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Conserved domains on  [gi|30725776|ref|NP_849249|]
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U3 small nucleolar RNA-associated protein 15 homolog [Mus musculus]

Protein Classification

U3 small nucleolar RNA-associated protein 15 homolog( domain architecture ID 10078053)

U3 small nucleolar RNA-associated protein 15 homolog is a ribosome biogenesis factor involved in nucleolar processing of pre-18S ribosomal RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 1.99e-61

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 198.48  E-value: 1.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   343 NYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKcvIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30725776   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 2.32e-58

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.98  E-value: 2.32e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 119 EGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKIFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 197 NKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 30725776 275 YSTTSYKVVHSFD-YAASILSLALSHQDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 1.99e-61

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 198.48  E-value: 1.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   343 NYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKcvIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30725776   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 2.32e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.98  E-value: 2.32e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 119 EGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKIFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 197 NKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 30725776 275 YSTTSYKVVHSFD-YAASILSLALSHQDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-298 1.91e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.91e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLpyNYAVTASS--RIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLR 116
Cdd:cd00200  10 GGVTCVAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 117 QFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKIFDART 196
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 197 NKnvlCVE----HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRK 271
Cdd:cd00200 167 GK---CVAtltgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                       250       260
                ....*....|....*....|....*...
gi 30725776 272 VKVYSTTSYKVVHSFD-YAASILSLALS 298
Cdd:cd00200 243 IRVWDLRTGECVQTLSgHTNSVTSLAWS 270
PTZ00421 PTZ00421
coronin; Provisional
 91-236 9.92e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.68  E-value: 9.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   91 DGQLLVAGSEDGVVQLFDI-------NGRAPLRQFEGHTKAVHTVDF--TADNYHVVSGADdYTVKLWDIPNSKEILTFK 161
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGAD-MVVNVWDVERGKAVEVIK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  162 EHSDYVrCGCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDM 234
Cdd:PTZ00421 166 CHSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDT 244


                 ..
gi 30725776  235 LK 236
Cdd:PTZ00421 245 RK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 4.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 30725776    114 PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
114-150 9.15e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.15e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30725776   114 PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 343-490 1.99e-61

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 198.48  E-value: 1.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   343 NYLKQRDDIMVSRPAKKHLEGYDKDLKSFRVSQALDRVLEPKcvIRTPEVTVSIIKELTRRGVLANALAGRDEKEVTRVL 422
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30725776   423 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSSVVDKKFIVLQELVEKEIDYQRELLETLGMMDML 490
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 2.32e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 198.98  E-value: 2.32e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQF 118
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 119 EGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKIFDART 196
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 197 NKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKV 274
Cdd:COG2319 236 GKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270
                ....*....|....*....|....*....|....
gi 30725776 275 YSTTSYKVVHSFD-YAASILSLALSHQDETIVVG 307
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
39-307 4.69e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 4.69e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLpyNYAVTASS--RIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLR 116
Cdd:COG2319 121 GAVRSVAFSPDG--KTLASGSAdgTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 117 QFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFVTGSYDHTVKIFDA 194
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS-VA--FSPDgrLLASGSADGTVRLWDL 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 195 RTNKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
Cdd:COG2319 276 ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 30725776 273 KVYSTTSYKVVHSF-DYAASILSLALSHQDETIVVG 307
Cdd:COG2319 355 RLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
38-315 3.36e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.50  E-value: 3.36e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  38 FGAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQ 117
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 118 FEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCgCAskLNPD--LFVTGSYDHTVKIFDAR 195
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS-VA--FSPDgkLLASGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 196 TNKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVK 273
Cdd:COG2319 193 TGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 30725776 274 VYSTTSYKVVHSFD-YAASILSLALSHQDETIVVGMTNGILSV 315
Cdd:COG2319 272 LWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
39-279 1.02e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.96  E-value: 1.02e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSP---QLpynyaVTASS--RIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRA 113
Cdd:COG2319 163 GAVTSVAFSPdgkLL-----ASGSDdgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 114 PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKI 191
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS---PDgkLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 192 FDARTNKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
Cdd:COG2319 315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDdGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                       250
                ....*....|
gi 30725776 270 RKVKVYSTTS 279
Cdd:COG2319 394 GTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-298 1.91e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 171.75  E-value: 1.91e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLpyNYAVTASS--RIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLR 116
Cdd:cd00200  10 GGVTCVAFSPDG--KLLATGSGdgTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 117 QFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKIFDART 196
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 197 NKnvlCVE----HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRK 271
Cdd:cd00200 167 GK---CVAtltgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGT 242

                       250       260
                ....*....|....*....|....*...
gi 30725776 272 VKVYSTTSYKVVHSFD-YAASILSLALS 298
Cdd:cd00200 243 IRVWDLRTGECVQTLSgHTNSVTSLAWS 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-315 4.22e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 170.98  E-value: 4.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  72 PVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDI 151
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 152 PNSKEILTFKEHSDYVRCgCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVE-HGQPVESVLLFPSGGLLVSAGG-RYV 229
Cdd:cd00200  81 ETGECVRTLTGHTSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 230 KVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDY-AASILSLALSHQDETIVVGM 308
Cdd:cd00200 160 KLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGS 238


                ....*..
gi 30725776 309 TNGILSV 315
Cdd:cd00200 239 EDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-276 1.07e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 167.13  E-value: 1.07e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  39 GAVSKVDFSPQLpyNYAVTASS----RIHIYGrySQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAP 114
Cdd:cd00200  52 GPVRDVAASADG--TYLASGSSdktiRLWDLE--TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 115 LRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKIFDA 194
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDL 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 195 RTNKNV-LCVEHGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
Cdd:cd00200 207 STGKCLgTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                ....
gi 30725776 273 KVYS 276
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
45-315 6.57e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 6.57e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  45 DFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHTKA 124
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 125 VHTVDFTADNYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASklnPD--LFVTGSYDHTVKIFDARTNKNVLC 202
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 203 VE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSY 280
Cdd:COG2319 158 LTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 30725776 281 KVVHSFD-YAASILSLALSHQDETIVVGMTNGILSV 315
Cdd:COG2319 237 KLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRL 272
PTZ00421 PTZ00421
coronin; Provisional
 91-236 9.92e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 60.68  E-value: 9.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   91 DGQLLVAGSEDGVVQLFDI-------NGRAPLRQFEGHTKAVHTVDF--TADNYHVVSGADdYTVKLWDIPNSKEILTFK 161
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGAD-MVVNVWDVERGKAVEVIK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  162 EHSDYVrCGCASKLNPDLFVTGSYDHTVKIFDARTNKNVLCVEHGQPVES--VLLFPSGGLLVSAG-----GRYVKVWDM 234
Cdd:PTZ00421 166 CHSDQI-TSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIITLGcsksqQRQIMLWDT 244


                 ..
gi 30725776  235 LK 236
Cdd:PTZ00421 245 RK 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-150 4.63e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 4.63e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 30725776    114 PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWD 150
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 85-318 8.73e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 8.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776   85 CA-TFRQDGQLLVAGSEDGVVQLFDIN-----GRA---PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWDIPNSK 155
Cdd:PLN00181 487 CAiGFDRDGEFFATAGVNKKIKIFECEsiikdGRDihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQ 566

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  156 EILTFKEHSDYVRCGCASKLNPDLFVTGSYDHTVKIFDA---------RTNKNVLCVEhgqpvesvllFPSG---GLLVS 223
Cdd:PLN00181 567 LVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSInqgvsigtiKTKANICCVQ----------FPSEsgrSLAFG 636

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  224 AGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQrLLSGSLDRKVKVY------STTSYKVVHSFDYAASILS-LA 296
Cdd:PLN00181 637 SADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWdlsmsiSGINETPLHSFMGHTNVKNfVG 715

                        250       260
                 ....*....|....*....|..
gi 30725776  297 LSHQDETIVVGMTNGILSVKHR 318
Cdd:PLN00181 716 LSVSDGYIATGSETNEVFVYHK 737
WD40 pfam00400
WD domain, G-beta repeat;
114-150 9.15e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.15e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 30725776   114 PLRQFEGHTKAVHTVDFTADNYHVVSGADDYTVKLWD 150
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-276 1.67e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.67e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 30725776    238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
238-276 4.10e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.10e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 30725776   238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 2.49e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.49e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 30725776    153 NSKEILTFKEHSDYVRCGCASKlNPDLFVTGSYDHTVKIFD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-193 4.46e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.46e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 30725776   154 SKEILTFKEHSDYVRCgCASKLNPDLFVTGSYDHTVKIFD 193
Cdd:pfam00400   1 GKLLKTLEGHTGSVTS-LAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 69-108 9.94e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 9.94e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 30725776     69 SQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFD 108
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
179-306 3.10e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 3.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 179 LFVTGSYDHTVKIFDARTNKNVLCVEHGQPVESVLLFPSGGLL--VSAGGRYVKVWDmLKGGQLLVSLKNhHKTVTCLCL 256
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyvADSGNGRVSVID-TATGKVVATIPV-GAGPHGIAV 159

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 30725776 257 SSSGQRLLSGSLDRK-----VKVYSTTSYKVVHSFDYAASILSLALSHQDETIVV 306
Cdd:COG3391 160 DPDGKRLYVANSGSNtvsviVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYV 214
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
55-197 1.20e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  55 AVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFDINGRAPLRQFEGHtKAVHTVDFTADN 134
Cdd:COG3391  85 ANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVDPDG 163

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30725776 135 YHV-VSGADDYT----VKLWDIPNSKEILTFKEHSDyvrcGCASKLNPD---LFVTGSY-------DHTVKIFDARTN 197
Cdd:COG3391 164 KRLyVANSGSNTvsviVSVIDTATGKVVATIPVGGG----PVGVAVSPDgrrLYVANRGsntsnggSNTVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
38-229 1.61e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776  38 FGAVSKVDFSPQLPYNYAVTASSRIHIYGRYSQEPVKTFSRFKDTAYCATFRQDGQLL-VAGSEDGVVQLFDINGRAPLR 116
Cdd:COG3391  25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30725776 117 QFEGHTKAvHTVDFTADNYHV-VSGADDYTVKLWDIPNSKEILTFKEHSDYVrcGCAskLNPD---LFVTGSYDHT---- 188
Cdd:COG3391 105 TIPVGGGP-RGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGPH--GIA--VDPDgkrLYVANSGSNTvsvi 179

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 30725776 189 VKIFDARTNKNVLCVEHG-QPVesvllfpsgGLLVSAGGRYV 229
Cdd:COG3391 180 VSVIDTATGKVVATIPVGgGPV---------GVAVSPDGRRL 212
WD40 pfam00400
WD domain, G-beta repeat;
71-108 1.89e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 30725776    71 EPVKTFSRFKDTAYCATFRQDGQLLVAGSEDGVVQLFD 108
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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