|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
7-547 |
0e+00 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 1100.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 7 MYDREFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDS 86
Cdd:PLN02590 1 MYDREFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 87 PQDFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGF 166
Cdd:PLN02590 81 PQDFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 167 TWLTSPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQT 246
Cdd:PLN02590 161 TWLTSPAATELEIIVLDWLAKLLQLPDHFLSTG--NGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 247 HSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGI 326
Cdd:PLN02590 239 HSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 327 WLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNY 406
Cdd:PLN02590 319 WLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 407 KDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAPVDGDEDQCNER 486
Cdd:PLN02590 399 KDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAPVDGDEDQCNER 478
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187001 487 NRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHASKFTRNDHY 547
Cdd:PLN02590 479 NRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHASKFTRNDHY 539
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
65-538 |
4.96e-154 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 448.51 E-value: 4.96e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 65 LREQGHIMVDFIADYYKNLqdspqDFPVLSQvQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYA 144
Cdd:COG0076 2 FRALLHQALDLAADYLAGL-----DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 145 SSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFlstgkgngGGVIQGTGCEAVLVVVLAARD 224
Cdd:COG0076 76 GGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA--------GGVFTSGGTEANLLALLAARD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 225 RILKKVGKTL----LPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFIC 300
Cdd:COG0076 148 RALARRVRAEglpgAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDE--DGRMDPDALEAAIDEDRAAGLNPIAVV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 301 ATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRY 380
Cdd:COG0076 226 ATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 381 SLIDALKTNPEYLEfkvSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEV 460
Cdd:COG0076 306 LLREAFSFHASYLG---PADDGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFEL 382
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334187001 461 VTTRYFSLVCFRLAPVDGDEDqcNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHA 538
Cdd:COG0076 383 LAPPELNIVCFRYKPAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAA 458
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
98-473 |
5.63e-135 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 396.79 E-value: 5.63e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 98 PGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 177
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 178 EIIVLDWLAKLLQLPDHFLSTGkgnGGGVIQGTGCEAVLVVVLAARDRILKKV---GK-----TLLPQLVVYGSDQTHSS 249
Cdd:pfam00282 81 ENVVMNWLGEMLGLPAEFLGQE---GGGVLQPGSSESNLLALLAARTKWIKRMkaaGKpadssGILAKLVAYTSDQAHSS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 250 FRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLH 329
Cdd:pfam00282 158 IEKAALYGGV---KLREIPSDD--NGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLH 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 330 VDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDtvvnYKDW 409
Cdd:pfam00282 233 VDAAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAYD----TGHK 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187001 410 QISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRL 473
Cdd:pfam00282 309 QIPLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRL 372
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
139-537 |
1.30e-111 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 335.71 E-value: 1.30e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 139 YFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflstgkGNGGGVIQGTGCEAVLVV 218
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPS-------EDADGVFTSGGSESNLLA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 219 VLAARDRILKKVGKTL---LPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFI 295
Cdd:cd06450 74 LLAARDRARKRLKAGGgrgIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDE--DGRMDPEALEAAIDEDKAEGLN 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 296 PFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLW 375
Cdd:cd06450 149 PIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 376 VkdryslidalktnpeylefkvskkdtvvnykdwqislsrrfRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQD 455
Cdd:cd06450 229 V-----------------------------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 456 PSFEVVTTRYFSLVCFRLAPvdgdEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQ 535
Cdd:cd06450 268 PGFELLGEPNLSLVCFRLKP----SVKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLEDIE 343
|
..
gi 334187001 536 KH 537
Cdd:cd06450 344 RA 345
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
7-547 |
0e+00 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 1100.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 7 MYDREFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDS 86
Cdd:PLN02590 1 MYDREFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 87 PQDFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGF 166
Cdd:PLN02590 81 PQDFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 167 TWLTSPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQT 246
Cdd:PLN02590 161 TWLTSPAATELEIIVLDWLAKLLQLPDHFLSTG--NGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 247 HSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGI 326
Cdd:PLN02590 239 HSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 327 WLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNY 406
Cdd:PLN02590 319 WLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDTVVNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 407 KDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAPVDGDEDQCNER 486
Cdd:PLN02590 399 KDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAPVDGDEDQCNER 478
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187001 487 NRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHASKFTRNDHY 547
Cdd:PLN02590 479 NRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHASKFTRNDHY 539
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
57-540 |
0e+00 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 825.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 57 MKPMDSELLREQGHIMVDFIADYYKNLQDspqdFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQS 136
Cdd:PLN02880 7 LRPMDAEQLRECGHRMVDFIADYYKSIEN----FPVLSQVQPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 137 PSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVL 216
Cdd:PLN02880 83 PNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLAKLLNLPEQFLSTG--NGGGVIQGTASEAVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 217 VVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIP 296
Cdd:PLN02880 161 VVLLAARDRVLRKVGKNALEKLVVYASDQTHSALQKACQIAGIHPENCRLLKTDSSTNYALAPELLSEAISTDLSSGLIP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 297 FFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWV 376
Cdd:PLN02880 241 FFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 377 KDRYSLIDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDP 456
Cdd:PLN02880 321 KDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGRRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 457 SFEVVTTRYFSLVCFRLAPVDGDEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQK 536
Cdd:PLN02880 401 RFEVVTPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAVNSSGKIFISHTVLSGKYVLRFAVGAPLTEERHVTAAWKVLQD 480
|
....
gi 334187001 537 HASK 540
Cdd:PLN02880 481 EASK 484
|
|
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
65-538 |
4.96e-154 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 448.51 E-value: 4.96e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 65 LREQGHIMVDFIADYYKNLqdspqDFPVLSQvQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYA 144
Cdd:COG0076 2 FRALLHQALDLAADYLAGL-----DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 145 SSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFlstgkgngGGVIQGTGCEAVLVVVLAARD 224
Cdd:COG0076 76 GGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA--------GGVFTSGGTEANLLALLAARD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 225 RILKKVGKTL----LPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFIC 300
Cdd:COG0076 148 RALARRVRAEglpgAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDE--DGRMDPDALEAAIDEDRAAGLNPIAVV 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 301 ATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRY 380
Cdd:COG0076 226 ATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 381 SLIDALKTNPEYLEfkvSKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEV 460
Cdd:COG0076 306 LLREAFSFHASYLG---PADDGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFEL 382
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 334187001 461 VTTRYFSLVCFRLAPVDGDEDqcNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQKHA 538
Cdd:COG0076 383 LAPPELNIVCFRYKPAGLDEE--DALNYALRDRLRARGRAFLSPTKLDGRVVLRLVVLNPRTTEDDVDALLDDLREAA 458
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
98-473 |
5.63e-135 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 396.79 E-value: 5.63e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 98 PGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 177
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 178 EIIVLDWLAKLLQLPDHFLSTGkgnGGGVIQGTGCEAVLVVVLAARDRILKKV---GK-----TLLPQLVVYGSDQTHSS 249
Cdd:pfam00282 81 ENVVMNWLGEMLGLPAEFLGQE---GGGVLQPGSSESNLLALLAARTKWIKRMkaaGKpadssGILAKLVAYTSDQAHSS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 250 FRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLH 329
Cdd:pfam00282 158 IEKAALYGGV---KLREIPSDD--NGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLH 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 330 VDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSKKDtvvnYKDW 409
Cdd:pfam00282 233 VDAAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAYD----TGHK 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 334187001 410 QISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRL 473
Cdd:pfam00282 309 QIPLSRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRL 372
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
139-537 |
1.30e-111 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 335.71 E-value: 1.30e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 139 YFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflstgkGNGGGVIQGTGCEAVLVV 218
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPS-------EDADGVFTSGGSESNLLA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 219 VLAARDRILKKVGKTL---LPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFI 295
Cdd:cd06450 74 LLAARDRARKRLKAGGgrgIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDE--DGRMDPEALEAAIDEDKAEGLN 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 296 PFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLW 375
Cdd:cd06450 149 PIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 376 VkdryslidalktnpeylefkvskkdtvvnykdwqislsrrfRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQD 455
Cdd:cd06450 229 V-----------------------------------------RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRAD 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 456 PSFEVVTTRYFSLVCFRLAPvdgdEDQCNERNRELLAAVNSTGKIFISHTALSGKFVLRFAVGAPLTEEKHVTEAWQIIQ 535
Cdd:cd06450 268 PGFELLGEPNLSLVCFRLKP----SVKLDELNYDLSDRLNERGGWHVPATTLGGPNVLRFVVTNPLTTRDDADALLEDIE 343
|
..
gi 334187001 536 KH 537
Cdd:cd06450 344 RA 345
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
174-377 |
6.16e-19 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 84.36 E-value: 6.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 174 ATELEiivlDWLAKLLQlpdhflstgKGNGGGVIQGTGCEAVLVVVLAArdrilkkvgktLLPQLVVYGSDQTHSSFRKA 253
Cdd:cd01494 2 LEELE----EKLARLLQ---------PGNDKAVFVPSGTGANEAALLAL-----------LGPGDEVIVDANGHGSRYWV 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 254 clIGGIHEENIRLLKTDsstNYGMPPESLEEAIshDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAA 333
Cdd:cd01494 58 --AAELAGAKPVPVPVD---DAGYGGLDVAILE--ELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAA 130
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 334187001 334 YAGNACICPEYRKFIDGienADSFNMNAHKWLFANQtCSPLWVK 377
Cdd:cd01494 131 SAGGASPAPGVLIPEGG---ADVVTFSLHKNLGGEG-GGVVIVK 170
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
176-450 |
1.77e-12 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 68.92 E-value: 1.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 176 ELEIIVLDWLAKLLQLPDHflstgkgNGGGVIQGTGCEAVLVVVLAARDrilkkvgktLLPQLVVYGSDQTHSSFRKACL 255
Cdd:PRK02769 65 DFERDVMNFFAELFKIPFN-------ESWGYITNGGTEGNLYGCYLARE---------LFPDGTLYYSKDTHYSVSKIAR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 256 IGGIHEENIRllktdSSTNYGMPPESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYGI---WLHVDA 332
Cdd:PRK02769 129 LLRIKSRVIT-----SLPNGEIDYDDLISKIKENKNQ---PPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 333 AYAGnACIC-----PEYrKFIDGIenaDSFNMNAHKWLFANQTCSPLWVKDRYslIDALKTNPEYlefkVSKKDTVvnyk 407
Cdd:PRK02769 201 ALSG-MILPfvnnpPPF-SFADGI---DSIAISGHKFIGSPMPCGIVLAKKKY--VERISVDVDY----IGSRDQT---- 265
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 334187001 408 dwqISLSRR-FRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFED 450
Cdd:PRK02769 266 ---ISGSRNgHTALLLWAAIRSLGSKGLRQRVQHCLDMAQYAVD 306
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
176-440 |
4.09e-06 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 49.05 E-value: 4.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 176 ELEIIVLDWLAKLLQL-PDHFLstgkgnggGVIQGTGCEAVLVVVLAARDRilkkvgktlLPQLVVYGSDQTHSSFRKAC 254
Cdd:PLN03032 66 QFEVGVLDWFARLWELeKDEYW--------GYITTCGTEGNLHGILVGREV---------FPDGILYASRESHYSVFKAA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 255 LIGGIHEENIRLLKTdSSTNYgmppESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYGI-----WLH 329
Cdd:PLN03032 129 RMYRMEAVKVPTLPS-GEIDY----DDLERALAKNRDK---PAILNVNIGTTVKGAVDDLDRILRILKELGYtedrfYIH 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 330 VDAAYAGNAC----ICPE--YRKFIdgienaDSFNMNAHKWLFANQTCSPLWVKDRYslIDALKTNPEYLefkvskkdtv 403
Cdd:PLN03032 201 CDGALFGLMMpfvsRAPEvtFRKPI------GSVSVSGHKFLGCPMPCGVALTRKKH--VKALSQNVEYL---------- 262
|
250 260 270
....*....|....*....|....*....|....*...
gi 334187001 404 vNYKDWQISLSRRFRS-LKLWMVLRLYGsenLRNFIRD 440
Cdd:PLN03032 263 -NSRDATIMGSRNGHApLYLWYTLRRKG---YRGIKRD 296
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
206-368 |
3.73e-05 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 45.67 E-value: 3.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 206 VIQGTGCEAVLVVVLAARdrilkkvgktllPQLVVYGsDQTHSSF---RKACLIGGIHeenIRLLKTDSSTNygMPPESL 282
Cdd:pfam01212 53 VPSGTAANQLALMAHCQR------------GDEVICG-EPAHIHFdetGGHAELGGVQ---PRPLDGDEAGN--MDLEDL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 283 EEAISHDLAKGFIPF-FICATVgTTSSAAVDPlVPLGN------IAKKYGIWLHVDAAYAGNACI---CP--EYRKFidg 350
Cdd:pfam01212 115 EAAIREVGADIFPPTgLISLEN-THNSAGGQV-VSLENlreiaaLAREHGIPVHLDGARFANAAValgVIvkEITSY--- 189
|
170
....*....|....*...
gi 334187001 351 ienADSFNMNAHKWLFAN 368
Cdd:pfam01212 190 ---ADSVTMCLSKGLGAP 204
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
176-393 |
8.61e-05 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 45.19 E-value: 8.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 176 ELEIIVLDWLAKLLQLpdhflstGKGNGGGVIQGTGCEAVLVVVLaardrilkkVGKTLLPQLVVYGSDQTHSSFRKACL 255
Cdd:PLN02263 133 QFEVGVLDWFARLWEI-------EKNEYWGYITNCGTEGNLHGIL---------VGREVFPDGILYASRESHYSVFKAAR 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 256 IggiheENIRLLKTDSSTNYGMPPESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYG-----IWLHV 330
Cdd:PLN02263 197 M-----YRMECVKVDTLVSGEIDCADFKAKLLANKDK---PAIINVNIGTTVKGAVDDLDLVIKTLEECGfsqdrFYIHC 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 334187001 331 DAAYAGnaCICP--------EYRKFIdgienaDSFNMNAHKWLFANQTCSPlwVKDRYSLIDALKTNPEYL 393
Cdd:PLN02263 269 DGALFG--LMMPfvkrapkvTFKKPI------GSVSVSGHKFVGCPMPCGV--QITRMEHINVLSSNVEYL 329
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
204-372 |
5.59e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 39.21 E-value: 5.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 204 GGVIQGTGCEAVLVVVLAArdrilkkvgkTLLPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSSTNYGMPPESLE 283
Cdd:pfam00155 64 AAVVFGSGAGANIEALIFL----------LANPGDAILVPAPTYASYIRIARLAGG---EVVRYPLYDSNDFHLDFDALE 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187001 284 EAIShDLAKGFI---PFFICATVgttssAAVDPLVPLGNIAKKYGIWLHVDAAYAGNAcicpeyrkFIDGIENADSFNMN 360
Cdd:pfam00155 131 AALK-EKPKVVLhtsPHNPTGTV-----ATLEELEKLLDLAKEHNILLLVDEAYAGFV--------FGSPDAVATRALLA 196
|
170
....*....|..
gi 334187001 361 AHKWLFANQTCS 372
Cdd:pfam00155 197 EGPNLLVVGSFS 208
|
|
| |
