam18345 |
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ... |
310-329 |
2.55e-05 |
|
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.
Pssm-ID: 465719 [Multi-domain] Cd Length: 19 Bit Score: 42.02 E-value: 2.55e-05
|
| zf-CCCH |
pfam00642 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
307-329 |
3.28e-05 |
|
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 41.80 E-value: 3.28e-05
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
555-725 |
1.07e-04 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 44.51 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 555 QKLPAWQKqdqilELLSKYQV-----LVVSGMTGCGKTTqIPQFILdasLKgppshvsNIICtqpRRISAISVAERVA-- 627
Cdd:cd18026 15 KKLYDWQK-----ECLSLPGLlegrnLVYSLPTSGGKTL-VAEILM---LK-------RLLE---RRKKALFVLPYVSiv 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 628 QERA---ERVGISVGYQI--------RLESVKSAATRLLYCT---TGVLLRRLEGDTTLQNVTHVVVDEVHERTEESD-- 691
Cdd:cd18026 76 QEKVdalSPLFEELGFRVegyagnkgRSPPKRRKSLSVAVCTiekANSLVNSLIEEGRLDELGLVVVDELHMLGDGHRga 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 281427338 692 FLLLVLKDVMVLRP-DLKIILMSAT----------LNAELFSCYF 725
Cdd:cd18026 156 LLELLLTKLLYAAQkNIQIVGMSATlpnleelaswLRAELYTTNF 200
|
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
309-329 |
1.39e-04 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 39.92 E-value: 1.39e-04
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
345-417 |
4.44e-04 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 41.16 E-value: 4.44e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281427338 345 NGNNNCLYELEVRFPKDnkYPYQAPLLAFySVNENLSMGCRLHITEYLYEKAlnIAQTSDPAVYTLVSCLEDE 417
Cdd:pfam05773 43 DSSHLPPLVLKFTLPED--YPDEPPKISL-SSPWNLSDEQVLSLLEELEELA--EENLGEVMIFELIEWLQEN 110
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
631-721 |
4.27e-03 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 41.46 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281427338 631 AERVGISVGYqirlESVKSAAtRLLYCTTGVLLRRL-EGDTTLQNVTHVVVDEVH-----ERT---EESdfLLLvlkdvm 701
Cdd:COG4581 94 AENVGLLTGD----ASVNPDA-PIVVMTTEILRNMLyREGADLEDVGVVVMDEFHyladpDRGwvwEEP--IIH------ 160
|
90 100
....*....|....*....|.
gi 281427338 702 vLRPDLKIILMSATL-NAELF 721
Cdd:COG4581 161 -LPARVQLVLLSATVgNAEEF 180
|
|
| zf-CCCH_2 |
pfam14608 |
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented ... |
309-329 |
6.98e-03 |
|
RNA-binding, Nab2-type zinc finger; This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA.
Pssm-ID: 464217 Cd Length: 19 Bit Score: 35.18 E-value: 6.98e-03
|
| |
