NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|28277925|gb|AAH45994|]
View 

Cell division cycle 37 homolog (S. cerevisiae) [Danio rerio]

Protein Classification

CDC37_N and CDC37_M domain-containing protein( domain architecture ID 10660770)

protein containing domains CDC37_N, CDC37_M, and CDC37_C

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 127-275 1.50e-53

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


:

Pssm-ID: 215010  Cd Length: 155  Bit Score: 174.10  E-value: 1.50e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    127 KSVVNVKPEQKQETEEEKEEKHKTFVEKHEKQIKHFGMLR--RWDDSQKYLSDNPHLVCEETANYLVIMCIDLEVEEKRA 204
Cdd:smart01070   1 TETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925    205 LMEQVAHQTIVMQFILELAKSLSVDPRGCFRQFFTKIKT----ADQQYQDAFNDELESFKERVRGRAKIRIEKAM 275
Cdd:smart01070  81 LMEQVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 4-128 3.62e-34

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


:

Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 123.68  E-value: 3.62e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925      4 IDYSVWDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVERMEAF-------------TQKGVELEKSLMESR----- 60
Cdd:smart01071   2 IDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIknlkyelimndhlNKRIDKLLKGLREEElspet 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925     61 ----RRLAEAQRRVQ---ELSSSSSSTELSRAQAEEKQLKKEERSLQRKMEEHRAEEKKMPWNVDTlsREGFSKS 128
Cdd:smart01071  82 ptynEMLAELQDQLKkelEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 287-367 1.17e-21

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


:

Pssm-ID: 215009  Cd Length: 93  Bit Score: 88.23  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    287 LGPGGL--DPAEVYDTLPAEMQKCFDEKDIQMLQEVISKMDPTEAKLHMKRCIDSGLW-VPNARADEDGDKE-EAQYEEL 362
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNAIEDETEFKElQEQYEVE 80


                   ....*
gi 28277925    363 QKEEQ 367
Cdd:smart01069  81 EEAEK 85
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 127-275 1.50e-53

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 174.10  E-value: 1.50e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    127 KSVVNVKPEQKQETEEEKEEKHKTFVEKHEKQIKHFGMLR--RWDDSQKYLSDNPHLVCEETANYLVIMCIDLEVEEKRA 204
Cdd:smart01070   1 TETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925    205 LMEQVAHQTIVMQFILELAKSLSVDPRGCFRQFFTKIKT----ADQQYQDAFNDELESFKERVRGRAKIRIEKAM 275
Cdd:smart01070  81 LMEQVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 4-128 3.62e-34

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 123.68  E-value: 3.62e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925      4 IDYSVWDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVERMEAF-------------TQKGVELEKSLMESR----- 60
Cdd:smart01071   2 IDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIknlkyelimndhlNKRIDKLLKGLREEElspet 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925     61 ----RRLAEAQRRVQ---ELSSSSSSTELSRAQAEEKQLKKEERSLQRKMEEHRAEEKKMPWNVDTlsREGFSKS 128
Cdd:smart01071  82 ptynEMLAELQDQLKkelEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 162-276 4.76e-25

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 98.03  E-value: 4.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925   162 FGMLRR--WDDSQKYLSDNPHLVCEETANYLVIMCIDLEVEEKRALMEQVAHQTIVMQFILELAkslsvDPRGCFRQFFT 239
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 28277925   240 KIKTADQQYQDAFNDELESFKERVRGRAKIRIEKAMK 276
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQAE 113
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 287-367 1.17e-21

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 88.23  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    287 LGPGGL--DPAEVYDTLPAEMQKCFDEKDIQMLQEVISKMDPTEAKLHMKRCIDSGLW-VPNARADEDGDKE-EAQYEEL 362
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNAIEDETEFKElQEQYEVE 80


                   ....*
gi 28277925    363 QKEEQ 367
Cdd:smart01069  81 EEAEK 85
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 290-365 2.53e-16

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 73.13  E-value: 2.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925   290 GGLDPAE-----VYDTLPAEMQKCFDEKDIQMLQEVISKMDPTEAKLHMKRCIDSGLWVPNAR-ADEDGDKEEAQYEELQ 363
Cdd:pfam08564   6 GSEDPEEqkaveIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGVEALlVDATTEEGEKEFKELQ 85


                  ..
gi 28277925   364 KE 365
Cdd:pfam08564  86 EE 87
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 9-41 2.76e-07

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 48.76  E-value: 2.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28277925     9 WDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVER 41
Cdd:pfam03234   2 WDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQR 39
 
Name Accession Description Interval E-value
CDC37_M smart01070
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 127-275 1.50e-53

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 whose function is unclear.


Pssm-ID: 215010  Cd Length: 155  Bit Score: 174.10  E-value: 1.50e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    127 KSVVNVKPEQKQETEEEKEEKHKTFVEKHEKQIKHFGMLR--RWDDSQKYLSDNPHLVCEETANYLVIMCIDLEVEEKRA 204
Cdd:smart01070   1 TETTSSKNPPSAPSEEEDEIDDKDFVLKLEPATKKFGMIPagDYDDSQKFLSEHPHIVSEETADALVMWAFDLELEGKEA 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925    205 LMEQVAHQTIVMQFILELAKSLSVDPRGCFRQFFTKIKT----ADQQYQDAFNDELESFKERVRGRAKIRIEKAM 275
Cdd:smart01070  81 LMEQVAHQAILMQYILELAKSLKVDPRNCVRLFFQKIKTpshpAKEGFLEDVQSEFEHIKTRVRIIAQEQAEEAM 155
CDC37_N smart01071
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 4-128 3.62e-34

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases.and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 198139 [Multi-domain]  Cd Length: 154  Bit Score: 123.68  E-value: 3.62e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925      4 IDYSVWDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVERMEAF-------------TQKGVELEKSLMESR----- 60
Cdd:smart01071   2 IDYSKWDKIELSDDSDiEVHPNVDKKSFIRWKqrdiHQARVERMEEIknlkyelimndhlNKRIDKLLKGLREEElspet 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28277925     61 ----RRLAEAQRRVQ---ELSSSSSSTELSRAQAEEKQLKKEERSLQRKMEEHRAEEKKMPWNVDTlsREGFSKS 128
Cdd:smart01071  82 ptynEMLAELQDQLKkelEEANGDSEGLLEELKKHRDKLKKEQKELRKKLDELEKEEKKKIWSVDT--HTGFDKS 154
CDC37_M pfam08565
Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of ...
 162-276 4.76e-25

Cdc37 Hsp90 binding domain; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the Hsp90 chaperone (Heat shocked protein 90) binding domain of Cdc37. It is found between the N terminal Cdc37 domain pfam03234, which is predominantly involved in kinase binding, and the C terminal domain of Cdc37 pfam08564 whose function is unclear.


Pssm-ID: 430078  Cd Length: 113  Bit Score: 98.03  E-value: 4.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925   162 FGMLRR--WDDSQKYLSDNPHLVCEETANYLVIMCIDLEVEEKRALMEQVAHQTIVMQFILELAkslsvDPRGCFRQFFT 239
Cdd:pfam08565   2 FAKIPSgdYKASEQFLLKHPEILSEQQKDALLMEAFDAQLEGKTKYARQCVHQSLLLQYCRQLD-----GRINGVKLFFK 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 28277925   240 KIKTADQQYQDAFNDELESFKERVRGRAKIRIEKAMK 276
Cdd:pfam08565  77 RITTKDHQAKKLFLDDVQSTYNHIKTRAEEIKQEQAE 113
CDC37_C smart01069
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 287-367 1.17e-21

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37.


Pssm-ID: 215009  Cd Length: 93  Bit Score: 88.23  E-value: 1.17e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925    287 LGPGGL--DPAEVYDTLPAEMQKCFDEKDIQMLQEVISKMDPTEAKLHMKRCIDSGLW-VPNARADEDGDKE-EAQYEEL 362
Cdd:smart01069   1 NLPGGLslDPEEVFESLPPELQKAFETKDLDMLNKVLAKMPVEEAEYHLERCIESGLWgVPNAIEDETEFKElQEQYEVE 80


                   ....*
gi 28277925    363 QKEEQ 367
Cdd:smart01069  81 EEAEK 85
CDC37_C pfam08564
Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic ...
 290-365 2.53e-16

Cdc37 C terminal domain; Cdc37 is a protein required for the activity of numerous eukaryotic protein kinases. This domains corresponds to the C terminal domain whose function is unclear. It is found C terminal to the Hsp90 chaperone (Heat shocked protein 90) binding domain pfam08565 and the N terminal kinase binding domain of Cdc37 pfam03234.


Pssm-ID: 430077  Cd Length: 87  Bit Score: 73.13  E-value: 2.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28277925   290 GGLDPAE-----VYDTLPAEMQKCFDEKDIQMLQEVISKMDPTEAKLHMKRCIDSGLWVPNAR-ADEDGDKEEAQYEELQ 363
Cdd:pfam08564   6 GSEDPEEqkaveIFESLPPEMQKALKTKSLDEVNKVLGKMPVEEAEEIVELFGEAGILGVEALlVDATTEEGEKEFKELQ 85


                  ..
gi 28277925   364 KE 365
Cdd:pfam08564  86 EE 87
CDC37_N pfam03234
Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of ...
 9-41 2.76e-07

Cdc37 N terminal kinase binding; Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain pfam08565. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function.


Pssm-ID: 427208 [Multi-domain]  Cd Length: 124  Bit Score: 48.76  E-value: 2.76e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 28277925     9 WDHIEVSDDED-DTHPNIDTPSLFRWR----HQARVER 41
Cdd:pfam03234   2 WDALELSDDSDiEVHPNVDKRSFIRWKqrdiHEKREQR 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH