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Conserved domains on  [gi|29612519|gb|AAH49946|]
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Fbxo11 protein, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBR-box_UBR6_FBXO11 cd19676
UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, ...
 158-226 2.51e-43

UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)) is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. FBXO11 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. FBXO11 does not bind N-terminal signals.


:

Pssm-ID: 439074  Cd Length: 69  Bit Score: 141.11  E-value: 2.51e-43
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29612519 158 CLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAG 226
Cdd:cd19676   1 CLYKISSYTSFPMHDFYRCLTCNTTDRNAICVNCIKKCHEGHDVEFIRHDRFFCDCGAGTLSNDCQLAG 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 1-142 6.57e-26

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 99.02  E-value: 6.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519     1 RNKIWGGQNGGILFYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAG 80
Cdd:pfam13229  15 NNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29612519    81 VLISTNSHPVLRKNRIFDGFAAGIEIT-NHATATLEGNQIFNNRFGGLFLASGV-NVTMKDNKI 142
Cdd:pfam13229  95 IYLSDSSNNTIENNIIHNNGGSGIVIEdSSNNVTISNNTVTNNKGAGILIVGGSsNNTVENNTF 158
 
Name Accession Description Interval E-value
UBR-box_UBR6_FBXO11 cd19676
UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, ...
 158-226 2.51e-43

UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)) is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. FBXO11 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. FBXO11 does not bind N-terminal signals.


Pssm-ID: 439074  Cd Length: 69  Bit Score: 141.11  E-value: 2.51e-43
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29612519 158 CLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAG 226
Cdd:cd19676   1 CLYKISSYTSFPMHDFYRCLTCNTTDRNAICVNCIKKCHEGHDVEFIRHDRFFCDCGAGTLSNDCQLAG 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 1-142 6.57e-26

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 99.02  E-value: 6.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519     1 RNKIWGGQNGGILFYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAG 80
Cdd:pfam13229  15 NNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29612519    81 VLISTNSHPVLRKNRIFDGFAAGIEIT-NHATATLEGNQIFNNRFGGLFLASGV-NVTMKDNKI 142
Cdd:pfam13229  95 IYLSDSSNNTIENNIIHNNGGSGIVIEdSSNNVTISNNTVTNNKGAGILIVGGSsNNTVENNTF 158
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 7-147 1.35e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 60.32  E-value: 1.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519   7 GQNGGILFYNSGLGCIEDNEIFDNAmAGVWIKTDSNPTLRRNKIHDGRDG------GICIFNGGRGLLEENDIfRNAQAG 80
Cdd:COG3420  96 DDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNNVIRNNTISGNRDLradrgnGIHLWNSPGNVIEGNTI-SGGRDG 173

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29612519  81 VLISTNSHPVLRKNRiFDGFAAGIEITNHATATLEGNQIFNNRfGGLFLASGVNVTMKDNKIMNNQD 147
Cdd:COG3420 174 IYLEFSDNNVIRNNT-IRNLRYGIHYMYSNDNLVEGNTFRDNG-AGIALMYSKGNTVRGNTILGNSG 238
ZnF_UBR1 smart00396
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain ...
 173-214 3.87e-09

Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain is involved in recognition of N-end rule substrates in yeast Ubr1p


Pssm-ID: 197698  Cd Length: 71  Bit Score: 52.06  E-value: 3.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 29612519    173 FYRCHTCNTTDRNAICVNC-IKKCHQGHDVEFIRHDR-FFCDCG 214
Cdd:smart00396  13 IYRCKTCGLDPTCVLCSDCfRPSCHKGHDVSLKTSRGsGICDCG 56
zf-UBR pfam02207
Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases ...
 173-214 2.35e-08

Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases that recognize N-recognins.


Pssm-ID: 460491  Cd Length: 68  Bit Score: 49.60  E-value: 2.35e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 29612519   173 FYRCHTCNTTDRNAICVNCIKKC-HQGHDVEFIRHDR-FFCDCG 214
Cdd:pfam02207  11 VYRCLTCSLDPTCVICYSCFINCdHEGHDYELFTSRGgGCCDCG 54
 
Name Accession Description Interval E-value
UBR-box_UBR6_FBXO11 cd19676
UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, ...
 158-226 2.51e-43

UBR-box found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11 (also called UBR6, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)) is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. FBXO11 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. FBXO11 does not bind N-terminal signals.


Pssm-ID: 439074  Cd Length: 69  Bit Score: 141.11  E-value: 2.51e-43
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29612519 158 CLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAG 226
Cdd:cd19676   1 CLYKISSYTSFPMHDFYRCLTCNTTDRNAICVNCIKKCHEGHDVEFIRHDRFFCDCGAGTLSNDCQLAG 69
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 1-142 6.57e-26

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 99.02  E-value: 6.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519     1 RNKIWGGQNGGILFYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAG 80
Cdd:pfam13229  15 NNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGGGIALRGSSNNLIENNTISNNGGAG 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29612519    81 VLISTNSHPVLRKNRIFDGFAAGIEIT-NHATATLEGNQIFNNRFGGLFLASGV-NVTMKDNKI 142
Cdd:pfam13229  95 IYLSDSSNNTIENNIIHNNGGSGIVIEdSSNNVTISNNTVTNNKGAGILIVGGSsNNTVENNTF 158
UBR-box_UBR4_5_6_7 cd19671
UBR-box found in UBR4, UBR5, UBR6/FBOX11, UBR7 and similar proteins; This family includes UBR4 ...
 161-224 2.53e-20

UBR-box found in UBR4, UBR5, UBR6/FBOX11, UBR7 and similar proteins; This family includes UBR4 (EC 2.3.2.27), UBR5 (EC 2.3.2.26), UBR6/FBOX11 and UBR7 (EC 2.3.2.27). Both UBR4 (also called 600 kDa retinoblastoma protein-associated factor, or N-recognin-4, or retinoblastoma-associated factor of 600 kDa, or RBAF600, or p600, or zinc finger UBR1-type protein 1) and UBR7 (also called N-recognin-7) are RING-type E3 ubiquitin ligases of the Arg/N-end rule degradation pathway. They recognize and bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR5 (also called E3 ubiquitin-protein ligase, HECT domain-containing 1, E3 ligase identified by differential display (EDD), hyperplastic discs protein homolog (HYD), progestin-induced protein, or N-recognin-5) is a HECT (homologous to E6-AP C-terminus)-type E3 ubiquitin-protein ligase that acts as a key regulator of the ubiquitin proteasome system in both cancer and developmental biology. It is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/beta-catenin. It also plays a key role in ciliogenesis by regulating centriolar satellite stability and primary cilia. UBR6 (also called FBOX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1)), is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. UBR6 is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. UBR6 does not bind N-terminal signals.


Pssm-ID: 439069  Cd Length: 67  Bit Score: 81.74  E-value: 2.53e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29612519 161 KISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTlSNPCTL 224
Cdd:cd19671   3 FEKTGRKYIKQPWYHCYTCGLIDGLGVCEACARKCHKGHDLVYIGYSNFYCDCGSSG-PGKCKC 65
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 33-148 3.97e-17

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 75.91  E-value: 3.97e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519    33 AGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATA 112
Cdd:pfam13229   1 SGILLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGGGIALRGSSNN 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 29612519   113 TLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDA 148
Cdd:pfam13229  81 LIENNTISNNGGAGIYLSDSSNNTIENNIIHNNGGS 116
UBR-box cd19669
UBR-box found in UBR family of E3 ubiquitin ligases (UBR1-7) and similar proteins; The UBR-box ...
 173-220 8.65e-16

UBR-box found in UBR family of E3 ubiquitin ligases (UBR1-7) and similar proteins; The UBR-box is a 70-residue zinc finger domain present in the UBR family of E3 ubiquitin ligases (UBR1-7, also called N-recognins) that directly binds N-terminal degradation signals (N-degrons) in substrate proteins to facilitate substrate ubiquitination and proteasomal degradation via the ubiquitin-proteasome system (UPS). UBR1 and UBR2 bind all type-1 and type-2 N-degrons. They mediate ubiquitination and proteolysis of short-lived regulators and misfolded proteins. UBR4 binds both type-1 and type-2 N-degrons and is involved in proteome-wide turnover of cell surface proteins. UBR5 preferentially binds type-1 N-degrons and mediates ubiquitination of short-lived proteins. UBR3, UBR6 (also called FBXO11), and UBR7 may not bind efficiently to N-degrons. UBR3 is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. UBR6 is an E3 ubiquitin ligase and a type II methyltransferase, which functions as a key regulator of tumor initiation and progression. It does not bind N-terminal signals. UBR7 is a RING-type E3 ubiquitin ligase that may play an important role in spermiogenesis and fertilization.


Pssm-ID: 439067  Cd Length: 66  Bit Score: 69.85  E-value: 8.65e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 29612519 173 FYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSN 220
Cdd:cd19669  12 MYHCLTCSLDDNSGICEECAKKCHEGHDVVYIGSGSGFCDCGDSSAKS 59
UBR-box_UBR4_like cd19674
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
 156-222 9.29e-15

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival. The family also includes Arabidopsis thaliana auxin transport protein BIG (also called protein attenuated shade avoidance 1, protein corymbosa1, protein dark over-expression of cab 1, protein low phosphate-resistant root 1, protein transport inhibitor response 3, or protein umbrella 1). It is a calossin-like protein required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses in Arabidopsis.


Pssm-ID: 439072  Cd Length: 72  Bit Score: 66.98  E-value: 9.29e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29612519 156 GQCLYKISSyTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPC 222
Cdd:cd19674   1 NVCTFASTG-KNYARQHWYECYTCFLNGNEGVCEVCARVCHKGHDLVYSKTSSFFCDCGAGGGPSKC 66
UBR-box_BIG_like cd19681
UBR-box found in Arabidopsis thaliana auxin transport protein BIG and similar proteins; BIG ...
 158-222 1.13e-14

UBR-box found in Arabidopsis thaliana auxin transport protein BIG and similar proteins; BIG (also called protein attenuated shade avoidance 1, protein corymbosa1, protein dark over-expression of cab 1, protein low phosphate-resistant root 1, protein transport inhibitor response 3, or protein umbrella 1) is a calossin-like protein required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses in Arabidopsis.


Pssm-ID: 439079  Cd Length: 74  Bit Score: 67.05  E-value: 1.13e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29612519 158 CLYkISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLS--NPC 222
Cdd:cd19681   3 CTY-VSSGSNFMEQHWYFCYTCGLVDSKGCCSVCAKVCHRGHDVVYSRYSRFFCDCGAGGAKrgRPC 68
UBR-box_UBR4 cd19680
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3. ...
 174-215 9.46e-14

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR4 and similar proteins; UBR4 (EC 2.3.2.27; also called 600 kDa retinoblastoma protein-associated factor, N-recognin-4, retinoblastoma-associated factor of 600 kDa, RBAF600, p600, or zinc finger UBR1-type protein 1) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR4 acts as a multifunctional protein with roles in anoikis, viral transformation, and protein degradation, as well as in neurogenesis, neuronal migration, neuronal signaling, and survival.


Pssm-ID: 439078  Cd Length: 71  Bit Score: 64.40  E-value: 9.46e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 29612519 174 YRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGA 215
Cdd:cd19680  18 YHCHTCKMVDGVGVCSVCAKVCHKDHDLSYAKYGSFFCDCGA 59
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 7-147 1.35e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 60.32  E-value: 1.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519   7 GQNGGILFYNSGLGCIEDNEIFDNAmAGVWIKTDSNPTLRRNKIHDGRDG------GICIFNGGRGLLEENDIfRNAQAG 80
Cdd:COG3420  96 DDDAGIYVRGADNAVIENNRIENNL-FGIYLEGSDNNVIRNNTISGNRDLradrgnGIHLWNSPGNVIEGNTI-SGGRDG 173

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 29612519  81 VLISTNSHPVLRKNRiFDGFAAGIEITNHATATLEGNQIFNNRfGGLFLASGVNVTMKDNKIMNNQD 147
Cdd:COG3420 174 IYLEFSDNNVIRNNT-IRNLRYGIHYMYSNDNLVEGNTFRDNG-AGIALMYSKGNTVRGNTILGNSG 238
ZnF_UBR1 smart00396
Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain ...
 173-214 3.87e-09

Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; Domain is involved in recognition of N-end rule substrates in yeast Ubr1p


Pssm-ID: 197698  Cd Length: 71  Bit Score: 52.06  E-value: 3.87e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 29612519    173 FYRCHTCNTTDRNAICVNC-IKKCHQGHDVEFIRHDR-FFCDCG 214
Cdd:smart00396  13 IYRCKTCGLDPTCVLCSDCfRPSCHKGHDVSLKTSRGsGICDCG 56
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 2-150 4.31e-09

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 56.08  E-value: 4.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519   2 NKIWGGQnGGILFYNSGLGCIEDNeIFDNAMAGVWIKTDSNPTLRRNKIHDGRdGGICIFNGGRGLLEENDIFRNAQAGV 81
Cdd:COG3420 165 NTISGGR-DGIYLEFSDNNVIRNN-TIRNLRYGIHYMYSNDNLVEGNTFRDNG-AGIALMYSKGNTVRGNTILGNSGYGI 241

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29612519  82 LISTNSHPVLRKNRIFDGfAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIE 150
Cdd:COG3420 242 LLKESSDSVIEGNTISGN-GKGIFIYNSNRNTIRGNLFAGNGIGIHLTAGSEGNRIYGNNFIGNRTQVK 309
zf-UBR pfam02207
Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases ...
 173-214 2.35e-08

Putative zinc finger in N-recognin (UBR box); This region is found in E3 ubiquitin ligases that recognize N-recognins.


Pssm-ID: 460491  Cd Length: 68  Bit Score: 49.60  E-value: 2.35e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 29612519   173 FYRCHTCNTTDRNAICVNCIKKC-HQGHDVEFIRHDR-FFCDCG 214
Cdd:pfam02207  11 VYRCLTCSLDPTCVICYSCFINCdHEGHDYELFTSRGgGCCDCG 54
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 2-146 3.37e-08

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 52.42  E-value: 3.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519     2 NKIWGGQNGgILFYNSGLGCIEDNEIFDNaMAGVWIKTDSNPTLRRNKIHDGRDGgICIFNGGRGLLEENDIFRNAQAGV 81
Cdd:pfam05048  35 NDIINSRDG-IYLDASNNNTITGNRISNL-RYGIHLMNSNDNTISDNVFSGNTAG-IALMSSSNNTLENNTISGNTNYGI 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29612519    82 LISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQ 146
Cdd:pfam05048 112 LLSDSSNNTISNNTISNNNGKGIFLYNSDYNTITGNRITSNGIGIHFLAGSNGNTIYNNYFINNS 176
UBR-box_UBR7 cd19677
UBR-box found in RING-type E3 ubiquitin-protein ligase UBR7 and similar proteins; UBR7 (EC 2.3. ...
 174-224 3.58e-08

UBR-box found in RING-type E3 ubiquitin-protein ligase UBR7 and similar proteins; UBR7 (EC 2.3.2.27; also called N-recognin-7) is a RING-type E3 ubiquitin ligase of the Arg/N-end rule degradation pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR7 may play an important role in spermiogenesis and fertilization.


Pssm-ID: 439075  Cd Length: 71  Bit Score: 49.23  E-value: 3.58e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 29612519 174 YRCHTCN---TTDRNAICVNCIKKCHQGHDVEFIRHDRFF-CDCG-AGTLSNPCTL 224
Cdd:cd19677  14 YACLTCTpagADQPAGICLACSLSCHEGHELEELYTKRNFrCDCGnSKFPSNPCKL 69
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 11-149 7.46e-08

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 51.27  E-value: 7.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519    11 GILFYNSGlGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRdGGICIFNGGRGLLEENDIFRNaQAGVLISTNSHPV 90
Cdd:pfam05048  21 GIQLWNTE-GNVISNNDIINSRDGIYLDASNNNTITGNRISNLR-YGIHLMNSNDNTISDNVFSGN-TAGIALMSSSNNT 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 29612519    91 LRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAI 149
Cdd:pfam05048  98 LENNTISGNTNYGILLSDSSNNTISNNTISNNNGKGIFLYNSDYNTITGNRITSNGIGI 156
UBR-box_UBR1_2_3 cd19670
UBR-box found in ubiquitin-protein ligase E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), E3-alpha-3 ...
 173-214 4.71e-07

UBR-box found in ubiquitin-protein ligase E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), E3-alpha-3 (UBR3) and similar proteins; This family includes UBR1, UBR2, and UBR3 (all belonging to EC 2.3.2.27). Both UBR1 (also called E3alpha-I or N-recognin-1) and UBR2 (also called E3-alpha-II or N-recognin-2), are RING-type E3 ubiquitin ligases of the Arg/N-end rule degradation pathway. They recognize and bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Deficiency of UBR1 causes Johanson-Blizzard syndrome. UBR2 is associated with chromatin and controls chromatin dynamics and gene expression in both germ cells and somatic cells. It plays an important role in spermatogenesis. UBR3, also called ubiquitin-protein ligase E3-alpha-III (E3alpha-III), or N-recognin-3, or zinc finger protein 650, is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. It negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. It acts as a positive regulator of Hedgehog (Hh) signaling in Drosophila and vertebrates. It also plays an important role for genome stability by controlling cellular levels of the essential DNA repair protein APE1.


Pssm-ID: 439068  Cd Length: 69  Bit Score: 46.20  E-value: 4.71e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 29612519 173 FYRCHTCNTTDRNAICVNC-IKKCHQGHDVEFIR-HDRFFCDCG 214
Cdd:cd19670  11 YYRCLDCSLDPSSCICEECfLNGNHEGHNYSLRTsSGGGVCDCG 54
UBR-box_UBR3 cd19673
UBR-box found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins; UBR3 (EC 2.3. ...
 173-214 3.69e-05

UBR-box found in ubiquitin-protein ligase E3-alpha-3 (UBR3) and similar proteins; UBR3 (EC 2.3.2.27), also called ubiquitin-protein ligase E3-alpha-III (E3alpha-III), or N-recognin-3, or zinc finger protein 650, is a RING-type E3 ubiquitin ligase with a function in olfactory and other sensory systems. It negatively regulates the mono-ubiquitination of non-muscle Myosin II, a protein associated with hearing loss in humans. It acts as a positive regulator of Hedgehog (Hh) signaling in Drosophila and vertebrates. It also plays an important role for genome stability by controlling cellular levels of the essential DNA repair protein APE1.


Pssm-ID: 439071  Cd Length: 72  Bit Score: 41.02  E-value: 3.69e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 29612519 173 FYRCHTCNTTDRNAICVNCIKKC-HQGHDVEFIRHDRF-FCDCG 214
Cdd:cd19673  14 AYRCRTCGLDPTCVICADCFQAGdHEGHDYSMYRSSAGgCCDCG 57
UBR-box_UBR5 cd19675
UBR-box found in HECT-type E3 ubiquitin-protein ligase UBR5 and similar proteins; UBR5 (EC 2.3. ...
 172-213 2.18e-03

UBR-box found in HECT-type E3 ubiquitin-protein ligase UBR5 and similar proteins; UBR5 (EC 2.3.2.26; also called E3 ubiquitin-protein ligase, HECT domain-containing 1, E3 ligase identified by differential display (EDD), hyperplastic discs protein homolog (HYD), progestin-induced protein, or N-recognin-5) is a HECT (homologous to E6-AP C-terminus)-type E3 ubiquitin-protein ligase that acts as a key regulator of the ubiquitin proteasome system in both cancer and developmental biology. It is required for Wnt signal responses in Drosophila and human cell lines downstream of activated Armadillo/beta-catenin. It also plays a key role in ciliogenesis by regulating centriolar satellite stability and primary cilia.


Pssm-ID: 439073  Cd Length: 76  Bit Score: 35.91  E-value: 2.18e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 29612519 172 DFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHD-RFFCDC 213
Cdd:cd19675  22 DIFECRTCGLVGSLCCCTECARVCHKGHDCKLKRTSpTAYCDC 64
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 51-149 2.58e-03

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 38.36  E-value: 2.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29612519  51 HDGRDGGICIFNGGRGLLEENDIfRNAQAGVLISTNSHPVLRKNRIFDG------FAAGIEITNHATATLEGNQIFNNRf 124
Cdd:COG3420  94 LTDDDAGIYVRGADNAVIENNRI-ENNLFGIYLEGSDNNVIRNNTISGNrdlradRGNGIHLWNSPGNVIEGNTISGGR- 171

                        90       100
                ....*....|....*....|....*
gi 29612519 125 GGLFLASGVNVTMKDNKIMNNQDAI 149
Cdd:COG3420 172 DGIYLEFSDNNVIRNNTIRNLRYGI 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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