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Conserved domains on  [gi|308153532|sp|Q8N8Z8|]
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RecName: Full=Zinc finger protein 441

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.17e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.17e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 308153532    3 SVAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNLDCIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-634 2.00e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 222 KPYEYEQCSTAFPAYSSTLRHERTHSGEKPYQCKQCGKAFSCS---CYTQLYERTHTGEQSYECKQCGKAFYHLGSFQRH 298
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 299 MIVHTGDGPHKCKICGKGFLSPSSVRRHKRTHTgeKPYECKYcgkafSDCTGFRRHMITHTG---DGPHKCKVCGKAFDS 375
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPL-----PGNNSSSVNTPQSNSlhpPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 376 PSLCRrHETTHTGEKPYKCECGKAFSDFYYFRNHETTHTGEKPYKCKQCGKAF----ICCTYLQI---HERIHTGERPYK 448
Cdd:COG5048  185 SLLIS-SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLsssDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 449 CKQcGKAFRSSNYIRVHEKTHTG-EKPYECKQCGKALSHLKSFQRHM--IMHTGDG--PHKCKI--CGKSFDSPSSFRRH 521
Cdd:COG5048  264 SLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 522 ERIHTGERPYKCKL--CGKGFRSSSYIQLHERTH-----TGEKPYGC--QQCGKALSDLSSFRRHMITHTGNGPH--KCK 590
Cdd:COG5048  343 ILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 308153532 591 ICGKGFDYPSSVQRHERTHTGEKPYECKECGKAFSHSSYLRIHE 634
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.17e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.17e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 308153532    3 SVAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNLDCIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 3.45e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 70.31  E-value: 3.45e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 308153532     4 VAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNLDCIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 4.52e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 4.52e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 308153532   4 VAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-634 2.00e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 222 KPYEYEQCSTAFPAYSSTLRHERTHSGEKPYQCKQCGKAFSCS---CYTQLYERTHTGEQSYECKQCGKAFYHLGSFQRH 298
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 299 MIVHTGDGPHKCKICGKGFLSPSSVRRHKRTHTgeKPYECKYcgkafSDCTGFRRHMITHTG---DGPHKCKVCGKAFDS 375
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPL-----PGNNSSSVNTPQSNSlhpPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 376 PSLCRrHETTHTGEKPYKCECGKAFSDFYYFRNHETTHTGEKPYKCKQCGKAF----ICCTYLQI---HERIHTGERPYK 448
Cdd:COG5048  185 SLLIS-SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLsssDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 449 CKQcGKAFRSSNYIRVHEKTHTG-EKPYECKQCGKALSHLKSFQRHM--IMHTGDG--PHKCKI--CGKSFDSPSSFRRH 521
Cdd:COG5048  264 SLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 522 ERIHTGERPYKCKL--CGKGFRSSSYIQLHERTH-----TGEKPYGC--QQCGKALSDLSSFRRHMITHTGNGPH--KCK 590
Cdd:COG5048  343 ILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 308153532 591 ICGKGFDYPSSVQRHERTHTGEKPYECKECGKAFSHSSYLRIHE 634
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-626 4.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 308153532  601 SVQRHERTHTGEKPYECKECGKAFSH 626
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.17e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.17e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 308153532    3 SVAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNLDCIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-44 3.45e-15

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 70.31  E-value: 3.45e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 308153532     4 VAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNLDCIG 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 4.52e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 4.52e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 308153532   4 VAFEDVAINFTCEEWALLGPSQKSLYRDVMQETIRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-634 2.00e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 222 KPYEYEQCSTAFPAYSSTLRHERTHSGEKPYQCKQCGKAFSCS---CYTQLYERTHTGEQSYECKQCGKAFYHLGSFQRH 298
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 299 MIVHTGDGPHKCKICGKGFLSPSSVRRHKRTHTgeKPYECKYcgkafSDCTGFRRHMITHTG---DGPHKCKVCGKAFDS 375
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPL-----PGNNSSSVNTPQSNSlhpPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 376 PSLCRrHETTHTGEKPYKCECGKAFSDFYYFRNHETTHTGEKPYKCKQCGKAF----ICCTYLQI---HERIHTGERPYK 448
Cdd:COG5048  185 SLLIS-SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLsssDSSSSASESPRS 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 449 CKQcGKAFRSSNYIRVHEKTHTG-EKPYECKQCGKALSHLKSFQRHM--IMHTGDG--PHKCKI--CGKSFDSPSSFRRH 521
Cdd:COG5048  264 SLP-TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESlkPFSCPYslCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 522 ERIHTGERPYKCKL--CGKGFRSSSYIQLHERTH-----TGEKPYGC--QQCGKALSDLSSFRRHMITHTGNGPH--KCK 590
Cdd:COG5048  343 ILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYncKNP 422

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 308153532 591 ICGKGFDYPSSVQRHERTHTGEKPYECKECGKAFSHSSYLRIHE 634
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-662 2.57e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 307 PHKCKICGKGFLSPSSVRRHKRTHTGEKPYECKY--CGKAFSDCTGFRRHMITHTGDGPHKCkvCGKAFDSPSLCRRHET 384
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 385 THTGEKPYKCE----CGKAFSDFYYFRNHETTHTGEKPYKCKQCGKAFI----------------------CCTYLQIHE 438
Cdd:COG5048  111 SSSSSNSNDNNllssHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 439 RIHTGERPYKCKQCGKAFRS---------SNYIRVHEKTHT----------------GEKPYECKQCGKALSHLKSFQRH 493
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSipssssdqnLENSSSSLPLTTnsqlspksllsqspssLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 494 ---------MIMHTGDG-PHKCKICGKSFDSPSSFRRHER--IHTGE--RPYKC--KLCGKGFRSSSYIQLHERTHTGEK 557
Cdd:COG5048  271 qssspnesdSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 558 PYGC--QQCGKALSDLSSFRRHMITHTGNGPHKCKI-------CGKGFDYPSSVQRHERTHTGEKPYECK--ECGKAFSH 626
Cdd:COG5048  351 PAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 308153532 627 SSYLRIHERVHTGEKPYKCKECGKPFHCPSAFHKHE 662
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
601-626 4.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 308153532  601 SVQRHERTHTGEKPYECKECGKAFSH 626
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-346 5.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.30e-04
                          10        20
                  ....*....|....*....|....*
gi 308153532  322 SVRRHKRTHTGEKPYECKYCGKAFS 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-458 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 308153532  433 YLQIHERIHTGERPYKCKQCGKAFRS 458
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
529-670 1.96e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308153532 529 RPYKCKLCGKGFRSSSYIQLHERTHTGEKPYGC--QQCGKALSDLSSFRRHMITHTGNGPHKCKICGKGFDYPSSVQRHE 606
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 308153532 607 RTHTGE-KPYECKECGKAFSHSSYLRIHERVHTGEKPYKCKEC-GKPFHCPSAFHKHERTHSMEKP 670
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS 177
zf-H2C2_2 pfam13465
Zinc-finger double domain;
241-263 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|...
gi 308153532  241 RHERTHSGEKPYQCKQCGKAFSC 263
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-542 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 308153532  517 SFRRHERIHTGERPYKCKLCGKGFRS 542
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
351-375 3.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.42e-03
                          10        20
                  ....*....|....*....|....*
gi 308153532  351 FRRHMITHTGDGPHKCKVCGKAFDS 375
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-514 4.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 308153532  489 SFQRHMIMHTGDGPHKCKICGKSFDS 514
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 6.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.05e-03
                          10        20
                  ....*....|....*....|....*.
gi 308153532  405 YFRNHETTHTGEKPYKCKQCGKAFIC 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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