NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|311352298|gb|ADP93334|]
View 

DNA recombinase protein RecA, partial [Clostridium perfringens]

Protein Classification

DNA recombination/repair protein RecA( domain architecture ID 1000164)

DNA recombination/repair protein RecA catalyzes an ATP-dependent DNA strand-exchange reaction, which is a critical step in the repair of DNA double-strand breaks by homologous recombination

Gene Ontology:  GO:0005524|GO:0006310|GO:0006281
PubMed:  31100988

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
recA super family cl35814
recombinase A; Provisional
 1-188 8.71e-151

recombinase A; Provisional


The actual alignment was detected with superfamily member PRK09354:

Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 421.12  E-value: 8.71e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:PRK09354 102 PVYAKKLGVDIDNLLVSQPDTGEQALEIADTLVRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:PRK09354 182 NISKSNTTVIFINQIREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTIKDGDEVIGNRTKVKVVKNKVAPPFKQAEF 261

                        170       180
                 ....*....|....*....|....*...
gi 311352298 161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:PRK09354 262 DIMYGEGISREGELIDLGVELGIIEKSG 289
 
Name Accession Description Interval E-value
recA PRK09354
recombinase A; Provisional
 1-188 8.71e-151

recombinase A; Provisional


Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 421.12  E-value: 8.71e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:PRK09354 102 PVYAKKLGVDIDNLLVSQPDTGEQALEIADTLVRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:PRK09354 182 NISKSNTTVIFINQIREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTIKDGDEVIGNRTKVKVVKNKVAPPFKQAEF 261

                        170       180
                 ....*....|....*....|....*...
gi 311352298 161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:PRK09354 262 DIMYGEGISREGELIDLGVELGIIEKSG 289
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
1-188 6.73e-149

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 416.49  E-value: 6.73e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:COG0468  105 PEYAKKLGVDIDNLLVSQPDTGEQALEIAETLVRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:COG0468  185 AISKSNTTVIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTIKDGDEVIGNRTRVKVVKNKVAPPFKEAEF 264

                        170       180
                 ....*....|....*....|....*...
gi 311352298 161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:COG0468  265 DIMYGEGISKEGELLDLAVELGIIEKSG 292
tigrfam_recA TIGR02012
protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization ...
 1-188 1.67e-132

protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization of homolgous regions of DNA. A segment of ssDNA can be hybridized to another ssDNA region, or to a dsDNA region. ATP is hydrolyzed in the process. Part of the SOS respones, it is regulated by LexA via autocatalytic cleavage. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 162659 [Multi-domain]  Cd Length: 321  Bit Score: 374.01  E-value: 1.67e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298    1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:TIGR02012  97 PVYARKLGVDIDNLLVSQPDTGEQALEIAETLVRSGAVDIIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:TIGR02012 177 ALSKSNTTAIFINQIREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTVKQGEEVVGNRTKVKVVKNKVAPPFREAEF 256

                         170       180
                  ....*....|....*....|....*...
gi 311352298  161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:TIGR02012 257 DILYGEGISKLGEIIDLAVELDIIKKSG 284
RecA cd00983
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-170 1.36e-122

recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.


Pssm-ID: 410863 [Multi-domain]  Cd Length: 235  Bit Score: 345.31  E-value: 1.36e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:cd00983   66 PEYAKKLGVDIDNLLVSQPDTGEQALEIADTLIRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:cd00983  146 SLSKSKTTVIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRIELIKEGEDVIGNRTKVKVVKNKVAPPFKQAEF 225

                        170
                 ....*....|
gi 311352298 161 DIMYNEGISK 170
Cdd:cd00983  226 DILYGEGISR 235
RecA pfam00154
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA ...
 1-169 6.41e-122

recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyzes an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.


Pssm-ID: 425488 [Multi-domain]  Cd Length: 262  Bit Score: 344.77  E-value: 6.41e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298    1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:pfam00154  94 PVYAKKLGVDIDNLLVSQPDTGEQALEIADMLVRSGAIDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:pfam00154 174 SISKSNTTVIFINQIREKIGVMFGNPETTTGGRALKFYASVRLDIRRIGQIKQGEEVIGNKTKVKVVKNKVAPPFKEAEF 253


                  ....*....
gi 311352298  161 DIMYNEGIS 169
Cdd:pfam00154 254 DIMYGEGIS 262
 
Name Accession Description Interval E-value
recA PRK09354
recombinase A; Provisional
 1-188 8.71e-151

recombinase A; Provisional


Pssm-ID: 236476 [Multi-domain]  Cd Length: 349  Bit Score: 421.12  E-value: 8.71e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:PRK09354 102 PVYAKKLGVDIDNLLVSQPDTGEQALEIADTLVRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:PRK09354 182 NISKSNTTVIFINQIREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTIKDGDEVIGNRTKVKVVKNKVAPPFKQAEF 261

                        170       180
                 ....*....|....*....|....*...
gi 311352298 161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:PRK09354 262 DIMYGEGISREGELIDLGVELGIIEKSG 289
RecA COG0468
RecA/RadA recombinase [Replication, recombination and repair];
1-188 6.73e-149

RecA/RadA recombinase [Replication, recombination and repair];


Pssm-ID: 440236 [Multi-domain]  Cd Length: 351  Bit Score: 416.49  E-value: 6.73e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:COG0468  105 PEYAKKLGVDIDNLLVSQPDTGEQALEIAETLVRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:COG0468  185 AISKSNTTVIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTIKDGDEVIGNRTRVKVVKNKVAPPFKEAEF 264

                        170       180
                 ....*....|....*....|....*...
gi 311352298 161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:COG0468  265 DIMYGEGISKEGELLDLAVELGIIEKSG 292
tigrfam_recA TIGR02012
protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization ...
 1-188 1.67e-132

protein RecA; This model describes orthologs of the recA protein. RecA promotes hybridization of homolgous regions of DNA. A segment of ssDNA can be hybridized to another ssDNA region, or to a dsDNA region. ATP is hydrolyzed in the process. Part of the SOS respones, it is regulated by LexA via autocatalytic cleavage. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 162659 [Multi-domain]  Cd Length: 321  Bit Score: 374.01  E-value: 1.67e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298    1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:TIGR02012  97 PVYARKLGVDIDNLLVSQPDTGEQALEIAETLVRSGAVDIIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:TIGR02012 177 ALSKSNTTAIFINQIREKIGVMFGNPETTTGGNALKFYASVRLDIRRIGTVKQGEEVVGNRTKVKVVKNKVAPPFREAEF 256

                         170       180
                  ....*....|....*....|....*...
gi 311352298  161 DIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:TIGR02012 257 DILYGEGISKLGEIIDLAVELDIIKKSG 284
RecA cd00983
recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 1-170 1.36e-122

recombinase A; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange.


Pssm-ID: 410863 [Multi-domain]  Cd Length: 235  Bit Score: 345.31  E-value: 1.36e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:cd00983   66 PEYAKKLGVDIDNLLVSQPDTGEQALEIADTLIRSGAVDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:cd00983  146 SLSKSKTTVIFINQLREKIGVMFGNPETTTGGNALKFYASVRLDIRRIELIKEGEDVIGNRTKVKVVKNKVAPPFKQAEF 225

                        170
                 ....*....|
gi 311352298 161 DIMYNEGISK 170
Cdd:cd00983  226 DILYGEGISR 235
RecA pfam00154
recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA ...
 1-169 6.41e-122

recA bacterial DNA recombination protein; RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyzes an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination.


Pssm-ID: 425488 [Multi-domain]  Cd Length: 262  Bit Score: 344.77  E-value: 6.41e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298    1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:pfam00154  94 PVYAKKLGVDIDNLLVSQPDTGEQALEIADMLVRSGAIDLIVVDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTG 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNKVAPPFKQAEF 160
Cdd:pfam00154 174 SISKSNTTVIFINQIREKIGVMFGNPETTTGGRALKFYASVRLDIRRIGQIKQGEEVIGNKTKVKVVKNKVAPPFKEAEF 253


                  ....*....
gi 311352298  161 DIMYNEGIS 169
Cdd:pfam00154 254 DIMYGEGIS 262
recA PRK09519
intein-containing recombinase RecA;
1-150 2.06e-76

intein-containing recombinase RecA;


Pssm-ID: 77219 [Multi-domain]  Cd Length: 790  Bit Score: 243.46  E-value: 2.06e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   1 PVYAKRLGVNIDDLVVSQPDTGEQALEITEALVRSGAIDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTG 80
Cdd:PRK09519 102 PDYAKKLGVDTDSLLVSQPDTGEQALEIADMLIRSGALDIVVIDSVAALVPRAELEGEMGDSHVGLQARLMSQALRKMTG 181

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  81 TINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKFYASVRMDIRRIDSIKQGDGITGNRTRVKIVKNK 150
Cdd:PRK09519 182 ALNNSGTTAIFINQLRDKIGVMFGSPETTTGGKALKFYASVRMDVRRVETLKDGTNAVGNRTRVKVVKNK 251
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
 7-127 7.85e-32

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 113.22  E-value: 7.85e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298   7 LGVNIDDLVVSQPDTGEQALEITEALVRSGA----IDVLVVDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKLTGTI 82
Cdd:cd01393   60 LAEALSRLLYFRPPDTLAHLLALDSLPESLFpppnTSLVVVDSVSALFRKAFPRGGDGDSSSSLRARLLSQLARALQKLA 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 311352298  83 NKSNCVVIFINQLREKVGIMFG-NPETTPGGRALKFYASVRMDIRR 127
Cdd:cd01393  140 AQFNLAVVVTNQVTTKIRGGSGaSLVPPALGNTWEHSVSTRLLLYR 185
recA PRK09519
intein-containing recombinase RecA;
146-188 4.10e-11

intein-containing recombinase RecA;


Pssm-ID: 77219 [Multi-domain]  Cd Length: 790  Bit Score: 60.88  E-value: 4.10e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 311352298 146 IVKNKVAPPFKQAEFDIMYNEGISKEGNIVDVGVKENIVQKSG 188
Cdd:PRK09519 687 VVVHNCSPPFKQAEFDILYGKGISREGSLIDMGVDQGLIRKSG 729
archRadB cd01394
archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional ...
 11-162 8.13e-06

archaeal RadB; The archaeal protein RadB shares similarity RadA, the archaeal functional homologue to the bacterial RecA. The precise function of RadB is unclear.


Pssm-ID: 410882 [Multi-domain]  Cd Length: 216  Bit Score: 44.61  E-value: 8.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  11 IDDLVVSQP-DTGEQALEI--TEALVRSGAIDVLVVDSVAALVpRAEiegEMGDShvGLQARLMSQaLRKLTGTINKSNC 87
Cdd:cd01394   75 ASNIIVFEPySFDEQGVAIqeAEKLLKSDKVDLVVVDSATALY-RLE---LGDDS--EANRELSRQ-MSKLLSIARKYDI 147

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 311352298  88 VVIFINQlrekVGIMFGNPETTP-GGRALKfYASvrMDIRRIDsiKQGDGitgnRTRVKIVKNKVAPPFKQAEFDI 162
Cdd:cd01394  148 PVVITNQ----VYSDIDDDRLKPvGGTLLE-HWS--KAIIRLE--KSPPG----LRRATLEKHRSRPEGQSAGFRI 210
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
 31-100 1.20e-04

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 41.51  E-value: 1.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  31 ALVRSGAIDVLVVDSVAALVpRAEIEGEMGDShvGLQARLMSQALRKLTGTINKSNCVVIFINQLREKVG 100
Cdd:cd19491  107 ALLERGPIRLVVIDSIAALF-RSEFDTSRSDL--VERAKYLRRLADHLKRLADKYNLAVVVVNQVTDRFD 173
archRadA cd19515
archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a ...
 38-127 2.18e-03

archaeal recombinase Rad51/RadA; This group includes the archaeal protein RadA which is a homolog of Rad51. RAD51 recombinase plays an essential role in DNA repair by homologous recombination (HR)


Pssm-ID: 410923 [Multi-domain]  Cd Length: 233  Bit Score: 37.73  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  38 IDVLVVDSVAALVpRAEIegeMGDSHVGLQARLMSQALRKLTGTINKSNCVVIFINQLREKVGIMFGNPETTPGGRALKF 117
Cdd:cd19515  116 IKLLIVDSLTSHF-RAEY---VGRGTLAERQQKLNKHLHDLHRLADLYNIAVLVTNQVMAKPDAFFGDPTQAIGGHILGH 191

                         90
                 ....*....|
gi 311352298 118 YASVRMDIRR 127
Cdd:cd19515  192 AATFRVYLRK 201
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 30-116 3.53e-03

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 35.94  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  30 EALVRSGAIDVLVVDSVAALVPRAEiegemgdshvGLQARLMSQALRKLTGTINKSNCVVIFINQLREKVGIMFGNPETT 109
Cdd:cd01120   43 EDLIEEKKLDIIIIDSLSSLARASQ----------GDRSSELLEDLAKLLRAARNTGITVIATIHSDKFDIDRGGSSNDE 112


                 ....*..
gi 311352298 110 PGGRALK 116
Cdd:cd01120  113 RLLKSLR 119
radA PRK04301
DNA repair and recombination protein RadA; Validated
 38-127 6.78e-03

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 36.39  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311352298  38 IDVLVVDSVAALVpRAEiegemgdsHVGL------QARLMsQALRKLTGTINKSNCVVIFINQLREKVGIMFGNPETTPG 111
Cdd:PRK04301 199 IKLVIVDSLTAHF-RAE--------YVGRgnlaerQQKLN-KHLHDLLRLADLYNAAVVVTNQVMARPDAFFGDPTQPIG 268

                         90
                 ....*....|....*.
gi 311352298 112 GRALKFYASVRMDIRR 127
Cdd:PRK04301 269 GHILGHTATFRIYLRK 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH