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Conserved domains on  [gi|308259437|gb|EFP03390|]
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hypothetical protein CRE_09627 [Caenorhabditis remanei]

Protein Classification

T-box-containing protein( domain architecture ID 10468688)

T-box-containing protein may act as a transcriptional regulator involved in developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 9-183 9.16e-85

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


:

Pssm-ID: 459990  Cd Length: 182  Bit Score: 253.25  E-value: 9.16e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437    9 VSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRPIE 87
Cdd:pfam00907   1 VSLENKELWKKFHELgTEMIIT-KSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   88 RKLHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQRENAEK--------EEFRFGVTEFMAV 159
Cdd:pfam00907  80 VYIHPDSPATGSHWMKQPVSFDKLKLTNNK-EDKNGHIILNSMHKYQPRLHIVRVGGDEpslpeenvKTFVFPETEFIAV 158

                         170       180
                  ....*....|....*....|....
gi 308259437  160 TAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:pfam00907 159 TAYQNEEITQLKIDNNPFAKGFRD 182
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 210-320 2.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  210 YGSVTPPSApWTPPYNPLTPL-RYNNTPVapmyhMYPWQMPM--GMYPMFPPMSSGMAPGMAPGVPMNS-----SMPPVA 281
Cdd:TIGR01628 387 MGSPMGGAM-GQPPYYGQGPQqQFNGQPL-----GWPRMSMMptPMGPGGPLRPNGLAPMNAVRAPSRNaqnaaQKPPMQ 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 308259437  282 DVfQNQPAMQQNPIYMGMPMGQWNMGNGNGM-------ENRTPQSE 320
Cdd:TIGR01628 461 PV-MYPPNYQSLPLSQDLPQPQSTASQGGQNkklaqvlASATPQMQ 505
 
Name Accession Description Interval E-value
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 9-183 9.16e-85

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 253.25  E-value: 9.16e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437    9 VSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRPIE 87
Cdd:pfam00907   1 VSLENKELWKKFHELgTEMIIT-KSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   88 RKLHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQRENAEK--------EEFRFGVTEFMAV 159
Cdd:pfam00907  80 VYIHPDSPATGSHWMKQPVSFDKLKLTNNK-EDKNGHIILNSMHKYQPRLHIVRVGGDEpslpeenvKTFVFPETEFIAV 158

                         170       180
                  ....*....|....*....|....
gi 308259437  160 TAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:pfam00907 159 TAYQNEEITQLKIDNNPFAKGFRD 182
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 7-175 5.48e-79

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 238.26  E-value: 5.48e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEI-R 84
Cdd:cd00182    1 ITVSLRNEELWKKFHELgTEMIVT-KSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGKAEPPpE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  85 PIERKLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDAVLVQSMHKHIPVLSIQRENAEKE------EFRFGVTEFMA 158
Cdd:cd00182   80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKEDKKEGHILLHSMHKYIPVLTIYEVDDNGLlsklvkEFRFPETEFIA 159

                        170
                 ....*....|....*..
gi 308259437 159 VTAYQNKNIIQLKIEMN 175
Cdd:cd00182  160 VTAYQNDEITQLKIDNN 176
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
7-185 2.58e-67

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 209.05  E-value: 2.58e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437     7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:smart00425   1 IKVSLEDKELWRKFHELgTEMIVT-KSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437    86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPEmDKDD--AVLVQSMHKHIPVLSI-QRENAEKE------EFRFGVTEF 156
Cdd:smart00425  80 SRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQS-DKNGhlQIILNSMHKYQPRLHIvEVDDISKEilsqfkTFVFPETQF 158

                          170       180
                   ....*....|....*....|....*....
gi 308259437   157 MAVTAYQNKNIIQLKIEMNRFASGFKEDG 185
Cdd:smart00425 159 IAVTAYQNQKITKLKIDNNPFAKGFRDQG 187
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 210-320 2.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  210 YGSVTPPSApWTPPYNPLTPL-RYNNTPVapmyhMYPWQMPM--GMYPMFPPMSSGMAPGMAPGVPMNS-----SMPPVA 281
Cdd:TIGR01628 387 MGSPMGGAM-GQPPYYGQGPQqQFNGQPL-----GWPRMSMMptPMGPGGPLRPNGLAPMNAVRAPSRNaqnaaQKPPMQ 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 308259437  282 DVfQNQPAMQQNPIYMGMPMGQWNMGNGNGM-------ENRTPQSE 320
Cdd:TIGR01628 461 PV-MYPPNYQSLPLSQDLPQPQSTASQGGQNkklaqvlASATPQMQ 505
NABP pfam07990
Nucleic acid binding protein NABP; Many members of this family are putative nucleic acid ...
 266-323 2.74e-03

Nucleic acid binding protein NABP; Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterized and contains two putative phosphorylation sites and a possible dimerization / leucine zipper domain.


Pssm-ID: 400378  Cd Length: 387  Bit Score: 38.98  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308259437  266 GMA-PGVPMNSSM---PPVAD---VFQNQ-----PAMQQNpiYMGMPMGQWNMGNGNGMENRTPQS---EFPN 323
Cdd:pfam07990 308 GMPyPGSPLASPVlpsSPVGSgspVRQGErnmrfPSGMRN--STGGVMGSWHSDNGGNMEEGFASSlleEFKS 378
 
Name Accession Description Interval E-value
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 9-183 9.16e-85

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 253.25  E-value: 9.16e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437    9 VSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRPIE 87
Cdd:pfam00907   1 VSLENKELWKKFHELgTEMIIT-KSGRRMFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVVAGKAEPHSPPR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   88 RKLHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQRENAEK--------EEFRFGVTEFMAV 159
Cdd:pfam00907  80 VYIHPDSPATGSHWMKQPVSFDKLKLTNNK-EDKNGHIILNSMHKYQPRLHIVRVGGDEpslpeenvKTFVFPETEFIAV 158

                         170       180
                  ....*....|....*....|....
gi 308259437  160 TAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:pfam00907 159 TAYQNEEITQLKIDNNPFAKGFRD 182
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 7-175 5.48e-79

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 238.26  E-value: 5.48e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEI-R 84
Cdd:cd00182    1 ITVSLRNEELWKKFHELgTEMIVT-KSGRRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGKAEPPpE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  85 PIERKLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDAVLVQSMHKHIPVLSIQRENAEKE------EFRFGVTEFMA 158
Cdd:cd00182   80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKEDKKEGHILLHSMHKYIPVLTIYEVDDNGLlsklvkEFRFPETEFIA 159

                        170
                 ....*....|....*..
gi 308259437 159 VTAYQNKNIIQLKIEMN 175
Cdd:cd00182  160 VTAYQNDEITQLKIDNN 176
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
7-185 2.58e-67

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 209.05  E-value: 2.58e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437     7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:smart00425   1 IKVSLEDKELWRKFHELgTEMIVT-KSGRRMFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGKAEPHMP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437    86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPEmDKDD--AVLVQSMHKHIPVLSI-QRENAEKE------EFRFGVTEF 156
Cdd:smart00425  80 SRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQS-DKNGhlQIILNSMHKYQPRLHIvEVDDISKEilsqfkTFVFPETQF 158

                          170       180
                   ....*....|....*....|....*....
gi 308259437   157 MAVTAYQNKNIIQLKIEMNRFASGFKEDG 185
Cdd:smart00425 159 IAVTAYQNQKITKLKIDNNPFAKGFRDQG 187
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 7-183 1.70e-47

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 158.32  E-value: 1.70e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYK--FSVNKWKEFAKGDEI 83
Cdd:cd20682    1 IQVELCSRELWLQFHNLgNEMIIT-KAGRRMFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRyvYHSSKWVVAGSGDVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  84 RPIERKLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDAVLVQSMHKHIPVLSIQR------------ENAEKEEFRF 151
Cdd:cd20682   80 PPANRYIHPDSPASGKYWMSQIVSFDKLKLTNNKEPKQKGQISLHSMHKYQPRIHIQPveddgrnvekaiNSSKALSFEF 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 308259437 152 GVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20682  160 PETSFITVTAYQNQQITKLKIASNPFAKGFRD 191
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 7-183 2.08e-47

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 157.88  E-value: 2.08e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNK-WKEFAKGDEIR 84
Cdd:cd20681    1 VKVTLKNRDLWQQFHREgTEMIIT-KSGRRMFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYSGNGgWVPAGGAEPQP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  85 PIERK--LHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQREN-------AEKEEFRFGVTE 155
Cdd:cd20681   80 PLPRRiyIHPDSPATGDHWMSQPISFSKVKLTNNT-LDPQGNIVLTSMHKYQPRIHIVRCSdtlalpwAPTASFTFPETE 158

                        170       180
                 ....*....|....*....|....*...
gi 308259437 156 FMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20681  159 FIAVTAYQNERITKLKIDNNPFAKGFRE 186
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 7-183 1.10e-44

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 150.49  E-value: 1.10e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPMT-EMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20192    1 IRVTLEDRELWKKFHSLTnEMIVT-KSGRRMFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYVNGEWVPGGKAEPPPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNdpEMDKDDAVLVQSMHKHIPVLSIQRENAEKEE-----FRFGVTEFMAVT 160
Cdd:cd20192   80 SSVYVHPDSPNFGAHWMKGPVSFSKVKLTN--KPNGEGQIMLNSLHKYEPRVHIVRVGSNNHErlvstFSFPETQFIAVT 157

                        170       180
                 ....*....|....*....|...
gi 308259437 161 AYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20192  158 AYQNEEITALKIKYNPFAKAFLD 180
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 7-183 1.78e-44

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 150.28  E-value: 1.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20189    1 IKVFLENRELWQKFHEVgTEMIIT-KAGRRMFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKFHDSEWVVAGKAEPAMP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQRENAEKEE---------FRFGVTEF 156
Cdd:cd20189   80 GRLYVHPDSPATGAHWMRQLVSFQKLKLTNN-HLDQFGHIILNSMHKYQPRIHIVQADDNNAFgskntafstHVFPETAF 158

                        170       180
                 ....*....|....*....|....*..
gi 308259437 157 MAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20189  159 IAVTAYQNHQITQLKIENNPFAKGFRG 185
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 7-183 8.53e-43

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 146.04  E-value: 8.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20188    3 PKVELEAKDLWDQFHKLgTEMVIT-KSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPEmDKDDAVLVQSMHKHIPVLSIQREN-------AEKEEFRFGVTEFMA 158
Cdd:cd20188   82 KRMYIHPDSPSTGEQWMQKVVSFHKLKLTNNIS-DKHGFTILNSMHKYQPRFHIVRANdilklpySTFRTYVFKETEFIA 160

                        170       180
                 ....*....|....*....|....*
gi 308259437 159 VTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20188  161 VTAYQNEKITQLKIDNNPFAKGFRD 185
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 6-183 9.63e-43

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 146.03  E-value: 9.63e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   6 GVEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSV--NKWKEFAKGDE 82
Cdd:cd20187    1 NVTVQLEMKALWDEFNQLgTEMIVT-KAGRRMFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRYAFhsSSWLVAGKADP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  83 IRPIERKLHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQRENAEKEE----------FRFG 152
Cdd:cd20187   80 AMPGRIHVHPDSPAKGAQWMKQIVSFDKLKLTNNL-LDDNGHIILNSMHRYQPRFHVVYVDPRKDSensaeenfktFIFP 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 308259437 153 VTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20187  159 ETKFTAVTAYQNHRITQLKIASNPFAKGFRD 189
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 7-183 2.13e-42

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 144.98  E-value: 2.13e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20197    1 VRASLEDQDLWKKFHQIgTEMIIT-KSGRRMFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRYKWNKDQWEVAGKAEPQPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQREN-------AEKEEFRFGVTEFMA 158
Cdd:cd20197   80 CRTYVHPDSPAPGSHWMKQPISFQKLKLTNN-TLDQHGHIILHSMHRYQPRFHIVQADdlfnvrwSLFQVFSFPETVFTA 158

                        170       180
                 ....*....|....*....|....*
gi 308259437 159 VTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20197  159 VTAYQNEKITKLKIDNNPFAKGFRE 183
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 7-183 4.05e-42

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 144.11  E-value: 4.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20195    1 ITVTLENNSMWNEFYRCgTEMILT-KQGRRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEPHVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPeMDKDDAVLVQSMHKHIPVLSIQRENAEKEE----------FRFGVTE 155
Cdd:cd20195   80 GRVFIHPESPATGRHWMDQPVSFYKLKLTNNT-LDQEGHIILHSMHRYLPRLHVVPADKEVDViqlngpdvhtFTFPQTE 158

                        170       180
                 ....*....|....*....|....*...
gi 308259437 156 FMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20195  159 FFAVTAYQNKQITQLKIDYNPFAKGFRE 186
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 7-183 2.73e-41

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 141.94  E-value: 2.73e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20190    1 VSLSLEDRELWKEFSSVgTEMIIT-KSGRRMFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKWNKRRWEPSGKAEPHLP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQREN-------AEKEEFRFGVTEFMA 158
Cdd:cd20190   80 DRVYIHPDSPAPGAHWMRQPISFHKLKLTNN-TLDPHGHLILHSMHKYQPRIHLVQSAdlcsqhwGGMASFRFPETTFIA 158

                        170       180
                 ....*....|....*....|....*
gi 308259437 159 VTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20190  159 VTAYQNPQITKLKIAANPFAKGFRE 183
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 7-183 2.30e-39

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 136.92  E-value: 2.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWkEFAKGDEIRP 85
Cdd:cd20196    1 VRMSLENAELWKQFSSVgTEMIIT-KAGRRMFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRWQGNSW-EASGKAEPRL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IER-KLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQREN------AEKEEFRFGVTEFMA 158
Cdd:cd20196   79 PDRvYIHPDSPATGAHWMRQPISFHRAKLTNN-TLDPHGHIILHSMHRYQPRVHVVRARdvlswgGGCASFTFPETQFIT 157

                        170       180
                 ....*....|....*....|....*
gi 308259437 159 VTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20196  158 VTAYQNPKITQLKINSNPFAKGFRE 182
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 7-183 4.70e-39

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 136.41  E-value: 4.70e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNK--WKEFAKGDEI 83
Cdd:cd20193    1 VQCHLETKELWDKFHELgTEMIIT-KSGRRMFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRssWLVAGKADPP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  84 RPIERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQR--------ENAEKEEFR---FG 152
Cdd:cd20193   80 LPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNN-ELDKHGHIILNSMHKYQPRVHIVKkkdhtaslVNLKSEEFRtfiFP 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 308259437 153 VTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20193  159 ETVFTAVTAYQNQLITKLKIDSNPFAKGFRD 189
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 7-183 3.95e-37

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 131.44  E-value: 3.95e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHP-MTEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20194    2 ASVYLCNRDLWLKFHQhQTEMIIT-KQGRRMFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKFQSGKWVPCGKAEGLPQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IER-KLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDAVLvQSMHKHIPVLSI-------QRENAEKEEFRFGVTEFM 157
Cdd:cd20194   81 GNRvYVHPDSPNTGAHWMKQEISFSKLKLTNNKGADQGMIVL-NSMHKYQPRIHVievggngPNEQRNLQTHSFPETQFI 159

                        170       180
                 ....*....|....*....|....*.
gi 308259437 158 AVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20194  160 AVTAYQNTDITQLKIDHNPFAKGFRD 185
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 7-183 5.77e-37

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 131.23  E-value: 5.77e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHP-MTEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20203    2 LQVLLNNHPLWSKFHKhQTEMIIT-KQGRRMFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRYQGGKWVQCGKAEGNMP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IER-KLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDA--VLVQSMHKHIPVLSIQRENAEKEE----------FRFG 152
Cdd:cd20203   81 GNRlYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTqmIVLQSLHKYQPRLHIVEVKEGETEeayssskthtFTFP 160

                        170       180       190
                 ....*....|....*....|....*....|.
gi 308259437 153 VTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20203  161 ETQFIAVTAYQNAEITQLKIDHNPFAKGFRD 191
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 7-181 1.22e-34

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 124.77  E-value: 1.22e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPMT-EMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGDEIRP 85
Cdd:cd20202    2 LKVSLEESELWLRFKELTnEMIVT-KNGRRMFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVPGGKPEPQAP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNdpEMDKDDAVLVQSMHKHIPVLSIQRENAEKE---EFRFGVTEFMAVTAY 162
Cdd:cd20202   81 SCVYIHPDSPNFGAHWMKAPVSFSKVKLTN--KLNGGGQIMLNSLHKYEPRIHIVRVGGPQRmitSHSFPETQFIAVTAY 158

                        170
                 ....*....|....*....
gi 308259437 163 QNKNIIQLKIEMNRFASGF 181
Cdd:cd20202  159 QNEEITALKIKYNPFAKAF 177
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 7-183 2.20e-34

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 124.23  E-value: 2.20e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSV--NKWKEFAKGDEI 83
Cdd:cd20191    3 IQVELQGSELWKRFHDIgTEMIIT-KAGRRMFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYhsSKWMVAGNADAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  84 RPIERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQRENA--------------EKEEF 149
Cdd:cd20191   82 VPPRVYIHPDSPASGETWMRQVVSFDKLKLTNN-EMDDQGHIILHSMHKYQPRVHVIRKDSstdlspkkpvppgeGVKTF 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 308259437 150 RFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20191  161 SFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 194
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 8-183 1.55e-32

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 119.45  E-value: 1.55e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   8 EVSLSNQDQWEKFHP-MTEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGD-EIRP 85
Cdd:cd20204    3 QVYLCNRPLWLKFHRhQTEMIIT-KQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADtNVQG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDA--VLVQSMHKHIPVLSIQRENAEKEE----------FRFGV 153
Cdd:cd20204   82 NRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGqmVVLQSLHKYQPRLHVVEVNEDGTEdtsqpgrvqtFTFPE 161

                        170       180       190
                 ....*....|....*....|....*....|
gi 308259437 154 TEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20204  162 TQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 9-184 7.31e-32

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 118.27  E-value: 7.31e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   9 VSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWK------------ 75
Cdd:cd20683    3 LLLEDADLWAQFHSVqNEMIIT-KSGRCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFRNGRWNpidkdqrgddaf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  76 -EFAKGDEIRPIERKLHKDGWRLGGHWMENPVSFEYFKITND-----------------PEMDKDDAVLVQSMHKHIPVL 137
Cdd:cd20683   82 sSGTADKSVLLPESYIHPDGPQTGAFWMANGISFAKIKLSNRqpnssdrdgpkenitnsISALPDGHFFLTSFHKYQPRL 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 308259437 138 S-IQRENAEKEE-----FRFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKED 184
Cdd:cd20683  162 HlIQHSAGDHDDilsttFTFEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 7-183 1.10e-31

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 117.33  E-value: 1.10e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   7 VEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYK--FSVNKWKEFAKGDEI 83
Cdd:cd20200    3 VQVELQGSELWKRFHEIgTEMIIT-KAGRRMFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRyvYHSSQWMVAGNTDHS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  84 RPIER-KLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQRENAEKE-------------EF 149
Cdd:cd20200   82 CITPRlYVHPDSPCSGETWMRQIISFDRVKLTNN-EMDDKGHIILQSMHKYKPRVHVILQDSRFDlsqiqslpaegvkTF 160

                        170       180       190
                 ....*....|....*....|....*....|....
gi 308259437 150 RFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20200  161 SFPETEFTTVTAYQNQQITKLKIDRNPFAKGFRD 194
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 8-183 2.11e-31

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 116.70  E-value: 2.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   8 EVSLSNQDQWEKFHP-MTEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGD-EIRP 85
Cdd:cd20205    3 QVYLCNRPLWLKFHRhQTEMIIT-KQGRRMFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADnNMQG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  86 IERKLHKDGWRLGGHWMENPVSFEYFKITNDPEMDKDDA--VLVQSMHKHIPVLSI----------QRENAEKEEFRFGV 153
Cdd:cd20205   82 NKVYVHPESPNTGAHWMRQEISFGKLKLTNNKGANNNNTqmIVLQSLHKYQPRLHIvevsedgvedLNDSSKTQTFTFPE 161

                        170       180       190
                 ....*....|....*....|....*....|
gi 308259437 154 TEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20205  162 NQFIAVTAYQNTDITQLKIDHNPFAKGFRD 191
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 3-181 3.35e-31

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 115.90  E-value: 3.35e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   3 TPSGVEVSLSNQDQWEKFHPMT-EMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYKFSVNKWKEFAKGD 81
Cdd:cd20201    2 TEKQLQVSLEDAELWQRFKEVTnEMIVT-KNGRRMFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYVNGEWVPAGKPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  82 EIRPIERKLHKDGWRLGGHWMENPVSFEYFKITNdpEMDKDDAVLVQSMHKHIPVLSIQRENAEKE---EFRFGVTEFMA 158
Cdd:cd20201   81 PHSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTN--KLNGGGQIMLNSLHKYEPQIHIVRVGGPHRmvtNCSFPETQFIA 158

                        170       180
                 ....*....|....*....|...
gi 308259437 159 VTAYQNKNIIQLKIEMNRFASGF 181
Cdd:cd20201  159 VTAYQNEEITALKIKYNPFAKAF 181
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 1-183 7.18e-31

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 115.21  E-value: 7.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   1 MTTPSGVEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYK--FSVNKWKEF 77
Cdd:cd20198    1 TSSMEEIQVELQCADLWKRFHDIgTEMIIT-KAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  78 AKGDEIRPIERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQRENAEKE---------- 147
Cdd:cd20198   80 GNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNN-ELDDQGHIILHSMHKYQPRVHVIRKDFSSDlsptkpvptg 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 308259437 148 ----EFRFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20198  159 dgvkTFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 198
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 4-183 2.50e-30

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 113.99  E-value: 2.50e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437   4 PSGVEVSLSNQDQWEKFHPM-TEMVVTrKAGRRLFPHLKYILKGLDPDAKYGLFLHFERMDNIKYK--FSVNKWKEFAKG 80
Cdd:cd20199    1 GEEVRVDLQGADLWKRFHEIgTEMIIT-KAGRRMFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRyvYHSSKWMVAGNA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  81 DEIRPIERKLHKDGWRLGGHWMENPVSFEYFKITNDpEMDKDDAVLVQSMHKHIPVLSIQRENAEKE------------- 147
Cdd:cd20199   80 DSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNN-ELDDQGHIILHSMHKYQPRVHVIRKECGEElspvkpipsgegv 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 308259437 148 -EFRFGVTEFMAVTAYQNKNIIQLKIEMNRFASGFKE 183
Cdd:cd20199  159 kAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGFRD 195
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 210-320 2.20e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.79  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 308259437  210 YGSVTPPSApWTPPYNPLTPL-RYNNTPVapmyhMYPWQMPM--GMYPMFPPMSSGMAPGMAPGVPMNS-----SMPPVA 281
Cdd:TIGR01628 387 MGSPMGGAM-GQPPYYGQGPQqQFNGQPL-----GWPRMSMMptPMGPGGPLRPNGLAPMNAVRAPSRNaqnaaQKPPMQ 460

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 308259437  282 DVfQNQPAMQQNPIYMGMPMGQWNMGNGNGM-------ENRTPQSE 320
Cdd:TIGR01628 461 PV-MYPPNYQSLPLSQDLPQPQSTASQGGQNkklaqvlASATPQMQ 505
NABP pfam07990
Nucleic acid binding protein NABP; Many members of this family are putative nucleic acid ...
 266-323 2.74e-03

Nucleic acid binding protein NABP; Many members of this family are putative nucleic acid binding proteins. One member of this family has been partially characterized and contains two putative phosphorylation sites and a possible dimerization / leucine zipper domain.


Pssm-ID: 400378  Cd Length: 387  Bit Score: 38.98  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 308259437  266 GMA-PGVPMNSSM---PPVAD---VFQNQ-----PAMQQNpiYMGMPMGQWNMGNGNGMENRTPQS---EFPN 323
Cdd:pfam07990 308 GMPyPGSPLASPVlpsSPVGSgspVRQGErnmrfPSGMRN--STGGVMGSWHSDNGGNMEEGFASSlleEFKS 378
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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