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Conserved domains on  [gi|292680328|dbj|BAI99543|]
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bundlin-2b [Escherichia coli O15:H34]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilS super family cl27040
PilS N terminal; Type IV pili are bacterial virulence-associated adhesins that promote ...
 38-187 1.31e-20

PilS N terminal; Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator. Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus.


The actual alignment was detected with superfamily member pfam05307:

Pssm-ID: 474887  Cd Length: 151  Bit Score: 83.45  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292680328   38 QSASDSNKSQNAISEVMSATSAINGLYIGQTSYSGLDSTILLNTSAIPDNYKDTTNRKITNPFGGELNVGPANN-NTAFG 116
Cdd:pfam05307   1 QSASDNNKLEQTLGELGSLISAVHSLYASQSNYTGLSEDVIAKNGSLPPSMVDPNNNDLVTPWGDQVAQGSGTEkVPALQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 292680328  117 YYLTLT-GLDKAACVSLATLNLGTSAKGYGVNISSENnttsfgnsadqAAKSTAITPAEAATACKKPDSTNK 187
Cdd:pfam05307  81 TVYQVTfGVPYGLCPAFARLQLGSSMVSLGVNGANSG-----------TDYTKPLSVSDAQSACSTAAAGDK 141
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
11-56 3.83e-03

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


:

Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 34.82  E-value: 3.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 292680328  11 EKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKSQNAISEVMSA 56
Cdd:COG4970    8 QRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAA 53
 
Name Accession Description Interval E-value
Bundlin pfam05307
Bundlin; This family consists of several bundlin proteins from E. coli. Bundlin is a type IV ...
 38-187 1.31e-20

Bundlin; This family consists of several bundlin proteins from E. coli. Bundlin is a type IV pilin protein that is the only known structural component of enteropathogenic Escherichia coli bundle-forming pili (BFP). BFP play a role in virulence, antigenicity, autoaggregation, and localized adherence to epithelial cells. These proteins contain an N-terminal methylation motif.


Pssm-ID: 461619  Cd Length: 151  Bit Score: 83.45  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292680328   38 QSASDSNKSQNAISEVMSATSAINGLYIGQTSYSGLDSTILLNTSAIPDNYKDTTNRKITNPFGGELNVGPANN-NTAFG 116
Cdd:pfam05307   1 QSASDNNKLEQTLGELGSLISAVHSLYASQSNYTGLSEDVIAKNGSLPPSMVDPNNNDLVTPWGDQVAQGSGTEkVPALQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 292680328  117 YYLTLT-GLDKAACVSLATLNLGTSAKGYGVNISSENnttsfgnsadqAAKSTAITPAEAATACKKPDSTNK 187
Cdd:pfam05307  81 TVYQVTfGVPYGLCPAFARLQLGSSMVSLGVNGANSG-----------TDYTKPLSVSDAQSACSTAAAGDK 141
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
11-56 3.83e-03

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 34.82  E-value: 3.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 292680328  11 EKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKSQNAISEVMSA 56
Cdd:COG4970    8 QRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAA 53
 
Name Accession Description Interval E-value
Bundlin pfam05307
Bundlin; This family consists of several bundlin proteins from E. coli. Bundlin is a type IV ...
 38-187 1.31e-20

Bundlin; This family consists of several bundlin proteins from E. coli. Bundlin is a type IV pilin protein that is the only known structural component of enteropathogenic Escherichia coli bundle-forming pili (BFP). BFP play a role in virulence, antigenicity, autoaggregation, and localized adherence to epithelial cells. These proteins contain an N-terminal methylation motif.


Pssm-ID: 461619  Cd Length: 151  Bit Score: 83.45  E-value: 1.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292680328   38 QSASDSNKSQNAISEVMSATSAINGLYIGQTSYSGLDSTILLNTSAIPDNYKDTTNRKITNPFGGELNVGPANN-NTAFG 116
Cdd:pfam05307   1 QSASDNNKLEQTLGELGSLISAVHSLYASQSNYTGLSEDVIAKNGSLPPSMVDPNNNDLVTPWGDQVAQGSGTEkVPALQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 292680328  117 YYLTLT-GLDKAACVSLATLNLGTSAKGYGVNISSENnttsfgnsadqAAKSTAITPAEAATACKKPDSTNK 187
Cdd:pfam05307  81 TVYQVTfGVPYGLCPAFARLQLGSSMVSLGVNGANSG-----------TDYTKPLSVSDAQSACSTAAAGDK 141
PilS pfam08805
PilS N terminal; Type IV pili are bacterial virulence-associated adhesins that promote ...
 51-190 7.81e-04

PilS N terminal; Type IV pili are bacterial virulence-associated adhesins that promote bacterial attachment to host cells. In Salmonella typhi, the structural pilin protein PilS interacts with the cystic fibrosis transmembrane conductance regulator. Mutagenesis studies suggest that residues on an alpha-beta loop and the C terminal disulphide-bonded region of PilS might be involved in binding specificity of the pilus.


Pssm-ID: 430227  Cd Length: 138  Bit Score: 38.30  E-value: 7.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 292680328   51 SEVMSATSAINGLYIGQTSYSGLDSTILLNTSAIPDNYkDTTNRKITNPFGGELNVGPANNNTAFG-YYLTLTGLDKAAC 129
Cdd:pfam08805   9 TNITTIQAGTKKLYKGRAGYDGLSNATLIAAKVVPTSM-TRTGDIYYNRWGGNVSVSPARGSGFNNsFTITYTNVPEGAC 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 292680328  130 VSLATlnLGTSAKGYGVNISSENNTTSFGNSadqaakstaiTPAEAATACKKPDsTNKVTY 190
Cdd:pfam08805  88 GDLST--MLSNAGWYSVTIGGTAMVDANVTV----------TLATATTACDRGD-ANTVIF 135
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
11-56 3.83e-03

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 34.82  E-value: 3.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 292680328  11 EKGLSLIESAMVLALAATVTAGVMFYYQSASDSNKSQNAISEVMSA 56
Cdd:COG4970    8 QRGFTLIELLVVLAILAILAAIAVPSFSSLIARQRLRAAANELAAA 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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