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Conserved domains on  [gi|307767648|gb|EFO26882|]
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synembryn [Loa loa]

Protein Classification

synembryn( domain architecture ID 10562755)

synembryn is a guanine nucleotide exchange factor (GEF) which promotes exchange of bound GDP for free GTP, similar to human synembryn-A (also known as Ric-8A) and synembryn-B (also known as Ric-8B)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-519 4.19e-104

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


:

Pssm-ID: 462973  Cd Length: 412  Bit Score: 319.53  E-value: 4.19e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648   67 ILRFLRILARDKQNLDQLLSSGLVQDVLGVGLLTERlfEFDWESFIQAEMCLINILFNSKLARDEFneiaSDLLLSRIRL 146
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDS--AGSSEVSREALRCLANALLLSPEARQIF----VDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  147 LSETSRSSSKQrNNDDIratekdigisakpkifeslveflnneqidlvaFYDLRIAFVASAQSKDLQLYWLKDGCEV--F 224
Cdd:pfam10165  75 ACEKLKLDKSQ-SSDDE--------------------------------FLDSRILFLLTALRTDIRLQLKKLIEGHslL 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  225 LKILEQSL--HFPERLKQN--SRWRSFAEHTNWALKILFNIFCYSRDDSVES-NAKQCMLLCSKIVTLENIDPS----LE 295
Cdd:pfam10165 122 AEAIEQILarHAKRYPDSSasSLSPMEDMALTETLKLLFNLTLFYPDLVPDSaFSPALPPILRLLLLLPIPSPDplepPL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  296 QSAVDVIAVFPLSfelltpkiqhtekkdTNVIHGGRDMTFANAVLHALERRLEAeNNEKNELLGTFLTVLIRLSSQVKEA 375
Cdd:pfam10165 202 SHLINALLNLPLT---------------DSKKYEGNNMDVVERLLDLLDKRLDA-YDELDELLTPLLTLLTRLYEAAREV 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  376 RRYLRLLVIPPLHatDVERRPDDGIELRNRMIRLMMSIS--NIQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGI 453
Cdd:pfam10165 266 RKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLtpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGL 343

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307767648  454 LNALNTPKHHSDSEASETEDYKAVETQVNPVTGCIDPAVE-NPFTGMTEEQKEYEVHRLMNDINKLM 519
Cdd:pfam10165 344 LGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLK 410
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-519 4.19e-104

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 319.53  E-value: 4.19e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648   67 ILRFLRILARDKQNLDQLLSSGLVQDVLGVGLLTERlfEFDWESFIQAEMCLINILFNSKLARDEFneiaSDLLLSRIRL 146
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDS--AGSSEVSREALRCLANALLLSPEARQIF----VDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  147 LSETSRSSSKQrNNDDIratekdigisakpkifeslveflnneqidlvaFYDLRIAFVASAQSKDLQLYWLKDGCEV--F 224
Cdd:pfam10165  75 ACEKLKLDKSQ-SSDDE--------------------------------FLDSRILFLLTALRTDIRLQLKKLIEGHslL 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  225 LKILEQSL--HFPERLKQN--SRWRSFAEHTNWALKILFNIFCYSRDDSVES-NAKQCMLLCSKIVTLENIDPS----LE 295
Cdd:pfam10165 122 AEAIEQILarHAKRYPDSSasSLSPMEDMALTETLKLLFNLTLFYPDLVPDSaFSPALPPILRLLLLLPIPSPDplepPL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  296 QSAVDVIAVFPLSfelltpkiqhtekkdTNVIHGGRDMTFANAVLHALERRLEAeNNEKNELLGTFLTVLIRLSSQVKEA 375
Cdd:pfam10165 202 SHLINALLNLPLT---------------DSKKYEGNNMDVVERLLDLLDKRLDA-YDELDELLTPLLTLLTRLYEAAREV 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  376 RRYLRLLVIPPLHatDVERRPDDGIELRNRMIRLMMSIS--NIQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGI 453
Cdd:pfam10165 266 RKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLtpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGL 343

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307767648  454 LNALNTPKHHSDSEASETEDYKAVETQVNPVTGCIDPAVE-NPFTGMTEEQKEYEVHRLMNDINKLM 519
Cdd:pfam10165 344 LGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLK 410
 
Name Accession Description Interval E-value
Ric8 pfam10165
Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter ...
 67-519 4.19e-104

Guanine nucleotide exchange factor synembryn; Ric8 is involved in the EGL-30 neurotransmitter signalling pathway. It is a guanine nucleotide exchange factor that regulates neurotransmitter secretion.


Pssm-ID: 462973  Cd Length: 412  Bit Score: 319.53  E-value: 4.19e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648   67 ILRFLRILARDKQNLDQLLSSGLVQDVLGVGLLTERlfEFDWESFIQAEMCLINILFNSKLARDEFneiaSDLLLSRIRL 146
Cdd:pfam10165   1 ALETLKILGRDPRGADPIFTKEGISTLLKLGLAFDS--AGSSEVSREALRCLANALLLSPEARQIF----VDRLLGYADK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  147 LSETSRSSSKQrNNDDIratekdigisakpkifeslveflnneqidlvaFYDLRIAFVASAQSKDLQLYWLKDGCEV--F 224
Cdd:pfam10165  75 ACEKLKLDKSQ-SSDDE--------------------------------FLDSRILFLLTALRTDIRLQLKKLIEGHslL 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  225 LKILEQSL--HFPERLKQN--SRWRSFAEHTNWALKILFNIFCYSRDDSVES-NAKQCMLLCSKIVTLENIDPS----LE 295
Cdd:pfam10165 122 AEAIEQILarHAKRYPDSSasSLSPMEDMALTETLKLLFNLTLFYPDLVPDSaFSPALPPILRLLLLLPIPSPDplepPL 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  296 QSAVDVIAVFPLSfelltpkiqhtekkdTNVIHGGRDMTFANAVLHALERRLEAeNNEKNELLGTFLTVLIRLSSQVKEA 375
Cdd:pfam10165 202 SHLINALLNLPLT---------------DSKKYEGNNMDVVERLLDLLDKRLDA-YDELDELLTPLLTLLTRLYEAAREV 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 307767648  376 RRYLRLLVIPPLHatDVERRPDDGIELRNRMIRLMMSIS--NIQDLAAEFIFILCKKSVNRFVKYCGFGHAAGLLANRGI 453
Cdd:pfam10165 266 RKYLRAKLLPPLK--DRKKRLEKGDTLRGRLLRLMTSPLtpRLKDAAAELLFVLCKEDASRFVKYVGYGNAAGFLANRGL 343

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 307767648  454 LNALNTPKHHSDSEASETEDYKAVETQVNPVTGCIDPAVE-NPFTGMTEEQKEYEVHRLMNDINKLM 519
Cdd:pfam10165 344 LGPGNAGEAYSSSEDSDTEEYKSAKRAINPITGQVEPPEPeNPMEEMTEEEKEREAERLFVLFDRLK 410
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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