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Conserved domains on  [gi|31542331|ref|NP_001545|]
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CCN family member 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
229-272 2.13e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 436914  Cd Length: 44  Bit Score: 77.69  E-value: 2.13e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 31542331   229 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 272
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNEECKLVTETRLCQLRPC 44
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
293-375 2.78e-13

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member pfam00007:

Pssm-ID: 451304  Cd Length: 105  Bit Score: 65.50  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542331   293 PEPVRFTYAGCLSVKKYRPKYC-GSCV-------DGR-------CCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNy 357
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86
                          90
                  ....*....|....*...
gi 31542331   358 NCPHANEAAFPFYRLFND 375
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.15e-10

Insulin-like growth factor binding protein;


:

Pssm-ID: 425534  Cd Length: 53  Bit Score: 55.04  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31542331    26 CPAAC---HCPLEAPKCAPGVglVRDGCGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPRCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 4.66e-09

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.66e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542331    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
229-272 2.13e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 436914  Cd Length: 44  Bit Score: 77.69  E-value: 2.13e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 31542331   229 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 272
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNEECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
293-375 2.78e-13

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 65.50  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542331   293 PEPVRFTYAGCLSVKKYRPKYC-GSCV-------DGR-------CCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNy 357
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86
                          90
                  ....*....|....*...
gi 31542331   358 NCPHANEAAFPFYRLFND 375
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
292-360 1.15e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.41  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542331    292 SPEPVRFTYAGCLSVKkYRPKYC-GSCVD------------GRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYN 358
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80

                   ..
gi 31542331    359 CP 360
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.15e-10

Insulin-like growth factor binding protein;


Pssm-ID: 425534  Cd Length: 53  Bit Score: 55.04  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31542331    26 CPAAC---HCPLEAPKCAPGVglVRDGCGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPRCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 4.66e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.66e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542331    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
100-160 6.22e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.96  E-value: 6.22e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31542331   100 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNPRLVKVTGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
32-84 1.47e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 48.23  E-value: 1.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 31542331     32 CPLEAPKCApgVGLVRDGCGCCKVCAKQLNEDCSK-TQPCdhTKGLECNFGASS 84
Cdd:smart00121  11 CPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGVyTPRC--APGLRCQPPPGE 60
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
232-272 7.88e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 7.88e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 31542331    232 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 272
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
229-272 2.13e-18

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 436914  Cd Length: 44  Bit Score: 77.69  E-value: 2.13e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 31542331   229 CIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPC 272
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNEECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
293-375 2.78e-13

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 65.50  E-value: 2.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542331   293 PEPVRFTYAGCLSVKKYRPKYC-GSCV-------DGR-------CCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNy 357
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86
                          90
                  ....*....|....*...
gi 31542331   358 NCPHANEAAFPFYRLFND 375
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDS 104
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
292-360 1.15e-10

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 57.41  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542331    292 SPEPVRFTYAGCLSVKkYRPKYC-GSCVD------------GRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYN 358
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80

                   ..
gi 31542331    359 CP 360
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.15e-10

Insulin-like growth factor binding protein;


Pssm-ID: 425534  Cd Length: 53  Bit Score: 55.04  E-value: 3.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31542331    26 CPAAC---HCPLEAPKCAPGVglVRDGCGCCKVCAKQLNEDCS-KTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPRCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 4.66e-09

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 52.13  E-value: 4.66e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31542331    100 CEYNSRIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPNPRLVKVTGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
100-160 6.22e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.96  E-value: 6.22e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31542331   100 CEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPNPRLVKVTGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
32-84 1.47e-07

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 48.23  E-value: 1.47e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 31542331     32 CPLEAPKCApgVGLVRDGCGCCKVCAKQLNEDCSK-TQPCdhTKGLECNFGASS 84
Cdd:smart00121  11 CPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGVyTPRC--APGLRCQPPPGE 60
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
234-272 7.78e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 436909 [Multi-domain]  Cd Length: 52  Bit Score: 37.25  E-value: 7.78e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 31542331   234 TSWSQCSKTCGTGISTRV-------TNDNPECRLVKETRICEVRPC 272
Cdd:pfam19028   7 SEWSECSKTCGGGVQTRTrtiivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
232-272 7.88e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.18  E-value: 7.88e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 31542331    232 QTTSWSQCSKTCGTGISTRV--------TNDNPECR-LVKETRICEVRPC 272
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
233-272 1.29e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 408800 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31542331   233 TTSWSQCSKTCGTGISTRV----------TNDNPECRLVK---ETRICEVRPC 272
Cdd:pfam19030   3 AGPWGECSVTCGGGVQTRLvqcvqklggsLVPDSQCSAQKkppETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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